Day: October 25, 2021

Product Details of 100-51-6. Chavarria, D; Fernandes, C; Silva, V; Silva, C; Gil-Martins, E; Soares, P; Silva, T; Silva, R; Remiao, F; Oliveira, PJ; Borges, F in [Chavarria, Daniel; Fernandes, Carlos; Silva, Vera; Silva, Catia; Gil-Martins, Eva; Soares, Pedro; Silva, Tiago; Borges, Fernanda] Univ Porto, Fac Sci, Dept Chem & Biochem, CIQUP, Porto, Portugal; [Chavarria, Daniel; Silva, Tiago; Oliveira, Paulo J.] Univ Coimbra, UC Biotech, CNC Ctr Neurosci & Cell Biol, Biocant Pk, Cantanhede, Portugal; [Silva, Vera; Gil-Martins, Eva; Silva, Renata; Remiao, Fernando] Univ Porto, Fac Pharm, Dept Biol Sci, UCIBIO,REQUIMTE,Lab Toxicol, Porto, Portugal published Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies in 2020.0, Cited 58.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Piperine has been associated with neuroprotective effects and monoamine oxidase (MAO) inhibition, thus being an attractive scaffold to develop new antiparkinsonian agents. Accordingly, we prepared a small library of piperine derivatives and screened the inhibitory activities towards human MAO isoforms (hMAO-A and hMAO-B). Structure-activity relationship (SAR) studies pointed out that the combination of alpha-cyano and benzyl ester groups increased both potency and selectivity towards hMAO-B. Kinetic experiments with compounds 7, 10 and 15 indicated a competitive hMAO-B inhibition mechanism. Compounds 15 and 16, at 10 mu M, caused a small but significant decrease in P-gp efflux activity in Caco-2 cells. Compound 15 stands out as the most potent piperine-based hMAO-B inhibitor (IC50 = 47.4 nM), displaying favourable drug-like properties and a broad safety window. Compound 15 is thus a suitable candidate for lead optimization and the development of multitarget-directed ligands. (C) 2019 Elsevier Masson SAS. All rights reserved.

About Benzyl Alcohol, If you have any questions, you can contact Chavarria, D; Fernandes, C; Silva, V; Silva, C; Gil-Martins, E; Soares, P; Silva, T; Silva, R; Remiao, F; Oliveira, PJ; Borges, F or concate me.. Product Details of 100-51-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 150-76-5. Recently I am researching about HYDROXAMIC ACID; EUGENOL; DERIVATIVES; ANTIOXIDANT; 5-LIPOXYGENASE; REARRANGEMENT; LIPOXYGENASE; DESIGN; PHENOL; SAR, Saw an article supported by the Research Council of Mashhad University of Medical Science [980124]. Published in WILEY in HOBOKEN ,Authors: Alavi, SJ; Seyedi, SM; Saberi, S; Safdari, H; Eshghi, H; Sadeghian, H. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol

In this study, a series of mono- and diallylphenol derivative were designed, synthesized, and evaluated as potential human 15-lipoxygenase-1 (15-hLOX-1) inhibitors. Radical scavenging potency of the synthetic allylphenol derivatives was assessed and the results were in accordance with lipoxygenase (LOX) inhibition potency. It was found that the electronic natures of allyl moiety andparasubstituents play the main role in radical scavenging activity and subsequently LOX inhibition potency of the synthetic inhibitors. Among the synthetic compounds, 2,6-diallyl-4-(hexyloxy)phenol (42) and 2,6-diallyl-4-aminophenol (47) showed the best results for LOX inhibition (IC50= 0.88 and 0.80 mu M, respectively).

About Mequinol, If you have any questions, you can contact Alavi, SJ; Seyedi, SM; Saberi, S; Safdari, H; Eshghi, H; Sadeghian, H or concate me.. Product Details of 150-76-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 3-(Trifluoromethyl)phenol. I found the field of Chemistry very interesting. Saw the article Vapochromic Luminescent pi-Conjugated Systems with Reversible Coordination-Number Control of Hypervalent Tin(IV)-Fused Azobenzene Complexes published in 2021, Reprint Addresses Tanaka, K (corresponding author), Kyoto Univ, Grad Sch Engn, Dept Polymer Chem, Nishikyo Ku, Kyoto 6158510, Japan.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol.

The dynamic and reversible changes of coordination numbers between five and six in solution and solid states, based on hypervalent tin(IV)-fused azobenzene (TAz) complexes, are reported. It was found that the TAz complexes showed deep-red emission owing to the hypervalent bond composed of an electron-donating three-center four-electron (3c-4e) bond and an electron-accepting nitrogen-tin (N-Sn) coordination. Furthermore, hypsochromic shifts in optical spectra were observed in Lewis basic solvents because of alteration of the coordination number from five to six. In particular, vapochromic luminescence was induced by attachment of dimethyl sulfoxide (DMSO) vapor to the coordination point at the tin atom accompanied with a crystal-crystal phase transition. Additionally, the color-change mechanism and degree of binding constants were well explained by theoretical calculation. To the best of our knowledge, this is the first example of vapochromic luminescence by using stable and variable coordination numbers of hypervalent bonds.

Application In Synthesis of 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Gon, M; Tanaka, K; Chujo, Y or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Kargar, S; Elhamifar, D; Zarnegaryan, A in ELSEVIER published article about in [Kargar, Shiva; Elhamifar, Dawood; Zarnegaryan, Ali] Univ Yasuj, Dept Chem, Yasuj 7591874831, Iran in 2021, Cited 83. Quality Control of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A novel ionic liquid modified graphene oxide supported Mo-complex [GO@IL/MoO2(acae)(2)] was successfully prepared, characterized and its catalytic application was investigated. The GO@IL/MoO2(acae)(2) catalyst was prepared through the surface modification of graphene oxide with alkyl imidazolium chloride followed by treatment with molybdenyl acetylacetonate. The GO@IL/MoO2(acae)(2) catalyst was characterized by using FT-IR, PXRD, TGA, EDX, and SEM analyses. This catalyst showed high activity in the green production of pyrazolo[b] phthalazine dione derivatives under ultrasonic conditions. The designed catalyst was effectively recovered and successfully reused at least eight times without significant loss in its efficiency.

Quality Control of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Kargar, S; Elhamifar, D; Zarnegaryan, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Moores, LC; Kaur, D; Smith, MD; Poole, JS in AMER CHEMICAL SOC published article about HOMOLYTIC AROMATIC-SUBSTITUTION; GAS-PHASE REACTIONS; LASER FLASH-PHOTOLYSIS; SET MODEL CHEMISTRY; ORGANIC-COMPOUNDS; RATE CONSTANTS; INORGANIC RADICALS; CENTERED RADICALS; OH RADICALS; KINETICS in [Moores, Lee C.; Kaur, Devinder; Smith, Mathew D.; Poole, James S.] Ball State Univ, Dept Chem, Muncie, IN 47306 USA; [Poole, James S.] St Cloud State Univ, Dept Chem & Biochem, St Cloud, MN 56301 USA in 2019, Cited 77. Formula: C7H5F3O. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

The regioselectivity of hydroxyl radical addition to arenes was studied using a novel analytical method capable of trapping radicals formed after the first elementary step of reaction, without alteration of the product distributions by secondary oxidation processes. Product analyses of these reactions indicate a preference for o- over p-substitution for electron donating groups, with both favored over m-addition. The observed distributions are qualitatively similar to those observed for the addition of other carbon-centered radicals, although the magnitude of the regioselectivity observed is greater for hydroxyl. The data, reproduced by high accuracy CBS-QB3 computational methods, indicate that both polar and radical stabilization effects play a role in the observed regioselectivities. The application and potential limitations of the analytical method used are discussed.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Moores, LC; Kaur, D; Smith, MD; Poole, JS or concate me.. Formula: C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Peshkov, AA; Bakulina, O; Dar’in, D; Kantin, G; Bannykh, A; Peshkov, VA; Krasavin, M in WILEY-V C H VERLAG GMBH published article about in [Peshkov, Anatoly A.; Bakulina, Olga; Dar’in, Dmitry; Kantin, Grigory; Bannykh, Anton; Krasavin, Mikhail] St Petersburg State Univ, Dept Nat Prod Chem, Inst Chem, 26 Univ Skyi Prospekt, Peterhof 198504, Russia; [Peshkov, Vsevolod A.] Nazarbayev Univ, Dept Chem, Sch Sci & Humanities, Nur Sultan 010000, Kazakhstan; [Krasavin, Mikhail] Immanuel Kant Baltic Fed Univ, Kaliningrad 236041, Russia; [Bannykh, Anton] Univ Jyvaskyla, Dept Chem, Survontie 9B, Jyvaskyla 40014, Finland in 2021.0, Cited 27.0. Quality Control of 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

A practical straightforward synthesis of medicinally important NH-delta-lactams through the three-component Castagnoli-Cushman reaction of 3-arylglutaconic anhydrides with carbonyl compound and ammonium acetate has been developed. The scope of the protocol has been thoroughly explored paying particular attention to the carbonyl component using wide array of aliphatic and aromatic aldehydes as well as rarely involved cyclic and acyclic ketones. Synthetic potential of prepared compounds was demonstrated by a series of post-modifications, including unexpected isomerization.

Quality Control of 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Peshkov, AA; Bakulina, O; Dar’in, D; Kantin, G; Bannykh, A; Peshkov, VA; Krasavin, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Effect of surface functionalized SiO2 particles filled polyolefin on the dielectric properties of laminates WOS:000674448300009 published article about THERMAL-CONDUCTIVITIES; BATIO3 NANOPARTICLES; COMPOSITES; NANOCOMPOSITES; CONSTANT; POLYMERIZATION; SILICA in [Wu, Bo; Xu, Yi; Wu, Nan; Tang, Xianzhong] Univ Elect Sci & Technol China, Sch Mat & Energy, Chengdu 611731, Peoples R China in 2021.0, Cited 42.0. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5. Category: indole-building-block

Dielectric materials play a crucial role in 5G communication technological applications such as printed circuit board (PCB) high-frequency substrate materials. Unfortunately, the fabrication of desirable dielectric performance in organic-inorganic composites is a great challenge because of lack of good interfacial compatibility and uniform dispersion between fillers and polymer. In this work, silicon dioxide (SiO2) was synchronously functionalized by gamma-methacryloxypropyltrimethoxysilane (MPS, s-SiO2) and 1,2-polybutadiene (PB, v-SiO2), which were then used as fillers to fabricate the s-SiO2/polyolefin or v-SiO2/polyolefin laminates. All the v-SiO2/polyolefin laminates exhibited better dielectric, thermal and mechanical properties than those of s-SiO2/polyolefin laminates under the same filler content. Specially, the 50 wt% v-SiO2/polyolefin laminate displays a low dielectric constant (3.42) and loss (3.55 x 10-3) at 10 GHz. Meanwhile, it also shows good stability of dielectric properties in a wide range of high-frequency. This work is conducive to develop laminates with superior dielectric properties and apply to PCB high-frequency substrate field.

Category: indole-building-block. About Mequinol, If you have any questions, you can contact Wu, B; Xu, Y; Wu, N; Tang, XZ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Awasthi, A; Yadav, P; Tiwari, DK in ROYAL SOC CHEMISTRY published article about in [Awasthi, Annapurna; Yadav, Pushpendra; Tiwari, Dharmendra Kumar] Ctr Biomed Res CBMR, Mol Synth & Drug Discovery Unit, SGPGIMS Campus,Raibareli Rd, Lucknow 226014, Uttar Pradesh, India; [Awasthi, Annapurna; Yadav, Pushpendra] Banaras Hindu Univ, Inst Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India in 2021.0, Cited 63.0. Product Details of 120-14-9. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

An efficient, general, and practical route for highly diastereoselective synthesis of aza-spirocyclic pyrazolones from easily available alpha-amino acids, aldehydes, and alkylidene pyrazolones by means of a decarboxylative annulation process is reported. This high-yielding reaction proceeds through a [3+2]-cycloaddition reaction between alkylidene pyrazolones and a nonstabilized azomethine ylide generated in situ. This method provides easy and smooth access to a variety of highly functionalized aza-spirocyclic pyrazolones in excellent yields (up to 96%). The obtained spiro-pyrazolones comprise four contiguous stereogenic centers including a quaternary carbon center.

Product Details of 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Awasthi, A; Yadav, P; Tiwari, DK or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 4-Hydroxyquinolin-2(1H)-one. Authors Chheda, PR; Kummer, DA; Nishimura, RT; McClure, KJ; Venkatesan, H in AMER CHEMICAL SOC published article about in [Kummer, David A.] Lundbeck La Jolla Res Ctr Inc, San Diego, CA 92121 USA; [Chheda, Pratik R.; Nishimura, Rachel T.; McClure, Kelly J.; Venkatesan, Hariharan] Janssen Res & Dev, Discovery Chem, San Diego, CA 92121 USA in 2021, Cited 63. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

A one-pot, Hantzsch ester-mediated Knoevenagel condensation-reduction reaction has been developed for alkylation of a wide range of substituted 2,4-quinoline diols and 2,4-pyridine diols with aldehydes. The process is operationally simple to perform, scalable, and provides highly useful C-3 alkylated quinoline and pyridine diols in yields of 58-92%. The alkylation products can be converted to 2,4-dihaloquinoline and pyridine substrates for further functionalization.

Quality Control of 4-Hydroxyquinolin-2(1H)-one. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Chheda, PR; Kummer, DA; Nishimura, RT; McClure, KJ; Venkatesan, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 SCI TOTAL ENVIRON published article about ACTIVITY-RELATIONSHIP QSAR; MOLECULAR-OXYGEN; OXIDATION; PHENOLS; CONTAMINANTS; DEGRADATION; MATTER; PHOTOOXYGENATION; PHOTOCHEMISTRY; DEACTIVATION in [Li, Tiantian; Huang, Yu; Zhang, Ya-nan; Zhao, Yuanhui; Li, Chao] Northeast Normal Univ, Sch Environm, State Environm Protect Key Lab Wetland Ecol & Veg, Changchun 130117, Peoples R China; [Wei, Gaoliang] Jilin Univ, Coll New Energy & Environm, Key Lab Groundwater Resources & Environm, Minist Educ, Changchun 130021, Peoples R China; [Crittenden, John C.] Georgia Inst Technol, Brook Byers Inst Sustainable Syst, Atlanta, GA 30332 USA; [Crittenden, John C.] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA in 2020.0, Cited 67.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. COA of Formula: C8H8O2

As singlet oxygen (O-1(2)) is ubiquitous in the environment, O-1(2)-involved oxidation may play an important role in the transformation and fate of organic pollutants. Accordingly, the reaction rate constants (k(1O2)) of organic compounds with O-1(2) are important to determine the environmental fate and persistence assessment of organic pollutants. However, currently there are limited k(1O2) data available, especially for organic chemicals with different charged (deprotonated/protonated) forms. Herein three quantitative structure-activity relationship (QSAR) models (one comprehensive model and two models for neutral and deprotonated molecules) were created for predicting aqueous k(1O2) values for diversely dissociating molecules. The models include larger datasets (180 chemicals) and have wider applicability domain than previous ones. Molecular structural characteristics (only half-wave potential is present in both models) determining the O-1(2) reaction rate of neutral and deprotonated molecules vary greatly. The comparison results of predicting k(1O2) values of organic compounds at certain pH conditions show that the combination of the QSAR models for neutral and deprotonated molecules has advantages over the comprehensive QSAR model. This work is the first study to predict k(1O2) for a wide variety of neutral and deprotonated molecules and provides an important tool for assessing the fate of organic pollutants in aquatic environments.

COA of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Li, TT; Huang, Y; Wei, GL; Zhang, YN; Zhao, YH; Crittenden, JC; Li, C or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles