Day: October 27, 2021

Authors Zhou, SH; Dai, FL; Xiang, ZY; Song, T; Liu, DT; Lu, FC; Qi, HS in ELSEVIER SCIENCE BV published article about CATALYTIC TRANSFER HYDROGENATION; LEWIS-ACID SITES; GAMMA-VALEROLACTONE; HETEROGENEOUS CATALYST; METHYL LEVULINATE; CONVERSION; CELLULOSE; ETHERIFICATION; TRANSFORMATION; MICROSPHERES in [Zhou, Shenghui; Dai, Fanglin; Xiang, Zhouyang; Song, Tao; Liu, Detao; Lu, Fachuang; Qi, Haisong] South China Univ Technol, State Key Lab Pulp & Paper Engn, Guangzhou 510691, Guangdong, Peoples R China; [Lu, Fachuang; Qi, Haisong] Dept Guangdong Engn Res Ctr Green Fine Chem, Guangzhou 510640, Guangdong, Peoples R China in 2019.0, Cited 55.0. SDS of cas: 100-51-6. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

Both value-added utilization of low-rank renewable feedstocks to prepare catalytic materials and selective transformation of bioderived aldehydes are very attractive topics. Herein, lignosulfonate, a waste by-product from the paper industry, was simply assembled with ZrCl4 under non-toxic hydrothermal conditions for scalable preparation of Zr-containing polyphenolic biopolymer catalysts (Zr-LS). Systematic characterizations indicated that the strong coordination between Zr4+ and phenolic hydroxyl groups in lignosulfonate led to the formation of strong Lewis acid-base couple sites (Zr4+-O2-) and porous inorganic-organic framework structure (mesopores centered at 6.1 nm), while the inherent sulfonic groups in lignosulphonate could serve as Bronsted acidic sites. The cooperative role of these versatile acid-base sites in Zr-LS afforded excellent catalytic performance for Meerwein-Ponndorf-Verley (MPV) reaction of a broad range of bioderived platform chemicals under mild conditions (80 degrees C), especially of furfural (FF) to furfuryl alcohol (FA), in quantitative yields (96%) with high FA formation rate of 9600 mu mol g(-1)h(-1) and TOF of 4.37 h(-1). Kinetic studies revealed that the activation energy of the MPV reduction of FF was as low as 52.25 kJ/mol, accounting for the high reaction rate. Isotopic labelling experiments demonstrated direct hydrogen transfer from the alpha-C of 2-PrOH to the alpha-C of FF on acid-base sites was the rate-determining step. Moreover, Zr-LS showed good recyclability for at least seven reaction cycles.

SDS of cas: 100-51-6. About Benzyl Alcohol, If you have any questions, you can contact Zhou, SH; Dai, FL; Xiang, ZY; Song, T; Liu, DT; Lu, FC; Qi, HS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Structure-activity relationship and biological evaluation of berberine derivatives as PCSK9 down-regulating agents WOS:000663790900001 published article about HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA; HIGH CARDIOVASCULAR RISK; LDL; DEGRADATION; INHIBITION; EVOLOCUMAB; EXPRESSION; EFFICACY; THERAPY; SAFETY in [Fan, Tian-Yun; Yang, Yu-Xin; Zeng, Qing-Xuan; Wang, Xue-Lei; Wei, Wei; Guo, Xi-Xi; Zhao, Li-Ping; Song, Dan-Qing; Wang, Yan-Xiang; Wang, Li; Hong, Bin] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing 10050, Peoples R China in 2021, Cited 31. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. SDS of cas: 120-14-9

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein and its deficiency markedly enhanced the survival rate of patient with cardiovascular diseases (CVDs). Forty berberine (BBR) derivatives were synthesized and evaluated for their activities on down-regulating the transcription of PCSK9 in HepG2 cells, taking BBR as the lead. Structure-activity relationship (SAR) analysis revealed that 2,3-dimethoxy moiety might be beneficial for activity. Among them, 9k displayed the most potent activity with IC50 value of 9.5 +/- 0.5 mu M, better than that of BBR. Also, it significantly decreased PCSK9 protein level at cellular level, as well as in the liver and serum of mice in vivo. Furthermore, 9k markedly increased LDLR expression and LDL-C clearance via downregulating PCSK9 protein. The mechanism of action of 9k is targeting HNF1 alpha and/or Sp1 cluster modulation upstream of PCSK9, a different one from BBR. Therefore, 9k might have the potential to be a novel PCSK9 transcriptional inhibitor for the treatment of atherosclerosis, worthy for further investigation.

SDS of cas: 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Fan, TY; Yang, YX; Zeng, QX; Wang, XL; Wei, W; Guo, XX; Zhao, LP; Song, DQ; Wang, YX; Wang, L; Hong, B or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 4-Methoxybenzaldehyde. Authors Potenti, S; Gualandi, A; Puggioli, A; Fermi, A; Bergamini, G; Cozzi, PG in WILEY-V C H VERLAG GMBH published article about in [Potenti, Simone; Gualandi, Andrea; Puggioli, Alessio; Fermi, Andrea; Bergamini, Giacomo; Cozzi, Pier Giorgio] Univ Bologna, Dipartimento Chim G Ciamician, Alma Mater Studiorum, Via Selmi 2, I-40126 Bologna, Italy; [Potenti, Simone] Scuola Normale Super Pisa, Lab atorio SMART, Piazza Cavalieri 7, I-56126 Pisa, Italy in 2021, Cited 43. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Organometallic allylic reagents are widely used in the construction of C-C bonds by Barbier-type reactions. In this communication, we have described a photoredox Barbier allylation of aldehydes mediated by bismuth, in absence of other metals as co-reductants. Mild reaction conditions, tolerance of oxygen, and use of aqueous solvent make this photoredox methodology attractive for green and sustainable synthesis of homoallylic alcohols.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Potenti, S; Gualandi, A; Puggioli, A; Fermi, A; Bergamini, G; Cozzi, PG or concate me.. Quality Control of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about HOMOLYTIC AROMATIC-SUBSTITUTION; GAS-PHASE REACTIONS; LASER FLASH-PHOTOLYSIS; SET MODEL CHEMISTRY; ORGANIC-COMPOUNDS; RATE CONSTANTS; INORGANIC RADICALS; CENTERED RADICALS; OH RADICALS; KINETICS, Saw an article supported by the American Chemical Society Petroleum Research FundAmerican Chemical Society; Indiana Academy of Science; BSU Graduate School. Name: 3-(Trifluoromethyl)phenol. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Moores, LC; Kaur, D; Smith, MD; Poole, JS. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

The regioselectivity of hydroxyl radical addition to arenes was studied using a novel analytical method capable of trapping radicals formed after the first elementary step of reaction, without alteration of the product distributions by secondary oxidation processes. Product analyses of these reactions indicate a preference for o- over p-substitution for electron donating groups, with both favored over m-addition. The observed distributions are qualitatively similar to those observed for the addition of other carbon-centered radicals, although the magnitude of the regioselectivity observed is greater for hydroxyl. The data, reproduced by high accuracy CBS-QB3 computational methods, indicate that both polar and radical stabilization effects play a role in the observed regioselectivities. The application and potential limitations of the analytical method used are discussed.

Name: 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Moores, LC; Kaur, D; Smith, MD; Poole, JS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Surface Grafting Polyphosphoesters on Cellulose Nanocrystals To Improve the Emulsification Efficacy WOS:000484644000024 published article about IN-WATER EMULSIONS; PICKERING EMULSIONS; NANOPARTICLES; PARTICLES; STABILIZATION; PH; MICROPARTICLES; DISPERSIBILITY; EMULSIFIERS; FABRICATION in [Hiranphinyophat, Suphatra] Kansai Univ, Grad Sch Sci & Engn, 3-3-35 Yamate Cho, Suita, Osaka 5640836, Japan; [Iwasaki, Yasuhiko] Kansai Univ, Fac Chem Mat & Bioengn, 3-3-35 Yamate Cho, Suita, Osaka 5640836, Japan; [Iwasaki, Yasuhiko] Kansai Univ, ORDIST, 3-3-35 Yamate Cho, Suita, Osaka 5640836, Japan; [Asaumi, Yuta] Osaka Inst Technol, Grad Sch Engn, Asahi Ku, 5-16-1 Omiya, Osaka 5358585, Japan; [Fujii, Syuji] Osaka Inst Technol, Fac Engn, Asahi Ku, 5-16-1 Omiya, Osaka 5358585, Japan; [Fujii, Syuji] Osaka Inst Technol, Nanomat Microdevices Res Ctr, Asahi Ku, 5-16-1 Omiya, Osaka 5358585, Japan in 2019.0, Cited 66.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Quality Control of Benzyl Alcohol

Particle-stabilized emulsion systems have been developed to address the problematic properties of conventional surfactants. However, the nature and properties of the fine particles used in such systems remain a critical issue for stability enhancement. Herein, we describe a thermoswitchable oil-in-water (O/W) particle-stabilized emulsion that exhibits improved stability due to the addition of cellulose nanocrystals (CNCs) modified with poly[2-isopropoxy-2-oxo-1,3,2-dioxaphospholane] (PIPP), which exhibits relatively good biocompatibility and biodegradability. Various parameters, such as surface activity, concentration of particles, polarity of solvents, and temperatures, on the formation of emulsions with CNCs grafted with PIPP (CNC-g-PIPP) were investigated. Results showed that the surface activity of CNC-g-PIPP was significantly improved compared with the unmodified material. Heptane-in-water particle-stabilized emulsions with CNC-g-PIPP were stably formed, and the effect of temperature on the stability of the emulsions was characterized. CNC-g-PIPP exhibited function as an effective particulate emulsifier at 4 degrees C because of the strong adsorption at the oil-water interface. However, the emulsions rapidly disintegrated at 45 degrees C, which is above the low critical solution temperature of PIPP on CNC, as the hydrophobized CNC-g-PIPP desorbed from the oil-water interface. Based on these findings, a thermally induced reversible emulsification/demulsification was presented. The resulting switchable particle-stabilized emulsion based on CNC-g-PIPP shows promise for the ability to control the stability of an emulsion in response to temperature, which is attractive for use in biological applications.

Quality Control of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Hiranphinyophat, S; Asaumi, Y; Fujii, S; Iwasaki, Y or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article DABCO Catalyzed Synthesis of beta-Hydroxy Ketones Derived from alpha-Methyl Ketones and Ninhydrin under Microwave Irradiations published in 2019.0. Name: 4′-Hydroxyacetophenone, Reprint Addresses Srivastava, V (corresponding author), Banaras Hindu Univ, Dept Chem, Indian Inst Technol, Varanasi 221005, Uttar Pradesh, India.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Microwave induced an efficient, green and rapid protocol for the synthesis of 2-substituted-2-hydroxyindan-1,3-dione derivatives from the reaction of ninhydrin and ketone by using inexpensive 1,4-diazabicyclo[2.2.2]octane (DABCO) organocatalyst in water has been developed. Mild reaction conditions, shorter reaction time, metal-free approach, water as a green solvent, scalability and broad substrate scope are the salient features of this protocol.

Name: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Verma, P; Mishra, A; Chauhan, S; Singh, S; Srivastava, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article A novel method of temporary solidification and extraction of underwater fragile relics in their original state WOS:000589895000001 published article about IN-SITU PRESERVATION; CULTURAL-HERITAGE; CONSOLIDANT; CONSERVATION; MENTHOL in [Chen, Xue-Qiang; Zhang, Bingjian] Zhejiang Univ, Dept Cultural Heritage & Museol, Hangzhou 310028, Peoples R China; [Chen, Xue-Qiang] Ningbo Univ Finance & Econ, Cultural Property Protect Ctr, Ningbo 315175, Peoples R China; [Zhang, Zhiguo] Natl Ctr Underwater Cultural Heritage, Beijing 100192, Peoples R China in 2021.0, Cited 22.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. COA of Formula: C9H10O3

Fragile cultural relics at underwater archaeological sites are difficult to preserve in situ over long time periods due to the effects of a complex and constantly changing surrounding environment. Thus, extracting the relics from water and preserving them in a controllable environment is of primary importance. In this paper, the technology of temporary reinforcement and extraction of underwater fragile relics with veratraldehyde followed by a process of secondary temporary reinforcement using polyethylene glycol (PEG) was studied. After investigating the melting temperature and permeability of PEGs with different molecular weights, we found that PEG-3000 is an excellent candidate as the secondary reinforcing agent for the extracted relics. In the laboratory, combined with veratraldehyde and polypropylene-fiber cloth as temporary underwater strengthening materials, and selected dispersed beaded jewelry and a broken three-dimensional crock as our research subject, we carried out an entire retrieval process-temporary stabilization and secondary temporary reinforcement, to systematically evaluate the technological aspects of safely excavating fragile underwater relics in the original state. After being extracted from water and subjected to secondary temporary reinforcement using PEG-3000, the beaded jewelry and broken crock retained their underwater shape and arrangement completely. The use of secondary reinforcing agent prevents the removal process of veratraldehyde and enclosed sediment from affecting the state of the relics.

COA of Formula: C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Chen, XQ; Zhang, BJ; Zhang, ZG or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Direct Access for the Regio- and Stereoselective Synthesis of N-Alkenylpyrazoles and Chromenopyrazoles WOS:000618540600019 published article about ONE-POT SYNTHESIS; REGIOSELECTIVE SYNTHESIS; FACILE SYNTHESIS; PYRAZOLES; HYDRAZONES; ALKYNES; TOSYLHYDRAZONES; DERIVATIVES; HYDRAZIDES; COMPLEXES in [Kurma, Siva Hariprasad; Bhimapaka, China Raju] CSIR Indian Inst Chem Technol, Dept Organ Synth & Proc Chem, Hyderabad 500007, India; [Kurma, Siva Hariprasad; Bhimapaka, China Raju] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India; [Sridhar, Balasubramanian] CSIR Indian Inst Chem Technol, Dept Analyt & Struct Chem, Hyderabad 500007, India in 2021.0, Cited 61.0. SDS of cas: 120-14-9. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

A highly regio- and stereoselective method was developed for the preparation of N-alkenylpyrazoles and chromenopyrazoles by the reaction of N-tosylhydrazones and salicyl N-tosylhydrazones with alkynes under neat conditions in the presence of La(OTf)(3). The present study was found to be efficient and convenient for direct access to N-alkenylpyrazoles and chromenopyrazoles through C-C, C-N, and C-O bond forming reactions. Structure assignment of N-alkenylpyrazole compound 5c was confirmed by X-ray analysis.

SDS of cas: 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Kurma, SH; Sridhar, B; Bhimapaka, CR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Marjani, AP; Khalafy, J; Farajollahi, A in WILEY published article about TETRAPROPYLAMMONIUM BROMIDE; BIOLOGICAL EVALUATION; DERIVATIVES; CATALYST; WATER in [Marjani, Ahmad Poursattar; Khalafy, Jabbar; Farajollahi, Ayda] Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh, Iran in 2019, Cited 41. Product Details of 86-95-3. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, H-1-NMR, and C-13-NMR spectral data and elemental analysis.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or concate me.. Product Details of 86-95-3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: (E)-2-Methylbut-2-enoic acid. In 2020 ORG LETT published article about RADICAL AMINOFLUORINATION; MEDICINAL CHEMISTRY; FLUORINATION; ALKENES; STRATEGIES; HALOFUNCTIONALIZATION; GENERATION; ALKALOIDS; CENTERS; ESTERS in [Xu, Zheyuan; Fu, Yao] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Urban Pollutant Convers, Anhui Prov Key Lab Biomass Clean Energy,iChEM, Hefei 230026, Anhui, Peoples R China; [Fei, Haiyang; Wu, Hongmiao; Zhu, Lin; Lu, Hongjian] Nanjing Univ, Inst Chem & BioMed Sci, Jiangsu Key Lab Adv Organ Mat, Sch Chem & Chem Engn, Nanjing 210093, Peoples R China; [Jalani, Hitesh B.] Yonsei Univ, Dept Pharm, Incheon 21983, South Korea; [Jalani, Hitesh B.] Yonsei Univ, Yonsei Inst Pharmaceut Sci, Incheon 21983, South Korea; [Li, Guigen] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA in 2020, Cited 55. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1.

An efficient fluorocyclization of alpha,beta-unsaturated amides through a formal halocyclization process is developed. The reaction proceeds under transition-metal-free conditions and leads to the formation of fluorinated oxazolidine-2,4-diones with excellent regio- and diastereoselectivity. The evaluation of the reaction mechanism based on preliminary experiments and density functional theory calculations suggests that a synergetic syn-oxo-fluorination occurs and is followed by an anti-oxo substitution reaction. The reaction opens a new window in the field of stereospecific fluorofunctionalization.

Name: (E)-2-Methylbut-2-enoic acid. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Fei, HY; Xu, ZY; Wu, HM; Zhu, L; Jalani, HB; Li, GG; Fu, Y; Lu, HJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles