Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， category: indole-building-block, Which mentioned a new discovery about 1011-65-0
A photoinduced procedure for the 1,4-addition of indoles to enones is described. This reaction occurs with modest to excellent yield for cyclic and some acyclic enones. This reaction is experimentally simple, requiring only irradiation (UVA lamps, ca. 350 nm) of the reagents in a CH2Cl 2 solution at room temperature, and avoids the necessity to use a Lewis acid. An important solvent effect was noticed, with CH2Cl 2 and CHCl3 being the optimal solvents. Various substituents are tolerated on the indole moiciy and an electronic trend was noticed, as electron-withdrawing groups can suppress this reaction. A mechanism involving single electron transfer between the enone triplet excited state and the indole is proposed and accounts for all experimental observations.
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Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles