Day: October 15, 2021

Recently I am researching about BIOGENIC SYNTHESIS; ENHANCED ANTIBACTERIAL; MALACHITE GREEN; LEAF EXTRACT; ANTIOXIDANT; DEGRADATION; REDUCTION, Saw an article supported by the . Published in SPRINGER HEIDELBERG in HEIDELBERG ,Authors: Jaffri, SB; Ahmad, KS. The CAS is 80-59-1. Through research, I have a further understanding and discovery of (E)-2-Methylbut-2-enoic acid. Name: (E)-2-Methylbut-2-enoic acid

Silver nanoparticles were fabricated in the presence and absence of light with silver nitrate and aqueous extract of Prunus cerasifera leaf via facile and one-pot green method. P. cerasifera leaf extract reduced and stabilized the nanoparticles with phytometabolites expunging the need for addition of external reducing agents. Optimized silver nanoparticle syntheses was done with variations in leaf extract concentration, time, temperature, and molarity for deciphering the photocatalytic, antifungal, and antibacterial potential of synthesized nanoparticles. Optical, compositional, and morphological analyses of the synthesized nanoparticles were done by UV-visible spectrometry (UV-Vis), Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), scanning electron microscopy (SEM), and X-ray diffraction (XRD). Formation of silver nanoparticles was confirmed firstly through UV-Vis by exhibition of peaks with 400-450 nm. FTIR confirmed the presence of major organic groups responsible for reduction of nanoparticles. AFM confirmed the spherical morphology of the synthesized nanoparticles with remarkable dispersion without any agglomeration. Phytochemical analysis for P. cerasifera leaf metabolites was done by GC-MS. Spherical nanoparticles having a size range of 57-144 nm were obtained with face-centered cubic crystals. The average crystallite size obtained from XRD spectra was 2.34 nm. Enhanced photocatalytic first-order kinetics were obtained for persistent organic pollutants, i.e., crystal violet, methylene blue, and malachite green (R-2 = 0.99, 0.99, 0.98) in less than 15 min. Biomedical and agricultural significance as an antibiotic drug and utilization as a fungicides substitute was explored against nine resistant microbes. Statistically significant variations were analyzed via one-way analysis of variance (ANOVA) and Kruskal-Wallis test and specific multi comparison tests. Active to highly active inhibition zones manifested the use of biogenic silver nanoparticles as potential candidate for applications in biological arenas and as environmental remediators.

Name: (E)-2-Methylbut-2-enoic acid. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Jaffri, SB; Ahmad, KS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Recently I am researching about Z ISOMERIZATION; ATOM ECONOMY; IONIC LIQUID; COUMARINS; BIOSYNTHESIS; DERIVATIVES; ALKYNOATES, Saw an article supported by the WWU Munster; CiM-IMPRS Graduate School. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Nevesely, T; Daniliuc, CG; Gilmour, R. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

An operationally simple one-pot protocol has been developed to enable the conversion of diversely substituted cinnamic acid derivatives into angularly-fused dihydrocoumarins (up to 94%). Inspired by coumarin biosynthesis, this reaction cascade harnesses photochemical E -> Z alkene isomerization enabled by energy transfer catalysis using inexpensive thioxanthen-9-one (TX) under irradiation at 402 nm. Subsequent lactonization generates the heterocyclic core prior to a second photosensitization event to induce a [2 + 2] cycloaddition, again mediated by TX. The tetracyclic products are generated efficiently, and proof of the structure was established by X-ray crystallography. Mechanistic investigations, including structural probes and NMR reaction monitoring, support the postulated order of events. The study underscores the synthetic value of inexpensive small-molecule organic photocatalysts in the generation of structural complexity via sequential pi-bond activation.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Nevesely, T; Daniliuc, CG; Gilmour, R or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; DERIVATIVES BEARING; MULTIKINASE INHIBITOR; CLICK CHEMISTRY; DESIGN; CANCER; DISCOVERY; MOIETY; METASTASIS, Saw an article supported by the Institute for the Promotion of Teaching Science and Technology (IPST) [19/2558]; The Thailand Research FundThailand Research Fund (TRF) [RTA6280004]; Department of Chemistry, Faculty of Science, Silpakorn University; Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Palakhachane, S; Ketkaew, Y; Chuaypen, N; Sirirak, J; Boonsombat, J; Ruchirawat, S; Tangkijvanich, P; Suksamrarn, A; Limpachayaporn, P. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol. Category: indole-building-block

A series of 1,2,3-triazole-containing Sorafenib analogues, in which the aryl urea moiety of Sorafenib (1) was replaced with a 1,2,3-triazole ring linking a substituted phenoxy fragment, were prepared successfully via Huisgen 1,3-dipolar cycloaddition and nucleophilic aromatic substitution. The studies of cytotoxicity towards human hepatocellular carcinoma (HCC) cell lines, HepG2 and Huh7, indicated that p-tert-butylphenoxy analogue 2m showed significant inhibitory activity against Huh7 with IC50 = 5.67 +/- 0.57 mu M. More importantly, 2m showed low cytotoxicity against human embryonal lung fibroblast cell line, MRC-5, with IC50 > 100 mu M, suggesting its highly selective cytotoxic activity (SI > 17.6) towards Huh7 which is much superior to that of Sorafenib (SI = 6.73). The molecular docking studies revealed that the analogue 2m bound B-RAF near the binding position of Sorafenib, while it interacted VEGFR2 efficiently at the same binding position of Sorafenib. However, 2m exhibited moderate inhibitory activity toward B-RAF, implying that its anti-Huh7 effect might not strictly relate to inhibition of B-RAF. Wound healing and BrdU cell proliferation assays confirmed anti-cell migration and anti-cell proliferative activities towards Huh7. With its inhibitory efficiency and high safety profile, 2m has been identified as a promising candidate for the treatment of HCC.

Category: indole-building-block. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Palakhachane, S; Ketkaew, Y; Chuaypen, N; Sirirak, J; Boonsombat, J; Ruchirawat, S; Tangkijvanich, P; Suksamrarn, A; Limpachayaporn, P or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 4-Methoxybenzaldehyde. Authors Suresh, P; Thamotharan, S; Ganesan, SS in WILEY-V C H VERLAG GMBH published article about in [Suresh, Pavithira; Selva Ganesan, Subramaniapillai] SASTRA Deemed Univ, Dept Chem, Sch Chem & Biotechnol, Thanjavur 613401, Tamil Nadu, India; [Thamotharan, Subbiah] SASTRA Deemed Univ, Sch Chem & Biotechnol, Biomol Crystallog Lab, Dept Bioinformat, Thanjavur 613401, Tamil Nadu, India in 2021.0, Cited 26.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Metal-free N-heterocyclic carbene (NHC) organocatalysis in D2O medium was elegantly utilised for the synthesis of highly diastereoselective deuterated spiropyran derivatives. Selective deuteration was exclusively achieved on the C5 carbon atom of the pyran ring. Quantum chemical calculations were performed to prove the preferential formation of a single diastereomer from the possible four diastereomers. The scope of NHC organocatalysis in D2O was also extended for the synthesis of deuterated spirooxindole derivative.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Suresh, P; Thamotharan, S; Ganesan, SS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: Mequinol. Recently I am researching about REFLECTION; TEXTURE; STORAGE; LIGHT; COLOR, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51573003]; Joint Fund of the Ministry of Education for Equipment Pre Research [6141A02033238]; Natural Science Foundation of Shaanxi Provincial Department of Education [17JK1157]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Yao, WH; Lan, RC; Li, KX; Zhang, LY. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol

A composite film with multiple anti-counterfeiting features was demonstrated by superposing quantum dots (QDs) polymer matrix (film A) and cholesteric liquid crystal film (film B) together. The first-line and second-line anti-counterfeiting characteristics were successfully implemented by employing thermochromic, angular photochromic, and circularly polarized discoloration of film B, respectively. By initiatively utilizing the different relative positions between the fluorescence emission peak (lambda(em)) of film A and the central selective reflection wavelength (lambda(em)) of film B at different temperatures, which resulted in changes in the fluorescence spectra or the different presence of latent patterns, the most important third-line anti-counterfeiting feature was successfully achieved.

About Mequinol, If you have any questions, you can contact Yao, WH; Lan, RC; Li, KX; Zhang, LY or concate me.. Recommanded Product: Mequinol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Zarnegar, Z; Monjezi, HR; Safari, J in ELSEVIER SCIENCE BV published article about HETEROGENEOUS CATALYST; COPPER; NANOPARTICLES; DIARYL; SUPPORT; HYBRID in [Monjezi, Homeyra Rostami; Safari, Javad] Univ Kashan, Fac Chem, Dept Organ Chem, Kashan 8731751167, Iran; [Zarnegar, Zohre] Univ Payame Noor, Dept Chem, POB 19395-4697, Tehran, Iran in 2019.0, Cited 29.0. Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Novel arginine-functionalized starch-based nanoparticles (Arg-SNPs) were synthesized and characterized by Fourier transforms infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDAX), X-ray diffraction (XRD) and thermos-gravimetric analyses (TGA) techniques. Arg-SNP was used as a highly efficient and macromolecule-supported recyclable nanocatalyst for the one-pot reaction between thiourea and iodine with various substituted methylcarbonyls to afford the corresponding diheteroaryl thioethers in high-to-quantitative yields. The nanocatalyst was recycled at least five times without significant decrease in the catalytic activity. (C) 2019 Elsevier B.V. All rights reserved.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Zarnegar, Z; Monjezi, HR; Safari, J or concate me.. Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Jia, WL; Ces, SV; Fernandez-Ibanez, MA in [Jia, Wen-Liang; Ces, Sabela Vega; Fernandez-Ibanez, M. Angeles] Univ Amsterdam, Vant Hoff Inst Mol Sci, NL-1098 XH Amsterdam, Netherlands published Divergent Total Syntheses of Yaequinolone-Related Natural Products by Late-Stage C-H Olefination in 2021.0, Cited 41.0. Name: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Divergent total syntheses of 10 yaequinolone-related natural products have been achieved for the first time by latestage C-H olefination of 3,4-dioxygenated 4-aryl-5-hydroxyquinolin-2(1H)-ones, core structures of this family of natural products. A robust synthetic methodology to construct the core structures has been established, and the C-H olefination reaction has been carried out with synthetically useful yields and high levels of site-selectivity under mild reaction conditions in the presence of a Pd/S,O-ligand catalyst.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Jia, WL; Ces, SV; Fernandez-Ibanez, MA or concate me.. Name: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 120-14-9. I found the field of Chemistry very interesting. Saw the article Synthesis, and biological screening of chloropyrazine conjugated benzothiazepine derivatives as potential antimicrobial, antitubercular and cytotoxic agents published in 2021.0, Reprint Addresses Shaik, AB (corresponding author), Jawaharlal Nehru Technol Univ, Vignan Pharm Coll, Dept Pharmaceut Chem, Vadlamudi 522213, Andhra Pradesh, India.; Bhandare, RR (corresponding author), Ajman Univ, Coll Pharm & Hlth Sci, Dept Pharmaceut Sci, POB 346, Ajman, U Arab Emirates.; Rahman, MM (corresponding author), Univ East London, Sch Hlth Sports & Biosci, Med Res Grp, Stratford Campus,Water Lane, London E15 4LZ, England.; Bhandare, RR (corresponding author), Ajman Univ, Ctr Med & Bioallied Hlth Sci Res, Ajman, U Arab Emirates.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde.

A series of twenty new chloropyrazine conjugated benzothiazepines (22-41) have been synthesized with 58%-95% yields. The compounds were characterized by using different spectroscopic techniques including FT-IR, H-1 NMR, C-13 NMR spectroscopy and mass spectrometry. The synthesized compounds (22-41) and their precursor chalcones (2-21) were evaluated for antitubercular and cytotoxic activities. Additionally, compounds 22-41 were also tested for antimicrobial activity. Among the chalcone series (2-21), compounds 7 and 14 showed significant antitubercular activities (MICs 25.51 and 23.89 mu M, respectively), whereas among benzothiazepines (22-41), compounds 27 and 34 displayed significant antimicrobial (MICs 38.02 mu M, 19.01 mu M) and antitubercular (MIC 18.10 mu M) activities. Compounds 7 and 41 displayed cytotoxic activities with IC50 of 46.03 +/- 1 and 35.10 +/- 2 mu M respectively. All the compounds were evaluated for cytotoxic activity on normal human liver cell lines (L02) and found to be relatively less selective towards this cell line. The most active compounds identified through this study could be considered as potential leads for the development of drugs with possible antimicrobial, antitubercular, and cytotoxic activities. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Shaik, AB; Bhandare, RR; Nissankararao, S; Lokesh, BVS; Shahanaaz, S; Rahman, MM or concate me.. SDS of cas: 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Kumar, MSL; Ali, K; Chaturvedi, P; Meena, S; Datta, D; Panda, G in ELSEVIER published article about in [Kumar, Srinivas Lavanya M.; Ali, Kasim; Panda, Gautam] Cent Drug Res Inst, CSIR, Med & Proc Chem Div, Sitapur Rd, Lucknow 226031, UP, India; [Chaturvedi, Priyank; Meena, Sanjeev; Datta, Dipak] Cent Drug Res Inst, CSIR, Canc Biol Div, Sitapur Rd, Lucknow 226031, UP, India in 2021.0, Cited 33.0. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

In this study, we attempted the chemical simplification of Psammaplin (PsA), while retaining its activity in vitro . Inspired by the previous Structure Activity Relationship (SAR) studies on various PsA analogues and relying on the fact that oxime is metabolically unstable, we initially designed and synthesized a diverse library of PsA analogues and evaluated for cytotoxic activity. Among 32 compounds of Psammaplin analogues synthesized, the compound 10b was almost equally active as parent Psammaplin in vitro. (C) 2020 Elsevier B.V. All rights reserved.

About Mequinol, If you have any questions, you can contact Kumar, MSL; Ali, K; Chaturvedi, P; Meena, S; Datta, D; Panda, G or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Eagon, S; Hammill, JT; Sigal, M; Ahn, KJ; Tryhorn, JE; Koch, G; Belanger, B; Chaplan, CA; Loop, L; Kashtanova, AS; Yniguez, K; Lazaro, H; Wilkinson, SP; Rice, AL; Falade, MO; Takahashi, R; Kim, K; Cheung, A; DiBernardo, C; Kimball, JJ; Winzeler, EA; Eribez, K; Mittal, N; Gamo, FJ; Crespo, B; Churchyard, A; Garcia-Barbazan, I; Baum, J; Anderson, MO; Laleu, B; Guy, RK in AMER CHEMICAL SOC published article about MOLECULAR-DYNAMICS SIMULATIONS; DRUG DISCOVERY; RESISTANCE; ACCURACY; AMBER; GAMETOCYTES; DESIGN in [Hammill, Jared T.; Rice, Amy L.; Falade, Mofolusho O.; Guy, R. Kiplin] Univ Kentucky, Dept Pharmaceut Sci, Lexington, KY 40508 USA; [Sigal, Martina] St Jude Childrens Res Hosp, Dept Chem Biol & Therapeut, 332 N Lauderdale St, Memphis, TN 38105 USA; [Eagon, Scott; Ahn, Kevin J.; Tryhorn, Julia E.; Belanger, Briana; Chaplan, Cory A.; Loop, Lauren; Kashtanova, Anna S.; Wilkinson, Steven P.; Takahashi, Rei; Kim, Katie; Cheung, Ashley; DiBernardo, Celine] Calif Polytech State Univ San Luis Obispo, Dept Chem & Biochem, San Luis Obispo, CA 93407 USA; [Koch, Grant] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA; [Yniguez, Kenya] SRI Int, Menlo Pk, CA 94025 USA; [Lazaro, Horacio; Kimball, Joshua J.] Promega Biosci, San Luis Obispo, CA 93401 USA; [Winzeler, Elizabeth A.; Eribez, Korina; Mittal, Nimisha] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA; [Gamo, Francisco-Javier; Crespo, Benigno] GlaxoSmithKline, DDW, Global Hlth, Madrid 28760, Spain; [Churchyard, Alisje; Garcia-Barbazan, Irene; Baum, Jake] Imperial Coll London, Dept Life Sci, London SW7 2AZ, England; [Anderson, Marc O.] San Francisco State Univ, Dept Chem & Biochem, San Francisco, CA 94132 USA; [Laleu, Benoit] Med Malaria Venture MMV, CH-1215 Geneva, Switzerland in 2020.0, Cited 56.0. Formula: C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Malaria remains one of the most deadly infectious diseases, causing hundreds of thousands of deaths each year, primarily in young children and pregnant mothers. Here, we report the discovery and derivatization of a series of pyrazolo[3,4-b]pyridines targeting Plasmodium falciparum, the deadliest species of the malaria parasite. Hit compounds in this series display sub-micromolar in vitro activity against the intraerythrocytic stage of the parasite as well as little to no toxicity against the human fibroblast BJ and liver HepG2 cell lines. In addition, our hit compounds show good activity against the liver stage of the parasite but little activity against the gametocyte stage. Parasitological profiles, including rate of killing, docking, and molecular dynamics studies, suggest that our compounds may target the Q(o) binding site of cytochrome bc(1).

Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Eagon, S; Hammill, JT; Sigal, M; Ahn, KJ; Tryhorn, JE; Koch, G; Belanger, B; Chaplan, CA; Loop, L; Kashtanova, AS; Yniguez, K; Lazaro, H; Wilkinson, SP; Rice, AL; Falade, MO; Takahashi, R; Kim, K; Cheung, A; DiBernardo, C; Kimball, JJ; Winzeler, EA; Eribez, K; Mittal, N; Gamo, FJ; Crespo, B; Churchyard, A; Garcia-Barbazan, I; Baum, J; Anderson, MO; Laleu, B; Guy, RK or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles