Day: October 15, 2021

Authors Wang, LY; Pan, D; Zhou, M; Liang, Q; Li, ZY in ELSEVIER published article about in [Wang, Luying; Zhou, Man; Liang, Qian; Li, Zhongyu] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Changzhou 213164, Jiangsu, Peoples R China; [Pan, Deng] Kings Coll London, Sch Global Affairs, London WC2R 2LS, England; [Li, Zhongyu] Changzhou Univ, Sch Environm & Safety Engn, Changzhou 213164, Jiangsu, Peoples R China; [Li, Zhongyu] Changzhou Univ, Adv Catalysis & Green Mfg Collaborat Innovat Ctr, Changzhou 213164, Jiangsu, Peoples R China in 2021.0, Cited 65.0. Computed Properties of C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

A series of tetra-substituted metal phthalocyanine-multi-walled carbon nanotube composites ([4a (OPh-p-Cl) MPc]-MWCNTs) were fabricated, which were used to effectively catalyze the oxidation of benzyl alcohol. The asprepared composites were characterized by ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction spectroscopy, scanning electron microscope and transmission electron microscope. In order to improve the catalytic activity, the effects of solvent, amount of oxidant, amount of catalyst, temperature and reaction time on catalytic oxidation of benzyl alcohol to benzaldehyde were studied. It can be found that the Cu phthalocyanine based composite [4a (OPh-p-Cl)CuPc]-MWCNTs have the best catalytic activity in the oxidation of benzyl alcohol. The conversion rate of benzyl alcohol can reached 70%, the selectivity of benzaldehyde was 87%, and the yield of benzaldehyde can reached to 61%. In addition, a possible mechanism for the enhanced catalytic activity of the optimized [4a (OPh-p-Cl)MPc]-MWCNTs has been discussed.

About Benzyl Alcohol, If you have any questions, you can contact Wang, LY; Pan, D; Zhou, M; Liang, Q; Li, ZY or concate me.. Computed Properties of C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 3-Hydroxybenzaldehyde. I found the field of Chemistry very interesting. Saw the article One-Pot Condensation Approach for Synthesis of Diverse Naphthopyranopyrimidines Utilizing Lactic Acid as Efficient and Eco-Friendly Catalyst published in 2019.0, Reprint Addresses Hazeri, N; Maghsoodlou, MT (corresponding author), Univ Sistan & Baluchestan, Fac Sci, Dept Chem, POB 98135-674, Zahedan, Iran.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde.

Lactic acid, as a biological, eco-friendly, and inexpensive compound, efficiently catalyzed the synthesis of 8,10-dimethyl-12-aryl-12H-naphtho[1 ‘,2 ‘:5,6]pyrano[2,3-d] pyrimidine-9,11-dione derivatives by an efficient one-pot, three-component reaction between aromatic aldehydes, beta-naphthol, and 6-amino-1,3-dimethyl uracil at 100 degrees C under solvent-free conditions. The benefits of the reaction are good yields, simple procedure, short reaction time, easy work-up, and cleaner reaction profiles.

Name: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Fatahpour, M; Hazeri, N; Maghsoodlou, MT; Lashkari, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H8O2. Recently I am researching about NITROALKENES; ALKYLATION; INDOLES; IONS; NAPHTHOLS; COMPLEX; ETHERS, Saw an article supported by the National Science FoundationNational Science Foundation (NSF) [CHE-0847358, CHE-1363375]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Mesa, KM; Hibbard, HA; Franz, AK. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

Sodium tetrakis[3,5-bis(trifluoromethyl)-phenyl]borate (NaBArF) demonstrates catalytic activity for Friedel-Crafts addition reactions of phenolic and other aromatic nucleophiles to trans-beta-nitrostyrene. Solubility studies demonstrate a chelating effect between the Na+ cation and the nitro group of trans-beta-nitrostyrene as the basis for catalytic activation. Mechanistic studies are presented, including a comparison with other sodium salts, additive effects, and reaction progress kinetics analysis using F-19 NMR spectroscopy.

COA of Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Mesa, KM; Hibbard, HA; Franz, AK or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about TRANSITION-METAL-FREE; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE CONSTRUCTION; FLUORINATED ALCOHOLS; CROSS-COUPLINGS; CYCLOADDITION REACTIONS; PRIVILEGED STRUCTURES; NAZAROV CYCLIZATION; QUATERNARY CENTER; NATURAL-PRODUCTS, Saw an article supported by the . Product Details of 150-19-6. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Aota, Y; Doko, Y; Kano, T; Maruoka, K. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

Nucleophilic addition to the oxy-allyl cation intermediate has emerged as a promising methodology for functionalization of the alpha-position of carbonyl compounds in an umpolung fashion. However, a structure of available carbon nucleophiles to trap the catalytically generated oxy-allyl cation has been limited to highly nucleophilic ones. Herein, we report the Bronsted acid-catalyzed alpha-arylation of ketones employing less explored phenolic nucleophiles as carbon nucleophiles in the oxy-allyl cation catalysis, affording ketones bearing an all carbon quaternary center at the alpha-position.

About m-Methoxyphenol, If you have any questions, you can contact Aota, Y; Doko, Y; Kano, T; Maruoka, K or concate me.. Product Details of 150-19-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Barhdadi, S; Mertens, B; Van Bossuyt, M; Van de Maele, J; Anthonissen, R; Canfyn, M; Courselle, P; Rogiers, V; Deconinck, E; Vanhaecke, T in PERGAMON-ELSEVIER SCIENCE LTD published article about MUTAGENICITY; CONSTITUENTS; CHEMICALS; FRAGRANCE; TOXICITY in [Barhdadi, Sophia; Mertens, Birgit; Van Bossuyt, Melissa; Van de Maele, Jolien; Anthonissen, Roel; Canfyn, Michael; Courselle, Patricia; Deconinck, Eric] Sciensano, Sci Direct Chem & Phys Hlth Risks, Brussels, Belgium; [Barhdadi, Sophia; Van Bossuyt, Melissa; Rogiers, Vera; Vanhaecke, Tamara] Vrije Univ Brussel VUB, Fac Med & Pharm, Dept In Vitro Toxicol & Dermatocosmetol IVTD, Brussels, Belgium; [Mertens, Birgit] Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium in 2021, Cited 44. COA of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

E-cigarettes have become very popular, a trend that has been stimulated by the wide variety of available e-liquid flavours. Considering the large number of e-liquid flavours (>7000), there is an urgent need to establish a screening strategy to prioritize the flavouring substances of highest concern for human health. In the present study, a prioritization strategy combining analytical screening, in silico tools and literature data was developed to identify potentially genotoxic e-liquid flavourings. Based on the analysis of 129 e-liquids collected on the Belgian market, 60 flavourings with positive in silico predictions for genotoxicity were identified. By using literature data, genotoxicity was excluded for 33 of them whereas for 5, i.e. estragole, safrole, 2-furylmethylketon, 2,5-dimethyl-4-hydroxyl-3(2H)-furanone and transhexanal, there was a clear concern for in vivo genotoxicity. A selection of 4 out of the remaining 22 flavourings was tested in two in vitro genotoxicity assays. Three out of the four tested flavourings induced gene mutations and chromosome damage in vitro, whereas equivocal results were obtained for the fourth compound. Thus, although there is a legislative framework which excludes the use of CMR compounds in e-liquids, flavourings of genotoxic concern are present and might pose a health risk for e-cigarette users.

COA of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Barhdadi, S; Mertens, B; Van Bossuyt, M; Van de Maele, J; Anthonissen, R; Canfyn, M; Courselle, P; Rogiers, V; Deconinck, E; Vanhaecke, T or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about FRUSTRATED LEWIS PAIRS; MAIN-GROUP ELEMENTS; REDUCTION; CO2; METHANOL; IMINES; ACID, Saw an article supported by the National Research Foundation SingaporeNational Research Foundation, Singapore; NRF-ANRFrench National Research Agency (ANR) [NRF2018-NRF-ANR026 Si-POP]; Ministry of Education SingaporeMinistry of Education, Singapore [MOE2019-T2-2-129, RG 17/17]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Chia, CC; Teo, YC; Cham, N; Ho, SYF; Ng, ZH; Toh, HM; Mezailles, N; So, CW. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde. Safety of 4-Methoxybenzaldehyde

This study describes the first use of a bis(phosphoranyl) methanido aluminum hydride, [ClC(PPh(2)NMes)(2)AlH2] (2, Mes = Me3C6H2), for the catalytic hydroboration of CO2. Complex 2 was synthesized by the reaction of a lithium carbenoid [Li(Cl)C(PPh(2)NMes)(2)] with 2 equiv of AlH3 center dot NEtMe2 in toluene at -78 degrees C. 2 (10 mol %) was able to catalyze the reduction of CO2 with HBpin in C6D6 at 110 degrees C for 2 days to afford a mixture of methoxyborane [MeOBpin] (3a; yield: 78%, TOF: 0.16 h(-1)) and bis(boryl)oxide [pinBOBpin] (3b). When more potent [BH3 center dot SMe2] was used instead of HBpin, the catalytic reaction was extremely pure, resulting in the formation of trimethyl borate [B(OMe)(3)] (3e) [catalytic loading: 1 mol % (10 mol %); reaction time: 60 min (5 min); yield: 97.6% (>99%); TOF: 292.8 h(-1) (356.4 h(-1))] and B2O3 (3f). Mechanistic studies show that the Al-H bond in complex 2 activated CO2 to form [ClC(PPh(2)NMes)(2)Al(H){OC(O)H}] (4), which was subsequently reacted with BH3 center dot SMe2 to form 3e and 3f, along with the regeneration of complex 2. Complex 2 also shows good catalytic activity toward the hydroboration of carbonyl, nitrile, and alkyne derivatives.

Safety of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Chia, CC; Teo, YC; Cham, N; Ho, SYF; Ng, ZH; Toh, HM; Mezailles, N; So, CW or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety WOS:000600418500058 published article about ORAL DRUGLIKENESS; PREDICTION; DERIVATIVES; SOLUBILITY; DISCOVERY in [Saglik, Begum Nurpelin; Osmaniye, Derya; Levent, Serkan; Cevik, Ulviye Acar; Ozkay, Yusuf; Kaplancikli, Zafer Asim] Anadolu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey; [Saglik, Begum Nurpelin; Osmaniye, Derya; Levent, Serkan; Cevik, Ulviye Acar; Ozkay, Yusuf] Anadolu Univ, Fac Pharm, Doping & Narcot Cpds Anal Lab, TR-26470 Eskisehir, Turkey; [Cavusoglu, Betul Kaya] Zonguldak Bulent Ecevit Univ, Fac Pharm, Dept Pharmaceut Chem, TR-67600 Zonguldak, Turkey in 2021, Cited 44. HPLC of Formula: C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Nonsteroidal anti-inflammatory drugs (NSAIDs) cause peptic lesions in the gastrointestinal mucosa by inhibiting the cyclooxygenase-1 (COX-1) enzyme. Selective COX-2 inhibition causes decreased side effects over current NSAIDs. Therefore, the studies about selective inhibition of COX-2 enzyme are very important for new drug development. The design, synthesis and biological activity evaluation of novel derivatives bearing thiazolylhydrazine-methyl sulfonyl moiety as selective COX-2 inhibitors were aimed in this paper. The structures of synthesized compounds were assigned using different spectroscopic techniques such as H-1 NMR, C-13 NMR and HRMS. In addition, the estimation of ADME parameters for all compounds was carried out using in silico process. The evaluation of in vitro COX-1/COX-2 enzyme inhibition was applied according to the fluorometric method. According to the enzyme inhibition results, synthesized compounds showed the selectivity against COX-2 enzyme inhibition as expected. Compounds 3a, 3e, 3f, 3g, 3i and 3j demonstrated significant COX-2 inhibition potencies. Among them, compound 3a was found to be the most effective derivative with an IC50 value of 0.140 +/- 0.006 mM. Moreover, it was seen that compound 3a displayed a more potent inhibition profile at least 12-fold than nimesulide (IC50 = 1.684 +/- 0.079 mu M), while it showed inhibitory activity at a similar rate of celecoxib (IC50 = 0.132 +/- 0.005 mu M). Molecular modelling studies aided in the understanding of the interaction modes between this compound and COX-2 enzyme. It was found that compound 3a had a significant binding property. In addition, the selectivity of obtained derivatives on COX-2 enzyme could be explained and discussed by molecular docking studies. (C) 2020 Elsevier Masson SAS. All rights reserved.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Saglik, BN; Osmaniye, D; Levent, S; Cevik, UA; Cavusoglu, BK; Ozkay, Y; Kaplancikli, ZA or concate me.. HPLC of Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 4-Methoxybenzaldehyde. Authors Sorrentino, JP; Orsi, DL; Altman, RA in AMER CHEMICAL SOC published article about in [Sorrentino, Jacob P.] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA; [Orsi, Douglas L.] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA; [Altman, Ryan A.] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47906 USA; [Altman, Ryan A.] Purdue Univ, Dept Chem, W Lafayette, IN 47906 USA in 2021.0, Cited 35.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The substitution of hydrogen atoms with fluorine in bioactive molecules can greatly impact physicochemical, pharmacokinetic, and pharmacodynamic properties. However, current synthetic methods cannot readily access many fluorinated motifs, which impedes utilization of these groups. Thus, the development of new methods to introduce fluorinated functional groups is critical for developing the next generation of biological probes and therapeutic agents. The synthesis of one such substructure, the alpha,alpha-difluoroalkylthioether, typically requires specialized conditions that necessitate early-stage installation. A late-stage and convergent approach to access alpha,alpha-difluoroalkylthioethers could involve nucleophilic addition of thiols across gem-difluorostyrenes. Unfortunately, under basic conditions, nucleophilic addition to gem-difluorostyrenes generates an anionic intermediate that can undergo facile elimination of fluoride to generate alpha-fluorovinylthioethers. To overcome this decomposition, we herein exploit an acid-based catalyst system to facilitate simultaneous nucleophilic addition and protonation of the unstable intermediate. Ultimately, the optimized mild conditions afford the desired alpha,alpha-difluoroalkylthioethers in high selectivity and moderate to excellent yields. These alpha,alpha-difluoroalkylthioethers are less nucleophilic and more oxidatively stable relative to nonfluorinated thioethers, suggesting the potential application of this unexplored functional group in biological probes and therapeutic agents.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Sorrentino, JP; Orsi, DL; Altman, RA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Torabi, M; Yarie, M; Zolfigol, MA; Rouhani, S; Azizi, S; Olomola, TO; Maaza, M; Msagati, TAM in ROYAL SOC CHEMISTRY published article about ONE-POT; MAGNETIC NANOPARTICLES; CLAISEN REARRANGEMENT; DERIVATIVES; EFFICIENT; GLYCALS; DRUGS; DECONTAMINATION; HETEROCYCLES; ANTICANCER in [Torabi, Morteza; Yarie, Meysam; Zolfigol, Mohammad Ali] Buali Sina Univ, Fac Chem, Dept Organ Chem, Hamadan 6517838683, Hamadan, Iran; [Rouhani, Shamila; Msagati, Titus A. M.] Univ South Africa, Coll Sci Engn & Technol, Inst Nanotechnol & Water Sustainabil iNanoWS, ZA-1709 Johannesburg, South Africa; [Azizi, Shohreh; Maaza, Malik] Univ South Africa, Coll Grad Studies, UNESCO UNISA Africa Chair Nanosci & Nanotech, POB 392, Pretoria, South Africa; [Azizi, Shohreh] iThemba LABS Natl Res Fdn, Nanosci African Network NANOAFNET, 1 Old Faure Rd,POB 722, ZA-7129 Western Cape, South Africa; [Olomola, Temitope O.] Obafemi Awolowo Univ, Dept Chem, Ife 220005, Nigeria; [Msagati, Titus A. M.] Nelson Mandela African Inst Sci & Technol, Sch Life Sci & Bioengn, POB 447, Arusha, Tanzania in 2021, Cited 96. Quality Control of 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

In the present study, we reported the synthesis of a novel quinoline-based dendrimer-like ionic liquid. After characterization of the mentioned ionic liquid with suitable techniques such as Fourier transform infrared spectroscopy (FT-IR), energy dispersive X-ray spectroscopy (EDX), elemental mapping, thermogravimetric analysis (TGA) and derivative thermogravimetry (DTG), its catalytic performance was investigated in the synthesis of new pyridines with sulfonamide moiety via a cooperative vinylogous anomeric-based oxidation mechanism under mild reaction conditions. All target molecules were achieved in short reaction times and high yields.

Quality Control of 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Torabi, M; Yarie, M; Zolfigol, MA; Rouhani, S; Azizi, S; Olomola, TO; Maaza, M; Msagati, TAM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Fe3O4/GO@melamine-ZnO nanocomposite: A promising versatile tool for organic catalysis and electrical capacitance WOS:000505567400031 published article about DIHYDROPYRANO 2,3-C PYRAZOLE; REDUCED GRAPHENE OXIDE; MULTICOMPONENT SYNTHESIS; ONE-POT; ACID; DERIVATIVES; EFFICIENT; GREEN; WATER in [Eivazzadeh-Keihan, Reza; Taheri-Ledari, Reza; Khosropour, Nastaran; Maleki, Ali] Iran Univ Sci & Technol, Dept Chem, Catalysts & Organ Synth Res Lab, Tehran 1684613114, Iran; [Dalvand, Samad; Mousavi-Khoshdel, S. Morteza] Iran Univ Sci & Technol, Fac Chem, Ind Electrochem Res Lab, Tehran 1684613114, Iran; [Sohrabi, Hessamaddin] Univ Tabriz, Fac Chem, Dept Analyt Chem, Tabriz, Iran in 2020.0, Cited 47.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Product Details of 100-83-4

Herein, an efficient versatile nanocomposite constructed of melamine-functionalized graphene oxide nano-sheets (GO@melamine), iron oxide nanoparticles (Fe3O4 NPs), and zinc oxide (ZnO NPs) is presented. Moreover, two different applications have been studied for the prepared Fe3O4/GO@melamine-ZnO nanocomposite: First, as a heterogeneous catalyst for synthesis of pyrano[2,3-c]pyrazole derivatives in short reaction time (10 min) with high yields (96 %), second, as a substantial electrical supercapacitor with typical capacitive behavior, high resistance, and excellent electrode stability. From the catalytic aspect, high effectiveness, convenient isolation, and significant reusability could be referred as the distinguished properties for the produced nanocomposite. Turn-over number (TON) and turn-over frequency (TOF) values for the presented catalytic system have been estimated 17.2 x 10(6) and 1.71 x 10(6) min(-1), respectively, which revealed high catalytic performance of this catalytic system. From electrochemical aspect, economic benefits for fabrication of the introduced nanocomposite containing low-cost materials, make it as a suitable electrical supercapacitor for industrial applications.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Eivazzadeh-Keihan, R; Taheri-Ledari, R; Khosropour, N; Dalvand, S; Maleki, A; Mousavi-Khoshdel, SM; Sohrabi, H or concate me.. Product Details of 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles