Day: October 25, 2021

Recommanded Product: 3,4-Dimethoxybenzaldehyde. In 2021.0 POLYCYCL AROMAT COMP published article about MICROWAVE-ASSISTED SYNTHESIS; REUSABLE CATALYST; HIGHLY EFFICIENT; ACID CATALYST; 1,8-DIOXO-DECAHYDROACRIDINE DERIVATIVES; MULTICOMPONENT REACTIONS; HETEROGENEOUS CATALYST; BIOLOGICAL-ACTIVITIES; RECYCLABLE CATALYST; MEDIATED SYNTHESIS in [Mousavi, Seyyed Rasul; Foroumadi, Alireza] Univ Tehran Med Sci, Dept Med Chem, Fac Pharm, Tehran, Iran; [Mousavi, Seyyed Rasul; Foroumadi, Alireza] Univ Tehran Med Sci, TIPS, Tehran, Iran; [Nodeh, Hamid Rashidi] SRI, Fac Food Ind & Agr, Dept Food Sci & Technol, Karaj, Iran in 2021.0, Cited 77.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

Acridine derivatives were synthesized by reaction of dimedone, aromatic amines/ammonium acetate and various aromatic aldehydes in the presence of a new and green graphene oxide incorporated strontium magnetic nanocatalyst (MSrGO NCs) under solvent-free conditions. This methodology offers many advantages including operational simplicity, good to excellent yields (up to 97%), short reaction times, the remarkable magnetic property of the nanocomposite, and easy separation of the nanocatalyst from the reaction mixture by magnetic decantation and reused several times without significant loss of catalytic activity.

Recommanded Product: 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Mousavi, SR; Nodeh, HR; Foroumadi, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3-Hydroxybenzaldehyde. In 2019.0 BIOORG MED CHEM LETT published article about DEMETHYLASE 1 LSD1; ANTITUMOR-ACTIVITY; HISTONE; ANTIOXIDANT in [Wang, Jiming; Zhang, Xiangyu; Yan, Jiangkun; Li, Wei; Jiang, Qinwen; Wang, Xinran; Zhao, Dongmei; Cheng, Maosheng] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China in 2019.0, Cited 26.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Histone lysine-specific demethylase 1 (LSD1) was the first discovered histone demethylase. Inactivating LSD1 or downregulating its expression inhibits cancer-cell development, and thus, it is an attractive molecular target for the development of novel cancer therapeutics. In this study, we worked on the structural optimization of natural products and identified 30 novel LSD1 inhibitors. Utilizing a structure-based drug design strategy, we designed and synthesized a series of curcumin analogues that were shown to be potent LSD1 inhibitors in the enzyme assay. Compound WB07 displayed the most potent LSD1 inhibitory activity, with an IC50 value of 0.8 mu M. Moreover, WA20 showed an anticlonogenic effect on A549 cells with an IC50 value of 4.4 mu M. Molecular docking simulations were also carried out, and the results indicated that the inhibitors bound to the protein active site located around the key residues of Asp555 and Asp556. These findings suggested that compounds WA20 and WB07 are the first curcumin analogue-based LSD1 inhibitors with remarkable A549 suppressive activity, providing a novel scaffold for the development of LSD1 inhibitors.

Recommanded Product: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Wang, JM; Zhang, XY; Yan, JK; Li, W; Jiang, QW; Wang, XR; Zhao, DM; Cheng, MS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 123-11-5. In 2021 MOLECULES published article about UV-RADIATION; IN-VITRO; PRODUCTS; EXPOSURE; EXTRACT in [Wijayanti, Lucia Wiwid; Swasono, Respati Tri; Jumina, Jumina] Univ Gadjah Mada, Fac Math & Nat Sci, Dept Chem, Bulaksumur 55281, Yogyakarta, Indonesia; [Wijayanti, Lucia Wiwid] Univ Sanata Dharma, Chem Educ Dept, Kampus 3 Paingan, Yogyakarta 55281, Indonesia; [Lee, Wonkoo] Sogang Univ, Dept Chem, Seoul 04107, South Korea in 2021, Cited 39. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in the research to develop sunscreen agent has been increasing. Chalcone is a promising compound to be developed as its chromophore absorbs in the UV region. Therefore, in the present work, we synthesized eight chalcone derivatives through Claisen-Schmidt condensation at room temperature. The evaluation of the optical properties of each chalcone derivatives in the UV region was conducted through spectroscopic and computational studies. The synthesized chalcones were obtained in good yields and they were active in the UV region. The results revealed that more methoxy substituents to chalcone leads toward red shift. All chalcone derivatives have high molar absorptivity value (21,000-56,000) demonstrating that they have the potential to be used as the sunscreen agent. The cytotoxicity assay showed that chalcone derivatives were demonstrating low toxicity toward normal human fibroblast cell, which is remarkable. Therefore, we concluded that the synthesized chalcones in this work were potential to be developed as novel sunscreen agents in real application.

Recommanded Product: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Wijayanti, LW; Swasono, RT; Lee, W; Jumina, J or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 BIOORG CHEM published article about ALZHEIMERS-DISEASE; DONEPEZIL; TACRINE; HYBRIDS; DESIGN; E2020 in [Kuzu, Burak; Tan, Meltem; Menges, Nurettin] Van Yuzuncu Yil Univ, Pharmaceut Chem Sect, TR-65080 Van, Turkey; [Kuzu, Burak; Tan, Meltem; Menges, Nurettin] YYU TEKNOKENT, SAFF Chem Reagent R&D Lab, TR-65080 Van, Turkey; [Taslimi, Parham; Gulcin, Ilhami] Ataturk Univ, Dept Chem, TR-25240 Erzurum, Turkey; [Taspinar, Mehmet] Van Yuzuncu Yil Univ, Dept Med Biol, TR-65080 Van, Turkey in 2019.0, Cited 32.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. SDS of cas: 99-93-4

Mono- or di-substituted imidazole derivatives were synthesized using a one-pot, two-step strategy. All imidazole derivatives were tested for AChE and BChE inhibition and showed nanomolar activity similar to that of the test compound donepezil and higher than that of tacrine. Structure activity relationship studies, docking studies to on X-ray crystal structure of AChE with PDB code 1B41, and adsorption, distribution, metabolism, and excretion (ADME) predictions were performed. The synthesized core skeleton was bound to important regions of the active site of AChE such as the peripheral anionic site (PAS), oxyanion hole (OH), and anionic subsite (AS). Selectivity of the reported test compounds was calculated and enzyme kinetic studies revealed that they behave as competitive inhibitors, while two of the test compounds showed noncompetitive inhibitory behavior. ADME predictions revealed that the synthesized molecules might pass through the blood brain barrier and intestinal epithelial barrier and circulate freely in the blood stream without binding to human serum albumin. While the toxicity of one compound on the WS1 (skin fibroblast) cell line was 1790 mu M, its toxicity on the SH-SY5Y (neuroblastoma) cell line was 950 mu M.

SDS of cas: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Kuzu, B; Tan, M; Taslimi, P; Gulcin, I; Taspinar, M; Menges, N or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Copper-Catalyzed Sonogashira-Cross-Coupling of Phenols Using Dichloroimidazolidinedione published in 2021.0. Product Details of 150-76-5, Reprint Addresses Mokhtari, J (corresponding author), Islamic Azad Univ, Dept Chem, Sci & Res Branch, POB 14515-775, Tehran, Iran.. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol

Phenols are considered as an ideal alternative to aryl halides as coupling partners in cross-coupling reactions. In this work a copper-catalyzed Sonogashira cross-coupling of phenols using Dichloroimidazolidinedione (DCID) as new C-O activation agent has been developed for the first time. Substituted phenols and phenyl acetylenes were well-matched with the optimizing reaction conditions.

Product Details of 150-76-5. About Mequinol, If you have any questions, you can contact Hosseini, N; Mokhtari, J; Yavari, I or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ESTERS; ACID; MECHANOCHEMISTRY; ULTRASOUND; CHALLENGES; MICROWAVE; MITSUNOBU; REAGENT; OIL, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21978270]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Zheng, L; Sun, C; Xu, WH; Dushkin, AV; Polyakov, N; Su, WK; Yu, JB. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone. Application In Synthesis of 4′-Hydroxyacetophenone

Herein, we describe two novel strategies for the synthesis of esters, as achieved under high-speed ball-milling (HSBM) conditions at room temperature. In the presence of I-2 and KH2PO2, the reactions afford the desired esterification derivatives in 45% to 91% yields within 20 min of grinding. Meanwhile, using KI and P(OEt)(3), esterification products can be obtained in 24% to 85% yields after 60 min of grinding. In addition, the I-2/KH2PO2 protocol was successfully extended to the late-stage diversification of natural products showing the robustness of this useful approach. Further application of this method in the synthesis of inositol nicotinate was also discussed.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Zheng, L; Sun, C; Xu, WH; Dushkin, AV; Polyakov, N; Su, WK; Yu, JB or concate me.. Application In Synthesis of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D-3 Dopamine Receptor Agonist WOS:000585210700031 published article about IMPULSE CONTROL DISORDERS; D3 RECEPTOR; IN-VIVO; HIGH-AFFINITY; CRYSTAL-STRUCTURE; BIVALENT LIGANDS; MPTP TOXICITY; FORCE-FIELD; POTENT; PRAMIPEXOLE in [Moritz, Amy E.; Free, R. Benjamin; Akano, Emmanuel O.; Sibley, David R.] NINDS, Mol Neuropharmacol Sect, Intramural Res Program, NIH, Bethesda, MD 20892 USA; [Weiner, Warren S.; Aube, Jeffrey; Frankowski, Kevin J.] Univ Kansas, Specialized Chem Ctr, Lawrence, KS 66047 USA; [Gandhi, Disha; Aube, Jeffrey; Frankowski, Kevin J.] UNC Eshelman Sch Pharm, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA; [Abramyan, Ara; Shi, Lei] NIDA, Computat Chem & Mol Biophys Unit, Mol Targets & Medicat Discovery Branch, Intramural Res Program,NIH, Baltimore, MD 21224 USA; [Keck, Thomas M.] Rowan Univ, Coll Sci & Math, Dept Chem & Biochem, Dept Mol & Cellular Biosci, Glassboro, NJ 08028 USA; [Ferrer, Marc; Hu, Xin; Southall, Noel] NIH, NIH Chem Genom Ctr, Div Preclin Innovat, Natl Ctr Adv Translat Sci, Rockville, MD 20850 USA; [Steiner, Joseph] NINDS, NeuroTherapeut Dev Unit, Intramural Res Program, NIH, Bethesda, MD 20892 USA in 2020.0, Cited 101.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Computed Properties of C7H8O2

To identify novel D-3 dopamine receptor (D3R) agonists, we conducted a high-throughput screen using a beta-arrestin recruitment assay. Counterscreening of the hit compounds provided an assessment of their selectivity, efficacy, and potency. The most promising scaffold was optimized through medicinal chemistry resulting in enhanced potency and selectivity. The optimized compound, ML417 (20), potently promotes D3R-mediated beta-arrestin translocation, G protein activation, and ERK1/2 phosphorylation (pERK) while lacking activity at other dopamine receptors. Screening of ML417 against multiple G protein-coupled receptors revealed exceptional global selectivity. Molecular modeling suggests that ML417 interacts with the D3R in a unique manner, possibly explaining its remarkable selectivity. ML417 was also found to protect against neurodegeneration of dopaminergic neurons derived from iPSCs. Together with promising pharmacokinetics and toxicology profiles, these results suggest that ML417 is a novel and uniquely selective D3R agonist that may serve as both a research tool and a therapeutic lead for the treatment of neuropsychiatric disorders.

About m-Methoxyphenol, If you have any questions, you can contact Moritz, AE; Free, RB; Weiner, WS; Akano, EO; Gandhi, D; Abramyan, A; Keck, TM; Ferrer, M; Hu, X; Southall, N; Steiner, J; Aube, J; Shi, L; Frankowski, KJ; Sibley, DR or concate me.. Computed Properties of C7H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Seralite SRC-120 resin catalyzed synthesis of bis(indolyl)methanes using indoles and low/high boiling point carbonyl compounds under solvent free conditions WOS:000592607300001 published article about FRIEDEL-CRAFTS ALKYLATION; EFFICIENT; 3,3′-DIINDOLYLMETHANE; ALDEHYDES; ACID; DERIVATIVES; INDOLYLMETHANES; ALKALOIDS; BACTERIUM; ACCESS in [Indurthi, Harish K.; Koli, Papita; Sharma, Deepak K.] Banaras Hindu Univ, Dept Pharmaceut Engn & Technol, Indian Inst Technol, Varanasi 221005, Uttar Pradesh, India; [Virdi, Reena] Overseas Healthcare Pvt Ltd, Phillaur, India; [Nageswara Rao, Desaboini] Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA 01655 USA in 2021, Cited 70. Computed Properties of C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A highly inexpensive, and operationally simple seralite SRC-120 (strongly acidic cation exchange resin) catalyzed synthesis of 3,3 ‘-bis(indolyl)methanes (BIMs) from indoles and low/high boiling point carbonyl compounds under solvent-free condition is reported. Synthesis of BIMs with low boiling point carbonyls at room temperature takes prolonged reaction time and give low yields at high temperature. The reported method overcomes these limitations and works remarkably well with low/high boiling point aldehydes/ketones in shorter reaction times (5-10 min) under microwave irradiation conditions and provides moderate to excellent yields (65-94%). Moreover, the recyclability of the catalyst for at least five times without notable loss in activity makes the whole process attractive and green protocol.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Indurthi, HK; Virdi, R; Koli, P; Rao, DN; Sharma, DK or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 98-17-9. In 2019 GREEN CHEM published article about ARYLBORONIC ACIDS; IPSO-HYDROXYLATION; ROOM-TEMPERATURE; PHENOLS; MILD; CONVERSION; CATALYSIS; LIGAND; ESTERS; O-2 in [Yin, Weiyan; Pan, Xizhi; Leng, Wenxi] Wuhan Text Univ, Hubei Key Lab Biomass Fibers & Ecodyeing & Finish, Sch Chem & Chem Engn, Wuhan 430073, Hubei, Peoples R China; [Chen, Jian] Wuhan Univ Technol, Sch Chem Chem Engn & Lift Sci, Wuhan 430070, Hubei, Peoples R China; [He, Haifeng] Jiangxi Sci & Technol Normal Univ, Sch Chem & Chem Engn, Nanchang 330013, Jiangxi, Peoples R China in 2019, Cited 30. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

Molecular oxygen is the most important green-oxidant due to its excellent properties. However, the effective utilization of molecular oxygen remains a major challenge in modern chemistry. Herein, we report the development a rapid, green and efficient microwave-assisted protocol for the air oxidation of boronic acids to phenols and alcohols under transition metal-free conditions. In the presence of KOH and DMSO, high yields of the expected phenols and alcohol were obtained with microwave-assistance, and a variety of functional groups were tolerated in this procedure. Notably, this transition metal-free method represents a breakthrough in both organic synthesis and green chemistry for the oxidative hydroxylation of boronic acids to phenols and alcohols.

Recommanded Product: 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Yin, WY; Pan, XZ; Leng, WX; Chen, J; He, HF or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 150-19-6. In 2020.0 CHEMISTRYSELECT published article about ONE-POT SYNTHESIS; ANTIMYCOBACTERIAL ACTIVITY; SELECTIVE HALOGENATION; CARBONYL-COMPOUNDS; METHYL KETONES; VISIBLE-LIGHT; EFFICIENT; DERIVATIVES; CHLORINATION; COUMARINS in [Vanammoole, Lakshmireddy; Kommera, Rajkumar; Kurma, Siva Hariprasad; Bhimapaka, China Raju] CSIR, Dept Organ Synth & Proc Chem, Indian Inst Chem Technol, Hyderabad 500007, India; [Vaidya, Jayathirtha Rao] CSIR, Fluoro Agrochem, Indian Inst Chem Technol, Hyderabad 500007, India; [Vanammoole, Lakshmireddy; Kommera, Rajkumar; Kurma, Siva Hariprasad; Vaidya, Jayathirtha Rao; Bhimapaka, China Raju] AcSIR Postal Staff Coll Area, Sect 19, Ghaziabad 201002, Uttar Pradesh, India in 2020.0, Cited 77.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

A systematic study has been conducted for the regioselective halogenation of 2H-chromenones to prepare 3-halo-2H-chromenones, 4-substituted 3-halo-2H-chromenones and 3-(2-haloacetyl)-2H-chromenones. Commercially available NaCl/NaBr has been used as halogen source and oxone as an oxidant to produce the compounds. Further, the method has been successfully applied for the preparation of pharmaceutically important halogenated 2H-chromenone natural products. The present approach is simple, economically viable and provided the target compounds with good yields.

About m-Methoxyphenol, If you have any questions, you can contact Vanammoole, L; Kommera, R; Kurma, SH; Vaidya, JR; Bhimapaka, CR or concate me.. Product Details of 150-19-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles