Day: October 21, 2021

SDS of cas: 86-95-3. Elbastawesy, MAI; Aly, AA; Ramadan, M; Elshaier, YAMM; Youssif, BGM; Brown, AB; Abuo-Rahma, GEDA in [Elbastawesy, Mohammed A., I; Ramadan, Mohamed] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Assiut 71524, Egypt; [Aly, Ashraf A.] Menia Univ, Fac Sci, Dept Chem, Al Minya 61519, Egypt; [Elshaier, Yaseen A. M. M.] Univ Sadat City, Fac Pharm, Dept Organ & Med Chem, Menoufia 32958, Egypt; [Youssif, Bahaa G. M.] Assiut Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Assiut 71526, Egypt; [Brown, Alan B.] Florida Inst Technol, Program Chem, Melbourne, FL 32901 USA; [Abuo-Rahma, Gamal El-Din A.] Menia Univ, Fac Pharm, Dept Med Chem, Al Minya 61519, Egypt published Novel Pyrazoloquinolin-2-ones: Design, synthesis, docking studies, and biological evaluation as antiproliferative EGFR-TK inhibitors in 2019, Cited 50. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

Two new series of diethyl 2-[2-(substituted-2-oxo-1,2-dihydroquinolin-4-yl)hydrazono]-succinates 6a-g and 1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been designed and synthesized. The structures of the synthesized compounds were proved by IR, mass, NMR (2D) spectra and elemental analyses. The target compounds were evaluated for their in vitro cytotoxic activity against 60 cancer cell lines according to NCI protocol. Consequently, seven compounds were further examined against the most sensitive cell lines, leukemia CCRFCEM, and MOLT-4. 5-Amino-1-(6-bromo-2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazole-3,4-dicarbonitrile (7f) was the most active product, with IC50= 1.35 uM and 2.42 uM against MOLT-4 and CCRF-CEM, respectively. Also, it showed a remarkable inhibitory activity compared to erlotinib on the EGFR TK with IC50 = 247.14 nM and 208.42 nM, respectively. Cell cycle analysis of MOLT-4 cells treated with 7f showed cell cycle arrest at G2/M phase (supported by Caspases, BAX and Bcl-2 studies) with a significant pro-apoptotic activity as indicated by annexin V-FITC staining. Moreover, the docking study indicated that both the pyrazole moiety and the quinolin-2-one ring showed good fitting into EGFR (PDB code: 1M17). In order to interpret SAR of the designed compounds, and provide a basis for further optimization, molecular docking of the synthesized compounds to known EGFR inhibitors was performed. The study illustrated the effect of several factors on the compounds’ activity.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Elbastawesy, MAI; Aly, AA; Ramadan, M; Elshaier, YAMM; Youssif, BGM; Brown, AB; Abuo-Rahma, GEDA or concate me.. SDS of cas: 86-95-3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 99-93-4. In 2021.0 J PHOTOCH PHOTOBIO A published article about STRUCTURAL-CHARACTERIZATION; CHEMICAL-EQUILIBRIA; PYRUVIC-ACID; ANTHOCYANIN; PYRANOANTHOCYANINS; PIGMENTS; ANALOGS; DYES in [Gomes, Vania; Pires, Ana Sofia; Fernandes, Iva; Mateus, Nuno; de Freitas, Victor; Cruz, Luis] Univ Porto, Dept Quim & Bioquim, REQUIMTE LAQV, Fac Ciencias, Rua Campo Alegre 687, P-4169007 Porto, Portugal in 2021.0, Cited 60.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Pyranoflavylium-derived compounds have been shown to have improved properties over the corresponding flavylium precursors, such as chemical and photochemical stability. In addition, they have the characteristic of responding to stimuli like pH due to the proton transfer reactions leading to different colored quinoidal bases. Thus, these dyes can be used as powerful pH-indicators for several sensing applications. In this work, the thermodynamic constants and photophysical properties of novel pyrano-3,7-deoxyanthocyanin dyes bearing phenol and catechol groups were studied by UV-vis absorbance and fluorescence measurements as a function of pH. The cytotoxicity properties of these compounds were also evaluated. Overall, the symmetrical phenol-based pyranoflavylium dye showed the greatest color variation within pH range of food spoilage process, remarkable fluorescence properties, and reduced cytotoxicity, which make it a promising candidate as a pH-dependent colorimetric and fluorescence sensor for food intelligent packaging.

SDS of cas: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Gomes, V; Pires, AS; Fernandes, I; Mateus, N; de Freitas, V; Cruz, L or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ORTHO-QUINONE METHIDES; ONE-POT; CHROMENES, Saw an article supported by the National Research Foundation of KoreaNational Research Foundation of Korea [NRF2018R1A6A1A03023718, NRF-2020R1A2C2005961]. Application In Synthesis of 4-Methoxybenzaldehyde. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Prasad, SS; Joshi, DR; Kim, I. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

A highly efficient synthetic route to polysubstituted 2H-chromenes was developed utilizing a domino O-alkylation/intramolecular Horner-Wadsworth-Emmons (HWE) olefination of diarylmethylphosphonates, which were readily accessed via Lewis acid mediated one-pot three-component coupling of aldehydes, phenols, and triethyl phosphite.

Application In Synthesis of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Prasad, SS; Joshi, DR; Kim, I or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Korff, M; Imberg, L; Will, JM; Buckreiss, N; Kalinina, SA; Wenzel, BM; Kastner, GA; Daniliuc, CG; Barth, M; Ovsepyan, RA; Butov, KR; Humpf, HU; Lehr, M; Panteleev, MA; Poso, A; Karst, U; Steinmetzer, T; Bendas, G; Kalinin, DV in AMER CHEMICAL SOC published article about in [Korff, Marvin; Imberg, Lukas; Kastner, Gregor A.; Barth, Maximilian; Lehr, Matthias; Kalinin, Dmitrii, V] Univ Munster, Inst Pharmaceut & Med Chem, D-48149 Munster, Germany; [Will, Jonas M.; Karst, Uwe] Univ Munster, Inst Inorgan & Analyt Chem, D-48149 Munster, Germany; [Bueckreiss, Nico; Bendas, Gerd] Univ Bonn, Pharmaceut Inst, D-53121 Bonn, Germany; [Kalinina, Svetlana A.; Humpf, Hans-Ulrich] Univ Munster, Inst Food Chem, D-48149 Munster, Germany; [Wenzel, Benjamin M.; Steinmetzer, Torsten] Philipps Univ Marburg, Inst Pharmaceut Chem, Dept Pharm, D-35032 Marburg, Germany; [Daniliuc, Constantin G.] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany; [Ovsepyan, Ruzanna A.; Butov, Kirill R.; Panteleev, Mikhail A.] Dmitriy Rogachev Natl Med Res Ctr Pediat Hematol, Lab Translat Med, Moscow 117997, Russia; [Ovsepyan, Ruzanna A.; Butov, Kirill R.; Panteleev, Mikhail A.] Russian Acad Sci, Ctr Theoret Problems Physicochem Pharmacol, Moscow 119991, Russia; [Panteleev, Mikhail A.] Lomonosov Moscow State Univ, Fac Phys, Moscow 119991, Russia; [Panteleev, Mikhail A.] Moscow Inst Phys & Technol, Fac Biol & Med Phys, Dolgoprudnyi 141700, Russia; [Poso, Antti] Univ Eastern Finland, Fac Hlth Sci, Sch Pharm, Kuopio 70211, Finland; [Poso, Antti] Univ Hosp Tubingen, Dept Internal Med 8, D-72076 Tubingen, Germany in 2020, Cited 75. Formula: C5H8O2. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1

We herein report the conventional and microscale parallel synthesis of selective inhibitors of human blood coagulation factor XIIa and thrombin exhibiting a 1,2,4-triazol-5-amine scaffold. Structural variations of this scaffold allowed identifying derivative 21i, a potent 29 nM inhibitor of FXIIa, with improved selectivity over other tested serine proteases and also finding compound 21m with 27 nM inhibitory activity toward thrombin. For the first time, acylated 1,2,4-triazol-5-amines were proved to have anticoagulant properties and the ability to affect thrombin- and cancer-cell-induced platelet aggregation. Performed mass spectrometric analysis and molecular modeling allowed us to discover previously unknown interactions between the synthesized inhibitors and the active site of FXIIa, which uncovered the mechanistic details of FXIIa inhibition. Synthesized compounds represent a promising starting point for the development of novel antithrombotic drugs or chemical tools for studying the role of FXIIa and thrombin in physiological and pathological processes.

Formula: C5H8O2. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Korff, M; Imberg, L; Will, JM; Buckreiss, N; Kalinina, SA; Wenzel, BM; Kastner, GA; Daniliuc, CG; Barth, M; Ovsepyan, RA; Butov, KR; Humpf, HU; Lehr, M; Panteleev, MA; Poso, A; Karst, U; Steinmetzer, T; Bendas, G; Kalinin, DV or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Recently I am researching about ACIDIC MEDIUM; CARBON-STEEL; BENZIMIDAZOLE DERIVATIVES; ELECTRONIC-STRUCTURE; COMBINED DFT; C-STEEL; ADSORPTION; MOLECULES; BEHAVIOR; INSIGHT, Saw an article supported by the Deanship of Scientific Research at King Khalid University [R.G.P.1/199/41]. Published in ELSEVIER in AMSTERDAM ,Authors: Chafiq, M; Chaouiki, A; Albayati, MR; Lgaz, H; Salghi, R; AbdelRaheem, SK; Ali, IH; Mohamed, SK; Chung, IM. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

The current investigation seeks to explore the adsorption mechanism of newly synthesized Naproxen-based hydrazones on mild steel (MS) surface in 1.0 M HCI solution and their corrosion inhibition efficiencies. To this end, two hydrazone derivatives namely, (E)-N’-(1-(4-chlorophenypethylidene)-2-(6-methoxynaphthalen-2-yl)propanehydrazide (PHD-Cl) and (E)-N’-(1-(4-hydroxyphenypethylidene)-2-(6-methoxynaphthalen-2-yl) propanehydrazide (PHD-OH) were synthesized, characterized and their corrosion inhibition effects were evaluated using a combined electrochemical and theoretical approach. It is evidently dear from the findings presented in this investigation that the two inhibitors exhibited excellent protection efficiency, and the best inhibition performance was shown by PHD-OH inhibitor (96% at 5 x 10(-3) M ). Weight loss measurements revealed that the optimum concentration of inhibitors is 5 x 10(-3) mol/L. The experimental results obtained by electrochemical techniques (potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS)) indicated that the presence of PHD-CI and PHD-OH compounds greatly increased the polarization resistance and affected both anodic and cathodic reactions, i.e. mixed-type inhibitors. Based on electrochemical results, the polarization resistance was greatly increased, from an initial value for the MS (in 1.0 moll HCI) of 29 up to 871 Omega cm(2) for the inhibited solution (1.0 mol/L HCl with 5 x 10(-3) mol/L. of PHD-OH). Furthermore, the adsorption isotherm coincides well with the Langmuir isotherm model. The effect of temperature on PHD-OH adsorption was investigated, experimentally using weight loss tests, and theoretically using molecular dynamic simulations (MD). Moreover, the study found that a protective barrier was set up through the adsorption of the studied compounds on MS surface which is confirmed by scanning electron microscopy with energy-dispersive X-ray analysis (SEM-EDX). Moreover, molecular proprieties of corrosion inhibitor molecules were explored from a theoretical viewpoint using Density Functional Theory (DFT), molecular dynamic (MD) simulation and radial distribution function (RDF) studies. Theoretical results that were in good agreement with experimental findings demonstrated strong interactions between inhibitor molecules and metal surface. (C) 2020 Elsevier B.V. All rights reserved.

Category: indole-building-block. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Chafiq, M; Chaouiki, A; Albayati, MR; Lgaz, H; Salghi, R; AbdelRaheem, SK; Ali, IH; Mohamed, SK; Chung, IM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C7H8O2. In 2019.0 EUR J MED CHEM published article about VASCULAR DISRUPTING AGENTS; INHIBITORS; COMPLEX; DESIGN in [Bueno, Oskia; Gargantilla, Marta; Jose Camarasa, Maria; Perez-Perez, Maria-Jesus; Priego, Eva-Maria] CSIC, IQM, Juan Cierva 3, Madrid 28006, Spain; [Estevez-Gallego, Juan; Fernando Diaz, J.] CSIC, CIB, Ramiro Maeztu 9, Madrid 28040, Spain; [Martins, Solange; Liekens, Sandra] Katholieke Univ Leuven, Rega Inst Med Res, Herestr 49, B-3000 Leuven, Belgium in 2019.0, Cited 39.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

Microtubule targeting agents represent a very active arena in the development of anticancer agents. In particular, compounds binding at the colchicine site in tubulin are being deeply studied, and the structural information recently available on this binding site allows structure-directed design of new ligands. Structural comparison of our recently reported high resolution X-Ray structure of the cyclohexanedione derivative TUB075 bound to tubulin and the tubulin-DAMA-colchicine complex has revealed a conformational change in the alpha T5 loop. By a grid-based computational analysis of the tubulin-DAMA-colchicine binding site, we have identified a new favourable binding area in the colchicine-site that was unexplored by our lead TUB075. Thus, based on a structure-guided design, new cyclohexanedione derivatives have been synthesized and tested for tubulin binding and in cellular assays. As a result, we have identified diphenyl ether derivatives with IC50 values around 10-40 nM against three different tumor cell lines and affinity constants for tubulin similar to that of colchicine around 10(7) M-1. As expected, they halted the cell cycle progression at G2/M phase at concentrations as low as 0.08 mu M. (C) 2019 Elsevier Masson SAS. All rights reserved.

HPLC of Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Bueno, O; Gargantilla, M; Estevez-Gallego, J; Martins, S; Diaz, JF; Camarasa, MJ; Liekens, S; Perez-Perez, MJ; Priego, EM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of m-Methoxyphenol. In 2019.0 SCI REP-UK published article about IMMUNE RECONSTITUTION; HIV-INFECTION; TUBERCULOSIS; THERAPY; AIDS; ASSOCIATION; INITIATION in [Yen, Yung-Feng] Taipei City Hosp, Sect Infect Dis, Taipei, Taiwan; [Yen, Yung-Feng; Chen, Yi-Ming Arthur] Kaohsiung Med Univ, Ctr Infect Dis & Canc Res, Kaohsiung, Taiwan; [Yen, Yung-Feng; Jen, I. -An; Lin, Su-I.] Natl Yang Ming Univ, Dept & Inst Publ Hlth, Taipei, Taiwan; [Yen, Yung-Feng] Natl Taipei Univ Nursing & Hlth Sci, Dept Hlth Care Management, Taipei, Taiwan; [Chen, Marcelo] Mackay Mem Hosp, Dept Urol, Taipei, Taiwan; [Chen, Marcelo] Mackay Jr Coll Med Nursing & Management, Dept Cosmet Applicat & Management, Taipei, Taiwan; [Chuang, Pei-Hung] Taipei Assoc Hlth & Welf Data Sci, Taipei, Taiwan; [Lee, Chun-Yuan] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan; [Lin, Su-I.] Natl Hlth Res Inst, Natl Mosquitoborne Dis Control Res Ctr, Zhunan, Miaoli County, Taiwan; [Chen, Yi-Ming Arthur] Taipei Med Univ, Sch Pharm, Clin Pharmacogen & Pharmacoprote Program, Taipei, Taiwan in 2019.0, Cited 21.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

Highly active antiretroviral therapy (HAART) causes a rapid increase of CD4+T cells counts during the first 3-6 months of treatment and may enhance the development of opportunistic infections (OIs). However, the short- and long-term effects of HAART exposure on the development of incident OIs has not been extensively studied. This nationwide longitudinal study followed up a total of 26,258 people living with HIV/AIDS (PLWHA) to ascertain the short- and long-term effects of HAART on incident OIs. During 150,196 person-years of follow-up, 6,413 (24.4%) PLWHA had new onset of OIs. After adjusting for demographics, comorbidities, and AIDS status, PLWHA who received HAART were more likely to develop OIs than those who did not receive HAART. Considering the short- and long-term effects of HAART on the development of OIs, HAART was found to be a risk factor for developing OIs during the first 90 days of treatment, but a protective factor against OIs after 180 days of HAART use. The risk for the development of active OIs significantly decreased as the duration of HAART increased (P < 0.001). Our study suggests that HAART is a risk factor for developing OIs in the short term, but is a protective factor in the long term. About m-Methoxyphenol, If you have any questions, you can contact Yen, YF; Chen, M; Jen, IA; Chuang, PH; Lee, CY; Lin, SI; Chen, YMA or concate me.. Application In Synthesis of m-Methoxyphenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Formation of furo[3,2-c]quinolone-2-carbonitriles and 4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carboxamides from reaction of quinoline-2,4-diones with 2-[bis(methylthio)methylene]malononitrile WOS:000513256900009 published article about DERIVATIVES; INHIBITORS; FUROQUINOLINE; ALKALOIDS; MODEL in [Aly, Ashraf A.; Mohamed, Asmaa H.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Ishak, Esam] Al Azhar Univ, Fac Sci, Dept Chem, Assiut, Egypt; [Ishak, Esam] Jouf Univ, Coll Sci & Arts, Dept Chem, Alquurrayate, Saudi Arabia; [Shwaky, Ahmed M.] Umm Al Qura Univ, STU, Mecca, Saudi Arabia in 2020, Cited 31. Recommanded Product: 4-Hydroxyquinolin-2(1H)-one. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

Quinoline-2,4-diones reacted with 2-[bis(methylthio)methylene]malononitrile in DMF/Et3N to produce 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carbonitriles and 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carboxamides in state of 2-imino-substituted 4-(methylthio)-5,6-dihydro-2H-pyrano[3,2-c]quinolone-3-carbonitriles. The structures of all new products were proved using NMR, IR, and mass spectral data. The possible mechanism for the reaction is also discussed. Graphic abstract

Recommanded Product: 4-Hydroxyquinolin-2(1H)-one. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Biomimetic Synthesis Enables the Structure Revision of Furoerioaustralasine WOS:000494553300055 published article about ERIOSTEMON; SYNTHASE in [Coleman, Matthew A.; Burchill, Laura; Sumby, Christopher J.; George, Jonathan H.] Univ Adelaide, Dept Chem, Adelaide, SA 5005, Australia in 2019, Cited 12. Computed Properties of C9H7NO2. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

The structure of furoerioaustralasine, a unique Australian alkaloid, has been revised based on a concise, biomimetic synthesis. The key step is a stereospecific, intramolecular ring opening of an epoxide to form a central dihydrofuran fused to a quinoline ring system.

Computed Properties of C9H7NO2. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Coleman, MA; Burchill, L; Sumby, CJ; George, JH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Futaki, E; Takeda, N; Yasui, M; Shinada, T; Miyata, O; Ueda, M in [Futaki, Erika; Takeda, Norihiko; Yasui, Motohiro; Miyata, Okiko; Ueda, Masafumi] Kobe Pharmaceut Univ, Higashinada Ku, Kobe, Hyogo 6588558, Japan; [Shinada, Tetsuro; Miyata, Okiko] Osaka City Univ, Grad Sch Sci, Sumiyoshi Ku, Osaka 5588585, Japan published gamma-C (sp(3))-H bond functionalisation of alpha,beta-unsaturated amides through an umpolung strategy in 2020, Cited 52. Product Details of 80-59-1. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1.

The nucleophilic gamma-phenylation and gamma-alkylation of alpha,beta-unsaturated amides have been developed. This umpolung reaction allows the regioselective introduction of phenyl and alkyl groups to a vinylketene N,O-acetal, which is generated in situ from an alpha,beta-unsaturated N-alkoxyamide, followed by N-O bond cleavage in a two-step, one-pot process.

Product Details of 80-59-1. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Futaki, E; Takeda, N; Yasui, M; Shinada, T; Miyata, O; Ueda, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles