Day: November 19, 2020

52562-50-2, 5-Methyl-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: (i) Preparation of the imines The aldehydes (0.20mmol) and 1,2-diaminoanthraquinone (0.24mmol) were dissolved separately in ethanol (4ml/mmol). The ethanolic solution of aldehyde and formic acid (0.04 ml/mmol of aldehyde) was added to the solution of 1,2-diaminoanthraquinone heated at reflux. The reaction mixture was heated under reflux overnight. (ii) Cyclisation of the imines After cooling, the ethanolic solution was evaporated and the crude imine was dissolved in a small volume of acetic acid (5 ml/mmol of imine). To this solution, lead tetraacetate was added (0.20mmol) and the mixture was stirred overnight at room temperature. Addition of water to the reaction mixture gave a solid which was isolated by filtration and purified by recrystalisation from diethyl ether/chloroform., 52562-50-2

52562-50-2 5-Methyl-1H-indole-3-carbaldehyde 259187, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Batista, Rosa M.F.; Oliveira, Elisabete; Costa, Susana P.G.; Lodeiro, Carlos; Raposo, M. Manuela M.; Supramolecular Chemistry; vol. 26; 2; (2014); p. 71 – 80;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348640-06-2,4-Bromo-7-azaindole,as a common compound, the synthetic route is as follows.

A solution of 4-bromo-lH-pyrrolo[2,3-b]pyridine (LXXIV) (10 g, 50.8 mmol, 1.0 eq) in anhydrous THF (150 mL) was degassed (x 3) with a water pump, then cooled to 0C under Ar. NaH (60% in mineral oil) (2.436 g, 60.9 mmol, 1.2 eq) was added portion wise slowly under Ar. The reaction was stirred at 0C for 30 min. (2- (chloromethoxy)ethyl)trimethylsilane (10.15 g, 60.9 mmol, 1.2 eq) was added dropwise slowly. The reaction was stirred at room temperature for 2.5 h. The reaction mixture was added water (2 inL) then was concentrated in vacuo and water (50 inL) was added and extracted with EtOAc (x 3). The organic layer was washed with brine and dried over Na2S04. Flash chromatography (PE:ETOAc=10: 1) gave 4-bromo-l-((2-(trimethylsilyl)ethoxy)methyl)-lH-pyrrolo[2,3-b]pyridine (LXXXVII) as a yellow oil (14.38 g, 43.9 mmol, 86.6% yield). ESIMS found for Ci3Hi9BrN2OSi mlz 327.0 (M+H)., 348640-06-2

As the paragraph descriping shows that 348640-06-2 is playing an increasingly important role.

Reference£º
Patent; SAMUMED, LLC.; KC, Sunil Kumar; WALLACE, David Mark; CAO, Jianguo; CHIRUTA, Chandramouli; HOOD, John; (253 pag.)WO2017/23996; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

942-26-7, 5-Chlorotryptamine hydrochloride is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,942-26-7

General procedure: A flask was charged with 5-chlorotryptamine hydrochloride (5 g, 0.0649 mol), 0.5 M hydrochloric acid(130 mL), and the substituted benzaldehyde (1.5 eq). The mixture was refluxed for 14 hr, cooled to roomtemperature, and vacuum filtered. The solid was resuspended in acetic acid (100 mL), stirred for 1 hr, andvacuum filtered. The solid was resuspended in ethyl acetate (100 mL), stirred for 1 hr, and vacuumfiltered to obtain the pure scaffold as a solid.

942-26-7 5-Chlorotryptamine hydrochloride 2827494, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Tikhmyanova, Nadezhda; Paparoidamis, Nicholas; Romero-Masters; Feng, Xin; Mohammed, Farheen Sultana; Reddy, Poli Adi Narayana; Kenney, Shannon C.; Lieberman, Paul M.; Salvino, Joseph M.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 16; (2019); p. 2259 – 2264;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.245-08-9,5H-Pyrido[3,2-b]indole,as a common compound, the synthetic route is as follows.,245-08-9

The compound a or b (5 g, 0.03 mol), 1, 3-dibromo benzene (2.8 g, 0.012 mol), copper iodide(1.04 g, 5.46 mmol), trans-1,2-diaminocyclohexane (1.33 g,10.92 mmol), and potassium phosphate tribasic (7.64 g, 0.036 mol) were dissolved in 1,4-dioxane (100 ml) and under N2 atmosphere. The mixture was allowed to stir at 110C for 48 h. After being cooled to room temperature, the mixture was diluted with THF. The copper catalyst and inorganic were removed by filtration under reduced pressure and the residue washed with dichloromethan(CH2Cl2), The organic layer was extracted with water and then CH2Cl2 was evaporated. The residue was recrystallized by CH2Cl2. The compound 1-4 were obtained as powder. 1,3-Bis(5H-pyrido[3,2-b]indol-5-yl)benzene (mCdP) (1) Yield:47% 1H NMR (500 MHz, CDCl3, ppm) delta 7.36 (2H, dd, J = 4.5 Hz, J = 8.5 Hz), 7.42 (2H, m), 7.58(4H, m), 7.72 (2H, dd, J = 2.0 Hz, J = 8.0 Hz), 7.80 (3H, m), 7.90 (1H, t, J = 8.0 Hz), 8.46(2H, d, J = 7.5 Hz), 8.64 (2H, dd, J = 1.5 Hz, J = 4.5 Hz). 13C NMR (125 MHz, CDCl3, ppm)delta 109.8, 116.6, 120.4, 121.1, 121.4, 122.8, 124.6, 125.8, 128.3, 131.6, 134.0, 138.7, 141.2, 142.5,143.0. EI-Mass (m/z): 410 [M+]

As the paragraph descriping shows that 245-08-9 is playing an increasingly important role.

Reference£º
Article; Wang, Hedan; Zhu, Jun; Shen, Bowen; Wei, Bin; Wang, Zixing; Molecular Crystals and Liquid Crystals; vol. 651; 1; (2017); p. 133 – 141;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91348-45-7,Ethyl 3-bromo-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.

91348-45-7, Intermediate 22a : Ethyl 3-bromo-1 -{[4′-(methoxycarbonyl)-4- methylbiphenyl-3-yl]methyl}-1 H-indole-2-carboxylateTo 68.3 g (0.266 mol) of methyl 3′-(hydroxymethyl)-4′-methylbiphenyl- 4-carboxylate in 1.0 L EtOAc was added at 100C 20.5 ml_ (0.280 mol) SOCI2 and 1 ml_ pyridine. The solution was then stirred at room temperature for 12 hrs then washed with 500 ml_ 1.0 N HCI (aq), 500 ml_ sat. NaHCO3 (aq) and 500 ml_ brine then dried over Na2SO4 and concentrated. To 750 mg (2.71 mmol) of this residue was added 660mg (2.46 mmol) of ethyl 3-bromo-1 H- indole-2-carboxylate in 8 ml_ DMF followed by 850 mg (6.16 mmol) K2CO3 and the mixture stirred at 7O0C for 4 hrs. The solution was cooled and 100 ml_ EtOAc was added. The solution was washed with three 25 ml_ portions of H2O and 25 ml_ brine then dried over Na2SO4, concentrated, and purified by silica gel chromatography (120 grams of silica gel eluting with 0-20% EtOAc in hexanes over 45 minutes) to give 1.02 g (82%) of ethyl 3-bromo-1 -{[4′- (methoxycarbonyl)-4-methylbiphenyl-3-yl]methyl}-1H-indole-2-carboxylate as white solid: 1 H NMR (400 MHz, CDCI3). delta 7.93 (d, 2H, J = 8.5 Hz), 7.74 (d, 1 H, J = 7.9 Hz), 7.40-7.22 (m, 7H), 6.54 (s, 1 H), 5.79 (s, 2H), 4.34 (q, 2H, J = 7.4 Hz), 3.87 (s, 3H), 2.46 (s, 3H), 1.32 (t, 3H, J = 7.4 Hz)

As the paragraph descriping shows that 91348-45-7 is playing an increasingly important role.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORAITON; OPLINGER, Jeffrey Alan; WO2008/28118; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.199526-97-1,4,6-Difluoroindole,as a common compound, the synthetic route is as follows.

d. EXAMPLE 4: 2-((1-(3-BROMOBENZYL)-4,6-DIFLUORO-1H-INDOL-3- YL)SULFONYL)-N-(PYRIDIN-2-YL)ACETAMIDE; [00443] Example 4 was prepared according to the following scheme.[00444] Step A. To a solution of 4,6-diflouro-indole (15.6 g, 0.102 mol) and methyl thioglycolate (9.1 mL, 0.102 mol) in methanol: water (240mL : 60 mL) was added iodine (26.0 g, 0.102 mmol) and potassium iodide (17.0 g, 0.102 mmol). The reaction mixture was stirred at ambient temperature for 60 hours. Methanol was removed in vacuo and the aqueous layer diluted with a saturated solution of sodium bicarbonate and extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, evaporated in vacuo and the resulting residue was purified on a silica gel column (0-100% ethyl acetate:hexanes over 48 min) to afford the desired product (20. lg, 76% yield). 1H NMR (400 MHz, DMSOD6) 11.74 (s, 1H), 7.51 (d, J = 2.4 Hz, 1H), 7.09 (dd, J = 2.0, 9.6 Hz, 1H), 6.90-6.85 (m, 1H), 3.54 (s, 3H), 3.51 (s, 2H).

199526-97-1, As the paragraph descriping shows that 199526-97-1 is playing an increasingly important role.

Reference£º
Patent; VANDERBILT UNIVERSITY; LINDSLEY, Craig, W.; CONN, P., Jeffrey; WOOD, Michael, R.; TARR, James, C.; BRIDGES, Thomas, M.; WO2011/163280; (2011); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

933-67-5, 7-Methyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

10 mL of Schlenk tube was added Eosin Y (0.01 mmol), sodium trifluoromethanesulfinate (0.3 mmol), triphenylphosphine(0.6 mmol), N-chlorophthalimide (0.3 mmol), evacuated and washed into dry nitrogen (this procedure was repeated three times)7-methylindole (0.2 mmol) was dissolved in the ultra-dry solvent acetonitrile and the resulting solution was passed through a syringe into a Schlenk tube. Room temperature, The reaction was allowed to stand under a white LED lamp and stirred for 6 hours. After completion of the reaction, the solvent was evaporated and the residue was passed through the residuePurification by silica gel column chromatography gave 40 mg of product, yield 87%.

933-67-5, The synthetic route of 933-67-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nanjing University of Science and Technology; Cai Chun; Bu Meijie; (9 pag.)CN106748608; (2017); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20289-26-3,4-Benzyloxyindole,as a common compound, the synthetic route is as follows.

EXAMPLE 17; 2-Amino-4-(3-bromo-4,5-dimethoxyphenyl)-3-cyano-7-hydroxymethyl-4H-pyrrolo[2,3-h]chromene; a) 1-Hydroxymethyl-4-hydroxy-indole:; A solution of 4-benzyloxyindole (1.0 g, 4.48 mmol), formaldehyde (2.0 mL, 26.8 mmol) and 2 N NaOH (2.24 mL, 4.48 mmol) in 10 mL EtOH was stirred at the room temperature for 4 h. The solvent was removed in vacuo. The crude material was purified by flash column chromatography (3:1, hexane:ethyl acetate) to yield 1.13 g of 4-benzyloxy-1-hydroxymethylindole, which was hydrogenated by 5% Pd/C in 40 mL methanol under H2 (50 psi) to yield 580 mg (79.5%) of the title compound. 1H NMR (CDCl3): 7.15-7.07 (m, 3H), 6.60-6.55 (m, 2H), 5.62 (d, J=7.5 Hz, 2H), 4.93 (s, 1H), 2.37 (t, J=7.2 Hz, 1H).

20289-26-3, The synthetic route of 20289-26-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Cytovia, Inc.; US2006/104998; (2006); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1670-83-3,Indole-7-carboxylic acid,as a common compound, the synthetic route is as follows.,1670-83-3

Example 73; Preparation of 1H-Indole-7-carboxylic acid butyl-(4-tert-butyl-benzyl)-amide 77; To a solution of 110 mg of 1H-indole-7-carboxylic acid (0.68 mmol) and 220 mg of TBTU (0.68 mmol) in 10 ml DMF, were added 0.59 ml (3.42 mmol) of N,N-diisopropylethyl amine. After stirring for 5 min at rt, 150 mg (0.68 mmol) of butyl-(4-tert-butyl-benzyl)-amine were added. After stirring for 2 h at rt, the reaction mixture was diluted with 100 ml water and extracted twice with EtOAc. The combined organic phases were washed with water and brine, dried with magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography (8 g silica gel; heptane/EtOAc 2:1) to give 209 mg (82%) of a light yellow viscous oil. MS (EI) 362.2 (M)+.

As the paragraph descriping shows that 1670-83-3 is playing an increasingly important role.

Reference£º
Patent; Conte-Mayweg, Aurelia; Kuehne, Holger; Luebbers, Thomas; Maugeais, Cyrille; Mueller, Werner; Pflieger, Philippe; US2006/30613; (2006); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

467451-91-8, 6-(Trifluoromethoxy)-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,467451-91-8

Oxalyl chloride (0.19 ml, 2.2 mmol, 1.1 eq) was added to (4) (0.40 g, 2.0 mmol, 1.0 eq) in Et2O (5 ml) at O0C. The reaction was allowed to reach room temperature and stirred for 4 h after which time the product was isolated by filtration. The filtrate was evaporated to give further product. The product was washed with Et2O (2 x 10ml) to provide (5) as a yellow solid (0.58 mg, 2.0 mmol, 100%).

467451-91-8 6-(Trifluoromethoxy)-1H-indole 22048958, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; LECTUS THERAPEUTICS LIMITED; KHAN, Nawaz Mohammed; BURCKHARDT, Svenja; CANSFIELD, Julie Elaine; VO, Ngoc-Tri; ARMER, Richard Edward; BOFFEY, Raymond John; WO2010/1179; (2010); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles