Day: October 9, 2021

Recently I am researching about CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ONE-POT SYNTHESIS; DERIVATIVES; EFFICIENT; INHIBITION; DIVERSITY; ALDEHYDES; ACID, Saw an article supported by the NIT Patna [EMR/2016/000960]; Department of Science and Technology, IndiaDepartment of Science & Technology (India) [EMR/2016/000960]. Published in SPRINGER in DORDRECHT ,Authors: Kumari, P; Bharti, R; Parvin, T. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Category: indole-building-block

An efficient, mild and environmentally benign protocol has been developed for the synthesis of aminouracil-tethered tri-substituted methane derivatives. The three-component reaction of 2-hydroxy-1,4-naphthaquinone, 6-amino-1,3-dimethyluracil and aldehydes in the presence of molecular iodine as catalyst under reflux conditions resulted in aminouracil-tethered tri-substituted methane derivatives 4 in aqueous medium. Similarly, the four-component reaction of 2-hydroxy-1,4-naphthaquinone, o-phenylenediamine, aldehydes and aminouracil derivatives resulted in aminouracil-tethered tri-substituted methane derivatives 6 under the same reaction conditions. The notable features of this protocol are simple experimental procedure, cheap catalyst, readily available starting materials, moderate-to-good yields of the products having biologically active important moieties such as aminouracil, hydroxy-naphthaquinone/benzophenazine. [GRAPHICS] .

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Kumari, P; Bharti, R; Parvin, T or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Atomically Dispersed Ru on Manganese Oxide Catalyst Boosts Oxidative Cyanation published in 2020.0. HPLC of Formula: C7H8O, Reprint Addresses Wang, L; Xiao, FS (corresponding author), Zhejiang Univ, Key Lab Biomass Chem Engn, Minist Educ, Coll Chem & Biol Engn, Hangzhou 310027, Peoples R China.; Yang, B (corresponding author), ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China.; Xiao, FS (corresponding author), Zhejiang Univ, Key Lab Appl Chem Zhejiang Prov, Dept Chem, Hangzhou 310027, Peoples R China.; Xiao, FS (corresponding author), Beijing Univ Chem Technol, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, Beijing 100029, Peoples R China.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

There is a strong incentive for environmentally benign and sustainable production of organic nitriles to avoid the use of toxic cyanides. Here we report that manganese oxide nanorod-supported single-site Ru catalysts are active, selective, and stable for oxidative cyanation of various alcohols to give the corresponding nitriles with molecular oxygen and ammonia as the reactants. The very low amount of Ru (0.1 wt %) with atomic dispersion boosts the catalytic performance of manganese oxides. Experimental and theoretical results show how the Ru sites enhance the ammonia resistance of the catalyst, bolstering its performance in alcohol dehydrogenation and oxygen activation, the key steps in the oxidative cyanation. This investigation demonstrates the high efficiency of a single-site Ru catalyst for nitrile production.

HPLC of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Wang, H; Xu, DY; Guan, EJ; Wang, L; Zhang, J; Wang, CT; Wang, S; Xu, H; Meng, XJ; Yang, B; Gates, BC; Xiao, FS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article A Thieno[2,3-d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D-2 Receptor WOS:000455561400011 published article about LIGAND DISCOVERY; D-3; PHARMACOLOGY; SELECTIVITY; INHIBITORS; SB269652; D2 in [Fyfe, Tim J.; Scammells, Peter J.; Capuano, Ben] Monash Univ, Med Chem, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia; [Fyfe, Tim J.; Lim, Herman D.; Lane, J. Robert] Monash Univ, Monash Inst Pharmaceut Sci, Drug Discovery Biol, Parkville, Vic 3052, Australia; [Fyfe, Tim J.; Kellam, Barrie; Mistry, Shailesh N.] Univ Nottingham, Ctr Biomol Sci, Sch Pharm, Nottingham NG7 2RD, England; [Zarzycka, Barbara; Katrich, Vsevolod] Univ Southern Calif, Bridge Inst, Dept Biol Sci, Los Angeles, CA 90089 USA; [Katrich, Vsevolod] Univ Southern Calif, Bridge Inst, Dept Chem, Los Angeles, CA 90089 USA in 2019, Cited 41. Category: indole-building-block. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

Recently, a novel negative allosteric modulator (NAM) of the D-2-like dopamine receptors 1 was identified through virtual ligand screening. This ligand comprises a thieno[2,3-d]pyrimidine scaffold that does not feature in known dopaminergic ligands. Herein, we provide pharmacological validation of an allosteric mode of action for 1, revealing that it is a NAM of dopamine efficacy and identify the structural determinants of this allostery. We find that key structural moieties are important for functional affinity and negative cooperativity, while functionalization of the thienopyrimidine at the 5- and 6-positions results in analogues with divergent cooperativity profiles. Successive compound iterations have yielded analogues exhibiting a 10-fold improvement in functional affinity, as well as enhanced negative cooperativity with dopamine affinity and efficacy. Furthermore, our study reveals a fragment-like core that maintains low mu M affinity and robust negative cooperativity with markedly improved ligand efficiency.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Fyfe, TJ; Zarzycka, B; Lim, HD; Kellam, B; Mistry, SN; Katrich, V; Scammells, PJ; Lane, JR; Capuano, B or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Reddy, VG; Jampaiah, D; Chalkidis, A; Sabri, YM; Mayes, ELH; Bhargava, SK in [Reddy, Velma Ganga; Jampaiah, Deshetti; Chalkidis, Anastasios; Sabri, Ylias M.; Bhargava, Suresh K.] RMIT Univ, Sch Sci, CAMIC, GPO Box 2476, Melbourne, Vic 3001, Australia; [Mayes, Edwin L. H.] RMIT Univ, RMMF, GPO Box 2476, Melbourne, Vic 3001, Australia published Highly dispersed cobalt oxide nanoparticles on manganese oxide nanotubes for aerobic oxidation of benzyl alcohol in 2019.0, Cited 34.0. Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Hybrid Co3O4/MnO2 nanotube-based catalysts were prepared by a simple hydrothermal synthesis method. The physico-chemical properties of Co3O4/MnO2 catalyst were then studied by different characterization techniques, namely, SEM, TEM and HR-TEM, XRD, BET surface area, XPS and H-2-TPR. The hybrid catalyst showed superior catalytic performance toward benzyl alcohol oxidation than pure MnO2 nanotubes and Co3O4 nanoparticles. The uniform dispersion of Co3O4 nanoparticles, good redox behaviour, the variable oxidation states of manganese and cobalt (Mn3+/4+ or Co3+/2+) as well as the abundance of active surface oxygen species were responsible for such a high catalytic activity.

About Benzyl Alcohol, If you have any questions, you can contact Reddy, VG; Jampaiah, D; Chalkidis, A; Sabri, YM; Mayes, ELH; Bhargava, SK or concate me.. Formula: C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about PHARMACOKINETICS; ANESTHESIA; SAFETY, Saw an article supported by the Key Research AMP; Development Projects of the Department of Science AMP; Technology of Sichuan Province [2019YFS0093]. HPLC of Formula: C7H8O. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Liu, LQ; Hong, PX; Song, XH; Zhou, CC; Ling, R; Kang, Y; Qi, QR; Yang, J. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

In this work, a series of water-soluble propofol prodrugs were synthesized, and their propofol release rate and pharmacodynamic characteristics were measured. We found that inserting glycolic acid as a linker between propofol and the cyclic amino acid accelerated the release of propofol from prodrugs into the plasma while preserving its safety. In animal experiments, prodrugs (3e, 3g, and 3j) were significantly better than fospropofol (the only water-soluble propofol prodrug that has been used clinically) in terms of safety, onset, and duration time of anesthesia. Their molar dose, onset time, and anesthesia duration time were comparable to those of propofol, helping to maintain the clinical benefits of propofol. The experimental results showed the potential of such compounds as water-soluble prodrugs of propofol.

HPLC of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Liu, LQ; Hong, PX; Song, XH; Zhou, CC; Ling, R; Kang, Y; Qi, QR; Yang, J or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Gein, VL; Pastukhova, EV in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Gein, V. L.; Pastukhova, E. V.] Perm State Pharmaceut Acad, Perm 614990, Russia in 2021, Cited 5. HPLC of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A series of new 1-aminocarbonylmethyl-5-aryl-4-aroyl-3-hydroxy-3-pyrrolin-2-ones has been synthesized through a three-component reaction of aroylpyruvic acid methyl ester with a mixture of aromatic aldehyde and glycinamide hydrochloride in glacial acetic acid in the presence of anhydrous sodium bicarbonate.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Gein, VL; Pastukhova, EV or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Thermal Coursed Effect of Comprehensive Changes in the Flavor/Taste of Cynanchi wilfordii WOS:000488796100001 published article about TONGUE; NOSE in [Kim, Da-som; Lee, Jookyeong Tracy; Hong, Seong Jun; Cho, Jin-Ju; Shin, Eui-Cheol] Gyeongnam Natl Univ Sci & Technol, Dept Food Sci, Jinju 52725, South Korea in 2019.0, Cited 32.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Quality Control of 4′-Hydroxyacetophenone

This study aims to investigate alterations in volatile compounds and chemical components that may affect the sensory properties of Cynanchi wilfordii roasted at 120 degrees C and 180 degrees C for various durations of time (0 to 4 min). For volatile compound profiles, tridecane, tetradecane, and ethyl hexyl ether were detected as major compounds of the sample without roasting. As the roasting temperature increased, the types of volatile compounds increased, whereas the content decreased with an increase in heterocyclic compound generation. The sample roasted at 120 degrees C for 1 min showed a notably different profile pattern from the other roasted samples. For the sniffing test performed by trained panelists using gas chromatography olfactometry, naphthalene and nonanal, which induce spicy and raw C. wilfordii, respectively, were perceived most intensely throughout all the samples. In the electronic tongue analysis, the sample roasting at 180 degrees C showed an increased and decreased pattern in umami taste and saltiness, respectively, with increased roasting time. Electronic tongue analysis results showed that the sample roasted at 180 degrees C for 4 min would have the best sensory preference. Along with the volatile compound profiles, the sample roasted at 120 degrees C for 1 min had more sourness than the other samples, and would potentially have distinctive sensory characteristics. This study should provide baseline data on variations in the sensory properties and industrial applications of C. wilfordii upon roasting. Practical Application Various applications of food ingredients through changes in sensory characteristics by roasting will provide consumers more options for food selections. Accordingly, this study will be utilized by (1) individuals and food companies who are interested in functional foods, (2) individuals and food industries that seek optimum roasting conditions for proper sensory characteristics of foods, and (3) farmers and crop producers who seek for utilization the applications of Cynanchi wilfordii as a food ingredient.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Kim, DS; Lee, JT; Hong, SJ; Cho, JJ; Shin, EC or concate me.. Quality Control of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article A new antifungal aminobenzamide derivative from the endophytic fungus Fusarium sp. WOS:000468924000005 published article about TETRACYCLIC TRITERPENOIDS; FUSARITHIOAMIDE; BUTYROLACTONES in [Ibrahim, Sabrin R. M.; Al Haidari, Rwaida A.; Zayed, Mohamed F.] Taibah Univ, Coll Pharm, Dept Pharmacognosy & Pharmaceut Chem, Al Madinah Al Munawwarah, Saudi Arabia; [Ibrahim, Sabrin R. M.] Assiut Univ, Fac Pharm, Dept Pharmacognosy, Assiut, Egypt; [Mohamed, Gamal A.] King Abdulaziz Univ, Fac Pharm, Dept Nat Prod & Alternat Med, Jeddah, Saudi Arabia; [Mohamed, Gamal A.] Al Azhar Univ, Assiut Branch, Fac Pharm, Dept Pharmacognosy, Assiut, Egypt; [Khayat, Maan T.] King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut Chem, Jeddah, Saudi Arabia; [El-Kholy, Amal A.] Taibah Univ, Coll Pharm, Dept Clin & Hosp Pharm, Al Madinah Al Munawwarah, Saudi Arabia; [El-Kholy, Amal A.] Ain Shams Univ, Dept Clin Pharm, Fac Pharm, Cairo, Egypt; [Zayed, Mohamed F.] Al Azhar Univ, Dept Pharmaceut Chem, Fac Pharm, Cairo, Egypt in 2019.0, Cited 17.0. Quality Control of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Background: Endophytic fungi attracted attention as a prolific source of bioactive natural products with a potent pharmaceutical activity and unique structure. Objective: The main goal of the study is to separate and identify the bioactive constituents from the endophytic fungus Fusarium sp. as well as to evaluate the antimicrobial of the new metabolites. Materials and Methods: The fungus was cultured on a rice medium, and then, the cultures were extracted with ethyl acetate (EtOAc). The EtOAc extract was chromatographed utilizing different chromatographic methods to give five metabolites. The structural determination of these metabolites was carried out by the analyses of various spectroscopic data, in addition to comparison with the formerly reported data. The antifungal and antibacterial potentials were evaluated toward various microbial strains using disc diffusion assay. Results: A new aminobenzamide derivative, namely fusaribenzamide A (2), and four known metabolites: (22E,24R)-stigmasta-5,7,22-trien-3–ol (1), adenosine (3), p-hydroxyacetophenone (4), and tyrosol (5) were isolated. Fusaribenzamide A (2) possessed significant antifungal activity toward Candida albicans with minimum inhibitory concentration (MIC) value 11.9 mg/disc compared to nystatin (MIC 4.9 mg/disc). Conclusion: The endophytic fungus Fusarium sp. could be considered as a wealthy pool for the isolation of aminobenzamide derivatives. Fusaribenzamide A may be a candidate for the discovery of a promising antifungal agent.

Quality Control of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Ibrahim, SRM; Mohamed, GA; Khayat, MT; Al Haidari, RA; El-Kholy, AA; Zayed, MF or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C7H8O2. Authors Shen, J; Li, QW; Zhang, XY; Wang, X; Li, GZ; Li, WZ; Yang, SD; Yang, B in AMER CHEMICAL SOC published article about in [Shen, Jian; Li, Qi-Wei; Zhang, Xin-Yue; Wang, Xue; Li, Gui-Zhi; Li, Wen-Zuo; Yang, Bin] Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China; [Yang, Shang-Dong] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China in 2021, Cited 112. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

A Tf2O/DMSO-based system for the dehydrogenative coupling of a wide range of alcohols, phenols, thiols, and thiophenols with diverse phosphorus reagents has been developed. This metal- and strong-oxidant-free strategy provides a facile approach to a great variety of organophosphinates and thiophosphates. The simple reaction system, good functional-group tolerance, and broad substrate scope enable the application of this method to the modification of natural products and the direct synthesis of bioactive molecules and flame retardants.

Computed Properties of C7H8O2. About Mequinol, If you have any questions, you can contact Shen, J; Li, QW; Zhang, XY; Wang, X; Li, GZ; Li, WZ; Yang, SD; Yang, B or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H8O. I found the field of Chemistry; Materials Science very interesting. Saw the article Facile synthesis of hydrothermally stable mesoporous ZSM-5 zeolite from Al- SBA-16 via steam assisted crystallization published in 2020, Reprint Addresses Cheralathan, KK (corresponding author), VIT, Sch Adv Sci, Dept Chem, Vellore 632014, Tamil Nadu, India.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol.

In this work, Al grafted SBA-16 (Al-SBA-16) is converted into a fully crystalline hierarchical mesoporous ZSM-5 zeolite with hydrothermal stability by steam assisted crystallization under controlled conditions. The secondary mesoporosity is due to reorganization and recrystallization events happening upon steaming the precursor. Two mesoporous aluminosilicates (Al-SBA-16s) are used as the precursors of zeolites. The precursors are obtained by post-synthetic Al grafting on the silica walls of SBA-16 with aluminium isopropoxide and sodium aluminate. Mesoporous ZSM-5 zeolites obtained from the Al-SBA-16 precursors and commercial ZSM-5 are characterized using XRD, XRF, FT-IR, TEM, N-2 adsorption, Al-27 and Si-29 MAS NMR, and TPD of NH3. The results indicated the presence of intraparticle mesoporosity in the prepared mesoporous zeolites and they have comparable crystallinity with commercial ZSM-5. Catalytic activity of the synthesized mesoporous zeolites in benzylation of mesitylene is found to be comparatively more than commercial ZSM-5, which shows existence of micro/meso hierarchical structure in the mesoporous ZSM-5 zeolites. The aluminium sources, aluminium isopropoxide and sodium aluminate have a remarkable influence on the textural, acidity, and hydrothermal stability characteristics of the synthesized mesoporous ZSM-5 zeolites.

About Benzyl Alcohol, If you have any questions, you can contact Kamil, MSM; Cheralathan, KK or concate me.. Formula: C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles