Day: October 28, 2021

Formula: C8H8O2. Liu, L; She, MY; Zhang, J; Wang, ZH; Liu, H; Tang, M; Liu, P; Zhang, SY; Li, JL in [Liu, Lang; She, Mengyao; Zhang, Jun; Wang, Zhaohui; Liu, Hua; Tang, Mi; Liu, Ping; Zhang, Shengyong; Li, Jianli] Northwest Univ, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Coll Chem & Mat Sci, Xian 710127, Shaanxi, Peoples R China; [She, Mengyao] Northwest Univ, Key Lab Resource Biol & Modern Biotechnol Western, Minist Educ, Coll Life Sci,Fac Life & Hlth Sci, Xian 710069, Shaanxi, Peoples R China published A practical strategy for construction and regulation of multi-functional triazepinium salts via highly efficient I-2-catalyzed cyclization in 2020, Cited 60. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Synthesis of new functional organic molecules is a critical path that may greatly accelerate the evolution of organic optoelectronic materials. We have achieved a facile synthesis strategy to produce unique saddle-shaped multi-functional triazepinium salts that exhibit excellent solid-state fluorescence. Their fluorescence performance could be easily regulated by adjusting the dihedral angle between the main skeleton and the substituted moiety, giving a large Stokes shift, non-aggregation quenching, long lifetime, and multilevel-redox characteristics.

Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Liu, L; She, MY; Zhang, J; Wang, ZH; Liu, H; Tang, M; Liu, P; Zhang, SY; Li, JL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 98-17-9. I found the field of Pharmacology & Pharmacy very interesting. Saw the article A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer published in 2019, Reprint Addresses Pertusati, F (corresponding author), Sch Pharm & Pharmaceut Sci, Redwood Bldg,King Edwards 7 Ave, Cardiff CF10 3NB, S Glam, Wales.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol.

SAR studies on bicalutamide, enobosarm and enzalutamide analogues, functionalised with polyfluorinated groups, is presented. Among the novel bicalutamide and enobosarm derivatives synthesised, several displayed significantly improved in vitro anticancer activity, with IC50 values in the low micromolar range against four different prostate cancer cell lines (LNCaP, VCaP, DU-145 and 22Rv1), showing up to 48-fold increase in comparison with the parent structures. In particular, SF5 enobosarm analogues were found to be most potent compounds, full AR antagonists and with favourable ADME properties. The most promising compound (48a) was evaluated for its in vivo efficacy in PC xenograft mouse model (22Rv1) with results comparable to the standard-of-care docetaxel. (C) 2019 Published by Elsevier Masson SAS.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Pertusati, F; Ferla, S; Bassetto, M; Brancale, A; Khandil, S; Westwell, AD; McGuigan, C or concate me.. Product Details of 98-17-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 4′-Hydroxyacetophenone. In 2019.0 ACS OMEGA published article about HYBRID COMPOUNDS; CYTOTOXIC ACTIVITY; TUBULIN POLYMERIZATION; BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; IMIDAZOLE; ISOLIQUIRITIGENIN; DERIVATIVES; INHIBITION; ANALOGS in [Yang, Jun-Li; Ma, Yong-Hui; Zhang, Yi-Peng; Tian, Hong-Chang; Huang, Yuan-Cheng; Chen, Wen] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resources, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China; [Yang, Jun-Li; Li, Yan-Hua; Yang, Li-Juan] Yunnan Minzu Univ, Engn Res Ctr Green Preparat Technol Biobased Mat, Sch Chem & Environm, Kunming 650500, Yunnan, Peoples R China; [Li, Yan] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China in 2019.0, Cited 44.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

A series of novel trimethoxyphenyl-derived chalcone-benzimidazolium salts were synthesized. The biological properties of the compounds were screened in vitro against five different human tumor cell lines. The results suggest that the 5,6-dimethyl-benzimidazole or 2-methyl-benzimidazole ring as well as the 2-naphthylmethyl, 4-methylbenzyl, or 2-naphthylacyl substituent at position-3 of the benzimidazole ring was important to the cytotoxic activity. Notably, (E)-5,6-dimethy1-3-(naphth alen-2-ylmethyl)-1-(3-(4-(3-(3,4,5-trime thoxyphenyl) a cryloyl) phenoxy)propyl)-1H-benzo [d] imidazol-3-ium bromide (7f) was more selective to HL-60, MCF-7, and SW-480 cell lines with IC50 values 8.0-, 11.1-, and 5.8-fold lower than DDP. Studies of the antitumor mechanism of action showed that compound 7f could induce cell-cycle G1 phase arrest and apoptosis in SMMC-7721 cells.

Recommanded Product: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Yang, JL; Ma, YH; Li, YH; Zhang, YP; Tian, HC; Huang, YC; Li, Y; Chen, W; Yang, LJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Discovery of hydrazide-containing oseltamivir analogues as potent inhibitors of influenza A neuraminidase WOS:000661282500043 published article about VIRUS; ZANAMIVIR; EPIDEMIOLOGY; DERIVATIVES; RESISTANCE in [Zhao, Hongqian; Jiang, Siyuan; Ye, Zhifan; Zhu, Hongxi; Meng, Peipei; Wang, Kuanglei; Tian, Yongshou] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Key Lab Struct Based Drug Design & Discovery, Minist Educ, 103 Wenhua Rd, Shenyang 110016, Peoples R China; [Hu, Baichun] Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Peoples R China; [Zhang, Huicong] Shenyang Pharmaceut Univ, Wuya Coll Innovat, 103 Wenhua Rd, Shenyang 110016, Peoples R China; [Hu, Yanmei; Wang, Jun] Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA in 2021, Cited 41. Product Details of 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Neuraminidase (NA) inhibitors play a prime role in treating influenza. However, a variety of viruses containing mutant NAs have developed severe drug resistance towards NA inhibitors, so it is of crucial significance to solve this problem. Encouraged by urea-containing compound 12 disclosed by our lab, we designed a series of oseltamivir derivatives bearing hydrazide fragment for targeting the 150 cavity. Among the synthesized compounds, compound 17a showed 8.77-fold, 4.12-fold, 203-fold and 6.23-fold more potent activity than oseltamivir carboxylate against NAs from H5N1, H1N1, H5N1-H274Y, H1N1-H274Y, respectively. Meanwhile, the best compound 17a exhibited satisfactory metabolic stability in vitro. This study offers an important reference for the structural optimization of oseltamivir aiming at potent inhibition against H274Y mutant of NAs. (C) 2021 Elsevier Masson SAS. All rights reserved.

Product Details of 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zhao, HQ; Jiang, SY; Ye, ZF; Zhu, HX; Hu, BC; Meng, PP; Hu, YM; Zhang, HC; Wang, KL; Wang, J; Tian, YS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Design and synthesis of quinoline-pyrimidine inspired hybrids as potential plasmodial inhibitors WOS:000643683200007 published article about MOLECULAR-DYNAMICS; ASSAY in [Kayamba, Francis; Kushwaha, Narva Deshwar; Mahlalela, Mavela; Karpoormath, Rajshekhar] Univ KwaZulu Natal, Coll Hlth Sci, Dept Pharmaceut Chem, ZA-4000 Durban, South Africa; [Malimabe, Teboho; van Zyl, Robyn L.] Univ Witwatersrand, Fac Hlth Sci, Dept Pharm & Pharmacol, Pharmacol Div, ZA-2193 Johannesburg, South Africa; [Malimabe, Teboho; van Zyl, Robyn L.] Univ Witwatersrand, Fac Hlth Sci, WITS Res Inst Malaria WRIM, ZA-2193 Johannesburg, South Africa; [Ademola, Idowu Kehinde; Gordon, Michelle] Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, ZA-4000 Durban, South Africa; [Pooe, Ofentse Jacob] Univ KwaZulu Natal, Sch Life Sci, Discipline Biochem, ZA-4000 Durban, South Africa; [Mudau, Pertunia T.; Zininga, Tawanda] Univ Venda, Sch Math & Nat Sci, Dept Biochem, ZA-0950 Thohoyandou, South Africa; [Zininga, Tawanda; Shonhai, Addmore] Stellenbosch Univ, Dept Biochem, ZA-7600 Stellenbosch, South Africa; [Nyamori, Vincent O.] Univ KwaZulu Natal, Sch Chem & Phys, Westville Campus, ZA-4000 Durban, South Africa in 2021, Cited 43. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Application In Synthesis of 3,4-Dimethoxybenzaldehyde

Presently, artemisinin-based combination therapy (ACT) is the first-line therapy of Plasmodium falciparum malaria. With the emergence of malaria parasites that are resistant to ACT, alternative antimalarial therapies are urgently needed. In line with this, we designed and synthesised a series of novel N-(7chloroquinolin-4-yl)-N’-(4,6-diphenylpyrimidin-2-yl)alkanediamine hybrids (6a-7c) and evaluated their inhibitory activity against the NF54 chloroquine-susceptible strain as a promising class of antimalarial compounds. The antiplasmodial screening revealed that seven analogues showed promising to good activity with half-maximal inhibitory concentration ( IC50) = 0.32 mu Me4.30 mM. Compound 7a with 1,4-diamine butyl linker and 4-hydroxyl phenyl on fourth and sixth position of pyrimidine core showed the most prominent activity with an IC50 value of 0.32 +/- 0.06 mM, with a favourable safety profile of 9.79 to human kidney epithelial (HEK293) cells. The remaining six analogues showed moderate activity with IC50 values ranging from 7.50 mM to 83.01 mM. We further investigated the binding affinities of the molecules to two essential cytosolic P. falciparum heat shock protein 70 homologues; PfHsp70-1 and PfHsp70-z. Compound 7a exhibited the highest binding affinity for both PfHsp70s with K-D in a lower nanomolar range (4.4-11.4 nM). Furthermore, molecular docking revealed that compounds 6, 6k, 7b and 7a exhibited better fitness in PfHsp70-1 with compound 7a showing the highest and lowest binding scores of similar to 9.8 kcal/mol. Therefore, we speculate that PfHsp70-1 is one of the targets of these inhibitors. The bioisoteric replacement of the groups at phenyl ring at the fourth and sixth position of the pyrimidine core had a constructive association with antiplasmodial activity. The promising antiplasmodial activity of the synthesised analogues illustrates how crucial molecular hybridisation is as a strategy in the development of quinoline-pyrimidine hybrids as prospective antiprotozoal agents. (C) 2021 Elsevier Masson SAS. All rights reserved.

Application In Synthesis of 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Kayamba, F; Malimabe, T; Ademola, IK; Pooe, OJ; Kushwaha, ND; Mahlalela, M; van Zyl, RL; Gordon, M; Mudau, PT; Zininga, T; Shonhai, A; Nyamori, VO; Karpoormath, R or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chen, L; Lin, ZY; Zhang, XF; Tan, LS; Zhang, M; Li, YB in [Chen, Lu; Lin, Zhenyuan; Zhang, Xuefang; Tan, Leshi; Zhang, Min; Li, Yibiao] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen, Peoples R China published Catalyst-free visible-light induced synthesis of nitrogen- and oxygen-containing heterocycles from 1,3-diketones in 2021.0, Cited 40.0. COA of Formula: C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

The synthesis of nitrogen- and oxygen-containing heterocycles has found many applications in the preparation of biomedical intermediates, yet actual synthetic procedures display limitations such as high-loading catalysts, harsh reaction conditions and tedious preparation of heterogeneous catalysts. Alternatively, photocatalysis allows to access functional products with minimum synthetic procedures and waste generation. Here, we present an efficient, simple, green protocol for the synthesis of N- and O-containing six-membered-ring compounds under mild conditions under visible blue light. Various aldehydes and 1,3-diketones can be reacted to afford eight series of corresponding 1,4-dihydropyridines and 4H-benzo[b]pyrans. This protocol has some merits such as the use of abundant and sustainable aqueous ethanol as solvent, short reaction time (within 60 min), no need of catalyst and broad functional group tolerance to afford 81 different series of target molecules in 75-96% yield under mild conditions.

COA of Formula: C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Chen, L; Lin, ZY; Zhang, XF; Tan, LS; Zhang, M; Li, YB or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Transition metal-free, visible-light-mediated construction of alpha,beta-diamino esters via decarboxylative radical addition at room temperature WOS:000472787400010 published article about MANNICH-TYPE ADDITIONS; GLYOXYLIC OXIME ETHER; ASYMMETRIC-SYNTHESIS; CARBOXYLIC-ACIDS; PHOTOCHEMICAL DECARBOXYLATION; MERGING PHOTOREDOX; DERIVATIVES; AMINO; IMINES in [Wu, Guibing; Wang, Jingwen; Liu, Chengyu; Sun, Maolin; Zhang, Lei; Ma, Yueyue; Ye, Jinxing] East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Shanghai Key Lab New Drug Design, Minist Educ,Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China; [Cheng, Ruihua] East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China in 2019, Cited 38. SDS of cas: 100-51-6. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

Transition-metal-free visible-light photoredox catalyzed decarboxylative radical addition has been developed for the construction of alpha,beta-diamino esters from amino acids with glyoxylic oxime ethers under mild conditions. Cyclic and chain amino acids, dipeptides, and simple aliphatic acids are amenable to this addition as the alkyl radical source. A variety of alpha,beta-diamino esters with broad functional groups were synthesized in satisfactory yields at room temperature. The employment of acridinium as the photocatalyst and its potential scalability also demonstrate the synthetic value in practice.

SDS of cas: 100-51-6. About Benzyl Alcohol, If you have any questions, you can contact Wu, GB; Wang, JW; Liu, CY; Sun, ML; Zhang, L; Ma, YY; Cheng, RH; Ye, JX or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article One-pot three-component reaction of p-quinone monoacetals, l-proline and naphthols to afford N-aryl-2-arylpyrrolidines WOS:000611795900014 published article about ALPHA-AMINO-ACIDS; C-H FUNCTIONALIZATION; DIELS-ALDER REACTIONS; METAL-FREE; DECARBOXYLATIVE ANNULATION; CONJUGATE ADDITION; COUPLING REACTION; MICHAEL ADDITION; VINYL ETHERS; DERIVATIVES in [Wang, Xin; Li, Gang; Li, Xiaojie; Zhu, Dunru; Shen, Ruwei] Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, Coll Chem & Chem Engn, Nanjing 210009, Peoples R China in 2021, Cited 56. Safety of Mequinol. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

The one-pot three-component reaction of p-quinone monoacetals (or p-quinol ethers), l-proline and naphthols is developed for the synthesis of N-aryl-2-arylpyrrolidines under mild conditions with high chemo- and regioselectivity. The reaction may involve multiple processes including condensation, decarboxylation and demethoxylation for the the generation of N-arylated 3,4-dihydro-2H-pyrrolium followed by controllable capture by naphthols. In the absence of a naphthol, p-quinone monoacetal coupled with l-proline to form a complex dipyrroloquinoline product.

About Mequinol, If you have any questions, you can contact Wang, X; Li, G; Li, XJ; Zhu, DR; Shen, RW or concate me.. Safety of Mequinol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Sustainable Aldehyde Oxidations in Continuous Flow Using in Situ-Generated Performic Acid WOS:000644738000005 published article about FREE AEROBIC OXIDATION; CARBOXYLIC-ACIDS; 2,5-FURANDICARBOXYLIC ACID; SELECTIVE OXIDATION; HYDROGEN-PEROXIDE; PRIMARY ALCOHOLS; PERACETIC-ACID; CHEMISTRY; CATALYSIS; KINETICS in [Prieschl, Michael; Otvos, Sandor B.; Kappe, C. Oliver] Res Ctr Pharmaceut Engn GmbH RCPE, Ctr Continuous Flow Synth & Proc CCFLOW, A-8010 Graz, Austria; [Prieschl, Michael; Otvos, Sandor B.; Kappe, C. Oliver] Karl Franzens Univ Graz, Inst Chem, NAWI Graz, A-8010 Graz, Austria in 2021, Cited 58. Recommanded Product: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The oxidation of aldehydes is one of the most prevalent methods for the synthesis of a diverse range of carboxylic acids. We herein present a performic acid generator and its application for aldehyde oxidations under continuous flow conditions. Low molecular weight performic acid, an environmentally benign and inexpensive oxidant, was readily formed in situ from formic acid and hydrogen peroxide. The safety hazards typically encountered when manipulating this potentially explosive reagent were eliminated, while at the same time a clean and efficient access to valuable carboxylic acids was ensured. By taking advantage of concentrated or even neat aldehyde streams, the amount of organic solvents utilized, and thus waste formation, was successfully minimized as demonstrated by E-factors in the range of 5-18. The process proved applicable for a wide range of aromatic as well as aliphatic aldehydes, while its synthetic utility and stability were corroborated by scale-out experiments leading to multigram-scale syntheses.

Recommanded Product: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Prieschl, M; Otvos, SB; Kappe, CO or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021.0 J ORG CHEM published article about QUINONE METHIDES; PHOTOCHEMICAL GENERATION; ALKYLATING-AGENTS; BENZYL CATIONS; OLIGONUCLEOTIDE; NUCLEOTIDE; OXYGEN; SUBSTITUENTS; REACTIVITY; STABILITY in [Fan, Heli; Peng, Xiaohua] Univ Wisconsin, Dept Chem & Biochem, Milwaukee, WI 53211 USA; [Fan, Heli; Peng, Xiaohua] Univ Wisconsin, Milwaukee Inst Drug Discovery, Milwaukee, WI 53211 USA in 2021.0, Cited 54.0. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5. COA of Formula: C7H8O2

We have synthesized and characterized two small libraries of 2-OMe or 2-NO2-benzene analogues 2a-i and 3a-i containing a wide variety of leaving groups. Irradiation of these compounds at 350 nm generated benzyl radicals that were spontaneously oxidized to benzyl cations directly producing DNA interstrand cross-links (ICLs). Compounds with a 2-methoxy substituent showed a faster cross-linking reaction rate and higher ICL efficiency than the corresponding 2-nitro analogues. Apart from the aromatic substituent, the benzylic leaving groups greatly affected DNA cross-linking efficiency. Higher ICL yields were observed for compounds with OCH3 (3b), OCH2Ph (3d), or Ph3P+ (3i) as leaving groups than those containing OAc (3a), NMe2 (3e), morpholine (3f), OCH2CH=CH2 (3c), SPh (3g), or SePh (3h). The heat stability study of the isolated ICL products indicated that dGs were the preferred alkylation sites in DNA for the benzyl cations produced from 2a-i, 3c, and 3e-i while 3a (L = OAc), 3b (L = OMe), and 3d (L = OCH2Ph) showed a similar photoreactivity toward dGs and dAs. Although the photogenerated benzyl cations alkylated dG, dC, and dA, ICL assay with variation of DNA sequences showed that the ICL reaction occurred with opposing dG/dC but not with staggered dA/dA.

About Mequinol, If you have any questions, you can contact Fan, HL; Peng, XH or concate me.. COA of Formula: C7H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles