Safety of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Xue, L; Shi, DH; Harjani, JR; Huang, F; Beveridge, JG; Dingjan, T; Ban, K; Diab, S; Duffy, S; Lucantoni, L; Fletcher, S; Chiu, FCK; Blundell, S; Ellis, K; Ralph, SA; Wirjanata, G; Teguh, S; Noviyanti, R; Chavchich, M; Creek, D; Price, RN; Marfurt, J; Charman, SA; Cuellar, ME; Strasser, JM; Dahlin, JL; Walters, MA; Edstein, MD; Avery, VM; Baell, JB or concate me.
An article 3,3 ‘-Disubstituted 5,5 ‘-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity WOS:000461537000019 published article about PLASMODIUM-FALCIPARUM; ASSAY INTERFERENCE; MALARIA; PREVENTION; PAINS in [Xue, Lian; Huang, Fei; Baell, Jonathan B.] Nanjing Tech Univ, Sch Pharmaceut Sci, 30 South Puzhu Rd, Nanjing 211816, Jiangsu, Peoples R China; [Shi, Da-Hua; Harjani, Jitendra R.; Beveridge, Julia G.; Dingjan, Tamir; Ban, Kung; Diab, Sarah; Teguh, Silvia; Baell, Jonathan B.] Monash Univ, Monash Inst Pharmaceut Sci, Med Chem, Parkville Campus,381 Royal Parade, Parkville, Vic 3052, Australia; [Duffy, Sandra; Lucantoni, Leonardo; Fletcher, Sabine; Avery, Vicky M.] Griffith Univ, Griffith Inst Drug Discovery, Discovery Biol, Brisbane Innovat Pk, Nathan, Qld 4111, Australia; [Ellis, Katherine; Creek, Darren] Monash Univ, Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, Parkville Campus,381 Royal Parade, Parkville, Vic 3052, Australia; [Ralph, Stuart A.] Univ Melbourne, Bio21 Inst, Parkville, Vic 3052, Australia; [Noviyanti, Rintis] Eijkman Inst Mol Biol, Jalan Diponegoro 69, Jakarta 10430, Indonesia; [Wirjanata, Grennady; Price, Ric N.; Marfurt, Jutta] Menzies Sch Hlth Res, Global & Trop Hlth Div, Rocklands Dr, Casuarina, NT 0810, Australia; [Wirjanata, Grennady; Price, Ric N.; Marfurt, Jutta] Charles Darwin Univ, Royal Darwin Hosp Campus, Rocklands Dr, Casuarina, NT 0810, Australia; [Price, Ric N.] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford OX3 7LJ, England; [Chavchich, Marina; Edstein, Michael D.] Australian Def Force Malaria & Infect Dis Inst, Dept Drug Evaluat, Brisbane, Qld 4052, Australia; [Chiu, Francis C. K.; Blundell, Scott; Charman, Susan A.] Monash Univ, Ctr Drug Candidate Optimisat, Parkville Campus,381 Royal Parade, Parkville, Vic 3052, Australia; [Cuellar, Matthew E.; Strasser, Jessica M.; Walters, Michael A.] Univ Minnesota, Inst Therapeut Discovery & Dev, 717 Delaware St SE, Minneapolis, MN USA; [Dahlin, Jayme L.] Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA in 2019, Cited 26. Safety of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
A series of 3,3′-disubstituted 5,5′-bi(1,2,4-triazine) derivatives was synthesized and screened against the erythrocytic stage of Plasmodium falciparum 3D7 line. The most potent dimer, 6k, with an IC50 (50% inhibitory concentration) of 0.008 mu M, had high in vitro potency against P. falciparum lines resistant to chloroquine (W2, IC50 = 0.0047 +/- 0.0011 mu M) and artemisinin (MRA1240, IC50 = 0.0086 +/- 0.0010 mu M). Excellent ex vivo potency of 6k was shown against clinical field isolates of both P. falciparum (IC50 = 0.022-0.034 mu M) and Plasmodium vivax (IC50 = 0.0093-0.031 mu M) from the blood of outpatients with uncomplicated malaria. Despite 6k being cleared relatively rapidly in mice, it suppressed parasitemia in the Peters 4-day test, with a mean ED50 value (50% effective dose) of 1.47 mg kg(-1) day(-1) following oral administration. The disubstituted triazine dimer 6k represents a new class of orally available antimalarial compounds of considerable interest for further development.
Safety of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Xue, L; Shi, DH; Harjani, JR; Huang, F; Beveridge, JG; Dingjan, T; Ban, K; Diab, S; Duffy, S; Lucantoni, L; Fletcher, S; Chiu, FCK; Blundell, S; Ellis, K; Ralph, SA; Wirjanata, G; Teguh, S; Noviyanti, R; Chavchich, M; Creek, D; Price, RN; Marfurt, J; Charman, SA; Cuellar, ME; Strasser, JM; Dahlin, JL; Walters, MA; Edstein, MD; Avery, VM; Baell, JB or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles