Month: October 2021

Recently I am researching about COVALENT POLYMER NETWORKS; SILICA, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51673016]; Molecular Foundry – Office of Science, Office of Basic Energy Sciences, of the U.S. Department of EnergyUnited States Department of Energy (DOE) [DE-AC02-05 CH11231]; Beijing Natural Science FoundationBeijing Natural Science Foundation [2194083]. Computed Properties of C8H8O2. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: He, CF; Shi, SW; Wang, D; Helms, BA; Russell, TP. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Vitrimers are network polymers that undergo associative bond exchange reactions in the condensed phase above a threshold temperature, dictated by the exchangeable bonds comprising the vitrimer. For vitrimers, chemistries reliant on poorly nudeophilic bond exchange partners (e.g., hydroxy-functionalized alkanes) or poorly electrophilic exchangeable bonds, catalysts are required to lower the threshold temperature, which is undesirable in that catalyst leaching or deactivation diminishes its influence over time and may compromise reuse. Here we show how to access catalyst-free bond exchange reactions in catalyst-dependent polyester vitrimers by obviating conventional ester bonds in favor of oxime-esters. Poly(oxime-ester) (POE) vitrimers are synthesized using thiol-ene click chemistry, affording high stretchability and malleability. POE vitrimers are readily recycled with little degradation of their initial mechanical properties, suggesting exciting opportunities for sustainable plastics.

Computed Properties of C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact He, CF; Shi, SW; Wang, D; Helms, BA; Russell, TP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about CARBON NITRIDE SEMICONDUCTORS; ADSORPTION PROPERTIES; ORGANIC FRAMEWORKS; AROMATIC ALCOHOLS; BUILDING-BLOCKS; STORAGE; CAPTURE; WATER, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51703031]. Published in ELSEVIER SCIENCE BV in AMSTERDAM ,Authors: Xu, CY; Qian, L; Lin, JY; Guo, ZY; Yan, D; Zhan, HB. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol. Product Details of 100-51-6

Heptazine units with highly rich nitrogen sites were employed to fabricate a new porous organic polymer (POP-HE) via direct coupling of 2,5,8-trichloro-s-heptazine and 4,4′,4 ”,4”’-(ethene-1,1,2,2-tetrayl)tetraaniline with the mild base N, N’-diisopropylethylamine (DIPEA) in tetrahydrofuran (THF) solution. POP-HE displays good CO2 uptake capacity (50.6 cm(3) g(-1), 10 wt%, 1 bar/273 K) and highly selectively adsorptive separation of CO2 over CH4 under ambient conditions. Impressively, at 273 K, the predicted IAST selectivity of POP-HE is 47.0-13.4 for the natural gas mixture (CO2/CH4 = 5:95) at pressures varying from 0 to 1 atm. Meanwhile, the result of calculated band gap value based on Tauc plot motivated us to investigate its photocatalytic activity. POP-HE was applied as heterogeneous photocatalyst for visible light-induced selective oxidation of benzyl alcohol to benzaldehyde, and exhibited great conversion of 33.6% under irradiation of white LED light, which is much higher than that of g-C3N4. Moreover, POP-HE can be recycled up to three times without significant decrease in catalytic activity.

Product Details of 100-51-6. About Benzyl Alcohol, If you have any questions, you can contact Xu, CY; Qian, L; Lin, JY; Guo, ZY; Yan, D; Zhan, HB or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 4-Hydroxyquinolin-2(1H)-one. Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH in [Aly, Ashraf A.; Mohamed, Asmaa H.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Ishak, Esam] Al Azhar Univ, Fac Sci, Dept Chem, Assiut, Egypt; [Ishak, Esam] Jouf Univ, Coll Sci & Arts, Dept Chem, Alquurrayate, Saudi Arabia; [Shwaky, Ahmed M.] Umm Al Qura Univ, STU, Mecca, Saudi Arabia published Formation of furo[3,2-c]quinolone-2-carbonitriles and 4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carboxamides from reaction of quinoline-2,4-diones with 2-[bis(methylthio)methylene]malononitrile in 2020, Cited 31. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

Quinoline-2,4-diones reacted with 2-[bis(methylthio)methylene]malononitrile in DMF/Et3N to produce 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carbonitriles and 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carboxamides in state of 2-imino-substituted 4-(methylthio)-5,6-dihydro-2H-pyrano[3,2-c]quinolone-3-carbonitriles. The structures of all new products were proved using NMR, IR, and mass spectral data. The possible mechanism for the reaction is also discussed. Graphic abstract

Name: 4-Hydroxyquinolin-2(1H)-one. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 100-51-6. Recently I am researching about PHENOLIC-COMPOUNDS; PHASE ADVANCES; ANTAGONISTS; DERIVATIVES; ACTIVATION; MT1, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81773612]; Program of Yunling Scholar; Youth Innovation Promotion Association, CAS [2013252]; Applied Basic Research Programs of Yunnan Province [2017FB137]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Chen, SY; Geng, CA; Ma, YB; Huang, XY; Yang, XT; Su, LH; He, XF; Li, TZ; Deng, ZT; Gao, Z; Zhang, XM; Chen, JJ. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

Gastrodia elata is a famous traditional Chinese herb with medicinal and edible application. In this study, nine polybenzyls (1-9), including six new ones (2-5, 7 and 9), were isolated from the EtOAc extract of G. elata. Five compounds 1, 3, 4, 6 and 8 were found to activate melatonin receptors. Especially, compound 1 showed agonistic effects on MT1 and MT2 receptors with EC50 values of 237 and 244 mu M. For better understanding their structure-activity relationships (SARs), ten polybenzyl analogs were further synthesized and assayed for their activities on melatonin receptors. Preliminary SARs study suggested that two para-hydroxy groups were the key pharmacophore for maintaining activity. Molecular docking simulations verified that compound 1 could strongly interact with MT2 receptor by bonding to Phe 118, Gly 121, His 208, Try 294 and Ala 297 residues.

About Benzyl Alcohol, If you have any questions, you can contact Chen, SY; Geng, CA; Ma, YB; Huang, XY; Yang, XT; Su, LH; He, XF; Li, TZ; Deng, ZT; Gao, Z; Zhang, XM; Chen, JJ or concate me.. Product Details of 100-51-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Devi, P; Bishnoi, A; Singh, V in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Devi, P.; Bishnoi, A.] Univ Lucknow, Dept Chem, Lucknow 226007, Uttar Pradesh, India; [Singh, V.] Inst Engn & Technol, Dept Biotechnol, Lucknow 226021, Uttar Pradesh, India in 2021, Cited 37. Name: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A highly efficient method for the multicomponent synthesis of substituted 4H-pyrido[1,2-a]pyrimidine-2-hydroxy-4-one derivatives, starting from 4H-pyrido[1,2-a]primidine-2-hydroxy-4-one, beta-naphthol, and substituted aromatic aldehydes, in moderate to good yields has been developed. The structure of the pyridopyrimidine derivatives was established by spectral methods. In vitro antibacterial activity of the newly synthesized compounds was evaluated against highly pathogenic Gram-positive [Staphylococcus aureus (MTCC 96)] and Gram-negative [Pseudomonas aeruginosa (MTCC 424), Salmonella typhi (MTCC 537), Klebsiella pneumoniae (MTCC 424), Escherichia coli (MTCC 64) and Chromobacterium violaceum] bacteria.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Devi, P; Bishnoi, A; Singh, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Helwa, AA; El-Dydamony, NM; Radwan, RA; Abdelraouf, SM; Abdelnaby, RM in [Helwa, Amira A.] Misr Univ Sci & Technol, Coll Pharmaceut Sci & Drug Mfg, Dept Organ Pharmaceut Chem, POB 77, 6th Of October City, Egypt; [El-Dydamony, Nehad M.] Misr Univ Sci & Technol, Coll Pharmaceut Sci & Drug Mfg, Dept Pharmaceut Chem, 6th Of October City, Egypt; [Radwan, Rasha A.] Sinai Univ, Fac Pharm & Pharmaceut Ind, Dept Biochem, Kantara Branch, New City, El Ismailia, Egypt; [Abdelraouf, Sahar M.] Misr Int Univ, Fac Pharm, Dept Biochem, Cairo, Egypt; [Abdelnaby, Rana M.] Heliopolis Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt published Novel antiproliferative agents bearing morpholinopyrimidine scaffold as PI3K inhibitors and apoptosis inducers; design, synthesis and molecular docking in 2020.0, Cited 46.0. COA of Formula: C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Two series of novel morpholinopyrimidine derivatives were synthesized and screened for their in-vitro cytotoxic activity against 60 tumor cell line by the National Cancer Institute, USA. The in-vitro cytotoxic IC50 values for the most active compounds 6e, 6g, and 6l against the most sensitive cell line leukemia SR were estimated (IC50 = 0.76, 13.59, and 4.37 uM, respectively). To investigate their PI3K enzyme inhibition activity, the assay was done on Class IA (alpha, beta, & delta) isoforms. The IC50 values were very promising: compound [6e = 11.73 (alpha), 6.09 (beta), 11.18 (delta)], compound [6g = 8.43 (alpha), 15.84 (beta), 30.62 (delta)], and compound [6l = 13.98 (alpha), 7.22 (beta), 10.94 (delta)], compared to the reference compound LY294002 = 6.28 (alpha), 4.51 (beta), 4.60 (delta) uM, respectively. Moreover, cell cycle analysis and annexin V-FITC staining were done on Leukemia SR, there was arrest at G2/M phase and apoptosis was induced. Finally, docking study was performed to analyze the interactive mode of these derivatives in PI3K alpha ATP-binding site. These outcomes proved that compounds 6e, 6g, and 6l are potential leads for further optimization as antileukemic agents.

COA of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Helwa, AA; El-Dydamony, NM; Radwan, RA; Abdelraouf, SM; Abdelnaby, RM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article An efficient and green synthesis of 1,4-dihydropyridine derivatives through multi-component reaction in subcritical EtOH WOS:000671550500009 published article about ONE-POT SYNTHESIS; HANTZSCH 1,4-DIHYDROPYRIDINES; OXIDATIVE DEALKYLATION; MICROWAVE IRRADIATION; SOLVENT; CATALYST; CHEMISTRY; ETHANOL; ABSENCE; SERIES in [Ersatir, Mehmet; Giray, Elife Sultan] Cukurova Univ, Arts & Sci Fac, Dept Chem, TR-01330 Adana, Turkey; [Turk, Murat] Cukurova Univ, Vocat Sch Ceyhan, Dept Property Protect & Secur, Adana, Turkey in 2021, Cited 41. Product Details of 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A simple, environmentally friendly and highly efficient method has been developed for the synthesis of 1,4-dihydropyridine compounds. A number of aromatic aldehydes, ethylaceto acetate and urea converted into corresponding in l,4Dihydropyridine derivatives via one-pot multicomponent reaction in sub-critical ethanol. This study shown that 1,4-dihyropyridines can be synthesized in sub-critical ethanol and has the advantage of excellent yields, short reaction time, and simple work-up conditions.

Product Details of 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Ersatir, M; Turk, M; Giray, ES or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about FATTY-ACID COMPOSITIONS; ENZYMATIC EXTRACTION; VOLATILE COMPOUNDS; OLEIFERA ABEL.; SEED OIL; PHYSICOCHEMICAL PROPERTIES; TRITERPENOID SAPONINS; TEA SAPONIN; PROTEIN; PHOSPHOLIPIDS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31560464]; Innovation Fund Designated for Graduate Students of Jiangxi Province [YC2015-B015]. Quality Control of Benzyl Alcohol. Published in WILEY in HOBOKEN ,Authors: Yang, JY; Li, J; Wang, M; Zou, XG; Peng, B; Yin, YL; Deng, ZY. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

Emulsion is inevitable during the aqueous extraction of oil from oilseeds. In this study, a new aqueous extraction method for camellia oil is investigated. During the extraction, the emulsified oil is collected, frozen, and thawed, and the free oil is obtained (AEEF). The optimal processing conditions are as follows: three times as much water as camellia seed powder (w/w), grinding at 70 degrees C for 6 min, repeating 2 cycles to collect the emulsified oil; then the emulsified oil is frozen (-20 degrees C) /thawed (50 degrees C) for 2 cycles. The yield of camellia oil is 89.37 +/- 0.51%, which is significantly higher (p < 0.05) than that of microwave-assisted aqueous enzymatic extraction (MAAEE, 83.05 +/- 1.14%), and is similar to that of cold press extraction (CPE, 90.85 +/- 2.05%), as well as solvent extraction (SE) coupled with refining. Additionally, the total oxidation value (TOTOX) of the free oil extracted by using AEEF (AEEF-Oil, 6.82 +/- 0.12%) is significantly lower (p < 0.05) than those of MAAEE, CEP, or SE. In comparison to SE-Oil and CEP-Oil, AEEF-Oil has higher (p < 0.05) contents of alpha-tocopherol and squalene, and lower (p < 0.05) benzo(a)pyrene contents, and contains more favorable natural volatile compounds. The results indicate that the novel AEEF may be a promising aqueous extraction method. Practical Application: The novel aqueous extraction method for camellia oil by emulsified oil - frozen/thawed has acceptable oil yields. The obtained camellia oil has high levels of bioactive components, low contents of hazardous substances, and more characteristic volatile flavor compounds. AEEF is an improved aqueous extraction technology for edible oil without refining and using n-hexane, which could be potentially applied in industrial production of camellia oil due to its safety, nutrition, and environment-friendly treatments. Quality Control of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Yang, JY; Li, J; Wang, M; Zou, XG; Peng, B; Yin, YL; Deng, ZY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling published in 2020. Recommanded Product: 3-(Trifluoromethyl)phenol, Reprint Addresses Kagechika, H (corresponding author), Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, 2-3-10 Kanda Surugadai, Tokyo 1010062, Japan.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

We report here structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK (STE20/ SPS1-related proline/alanine-rich kinase) inhibitors. Abnormal activation of the signal cascade of with-no-lysine kinase (WNK) with OSR1 (oxidative stress-responsive kinase 1)/SPAK and NCC (NaCl cotransporter) results in characteristic salt-sensitive hypertension, and therefore inhibitors of the WNK-OSR1/SPAK-NCC cascade are candidates for antihypertensive drugs. Based on the structure of lead compound 2, we examined the SAR of N-(4-phenoxyphenyl)benzamide derivatives, and developed compound 20l as a potent SPAK inhibitor. Compounds 20l is a promising candidate for a new class of antihypertensive drugs.

Recommanded Product: 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Fujii, S; Kikuchi, E; Watanabe, Y; Suzuyama, H; Ishigami-Yuasa, M; Mori, T; Isobe, K; Uchida, S; Kagechika, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Gokkaya, DS; Sert, M; Saglam, M; Yuksel, M; Ballice, L in ELSEVIER published article about SUPERCRITICAL WATER GASIFICATION; HOT-COMPRESSED WATER; HYDROGEN-RICH GAS; BIOMASS GASIFICATION; CATALYTIC GASIFICATION; CELLULOSE; LIGNIN; GLUCOSE; TEMPERATURE; CONVERSION in [Gokkaya, Dilek Selvi; Sert, Murat; Saglam, Mehmet; Yuksel, Mithat; Ballice, Levent] Ege Univ, Engn Fac, Dept Chem Engn, Izmir, Turkey in 2020.0, Cited 51.0. Recommanded Product: 150-19-6. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

Hydrothermal gasification of isolated hemicellulose from the white poplar (Populus alba L.) and white poplar sawdust were studied to evaluate the effects of temperature (in the range of 300-600 degrees C) and the catalyst on the yield of the products. Hydrothermal gasification of poplar sawdust represents a future alternative to the waste management of agricultural residues, and industry waste. Hydrothermal gasification of isolated hemicellulose was helpful to understand and analyze the catalytic gasification characteristics of natural biomass material with high hemicellulose composition. The results indicated that hemicellulose isolated from poplar produced more gaseous products than poplar sawdust. The hemicellulose isolated from poplar wood left lower amount of ingasified solid residue than the biomass studied. Also yields of xylose, which is commercially available as hemicellulosic fraction and was studied in our previous study, was compared with isolated hemicellulose and real biomass. Among them, isolated hemicellulose had the highest yield in gasification. (C) 2020 Elsevier B.V. All rights reserved.

Recommanded Product: 150-19-6. About m-Methoxyphenol, If you have any questions, you can contact Gokkaya, DS; Sert, M; Saglam, M; Yuksel, M; Ballice, L or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles