Day: October 21, 2021

Recommanded Product: 4-Methoxybenzaldehyde. Authors Chu, PC; Wu, YC; Chen, CY; Hung, YS; Chang, CS in FUTURE SCI LTD published article about in [Chu, Po-Chen] China Med Univ, Dept Cosmeceut, Taichung 40402, Taiwan; [Chu, Po-Chen] China Med Univ, Grad Inst Cosmeceut, Taichung 40402, Taiwan; [Chu, Po-Chen; Chang, Chih-Shiang] China Med Univ, Drug Dev Ctr, Taichung 40402, Taiwan; [Wu, Yu-Chieh; Chen, Chien-Yu; Hung, Yu-Syuan; Chang, Chih-Shiang] China Med Univ, Sch Pharm, Coll Pharm, Taichung 40402, Taiwan in 2021, Cited 35. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Aim: Tumor cells adapt to hypoxic microenvironments by releasing the key transcription factor HIF-1 alpha, which promotes angiogenesis, glycolytic phenotype, metastasis and erythropoiesis, allowing proliferation amid low oxygen levels. Therefore, therapeutic targeting of HIF-1 alpha represents a viable strategy for cancer therapy. Methods & Results: The authors synthesized a series of novel tetrahydroquinazoline derivatives in six steps and demonstrated that their development had a unique ability to suppress HIF-1 alpha expression through proteasomal degradation. Conclusion: Among these compounds, CDMP-TQZ (8bf) exhibited the highest antiproliferative potency in human cancer cells, in part through downregulation of HIF-1 alpha.

Recommanded Product: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Chu, PC; Wu, YC; Chen, CY; Hung, YS; Chang, CS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis, crystal structure and catalytic properties in the diastereoselective nitroaldol (Henry) reaction of new zinc(II) and cadmium(II) compounds WOS:000458228500009 published article about DOUBLE SULFATES; COMPLEXES; SPECTRA; NITRATE; LIGANDS; DESIGN; CU(II) in [Jlassi, Raja; Khalladi, Ahmed; Naili, Houcine; Rekik, Walid] Univ Sfax, Lab Physicochim Etat Solide, Dept Chim, Fac Sci Sfax, BP 1171, Sfax 3000, Tunisia; [Khalladi, Ahmed; Ruffer, Tobias; Lang, Heinrich] Tech Univ Chemnitz, Fak Nat Wissensch, Inst Chem, Anorgan Chem, D-09107 Chemnitz, Germany in 2019.0, Cited 40.0. Computed Properties of C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

The new complex [Zn(im)(4)](NO3)(2) (1) was synthesized and crystallographically characterized. In the solid state, 1 is built up by [Zn(C3H4N2)](2+) cations and NO3- anions interlinked by N-H center dot center dot center dot O hydrogen bonds which give rise to the formation of a 3D network. Complex 1 and [CdNa2(mu-L-2)](n)center dot 6.34H(2)O (2), (L=2-(2-(4,4-dimethyl-2,6-dioxocyclohexylidene) hydrazinyl)terephthalate) were used as catalysts for the Henry reaction, and high yields were obtained under optimum conditions. Both 1 and 2 act as very efficient catalysts for the Henry reaction and convert nitroethane and aldehydes to beta-nitroalcohols in yields of up to 89%. The threo/erythro diastereoselectivity depends on the choice of catalyst and also the selection of the reaction substrate, reaching values up to 89:11. (C) 2018 Elsevier Ltd. All rights reserved.

Computed Properties of C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Jlassi, R; Khalladi, A; Naili, H; Ruffer, T; Lang, H; Rekik, W or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Novel SO3H-functionalized polyoxometalate-based ionic liquids as highly efficient catalysts for esterification reaction WOS:000466710300032 published article about HETEROPOLY COMPOUNDS; SELECTIVE OXIDATION; ACID in [Keshavarz, Mosadegh] Univ Yasuj, Fac Gas & Petr, Dept Chem, Gachsaran 7591874831, Iran; [Iravani, Nasir] Islamic Azad Univ, Dept Chem, Gachsaran Branch, Gachsaran, Iran; [Parhami, Abolfath] Payame Noor Univ, Dept Chem, Tehran 193954697, Iran in 2019.0, Cited 25.0. Quality Control of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

Three novel heteropolyanion-based Bronsted acidic ionic liquids (BAILs), butane mono sulfoacid-functionalized 1,10-phenanthrolinum, butane mono and bis sulfoacid-functionalized 1,4-dimethylpiperazinium salts of phosphortungstate catalyst (PhBs(1)-PW, [PipBs(1)](3)-PW and [PipBs(2)](3)-(PW)(2)) were synthesized and well characterized with FTIR, H-1 and C-13 NMR, Electro-Spray Ionization Mass Spectrometry (ESI-MS), Elemental analysis (CHNS), EDX and TG analysis techniques. The esterification reactions of monocarboxylic acids with monohydric alcohols were carried out using these catalysts. The introduced catalysts present a self-separation performance after reaction, which can be easily recovered and quite steadily reused as confirmed by six-run recycling test. Moreover, bis sulfoacidfunctionalized 1,4-dimethylpiperazinium salt of phosphortungstate showed the best catalytic performance among the prepared catalysts for the esterification reaction. (C) 2019 Elsevier B.V. All rights reserved.

Quality Control of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Keshavarz, M; Iravani, N; Parhami, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Block, TM; Young, JAT; Javanbakht, H; Sofia, MJ; Zhou, TL in [Block, Timothy M.; Zhou, Tianlun] Baruch S Blumberg Inst, Doylestown, PA 18902 USA; [Young, John A. T.] F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Roche Pharma Res & Early Dev, Basel, Switzerland; [Javanbakht, Hassan] SQZ Biotechnol, 200 Arsenal Yards Blvd,Suite 210, Watertown, MA 02472 USA; [Sofia, Michael J.] Arbutus Biopharma Inc, 701 Vet Circle, Warminster, PA 18974 USA published Host RNA quality control as a hepatitis B antiviral target in 2021, Cited 69. Recommanded Product: 86-95-3. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

Inhibition of the host RNA polyadenylating polymerases, PAPD5 and PAPD7 (PAPD5/7), with dihydroquinolizinone, a small orally available, molecule, results in a rapid and selective degradation of hepatitis B virus (HBV) RNA, and hence reduction in the amounts of viral gene products. DHQ, is a first in class investigational agent and could represent an entirely new category of HBV antivirals. PAPD5 and PAPD7 are noncanonical, cell specified, polyadenylating polymerases, also called terminal nucleotidyl transferases 4B and 4A (TENT4B/A), respectively. They are involved in the degradation of poor-quality cell transcripts, mostly noncoding RNAs and in the maturation of a sub-set of transcripts. They also appear to play a role in shielding some mRNA from degradation. The results of studies with DHQ, along with other recent findings, provide evidence that repression of the PAPD5/7 arm of the cell RNA quality control pathway, causes a profound (multifold) reduction rather than increase, in the amount of HBV pre-genomic, pre-core and HBsAg mRNA levels in tissue culture and animal models, as well. In this review we will briefly discuss the need for new HBV therapeutics and provide background about HBV transcription. We also discuss cellular degradation of host transcripts, as it relates to a new family of anti-HBV drugs that interfere with these processes. Finally, since HBV mRNA maturation appears to be selectively sensitive to PAPD5/7 inhibition in hepatocytes, we discuss the possibility of targeting host RNA quality control as an antiviral strategy.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Block, TM; Young, JAT; Javanbakht, H; Sofia, MJ; Zhou, TL or concate me.. Recommanded Product: 86-95-3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about TETRAPROPYLAMMONIUM BROMIDE; BIOLOGICAL EVALUATION; DERIVATIVES; CATALYST; WATER, Saw an article supported by the Urmia University. Published in WILEY in HOBOKEN ,Authors: Marjani, AP; Khalafy, J; Farajollahi, A. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one. Product Details of 86-95-3

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, H-1-NMR, and C-13-NMR spectral data and elemental analysis.

Product Details of 86-95-3. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Novel Pyrazoloquinolin-2-ones: Design, synthesis, docking studies, and biological evaluation as antiproliferative EGFR-TK inhibitors WOS:000479184600037 published article about FACTOR RECEPTOR KINASE; SUBSTITUTED QUINOLINONES; PYRAZOLE DERIVATIVES; POTENTIAL ANTICANCER; ERLOTINIB; CANCER; CRIZOTINIB; CHEMISTRY; ASSAY in [Elbastawesy, Mohammed A., I; Ramadan, Mohamed] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Assiut 71524, Egypt; [Aly, Ashraf A.] Menia Univ, Fac Sci, Dept Chem, Al Minya 61519, Egypt; [Elshaier, Yaseen A. M. M.] Univ Sadat City, Fac Pharm, Dept Organ & Med Chem, Menoufia 32958, Egypt; [Youssif, Bahaa G. M.] Assiut Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Assiut 71526, Egypt; [Brown, Alan B.] Florida Inst Technol, Program Chem, Melbourne, FL 32901 USA; [Abuo-Rahma, Gamal El-Din A.] Menia Univ, Fac Pharm, Dept Med Chem, Al Minya 61519, Egypt in 2019, Cited 50. Quality Control of 4-Hydroxyquinolin-2(1H)-one. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

Two new series of diethyl 2-[2-(substituted-2-oxo-1,2-dihydroquinolin-4-yl)hydrazono]-succinates 6a-g and 1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been designed and synthesized. The structures of the synthesized compounds were proved by IR, mass, NMR (2D) spectra and elemental analyses. The target compounds were evaluated for their in vitro cytotoxic activity against 60 cancer cell lines according to NCI protocol. Consequently, seven compounds were further examined against the most sensitive cell lines, leukemia CCRFCEM, and MOLT-4. 5-Amino-1-(6-bromo-2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazole-3,4-dicarbonitrile (7f) was the most active product, with IC50= 1.35 uM and 2.42 uM against MOLT-4 and CCRF-CEM, respectively. Also, it showed a remarkable inhibitory activity compared to erlotinib on the EGFR TK with IC50 = 247.14 nM and 208.42 nM, respectively. Cell cycle analysis of MOLT-4 cells treated with 7f showed cell cycle arrest at G2/M phase (supported by Caspases, BAX and Bcl-2 studies) with a significant pro-apoptotic activity as indicated by annexin V-FITC staining. Moreover, the docking study indicated that both the pyrazole moiety and the quinolin-2-one ring showed good fitting into EGFR (PDB code: 1M17). In order to interpret SAR of the designed compounds, and provide a basis for further optimization, molecular docking of the synthesized compounds to known EGFR inhibitors was performed. The study illustrated the effect of several factors on the compounds’ activity.

Quality Control of 4-Hydroxyquinolin-2(1H)-one. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Elbastawesy, MAI; Aly, AA; Ramadan, M; Elshaier, YAMM; Youssif, BGM; Brown, AB; Abuo-Rahma, GEDA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about CATALYZED OXIDATIVE SYNTHESIS; ONE-POT SYNTHESIS; 4(3H)-QUINAZOLINONE DERIVATIVES; CASCADE SYNTHESIS; BENZYL ALCOHOLS; QUINAZOLINONES; METAL; EFFICIENT; SILICA; OXIDE, Saw an article supported by the University Grants CommissionUniversity Grants Commission, India; Council of Scientific and Industrial Research, New Delhi, IndiaCouncil of Scientific & Industrial Research (CSIR) – India. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Gupta, R; Arora, G; Yadav, P; Dixit, R; Srivastava, A; Sharma, RK. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde. SDS of cas: 120-14-9

In the present work, we report the design and fabrication of a copper-containing ionic liquid supported magnetic nanocatalyst via a convenient and straightforward synthetic approach for the formation of 2-phenylquinazolin-4(3H)-ones using o-aminobenzamide and benzaldehydes as the reaction partners. The successful formation and properties of the as-prepared catalyst have been thoroughly investigated using diverse physico-chemical techniques including FT-IR, XRD, FE-SEM, TEM, ICP, VSM, BET and TGA. Using this nanocatalytic system, a variety of 2-phenylquinazolin-4(3H)-ones are synthesized in excellent yields with operational ease and short reaction times in an environmentally preferable solvent under open air and without using any external oxidizing agent. Besides, the catalyst possessed facile magnetic recoverability and remarkable reusability for six consecutive runs without any appreciable decrease in the catalytic efficiency.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Gupta, R; Arora, G; Yadav, P; Dixit, R; Srivastava, A; Sharma, RK or concate me.. SDS of cas: 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Polaquini, CR; Marques, BC; Ayusso, GM; Morao, LG; Sardi, JCO; Campos, DL; Silva, IC; Cavalca, LB; Scheffers, DJ; Rosalen, PL; Pavan, FR; Ferreira, H; Regasini, LO in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Polaquini, Carlos R.; Marques, Beatriz C.; Ayusso, Gabriela M.; Regasini, Luis O.] Sao Paulo State Univ Unesp, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil; [Morao, Luana G.; Cavalca, Lucia B.; Ferreira, Henrique] Sao Paulo State Univ Unesp, Inst Biosci, Dept Biochem & Microbiol, BR-13050690 Rio Claro, SP, Brazil; [Sardi, Janaina C. O.; Rosalen, Pedro L.] Univ Campinas Unicamp, Piracicaba Dent Sch, Dept Physiol Sci, BR-13414903 Campinas, SP, Brazil; [Sardi, Janaina C. O.] Fed Univ Mato Grosso do Sul Ufms, Sch Pharmaceut Sci Food & Nutr, BR-79070900 Campo Grande, MS, Brazil; [Campos, Debora L.; Silva, Isabel C.; Pavan, Fernando R.] Sao Paulo State Univ Unesp, Sch Pharmaceut Sci, Dept Biol Sci, BR-14800903 Araraquara, SP, Brazil; [Cavalca, Lucia B.; Scheffers, Dirk-Jan] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Microbiol, NL-9747 AG Groningen, Netherlands; [Rosalen, Pedro L.] Fed Univ Alfenas Unifal, Sch Dent, BR-37130000 Alfenas, MG, Brazil in 2021, Cited 75. Computed Properties of C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Curcumin (CUR) is a symmetrical dicarbonyl compound with antibacterial activity. On the other hand, pharmacokinetic and chemical stability limitations hinder its therapeutic application. Monocarbonyl analogs of curcumin (MACs) have been shown to overcome these barriers. We synthesized and investigated the antibacterial activity of a series of unsymmetrical MACs derived from acetone against Mycobacterium tuberculosis and Gram-negative and Gram-positive species. Phenolic MACs 4, 6 and 8 showed a broad spectrum and potent activity, mainly against M. tuberculosis, Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus (MRSA), with MIC (minimum inhibitory concentration) values ranging from 0.9 to 15.6 mu g/mL. The investigation regarding toxicity on human lung cells (MRC-5 and A549 lines) revealed MAC 4 was more selective than MACs 6 and 8, with SI (selectivity index) values ranging from 5.4 to 15.6. In addition, MAC 4 did not demonstrate genotoxic effects on A549 cells and it was more stable than CUR in phosphate buffer (pH 7.4) for 24 h at 37 degrees C. Fluorescence and phase contrast microscopies indicated that MAC 4 has the ability to disrupt the divisome of Bacillus subtilis without damaging its cytoplasmic membrane. However, biochemical investigations demonstrated that MAC 4 did not affect the GTPase activity of B. subtilis FtsZ, which is the main constituent of the bacterial divisome. These results corroborated that MAC 4 is a promising antitubercular and antibacterial agent.

Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Polaquini, CR; Marques, BC; Ayusso, GM; Morao, LG; Sardi, JCO; Campos, DL; Silva, IC; Cavalca, LB; Scheffers, DJ; Rosalen, PL; Pavan, FR; Ferreira, H; Regasini, LO or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Zenkov, IS; Abel, AS; Averin, AD; Butov, GM; Beletskaya, IP in SPRINGER published article about AMINATION; HETEROARYLATION; CHEMISTRY; AMINES; SCOPE in [Zenkov, I. S.; Abel, A. S.; Averin, A. D.; Beletskaya, I. P.] Lomonosov Moscow State Univ, Dept Chem, 3 Build,1 Leninskie Gory, Moscow 119991, Russia; [Averin, A. D.; Beletskaya, I. P.] Russian Acad Sci, Frumkin Inst Phys Chem & Electrochem, 4 Build,31 Leninsky Prosp, Moscow 119991, Russia; [Butov, G. M.] Volgograd State Tech Univ, Volzhsky Polytech Inst Branch, 42a Ul Engelsa, Volzhskii 404121, Russia in 2021, Cited 33. Computed Properties of C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

An addition of the Morita-Baylis-Hillman (MBH) carbonates to adamantane-containing isothiocyanates was studied. The MBH carbonates react with 1-(4-isothiocyanatophenyl)-adamantane in the presence of triphenylphosphine to give 5-aryl-substituted adamantane-containing 2-amino-4-methoxycarbonylthiophenes in 31-59% yields, while 1- and 2-isothio-cyanatoadamantanes were found unreactive in this reaction.

Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zenkov, IS; Abel, AS; Averin, AD; Butov, GM; Beletskaya, IP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ORGANIC FLUORINE-COMPOUNDS; CYCLIC SULFATES; BREAST-CANCER; ESTERS; DECARBOXYLATION; ESTERIFICATION; RESOLUTION; CARNITINE, Saw an article supported by the Natural Science and Engineering Research Council of Canada (NSERC)Natural Sciences and Engineering Research Council of Canada (NSERC); Dianne and Irving Kipnes Foundation. Name: Benzyl Alcohol. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Mattingly, SJ; Wuest, F; Schirrmacher, R. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

The butyric acid scaffold is the base structure of several human metabolites that serve diverse and prominent biochemical roles including as oxidative sources of cellular energy and as substrates for biosynthesis. Derivatization of metabolites through incorporation of fluorine often alters bioactivity and can facilitate detection and analysis by nuclear magnetic resonance or positron emission tomography depending upon the fluorine isotope employed. We describe the synthesis of two new fluorinated butyric acids (and three related esters) that are derivatives of the metabolites acetoacetic acid and 3-hydroxybutyric acid. 4-Fluoro-3-hydroxybutyric acid is prepared from epoxy ester precursors via ring opening by triethylamine trihydrofluoride. 2-Fluoroacetoacetic acid is prepared by electrophilic fluorination of an acid-labile -keto ester. The gradual pH-dependent decarboxylation of 2-fluoroacetoacetic acid is investigated by (19) F NMR spectroscopy.

Name: Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Mattingly, SJ; Wuest, F; Schirrmacher, R or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles