Month: October 2021

An article Magnetically recoverable graphene oxide supported Co@Fe3O4/L-dopa for C-C cross-coupling and oxidation reactions in aqueous medium WOS:000466253900004 published article about HIGHLY EFFICIENT; CATALYST; SUZUKI; REDUCTION; NANOPARTICLES; NANOCATALYSTS; HECK; NITROAROMATICS; NANOCOMPOSITE; COMPOSITE in [Sharma, Harsha; Sharma, Shally; Sharma, Chandan; Paul, Satya] Univ Jammu, Dept Chem, Jammu 180006, Jammu & Kashmir, India; [Clark, James H.] Univ York, Dept Chem, Green Chem Ctr Excellence, York YO10 5DD, N Yorkshire, England in 2019, Cited 50. Application In Synthesis of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

We report the synthesis of inexpensive and environmentally benign cobalt(0) nanoparticles on L-3,4-dihydroxyphenylalanine (L-dopa) functionalized and magnetite (Fe3O4) grafted graphene oxide (Co@GO/Fe3O4/L-dopa) which was fully characterized with different techniques such as Scanning Electron Microscopy (SEM), High Resolution Transmission Electron Microscopy (HR-TEM), X-Ray Photoelectron Spectroscopy (XPS), X-ray Powder Diffraction (XRD), Thermogravimetric analysis (TGA), Fourier Transform Infrared Spectroscopy (FTIR), Vibrating Sample Magnetometer (VSM), Carbon Hydrogen Nitrogen (CHN) analysis, Energy Dispersive X-ray (EDX) and Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES). Graphene oxide was used as the core material due to its mechanical, electrical and thermal properties. In order to avoid the cumbersome process of separation, magnetite nanoparticles were coated over the graphene oxide. After the successful preparation of graphene oxide based magnetic nanoparticles, L-dopa was grafted over Fe3O4 nanoparticles so as to provide firm anchoring agent for cobalt nanoparticles. Finally, cobalt(0) nanoparticles were immobilized on the developed magnetic support. The catalytic efficiency of the synthesized catalyst was tested for Suzuki cross-coupling and oxidation reactions, usually carried out by precious and expensive second and third row transition metals; products were obtained in good to excellent yields. The synthesized catalyst represents an attractive alternative to conventional catalysts for Suzuki cross-coupling and oxidation reactions, and is recyclable up to five runs.

Application In Synthesis of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Sharma, H; Sharma, S; Sharma, C; Paul, S; Clark, JH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of Benzyl Alcohol. In 2019 J MATER CHEM A published article about OXYGEN EVOLUTION REACTION; GRAPHITIC CARBON NITRIDE; EFFICIENT; CATALYST; RU; IR; ELECTROCATALYST; HYDROGENATION; ELECTROLYSIS; OXIDES in [Babu, Dickson D.; Huang, Yiyin; Anandhababu, Ganesan; Wu, Maoxiang; Li, Qiaohong; Wang, Yaobing] Chinese Acad Sci, CAS Key Lab Design & Assembly Funct Nanostruct, Fujian Prov Key Lab Nanomat,State Key Lab Struct, Key Lab Optoelect Mat Chem & Phys,Fujian Inst Res, Fuzhou 350002, Fujian, Peoples R China; [Wang, Xu; Si, Rui] Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys, 239 Zhangheng Rd, Shanghai 201204, Peoples R China; [Yao, Jiannian] Chinese Acad Sci, Inst Chem, BNLMS, Beijing 100190, Peoples R China in 2019, Cited 37. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Atomization of noble metals enable their electrocatalysis applications with low cost, whereas the isolated mononuclear site after atomization might lead leads to limited performance. Herein, we present a general strategy of atomically confined alloying (ACA) to synthesize an electrocatalyst of single atom iridium-trapping cobalt nanosheets with dual-reactive Ir-Co sites. The atomic Ir@Co nanosheets (1.7 wt% Ir) exhibit excellent oxygen evolution reaction (OER) performance with a small overpotential (273 mV at 10 mA cm(-2)) and high stability, higher than that of the Ir/C catalyst (290 mV at 10 mA cm(-2)). More importantly, density functional theory (DFT) calculations combined with experiments demonstrated that water oxidation proceeded on atomic Ir@Co nanosheets via a dinuclear tandem mechanism, in which Ir-Co dual sites cooperatively worked in favour of the sequential transfer from Co-OH* to Ir-O* via a Co-O-Ir intermediate, and stabilization of OOH* species by hydrogen bonding interaction. The cooperative mechanism based on a dinuclear electrocatalyst by ACA is hoped to open up more possibilities of single atom noble metal electrocatalysts for various applications.

Safety of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Babu, DD; Huang, YY; Anandhababu, G; Wang, X; Si, R; Wu, MX; Li, QH; Wang, YB; Yao, JN or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 4-Methoxybenzaldehyde. Dickenson, JC; Haley, ME; Hyde, JT; Reid, ZM; Tarring, TJ; Iovan, DA; Harrison, DP in [Dickenson, John C.; Haley, MacKenzie E.; Hyde, Jacob T.; Reid, Zachary M.; Tarring, Travis J.; Harrison, Daniel P.] Virginia Mil Inst, Dept Chem, Lexington, VA 24450 USA; [Iovan, Diana A.] Virginia Tech, Dept Chem, Blacksburg, VA 24060 USA published Fine-Tuning Metal and Ligand-Centered Redox Potentials of Homoleptic Bis-Terpyridine Complexes with 4 ‘-Aryl Substituents in 2021, Cited 71. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Homoleptic transition-metal complexes of 2,2′:6′,2 ”-terpyridine (terpy) and substituted derivatives of the form [M(R-terpy)(2)](2+) display a wide range of redox potentials that correlate well to the Hammett parameter of the terpy substituents. Less is known about the impact of incorporating a phenyl spacer between the functional group responsible for controlling the electron density of terpy and how that translates to metal complexes of the form [M(4′-aryl-terpy)(2)](2+), where M = Mn, Fe, Co, Ni, and Zn. Herein, we report our studies on these complexes revealed a good correlation of redox potentials of both metal- and ligand-centered events with the Hammett parameters of the aryl substituents, regardless of aryl-substitution pattern (i.e., the presence of multiple functional groups, combinations of withdrawing and donating functional groups). The phenyl spacer results in 60-80% attenuation of electron density as compared to the 4’-substituted terpy analogue, depending on the metal and redox couple analyzed. Density functional theory calculations performed on a simple model system revealed a strong correlation between the Hammett parameters and lowest unoccupied molecular orbital energies of the corresponding substituted pyridine models, thus serving as an inexpensive predictive tool when coupled with electrochemical data. Overall, these data suggest that such ligand modifications may be used in combination with previous approaches to further fine-tune the redox potentials of homoleptic transition-metal complexes, which may have applications in photochemical and electrochemical catalytic processes.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Dickenson, JC; Haley, ME; Hyde, JT; Reid, ZM; Tarring, TJ; Iovan, DA; Harrison, DP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Organometallic Elaboration as a Strategy for Tuning the Supramolecular Characteristics of Aza-Crown Ethers WOS:000500038800005 published article about METHANOL CARBONYLATION; MACROCYCLE INTERACTION; ORGANIC-CHEMISTRY; METAL-CATIONS; KINETIC-DATA; BINDING; COMPLEXES; REACTIVITY; MOLECULES; CONSTANTS in [Smith, Jacob B.; Camp, Andrew M.; Farquhar, Alexandra H.; Kerr, Stewart H.; Chen, Chun-Hsing; Miller, Alexander J. M.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA in 2019.0, Cited 58.0. Application In Synthesis of 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Outfitting an aza-crown ether with an organotransition-metal pendant provides a mechanism for tuning its supramolecular properties. The binding affinity can be tuned by more than 2 orders of magnitude by changing the identity of the transition metal-center, altering the overall charge of the complex, or engaging in organometallic ligand substitution reactions. High Li+ selectivity (up to 29-fold higher affinity in comparison to Na+), proton-responsive behavior, and ion pair (ditopic) binding capabilities are observed in the metallacrown ethers.

Application In Synthesis of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Smith, JB; Camp, AM; Farquhar, AH; Kerr, SH; Chen, CH; Miller, AJM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article TPG-lite: A new, simplified designer surfactant for general use in synthesis under micellar catalysis conditions in recyclable water WOS:000645466300004 published article about MIYAURA CROSS-COUPLINGS; LEVEL PD CATALYSIS; ROOM-TEMPERATURE; SONOGASHIRA COUPLINGS; ORGANIC-CHEMISTRY; ARYL BROMIDES; PPM LEVELS; AMPHIPHILE; TPGS-750-M; MILD in [Thakore, Ruchita R.; Takale, Balaram S.; Hu, Yuting; Lipshutz, Bruce H.] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA; [Ramer, Selene; Kostal, Jakub] George Washington Univ, Sci & Engn Hall 4520, Washington, DC 20052 USA; [Gallou, Fabrice] Novartis Pharma AG, CHAD, CH-4056 Basel, Switzerland in 2021.0, Cited 49.0. Recommanded Product: 120-14-9. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Using the oxidized, carboxylic acid-containing form of MPEG-750, esterification with racemic vitamin E affords a new surfactant (TPG-lite) that functions as an enabling, nanoreactor-forming amphiphile for use in many types of important reactions in synthesis. The presence of a single ester bond is suggestive of simplified treatment as a component of (eventual) reaction waste water, after recycling. Many types of reactions, including aminations, Suzuki-Miyaura, SNAr, and several others are compared directly with TPGS-750-M, leading to the conclusion that TPG-lite can function as an equivalent nanomicelle-forming surfactant in water. Prima facie evidence amassed via DLS and cryo-TEM analyses support these experimental observations. In silico evaluations of the aquatic toxicity and carcinogenicity of TPG-lite indicate that it is safe to use. (C) 2021 Elsevier Ltd. All rights reserved.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Thakore, RR; Takale, BS; Hu, YT; Ramer, S; Kostal, J; Gallou, F; Lipshutz, BH or concate me.. Recommanded Product: 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wang, CQ; Wang, Y; Deng, QS; Liu, XJ in [Wang, Chaoqing; Wang, Yan; Deng, Qingsong; Liu, Xiujie] Tianjin Univ Technol, Sch Chem & Chem Engn, Tianjin 300384, Peoples R China; [Wang, Chaoqing; Liu, Xiujie] Tianjin Univ Technol, Tianjin Key Lab Organ Solar Cells & Photochem Co, Sch Chem & Chem Engn, Tianjin 300384, Peoples R China published Synthesis of 4-Methoxy-1, 3-Benzenediolylhydrazones and Evaluation of Their Anti-Platelet Aggregation Activity in 2019.0, Cited 28.0. Name: 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

In our present investigation, a series of novel 4-methoxy-1,3-benzenediolyl-hydrazones were designed and synthesized, and their ability to inhibit platelet aggregation was evaluated by adenosine diphosphate (ADP) and arachidonic acid (AA). The structures of the synthesized compounds were confirmed by spectral data. Results demonstrated that the activities of all compounds excelled the positive drug Picotamide (25.1% inhibition rate) and seven compounds (PNN01, PNN03, PNN05, PNN07, PNN09, PNN12, and PNN14) have efficiently inhibited platelet aggregation even higher than Clopidogrel (37.6% inhibition rate) induced by AA. Among them, PNN07 (39.8% inhibition rate) was considered as the most potent analogue. Evaluation of cytotoxic activity of the compounds against L929 cell line revealed that none of the compounds have significant cytotoxicity. Thus, diolylhydrazones derives are potential to be antiplatelet aggregation inhibitors and maybe working in AA-induced selectively.

Name: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Wang, CQ; Wang, Y; Deng, QS; Liu, XJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Synthesis of Ethyl 2-Amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates by a One-pot, Three-Component Reaction in the Presence of TPAB published in 2019. Name: 4-Hydroxyquinolin-2(1H)-one, Reprint Addresses Marjani, AP (corresponding author), Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh, Iran.. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, H-1-NMR, and C-13-NMR spectral data and elemental analysis.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or concate me.. Name: 4-Hydroxyquinolin-2(1H)-one

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Suzuki, H; Yamaguchi, E; Itoh, A in [Suzuki, Hiroyuki; Yamaguchi, Eiji; Itoh, Akichika] Gifu Pharmaceut Univ, Lab Pharmaceut Synthet Chem, 1-25-4 Daigaku Nishi, Gifu 5011196, Japan published Nickel-Catalyzed Reductive Allylation of Aldehydes with Allyl Acetates in 2021, Cited 68. Quality Control of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Carbonyl allylation reactions constitute an important step in the formation of carbon-carbon reactions, and involve various related reactions that chiefly use allylmetal reagents. This report presents a nickel-catalyzed carbonyl allylation reaction using allyl acetate, which produces homoallyl alcohols in moderate to good yields, as an efficient methodology under reductive coupling conditions.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Suzuki, H; Yamaguchi, E; Itoh, A or concate me.. Quality Control of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Benzyl C-O and C-N Bond Construction via C-C Bond Dissociation of Oxime Ester under Visible Light Irradiation WOS:000485342000001 published article about PROPARGYLIC SUBSTITUTION-REACTIONS; METAL-FREE; CATALYZED MONOALKYLATION; EFFICIENT CATALYSTS; ACYL OXIMES; AMINATION; ACTIVATION; ALCOHOLS; ACID; CHEMOSELECTIVITY in [Fan, Xiuwei; Lei, Tao; Liu, Zan; Yang, Xiu-Long; Cheng, Yuan-Yuan; Liang, Ge; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu] Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, Tech Inst Phys & Chem, Beijing 100190, Peoples R China; [Fan, Xiuwei; Lei, Tao; Liu, Zan; Yang, Xiu-Long; Cheng, Yuan-Yuan; Liang, Ge; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu] Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China in 2020.0, Cited 49.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Category: indole-building-block

A photoredox benzyl activation was developed via formidable C(sp(3))-C(sp(3)) bond dissociation of 1-aryl acetone oxime esters, which were easily prepared from benzyl ketones. Further coupling with O- and N- nucleophiles successfully forged important benzyl ether and amines derivatives in one pot. In this process, different substitutions on oxime esters were found compatible and various primary and secondary alcohols and amines, as well as amides showed good performance as nucleophiles. Mechanistic studies by control experiments, electrochemical measurements and in-situ NMR spectra proposed a N-O bond interruption/C-C bond fragmentation/oxidation sequence to provide the key cation intermediate for the next electrophilic S-N process. The features of mild condition, short reaction time and broad substrate scope made this new strategy much promising in the transformation of benzyl compounds, which might be valuable in last-stage functionalizations.

About Benzyl Alcohol, If you have any questions, you can contact Fan, XW; Lei, T; Liu, Z; Yang, XL; Cheng, YY; Liang, G; Chen, B; Tung, CH; Wu, LZ or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3-Hydroxybenzaldehyde. Recently I am researching about ALPHA-FLUORINATED ETHERS; LASER FLASH-PHOTOLYSIS; TRANSITION-METAL-FREE; ELECTROCHEMICAL OXIDATION; PHOTOREDOX CATALYSIS; ALCOHOL OXIDATION; NITROXYL RADICALS; ELECTRON-TRANSFER; EFFICIENT; CHEMISTRY, Saw an article supported by the NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [R35GM119652]; NSFNational Science Foundation (NSF) [CHE-1827902, CHE-1654122, ACI-1053575]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Lee, JW; Lim, S; Maienshein, DN; Liu, P; Ngai, MY. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

Applications of TEMPO(.)catalysis for the development of redox-neutral transformations are rare. Reported here is the first TEMPO.-catalyzed, redox-neutral C-H di- and trifluoromethoxylation of (hetero)arenes. The reaction exhibits a broad substrate scope, has high functional-group tolerance, and can be employed for the late-stage functionalization of complex druglike molecules. Kinetic measurements, isolation and resubjection of catalytic intermediates, UV/Vis studies, and DFT calculations support the proposed oxidative TEMPO./TEMPO(+)redox catalytic cycle. Mechanistic studies also suggest that Li(2)CO(3)plays an important role in preventing catalyst deactivation. These findings will provide new insights into the design and development of novel reactions through redox-neutral TEMPO(.)catalysis.

Recommanded Product: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Lee, JW; Lim, S; Maienshein, DN; Liu, P; Ngai, MY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles