Day: October 21, 2021

Category: indole-building-block. In 2021.0 ANGEW CHEM INT EDIT published article about CONJUGATED DIENES; ENANTIOSELECTIVE 1,2-DIFUNCTIONALIZATION; INTERMOLECULAR 1,2-DIAMINATION; REGIOSELECTIVE DIAMINATION; PALLADIUM; ALKENES; OLEFINS; ALKYL; ISOTHIOCYANATES; CHEMISTRY in [Guo, Weisi; Wang, Qian; Zhu, Jieping] Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Synth & Nat Prod, EPFL,SB,ISIC,LSPN, BCH 5304, CH-1015 Lausanne, Switzerland; [Guo, Weisi] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, 53 Zhengzhou Rd, Qingdao, Peoples R China in 2021.0, Cited 86.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

Selective three-component 1,2-diamination of 1,3-dienes with concurrent introduction of two orthogonally protected amino groups remains unknown despite its significant synthetic potential. We report herein that reaction of conjugated dienes with N-aminopyridinium salts and TMSNCS affords 1,2-aminoisothiocyanation products in a highly chemo- and regio-selective manner under mild photoredox catalytic conditions. Mechanistic studies indicate that the facile isomerization of allyl thiocyanates to allyl isothiocyanates under photocatalytic conditions is responsible for the selective formation of the observed products. The mild isomerization protocol is expected to find applications in the synthesis of allyl isothiocyanates in a broad sense.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Guo, WS; Wang, Q; Zhu, JP or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 ORG LETT published article about C-H AMINATION; ALLYLIC AMINATION; METALLORADICAL CATALYSIS; UNFUNCTIONALIZED DIENES; MECHANISTIC ASPECTS; PHENYL ISOCYANATE; PHOSPHORUS-ACIDS; O-NITROSTYRENES; CARBON-MONOXIDE; ALPHA-AMINOOXY in [Ford, Russell L.; Alt, Isabel; Jana, Navendu; Driver, Tom G.] Univ Illinois, Dept Chem, 845 West Taylor St, Chicago, IL 60607 USA; [Alt, Isabel] Univ Stuttgart, Inst Organ Chem, Pfaffenwaldring 55, DE-70569 Stuttgart, Germany in 2019.0, Cited 76.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. HPLC of Formula: C7H8O

A palladium-catalyzed reductive cyclization of nitroarenes has been designed to construct sp(3)-C-NHAr bonds from sp(3)-C-H bonds by using an enolizable nucleophile to intercept a nitrosoarene intermediate. Exposure of ortho-substituted nitroarenes to 5 mol % of Pd(OAc)(2) and 10 mol % of phenanthroline under 2 atm of CO constructs partially saturated 5-, 6-, or 7-membered N-heterocycles using alpha-pyridyl carboxylates, malonates, 1,3-dimethylbarbituric acid, 1,3-diones, or difurans as the nucleophile.

About Benzyl Alcohol, If you have any questions, you can contact Ford, RL; Alt, I; Jana, N; Driver, TG or concate me.. HPLC of Formula: C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of Benzyl Alcohol. Hiranphinyophat, S; Asaumi, Y; Fujii, S; Iwasaki, Y in [Hiranphinyophat, Suphatra] Kansai Univ, Grad Sch Sci & Engn, 3-3-35 Yamate Cho, Suita, Osaka 5640836, Japan; [Iwasaki, Yasuhiko] Kansai Univ, Fac Chem Mat & Bioengn, 3-3-35 Yamate Cho, Suita, Osaka 5640836, Japan; [Iwasaki, Yasuhiko] Kansai Univ, ORDIST, 3-3-35 Yamate Cho, Suita, Osaka 5640836, Japan; [Asaumi, Yuta] Osaka Inst Technol, Grad Sch Engn, Asahi Ku, 5-16-1 Omiya, Osaka 5358585, Japan; [Fujii, Syuji] Osaka Inst Technol, Fac Engn, Asahi Ku, 5-16-1 Omiya, Osaka 5358585, Japan; [Fujii, Syuji] Osaka Inst Technol, Nanomat Microdevices Res Ctr, Asahi Ku, 5-16-1 Omiya, Osaka 5358585, Japan published Surface Grafting Polyphosphoesters on Cellulose Nanocrystals To Improve the Emulsification Efficacy in 2019.0, Cited 66.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Particle-stabilized emulsion systems have been developed to address the problematic properties of conventional surfactants. However, the nature and properties of the fine particles used in such systems remain a critical issue for stability enhancement. Herein, we describe a thermoswitchable oil-in-water (O/W) particle-stabilized emulsion that exhibits improved stability due to the addition of cellulose nanocrystals (CNCs) modified with poly[2-isopropoxy-2-oxo-1,3,2-dioxaphospholane] (PIPP), which exhibits relatively good biocompatibility and biodegradability. Various parameters, such as surface activity, concentration of particles, polarity of solvents, and temperatures, on the formation of emulsions with CNCs grafted with PIPP (CNC-g-PIPP) were investigated. Results showed that the surface activity of CNC-g-PIPP was significantly improved compared with the unmodified material. Heptane-in-water particle-stabilized emulsions with CNC-g-PIPP were stably formed, and the effect of temperature on the stability of the emulsions was characterized. CNC-g-PIPP exhibited function as an effective particulate emulsifier at 4 degrees C because of the strong adsorption at the oil-water interface. However, the emulsions rapidly disintegrated at 45 degrees C, which is above the low critical solution temperature of PIPP on CNC, as the hydrophobized CNC-g-PIPP desorbed from the oil-water interface. Based on these findings, a thermally induced reversible emulsification/demulsification was presented. The resulting switchable particle-stabilized emulsion based on CNC-g-PIPP shows promise for the ability to control the stability of an emulsion in response to temperature, which is attractive for use in biological applications.

Quality Control of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Hiranphinyophat, S; Asaumi, Y; Fujii, S; Iwasaki, Y or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Reactivity studies on a trihydride niobocene complex towards alpha,beta-Unsaturated carboxylic acids WOS:000477575000016 published article about RAY CRYSTAL-STRUCTURE; SPECTROSCOPIC PROPERTIES; HYDRIDE; ALKYL; CHEMISTRY; HYDROGENATION; NIOBIUM; KETENE; OXYGEN; CP’ in [Antinolo, Antonio; Garcia-Yuste, Santiago; Lopez-Solera, Isabel; Otero, Antonio; Teresa Tercero-Morales, Maria; Carrillo-Hermosilla, Fernando] Univ Castilla La Mancha, Fac Ciencias & Tecnol Quim, Dept Quim Inorgan Organ & Bioquim, Ctr Innovac Quim Avanzada ORFEO CINQA, Campus Ciudad Real,Campus Univ, E-13071 Ciudad Real, Spain in 2019, Cited 24. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1. Computed Properties of C5H8O2

The reactions of the trihydride niobocene complex [NbCp’H-2(3)] (Cp’ = eta(5)-C5H4SiMe3) (1) with different alpha,beta-unsaturated carboxylic acids have been studied. The reactions with fumaric and maleic acids (A and B) gave a new dinuclear carboxylato-containing niobocene derivative [(NbCp'(2))(2)(mu-kappa O-2,O-OOC-CH2-CH2-COO-kappa O-2,O)] (2), due to the occurrence of two processes, dihydrogen elimination and hydrogenation of the C=C bond of the alpha,beta-unsaturated carboxylic acid. Likewise, the use of an alpha,beta-unsaturated carboxylic acid derivative such as mono-methyl fumarate (ester) (C) gave the mononuclear [NbCp'(2)(OOC-CH2-CH2-COOMe-kappa O-2,O)] (3). When other alpha,beta-unsaturated carboxylic acids with less activated alkenes were used, such as trans-cinnamic acid (F), (E)-2-methyl-3-phenylacrylic acid (G), cyclohex-1-ene-1-carboxylic acid (H), 3-methylbut-2-enoic acid (I), (E)-2-methylbut-2-enoic acid (J) or (E)-pent-2-enoic acid (K), only the complexes [NbCp'(2)(OOCR-kappa O-2,O)], (R = trans-CH = CHPh (4), trans-CMe = CHPh (5), 1-cyclohexenyl (6), (CH = CMe2) (7), (cis-CMe = CHMe) (8), (trans-C(H) = CH-Et) (9)), were isolated, respectively, resulting from a process with dihydrogen elimination and the hydrogenation of the C=C bond do not takes place. Treatment of 2-9 with CO (3 atm) promote that the coordination mode of the carboxylate ligand changes from (kappa O-2,O-OOC-R) to (kappa O-1-OOC-R) and yielding new carbonyl derivatives [(NbCp'(2))(2)(mu-kappa O-1-OOC-CH2-CH2-COO-kappa O-1) (CO)(2)] (10); and [NbCp'(2)(OOCR-kappa O-1) (CO)] (R = CH2-CH2-COOMe (11), trans-CH = CHPh (12), trans-CMe = CHPh (13), 1-cyclohexenyl (14), CH = CMe2 (15), cis-CMe = CHMe (16) and R = trans-CH] CH-Et) (17)). Reaction of 2 with O-2 afford a new diperoxo compound [{NbCp'(2)(O-2-kappa O-2,O)}(2) (mu – kappa O-1-OOC-CH2-CH2-COO-kappa O-1)] (19), through a monoperoxo derivative [NbCp'(2)(O-2-kappa O-2,O) (mu-kappa O-1-OOC-CH2-CH2-COO-kappa O-2,O) NbCp'(2)] (18). All the new complexes were characterized by usual IR and NMR spectroscopic methods and the crystal structure of 16 and 18 were determined by X-ray diffraction studies. (c) 2019 Elsevier B.V. All rights reserved.

Computed Properties of C5H8O2. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Antinolo, A; Garcia-Yuste, S; Lopez-Solera, I; Otero, A; Tercero-Morales, MT; Carrillo-Hermosilla, F or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 4-Methoxybenzaldehyde. Authors Thi, TAD; Le-Nhat-Thuy, G; Thi, QGN; Thi, PH; Tuan, AN; Mai, HH; Ha, TN; Le, TA; Nguyen, TV in SPRINGER published article about in [Thi, Tuyet Anh Dang; Le-Nhat-Thuy, Giang; Thi, Quynh Giang Nguyen; Thi, Phuong Hoang; Tuan, Anh Nguyen; Mai, Ha Hoang; Ha, Thanh Nguyen; Van Nguyen, Tuyen] Vietnam Acad Sci & Technol, Inst Chem, 18 Hoang Quoc Viet St, Hanoi 100000, Vietnam; [Thi, Tuyet Anh Dang; Le-Nhat-Thuy, Giang; Thi, Quynh Giang Nguyen; Mai, Ha Hoang; Van Nguyen, Tuyen] Vietnam Acad Sci & Technol, Grad Univ Sci & Technol, 18 Hoang Quoc Viet St, Hanoi 100000, Vietnam; [Le, Tuan Anh] Vietnam Natl Univ Hanoi, Univ Sci, Fac Chem, 334 Nguyen Trai, Hanoi 100000, Vietnam in 2021.0, Cited 37.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Synthesis of novel 3-arylated 2-hydroxy-1,4-naphthoquinone derivatives via microwave-assisted three-component reaction starting from 2-hydroxy-1,4-naphthoquinone, tetronic acid, and various aromatic aldehydes has been described. This multicomponent domino reaction proceeded through the Knoevenagel condensation, Michael addition, deprotonation, and 1,3-H shift steps. Five of the synthesized compounds displayed good cytotoxic activity against two human cancer cell lines, KB and HepG2, with half maximal inhibitory concentration values in a range of 4-20 mu M.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Thi, TAD; Le-Nhat-Thuy, G; Thi, QGN; Thi, PH; Tuan, AN; Mai, HH; Ha, TN; Le, TA; Nguyen, TV or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Regioselective Monobromination of Phenols with KBr and ZnAl-BrO3–Layered Double Hydroxides WOS:000522454500150 published article about N-BROMOSUCCINIMIDE NBS; AROMATIC-COMPOUNDS; OXIDATIVE BROMINATION; SELECTIVE MONOBROMINATION; SUBSTITUTED PHENOLS; EFFICIENT SYNTHESIS; MILD; BROMIDE; ACID; ANILINES in [Wang, Ligeng; Feng, Chun; Zhang, Yan; Hu, Jun] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310004, Peoples R China in 2020, Cited 69. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Computed Properties of C7H5F3O

The regioselective mono-bromination of phenols has been successfully developed with KBr and ZnAl-BrO3–layered double hydroxides (abbreviated as ZnAl-BrO3–LDHs) as brominating reagents. The para site is much favorable and the ortho site takes the priority if para site is occupied. This reaction featured with excellent regioselectivity, cheap brominating reagents, mild reaction condition, high atom economy, broad substrate scope, and provided an efficient method to synthesize bromophenols.

Computed Properties of C7H5F3O. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Wang, LG; Feng, C; Zhang, Y; Hu, J or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020 CHEMISTRYSELECT published article about COPPER-CATALYZED HYDROXYLATION; ARYLBORONIC ACIDS; IPSO-HYDROXYLATION; BORONIC ACIDS; HETEROGENEOUS CATALYST; ORGANOCATALYTIC OXIDATION; ARYL HALIDES; NANOPARTICLES; MILD; ALDEHYDES in [Gujjarappa, Raghuram; Vodnala, Nagaraju; Malakar, Chandi C.] Natl Inst Technol Manipur, Dept Chem, Imphal 795004, Manipur, India; [Garg, Aakriti; Gupta, Sreya] NIPER, Dept Med Chem, 168 Maniktala Main Rd, Kolkata 700054, India; [Hazra, Chinmoy K.] Indian Inst Technol Delhi, Dept Chem, Hauz Khas, New Delhi 110016, India in 2020, Cited 80. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

An efficient amino-acid-mediated ipso-hydroxylation of arylboronic acids, aryl boronate esters and aryl trifluoroborates to aryl alcohols has been described. The current protocol was realized by using sub-stoichiometric amount of l-histidine in presence of triethylamine under aerobic conditions in DMF as solvent. This amino-acid-mediated process provides an alternative route for the hydroxylation of organoborons through in situ generation of hydrogen peroxide. The present protocol explores the synthetic utility of amino acids as organocatalysts for the preparation of aryl alcohols. It was observed that l-histidine plays an important role for the conversion of aerial oxygen in to hydrogen peroxide via thermal excitation process followed by thermal degradation of Et3N. The developed approach holds good for a wide range of compounds with excellent yields and competent functional group tolerance.

Safety of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Gujjarappa, R; Vodnala, N; Garg, A; Hazra, CK; Gupta, S; Malakar, CC or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Mitsui, A; Nagao, K; Ohmiya, H in WILEY-V C H VERLAG GMBH published article about in [Mitsui, Atsuhisa; Nagao, Kazunori; Ohmiya, Hirohisa] Kanazawa Univ, Grad Sch Med Sci, Div Pharmaceut Sci, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan; [Ohmiya, Hirohisa] PRESTO, JST, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan in 2021.0, Cited 59.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A reductive cross-coupling reaction between aromatic aldehydes and arylnitriles using a copper catalyst and a silylboronate as a reductant is reported. This protocol represents an unprecedented approach to the chemoselective synthesis of alpha-hydroxy ketones by electrophile-electrophile cross-coupling.

Category: indole-building-block. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Mitsui, A; Nagao, K; Ohmiya, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Wu, RP; Gao, K in ROYAL SOC CHEMISTRY published article about in [Wu, Rongpei; Gao, Ke] Cent China Normal Univ, Coll Chem, 152 Luoyu Rd, Wuhan, Hubei, Peoples R China in 2021.0, Cited 44.0. Name: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A highly efficient B(C6F5)(3)-catalyzed tandem protonation/deuteration and reduction of in situ-formed enamines in the presence of water and pinacolborane was developed. Regioselective beta-deuteration of tertiary amines was achieved with high chemo- and regioselectivity. D2O was used as a readily available and cheap source of deuterium. Mechanistic studies indicated that B(C6F5)(3) could activate water to promote the protonation and reduction of enamines.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Wu, RP; Gao, K or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Visible light-induced mono-bromination of arenes with BrCCl3 published in 2021. Application In Synthesis of m-Methoxyphenol, Reprint Addresses Cheng, XM; Lu, YN; Loh, TP (corresponding author), Nanjing Tech Univ, Inst Adv Synth, Sch Chem & Mol Engn, Jiangsu Natl Synerget Innovat Ctr Adv Mat,Nanjing, Nanjing 211816, Peoples R China.; Loh, TP (corresponding author), Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore.. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

A highly efficient and regioselective bromination of electron-rich arenes and heteroarenes using commercially available BrCCl3 as a Br source has been developed. The reaction was performed in air under mild conditions with photocatalyst Ru(bpy)(3)Cl-2 center dot 6H(2)O, avoiding the usage of strong acids and strong oxidants. Mono-brominated products were obtained with medium to excellent yields (up to 94%). This strategy has shown good compatibility and high para-selectivity, which will facilitate the complicated synthesis.

Application In Synthesis of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Fan, JL; Wei, QC; Zhu, ES; Gao, J; Cheng, XM; Lu, YN; Loh, TP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles