Month: October 2021

In 2020.0 INORG CHEM COMMUN published article about HETEROGENEOUS CATALYST; SELECTIVE OXIDATION; FE3O4 NANOPARTICLES; AEROBIC OXIDATION; MOLECULAR-OXYGEN; GREEN OXIDATION; EFFICIENT; REDUCTION; WATER in [Salimi, Mehri; Zamanpour, Azadeh] Univ Birjand, Fac Sci, Dept Chem, POB 97175-615, Birjand, Iran in 2020.0, Cited 27.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Application In Synthesis of Benzyl Alcohol

Hydrotalcite (HT) modified with magnetic nanoparticle and thiol groups for the immobilization of silver to the preparation of Fe3O4/HT-SH-Ag was used. The catalyst was completely characterized using XRD, ICP, SEM, EDS, VSM, FT-IR, and TEM analyzes. The Fe3O4/HT-SH-Ag catalyst is useful in oxidizing of primary and secondary aliphatic and benzyl alcohols to the relevant carbonyl products (aldehyde/ketone). To demonstrate the effect of Ag over the reaction, Fe3O4/HT-SH catalyst performance, and also some other control tests were studied. For this purpose, the model reaction was carried out in the presence of AgNO3, HT (I), and Fe3O4/HT (II), and low yield was obtained (20-50%). High to good efficiency were obtained for all entries, whether benzaldehyde derivatives, in short times. The catalyst can be reused for several continuous runs with a simple external magnet without losing significant reactivity.

Application In Synthesis of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Salimi, M; Zamanpour, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about BIOLOGICAL EVALUATION; CHALCONE; DERIVATIVES; RESISTANCE; DISCOVERY; AGENTS, Saw an article supported by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah [DF4521661441]; DSR. Computed Properties of C8H8O2. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Ibrahim, TS; Almalki, AJ; Moustafa, AH; Allam, RM; Abuo-Rahma, GEDA; El Subbagh, HI; Mohamed, MFA. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

New antibacterial drugs are urgently needed to tackle the rapid rise in multi-drug resistant bacteria. DNA gyrase is a validated target for the development of new antibacterial drugs. Thus, in the present investigation, a novel series of 1,2,4-oxadiazole-chalcone/oxime (6a-f) and (7a-f) were synthesized and characterized by IR, NMR (1H and 13C) and elemental analyses. The title compounds were evaluated for their in-vitro antimicrobial activity by the modified agar diffusion method as well as their E. coli DNA gyrase inhibitory activity. The minimum inhibitory concentration (MIC) and the structure activity relationships (SARs) were evaluated. Among all, compounds 6a, 6c-e, 7b and 7e were the most potent and proved to possess broad spectrum activity against the tested Gram-positive and Gram-negative organisms. Additionally, compounds 6a (against S. aureus), 6c (against B. subtilis and E. hirae), 6e (against E. hirae), 6f, 7a and 7c (against E. coli) and 7d (against B. subtilis), with MIC value of 3.12 mu M were two-fold more potent than the standard ciprofloxacin (MIC = 6.25 mu M). Mechanistically, compounds 6c, 7c, 7e and 7b had good inhibitory activity against E. coli gyrase with IC50 values of 17.05, 13.4, 16.9, and 19.6 mu M, respectively, in comparison with novobiocin (IC50 = 12.3 mu M) and ciprofloxacin (IC50 = 10.5 mu M). The molecular docking results at DNA gyrase active site revealed that the most potent compounds 6c and 7c have binding mode and docking scores comparable to that of ciprofloxacin and novobiocin suggesting their antibacterial activity via inhibition of DNA gyrase. Finally, the predicted parameters of Lipinski’s rule of five and ADMET analysis showed that 6c and 7c had good drug-likeness and acceptable physicochemical properties. Therefore, the hybridization of the chalcone and oxadiazole moieties could be promising lead as antibacterial candidate which merit further future structural optimizations.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Ibrahim, TS; Almalki, AJ; Moustafa, AH; Allam, RM; Abuo-Rahma, GEDA; El Subbagh, HI; Mohamed, MFA or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H8O2. Authors Gong, YX; Zhu, ZD; Qian, Q; Tong, WQ; Gong, HG in AMER CHEMICAL SOC published article about in [Gong, Yuxin; Zhu, Zhaodong; Qian, Qun; Tong, Weiqi; Gong, Hegui] Shanghai Univ, Ctr Supramol Chem & Catalysis, Dept Chem, Shanghai 200444, Peoples R China in 2021.0, Cited 36.0. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

We describe here the facile construction of sterically hindered tertiary alkyl ethers and thioethers via the Zn(OTf)(2)-catalyzed coupling of alcohols/phenols with unactivated tertiary alkyl bromides and the Cu(OTf)(2)-catalyzed thiolation of unactivated tertiary alkyl oxalates with thiols. The present protocol represents one of the most effective unactivated tertiary C(sp(3))-heteroatom bond-forming conditions via readily accessible Lewis acid catalysis that is surprisingly less developed.

About Mequinol, If you have any questions, you can contact Gong, YX; Zhu, ZD; Qian, Q; Tong, WQ; Gong, HG or concate me.. Formula: C7H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: Benzyl Alcohol. Otrisal, P; Obsel, V; Forus, S; Bungau, C; Aleya, L; Bungau, S in [Otrisal, Pave; Obsel, Vladimir; Forus, Stanislav] Univ Def, Nucl Biol & Chem Def Inst, Vyskov 68201, Czech Republic; [Obsel, Vladimir] DEZA Detect & Capture Harmful Substances, Hochmanova 1, Brno 62800, Czech Republic; [Bungau, Constantin] Univ Oradea, Fac Management & Technol Engn, Dept Engn & Management, Oradea 410087, Romania; [Aleya, Lotfi] Univ Bourgogne Franche Comte, CNRS 6249, Lab Chronoenvironm, Besancon, France; [Bungau, Simona] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania published Protecting emergency workers and armed forces from volatile toxic compounds: Applicability of reversible conductive polymer-based sensors in barrier materials in 2019.0, Cited 34.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Barrier materials have wide applicability in both professional (military, medical, industrial) and non-professional (leisure and sports) fields. This paper focuses on the preparation of real conductive polymer (CP) sensors, for the study of the permeation of volatile toxic compounds through barrier materials. Use of such a CP sensor can help improve the quality of barrier materials used in protective clothing. Several types of platforms have been manufactured or purchased for use as comb sensors with different electrode dimensions, and a suitable method of applying the detection layer of conductive polymers (polyaniline and poly-pyrrole) has been developed. Prepared sensors were obtained using various technologies and were assessed not only for response to exposure to vapors of volatile toxic substances, but also for the possibility of their incorporation into a permeation cell, in order to expand the possibilities of using existing permeation devices. The resulting conductivity of the surface film ranges from 50 to 10,000 mu S/cm. When exposed to ethanol vapors, the conductivity of the sensors dropped significantly and returned to the original value after exposure ended. The conductivity of the B12 CP sensor was in the range of 10-100 mS/cm and is considered the most valuable tested sensor. CPs deposited on this substrate have very high sensitivity in units of ppm (in special cases, even ppb) within the detection of analytes (in this case toxic vapors of ethanol, acetic acid) and the ability to return to initial (zero) conductivity. (C) 2019 Elsevier B.V. All rights reserved.

About Benzyl Alcohol, If you have any questions, you can contact Otrisal, P; Obsel, V; Forus, S; Bungau, C; Aleya, L; Bungau, S or concate me.. Recommanded Product: Benzyl Alcohol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about BENZOXAZINE MONOMERS; OPENING POLYMERIZATION; COPOLYMERIZATION, Saw an article supported by the MINECO/FEDER [CTQ2015-65439-R, 2016-81797-REDC]; Generalitat de CatalunyaGeneralitat de Catalunya [2017 SGR00465]; MAPEX Center for Materials and Processes. Name: m-Methoxyphenol. Published in MDPI in BASEL ,Authors: Martos, A; Soto, M; Schafer, H; Koschek, K; Marquet, J; Sebastian, RM. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

It is possible to control the crosslink density of polymers derived from monobenzoxazines by switching the type of substituents in the phenolic ring and their relative position with respect to the phenol group. We prepared several substituted monobenzoxazines in the para and meta positions of the phenolic ring and studied how these substituents affected the polymerization temperature of monomers and the thermal stability of the final polymers and, more extensively, how they affected the crosslink network of the final polymers. Gel content and dynamic mechanical analysis confirm that ortho- and para-orienting substituents in the meta position generate highly crosslinked materials compared to para ones. This fact can lead to the design of materials with highly crosslinked networks based on monobenzoxazines, simpler and more versatile monomers than the commercial bisbenzoxazines currently in use.

Name: m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Martos, A; Soto, M; Schafer, H; Koschek, K; Marquet, J; Sebastian, RM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Toward hydrogen economy: Selective guaiacol hydrogenolysis under ambient hydrogen pressure WOS:000526110500045 published article about LIGNIN-DERIVED PHENOLS; MODEL-COMPOUND; HYDRODEOXYGENATION; CYCLOHEXANOL; CONVERSION; CATALYSTS; PD/C; DEPOLYMERIZATION; CLEAVAGE; METHANOL in [Zhou, Hui; Wang, Hsin; Sadow, Aaron D.; Slowing, Igor I.] US DOE, Ames Lab, Ames, IA 50011 USA; [Wang, Hsin; Sadow, Aaron D.; Slowing, Igor I.] Iowa State Univ, Dept Chem, Ames, IA 50011 USA in 2020.0, Cited 42.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Safety of m-Methoxyphenol

The conversion of guaiacol into the nylon precursors, cyclohexanol and cyclohexanone, is catalyzed by palladium supported on high surface area ceria (Pd/HS CeO2) under mild conditions (100 degrees C, <= 1 bar H-2) via sequential hydrodemethoxylation and hydrogenation. In contrast, the 2-methoxycyclohexanol side product is generated by direct guaiacol hydrogenation. Reaction selectivity is determined by competing CeO bond hydrogenolysis versus arene hydrogenation. Hydrogenolysis selectivity increases as H-2 pressure decreases, and over 80 % H-2 is incorporated into the products at 1 bar H-2. Higher reactivity of guaiacol than anisole implies that the hydroxyl group is essential in Pd/HS CeO2 catalysis. Participation of water in the conversion is evidenced by deuterium incorporation at non-exchangeable positions when the reaction is performed in D2O. The combination of near quantitative mass balance of H-2, high recyclability, and use of water as a solvent offers a simple, green and efficient conversion of lignin-derived aromatics into commercial products. Safety of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Zhou, H; Wang, H; Sadow, AD; Slowing, II or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C9H7NO2. Authors Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S in SAGE PUBLICATIONS LTD published article about in [Aly, Ashraf A.; Hassan, Alaa A.; Mohamed, Nasr K.; Abd El-Haleem, Lamiaa E.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Brase, Stefan] Karlsruhe Inst Technol, Inst Biol & Chem Syst Funct Mol Syst IBCS FMS, Eggenstein Leopoldshafen, Germany in 2020, Cited 13. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

A novel series of 7,8-dichlorobenzofuro[3,2-c]quinoline-6,9,10(5H)-triones was obtained regioselectively in good yields. The products were formed by the reactions of the 4-hydroxy-2(1H)-quinolinones with 3,4,5,6-tetrachloro-1,2-benzoquinone in tetrahydrofuran as the solvent. Infrared, nuclear magnetic resonance (two-dimensional nuclear magnetic resonance), mass spectra and elemental analysis were used to elucidate the structures of new compounds.

HPLC of Formula: C9H7NO2. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of (E)-2-Methylbut-2-enoic acid. Authors Tuniyazi, M; He, JY; Guo, J; Li, S; Zhang, NS; Hu, XY; Fu, YH in BMC published article about in [Tuniyazi, Maimaiti; He, Junying; Guo, Jian; Li, Shuang; Zhang, Naisheng; Hu, Xiaoyu; Fu, Yunhe] Jilin Univ, Dept Clin Vet Med, Coll Vet Med, Changchun 130062, Jilin, Peoples R China in 2021, Cited 42. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1

BackgroundLaminitis is a common and serve disease which caused by inflammation and pathological changes of the laminar junction. However, the pathologic mechanism remains unclear. In this study we aimed to investigate changes of the gut microbiota and metabolomics in oligofructose-induced laminitis of horses.ResultsAnimals submitted to treatment with oligofructose had lower fecal pH but higher lactic acid, histamine, and Lipopolysaccharide (LPS) in serum. Meanwhile, oligofructose altered composition of the hindgut bacterial community, demonstrated by increasing relative abundance of Lactobacillus and Megasphaera. In addition, the metabolome analysis revealed that treatment with oligofructose decreased 84 metabolites while 53 metabolites increased, such as dihydrothymine, N3,N4-Dimethyl-L-arginine, 10E,12Z-Octadecadienoic acid, and asparagine. Pathway analysis revealed that aldosterone synthesis and secretion, regulation of lipolysis in adipocytes, steroid hormone biosynthesis, pyrimidine metabolism, biosynthesis of unsaturated fatty acids, and galactose metabolism were significantly different between healthy and laminitis horses. Furthermore, correlation analysis between gut microbiota and metabolites indicated that Lactobacillus and/or Megasphaera were positively associated with the dihydrothymine, N3,N4-Dimethyl-L-arginine, 10E,12Z-Octadecadienoic acid, and asparagine.ConclusionsThese results revealed that disturbance of gut microbiota and changes of metabolites were occurred during the development of equine laminitis, and these results may provide novel insights to detect biomarkers for a better understanding of the potential mechanism and prevention strategies for laminitis in horses.

Quality Control of (E)-2-Methylbut-2-enoic acid. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Tuniyazi, M; He, JY; Guo, J; Li, S; Zhang, NS; Hu, XY; Fu, YH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Selective Synthesis of Conjugated Chiral Macrocycles: Sidewall Segments of (-)/(+)-(12,4) Carbon Nanotubes with Strong Circularly Polarized Luminescence WOS:000500431400001 published article about SHAPE-PERSISTENT MACROCYCLES; BOTTOM-UP SYNTHESIS; NANOHOOPS; ARYLENE in [Wang, Jinyi; Chen, Muqing; Lu, Dapeng; Huang, Qiang; Jia, Hongxing; Cui, Shengsheng; Yang, Shangfeng; Du, Pingwu] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Mat Energy Convers, Dept Mat Sci & Engn,iChEM Collaborat Innovat Ctr, Hefei 230026, Anhui, Peoples R China; [Zhuang, Guilin] Zhejiang Univ Technol, Coll Chem Engn, 18 Chaowang Rd, Hangzhou 310032, Zhejiang, Peoples R China; [Li, Zhe; Shao, Xiang] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Dept Chem Phys, Hefei 230026, Anhui, Peoples R China in 2020.0, Cited 68.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Computed Properties of C7H8O2

Carbon nanotubes (CNTs) have unusual physical properties that are valuable for nanotechnology and electronics, but the chemical synthesis of chirality- and diameter-specific CNTs and pi-conjugated CNT segments is still a great challenge. Reported here are the selective syntheses, isolations, characterizations, and photophysical properties of two novel chiral conjugated macrocycles ([4]cyclo-2,6-anthracene; [4]CAn(2,6)), as (-)/(+)-(12,4) carbon nanotube segments. These conjugated macrocyclic molecules were obtained using a bottom-up assembly approach and subsequent reductive elimination reaction. The hoop-shaped molecules can be directly viewed by a STM technique. In addition, chiral enantiomers with (-)/(+) helicity of the [4]CAn(2,6) were successfully isolated by HPLC. The new tubular CNT segments exhibit large absorption and photoluminescence redshifts compared to the monomer unit. The carbon enantiomers are also observed to show strong circularly polarized luminescence (g(lum)approximate to 0.1). The results reported here expand the scope of materials design for bottom-up synthesis of chiral macrocycles and enrich existing knowledge of their optoelectronic properties.

About m-Methoxyphenol, If you have any questions, you can contact Wang, JY; Zhuang, GL; Chen, MQ; Lu, DP; Li, Z; Huang, Q; Jia, HX; Cui, SS; Shao, X; Yang, SF; Du, PW or concate me.. Computed Properties of C7H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C8H8O2. Authors Mourad, AAE; Khodir, AE; Saber, S; Mourad, MAE in MDPI published article about in [Mourad, Ahmed A. E.] Port Said Univ, Fac Pharm, Pharmacol & Toxicol Dept, Port Said 42511, Egypt; [Khodir, Ahmed E.] Horus Univ, Fac Pharm, Pharmacol Dept, New Damietta 34518, Egypt; [Saber, Sameh] Delta Univ Sci & Technol, Fac Pharm, Pharmacol Dept, Mansoura 11152, Dakahlia, Egypt; [Mourad, Mai A. E.] Port Said Univ, Fac Pharm, Med Chem Dept, Port Said 42511, Egypt in 2021, Cited 55. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as anti-hyperglycemic agents that improve glycemic control in type 2 diabetic patients, either as monotherapy or in combination with other antidiabetic drugs. Methods: A novel series of dihydropyrimidine phthalimide hybrids was synthesized and evaluated for their in vitro and in vivo DPP-4 inhibition activity and selectivity using alogliptin as reference. Oral glucose tolerance test was assessed in type 2 diabetic rats after chronic treatment with the synthesized hybrids +/- metformin. Cytotoxicity and antioxidant assays were performed. Additionally, molecular docking study with DPP-4 and structure activity relationship of the novel hybrids were also studied. Results: Among the synthesized hybrids, 10g, 10i, 10e, 10d and 10b had stronger in vitro DPP-4 inhibitory activity than alogliptin. Moreover, an in vivo DPP-4 inhibition assay revealed that 10g and 10i have the strongest and the most extended blood DPP-4 inhibitory activity compared to alogliptin. In type 2 diabetic rats, hybrids 10g, 10i and 10e exhibited better glycemic control than alogliptin, an effect that further supported by metformin combination. Finally, 10j, 10e, 10h and 10d had the highest radical scavenging activity in DPPH assay. Conclusions: Hybrids 10g, 10i and 10e are potent DPP-4 inhibitors which may be beneficial for T2DM treatment.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Mourad, AAE; Khodir, AE; Saber, S; Mourad, MAE or concate me.. COA of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles