Some scientific research about C7H8O2

Formula: C7H8O2. Welcome to talk about 150-76-5, If you have any questions, you can contact Nesaragi, AR; Kamble, RR; Dixit, S; Kodasi, B; Hoolageri, SR; Bayannavar, PK; Dasappa, JP; Vootla, S; Joshi, SD; Kumbar, VM or send Email.

Formula: C7H8O2. Nesaragi, AR; Kamble, RR; Dixit, S; Kodasi, B; Hoolageri, SR; Bayannavar, PK; Dasappa, JP; Vootla, S; Joshi, SD; Kumbar, VM in [Nesaragi, Aravind R.; Kamble, Ravindra R.; Kodasi, Barnabas; Hoolageri, Swati R.; Bayannavar, Praveen K.] Karnatak Univ, Dept Studies Chem, Dharwad 580003, Karnataka, India; [Dixit, Shruti; Vootla, Shyamkumar] Karnatak Univ, Dept Biotechnol & Microbiol, Dharwad 580003, Karnataka, India; [Dasappa, Jagadeesh Prasad] Mangalore Univ, Dept Chem, Mangalagangothri 574199, Konaje, India; [Joshi, Shrinivas D.] SETs Coll Pharm, Dept Pharmaceut Chem, Novel Drug Design & Discovery Lab, Dharwad 580002, Karnataka, India; [Kumbar, Vijay M.] Maratha Mandals NGH Inst Dent Sci & Res Ctr, Cent Res Lab, Belagavi 590010, India published Green synthesis of therapeutically active 1,3,4-oxadiazoles as antioxidants, selective COX-2 inhibitors and their in silico studies in 2021, Cited 24. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5.

A modest, competent and green synthetic procedure for novel coumarinyl-1,3,4-oxadiazolyl-2mercaptobenzoxazoles 8i-t has been reported. Analysis of the docked (PDB ID: 5IKR; A-Chain) poses of the compounds illustrated that they adopt identical conformations to the extremely selective COX-2 inhibitor. The biological outcomes as well as computational study suggested that the compounds originated to have elevated resemblance towards COX-2 enzyme than COX-1. The compounds 8i, 8l, 8q, 8r, 8s and 8t emerged as most potent and selective COX-2 inhibitors in contrast with Mefenamic acid. The selectivity index of 8l, 8n and 8r was respectively found to be 33.95, 20.25 and 24.98 which manifested their high selectivity against COX-2. Interestingly, the compounds which were active as COX-2 inhibitors were also active as antioxidant agents.

Formula: C7H8O2. Welcome to talk about 150-76-5, If you have any questions, you can contact Nesaragi, AR; Kamble, RR; Dixit, S; Kodasi, B; Hoolageri, SR; Bayannavar, PK; Dasappa, JP; Vootla, S; Joshi, SD; Kumbar, VM or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

What advice would you give a new faculty member or graduate student interested in a career Benzyl Alcohol

Computed Properties of C7H8O. Welcome to talk about 100-51-6, If you have any questions, you can contact Jung, DW; Kim, JM; Yoon, HW; Nam, KM; Kwon, YE; Jeong, S; Baek, YH; Choi, YS; Chang, SJ; Yi, GR; Cho, JY; Lee, G or send Email.

An article Solution-processable thermally conductive polymer composite adhesives of benzyl-alcohol-modified boron nitride two-dimensional nanoplates WOS:000457096400077 published article about EPOXY-RESIN; GRAPHENE; FILLER; RESISTANCE; OXIDATION; GRAPHITE; PLASMA in [Jung, Dae-Woong; Kim, Jun Min; Yi, Gi-Ra] Sungkyunkwan Univ, Dept Chem Engn, Suwon 16419, South Korea; [Jung, Dae-Woong; Kim, Jun Min; Kwon, Yong-Eun; Jeong, Sooyeol; Baek, Young Hee; Choi, Yeon Suk; Lee, Gaehang] Korea Basic Sci Inst, Daejeon 34133, South Korea; [Yoon, Hyun-Woo; Nam, Ki Min] Mokpo Natl Univ, Dept Chem, Mokpo 58554, South Korea; [Chang, Sung-Jin] Natl Nanofab Ctr, Measurement & Anal Team, Daejeon 34141, South Korea; [Cho, Jung Young] Korea Inst Ceram Engn & Technol, Jinju 52851, South Korea in 2019.0, Cited 47.0. Computed Properties of C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

We prepared a high-concentration suspension of boron nitride (BN) nanoplates stabilized with benzyl alcohol (BBN) in epoxy resin as a polymer composite adhesive for a highly efficient heat dissipation. At a BN concentration of 40 wt%, the polymer composite with B-BN exhibited a high thermal conductivity (kappa = 1.51 W/m center dot K at 25 degrees C) comparable to that of a composite with bulk BN and significantly higher than that of a composite with a chemically modified BN (S-BN). Furthermore, the concentration of B-BN in the epoxy resin was increased to 46 wt% without a significant increase in viscosity, leading to a further improvement in the thermal conductivity to 2.11 W/m.K. The epoxy resin with B-BN exhibited a low coefficient of thermal expansion and high effective modulus owing to the strong affinity to the epoxy. Finally, we recycled benzyl alcohol more than 10 times for the preparation of B-BN, which may reduce the manufacturing cost and environmental pollution. Therefore, B-BN could be a promising filler for heat dissipation as well as starting material for additional modification.

Computed Properties of C7H8O. Welcome to talk about 100-51-6, If you have any questions, you can contact Jung, DW; Kim, JM; Yoon, HW; Nam, KM; Kwon, YE; Jeong, S; Baek, YH; Choi, YS; Chang, SJ; Yi, GR; Cho, JY; Lee, G or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chemistry Milestones Of 3-(Trifluoromethyl)phenol

Welcome to talk about 98-17-9, If you have any questions, you can contact Zhang, FH; Zeng, JW; Gao, MH; Wang, LZ; Chen, GQ; Lu, YX; Zhang, XM or send Email.. Computed Properties of C7H5F3O

Computed Properties of C7H5F3O. Recently I am researching about GENERAL STRATEGY; ACCESS, Saw an article supported by the Shenzhen Science and Technology Innovation Committee [KQTD20150717103157174]; Shenzhen Nobel Prize Scientists Laboratory Project [C17783101]; Key-Area Research and Development Program of Guangdong Province [2020B010188001]; Innovative Team of Universities in Guangdong Province [2020KCXTD016]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21991113, 21901107]; Southern University of Science and Technology (start-up fund). Published in NATURE RESEARCH in BERLIN ,Authors: Zhang, FH; Zeng, JW; Gao, MH; Wang, LZ; Chen, GQ; Lu, YX; Zhang, XM. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

Prostaglandins are among the most important natural isolates owing to their broad range of bioactivities and unique structures. However, current methods for the synthesis of prostaglandins suffer from low yields and lengthy steps. Here, we report a practicability-oriented synthetic strategy for the enantioselective and divergent synthesis of prostaglandins. In this approach, the multiply substituted five-membered rings in prostaglandins were constructed via the key enyne cycloisomerization with excellent selectivity (>20:1 d.r., 98% e.e.). The crucial chiral centre on the scaffold of the prostaglandins was installed using the asymmetric hydrogenation method (up to 98% yield and 98% e.e.). From our versatile common intermediates, a series of prostaglandins and related drugs could be produced in two steps, and fluprostenol could be prepared on a 20-gram scale.

Welcome to talk about 98-17-9, If you have any questions, you can contact Zhang, FH; Zeng, JW; Gao, MH; Wang, LZ; Chen, GQ; Lu, YX; Zhang, XM or send Email.. Computed Properties of C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Extracurricular laboratory: Synthetic route of C7H8O

Welcome to talk about 100-51-6, If you have any questions, you can contact Chen, SY; Geng, CA; Ma, YB; Huang, XY; Yang, XT; Su, LH; He, XF; Li, TZ; Deng, ZT; Gao, Z; Zhang, XM; Chen, JJ or send Email.. SDS of cas: 100-51-6

SDS of cas: 100-51-6. In 2019.0 BIOORGAN MED CHEM published article about PHENOLIC-COMPOUNDS; PHASE ADVANCES; ANTAGONISTS; DERIVATIVES; ACTIVATION; MT1 in [Chen, Si-Yue; Geng, Chang-An; Ma, Yun-Bao; Huang, Xiao-Yan; Yang, Xiao-Tong; Su, Li-Hua; He, Xiao-Feng; Li, Tian-Ze; Deng, Zhen-Tao; Gao, Zhen; Zhang, Xue-Mei; Chen, Ji-Jun] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China; [Chen, Si-Yue; Geng, Chang-An; Ma, Yun-Bao; Huang, Xiao-Yan; Yang, Xiao-Tong; Su, Li-Hua; He, Xiao-Feng; Li, Tian-Ze; Deng, Zhen-Tao; Gao, Zhen; Zhang, Xue-Mei; Chen, Ji-Jun] Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China; [Chen, Si-Yue; Yang, Xiao-Tong; Su, Li-Hua; He, Xiao-Feng; Deng, Zhen-Tao; Gao, Zhen; Chen, Ji-Jun] Univ Chinese Acad Sci, Beijing 100049, Peoples R China in 2019.0, Cited 29.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Gastrodia elata is a famous traditional Chinese herb with medicinal and edible application. In this study, nine polybenzyls (1-9), including six new ones (2-5, 7 and 9), were isolated from the EtOAc extract of G. elata. Five compounds 1, 3, 4, 6 and 8 were found to activate melatonin receptors. Especially, compound 1 showed agonistic effects on MT1 and MT2 receptors with EC50 values of 237 and 244 mu M. For better understanding their structure-activity relationships (SARs), ten polybenzyl analogs were further synthesized and assayed for their activities on melatonin receptors. Preliminary SARs study suggested that two para-hydroxy groups were the key pharmacophore for maintaining activity. Molecular docking simulations verified that compound 1 could strongly interact with MT2 receptor by bonding to Phe 118, Gly 121, His 208, Try 294 and Ala 297 residues.

Welcome to talk about 100-51-6, If you have any questions, you can contact Chen, SY; Geng, CA; Ma, YB; Huang, XY; Yang, XT; Su, LH; He, XF; Li, TZ; Deng, ZT; Gao, Z; Zhang, XM; Chen, JJ or send Email.. SDS of cas: 100-51-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

New explortion of 3-Hydroxybenzaldehyde

Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.. Formula: C7H6O2

Formula: C7H6O2. In 2019.0 BIOORG MED CHEM LETT published article about HEMORRHAGIC-FEVER VIRUSES; LASSA FEVER; IDENTIFICATION; RIBAVIRIN in [Plewe, Michael B.; Naik, Shibani; Brown, Eric R.; Sokolova, Nadezda, V; Gantla, Vidyasagar Reddy; Henkel, Greg; McCormack, Ken] Arisan Therapeut, 11189 Sorrento Valley Rd,Suite 104, San Diego, CA 92054 USA; [Whitby, Landon R.; Boger, Dale L.] Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA; [Boger, Dale L.] Scripps Res Inst, Skaggs Inst Chem Biol, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA; [York, Joanne; Nunberg, Jack H.] Univ Montana, Montana Biotechnol Ctr, Missoula, MT 59812 USA; [Zhang, Lihong; Kalveram, Birte; Freiberg, Alexander N.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA; [Freiberg, Alexander N.] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA in 2019.0, Cited 32.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Old World (Africa) and New World (South America) arenaviruses are associated with human hemorrhagic fevers. Efforts to develop small molecule therapeutics have yielded several chemical series including the 4-acyl-1,6-dialkylpiperazin-2-ones. Herein, we describe an extensive exploration of this chemotype. In initial Phase I studies, R-1 and R-4 scanning libraries were assayed to identify potent substituents against Old World (Lassa) virus. In subsequent Phase II studies, R-6 substituents and iterative R-1, R-4 and R-6 substituent combinations were evaluated to obtain compounds with improved Lassa and New World (Machupo, Junin, and Tacaribe) arenavirus inhibitory activity, in vitro human liver microsome metabolic stability and aqueous solubility.

Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.. Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Simple exploration of 99-93-4

Recommanded Product: 99-93-4. Welcome to talk about 99-93-4, If you have any questions, you can contact Caceres-Castillo, D; Carballo, RM; Quijano-Quinones, R; Miron-Lopez, G; Graniel-Sabido, M; Moo-Puc, RE; Mena-Rejon, GJ or send Email.

An article Synthesis, in vitro antigiardial activity, SAR analysis and docking study of substituted chalcones WOS:000504587900001 published article about ENTAMOEBA-HISTOLYTICA; BINDING-SITE; GIARDIA; TUBULIN; DERIVATIVES; RESISTANCE; MECHANISMS; INHIBITORS; DISEASE in [Caceres-Castillo, David; Carballo, Ruben M.; Quijano-Quinones, Ramiro; Miron-Lopez, Gumersindo; Graniel-Sabido, Manlio; Mena-Rejon, Gonzalo J.] Univ Autonoma Yucatan, Fac Quim, C 43 613, Merida 97069, Yucatan, Mexico; [Moo-Puc, Rosa E.] Ctr Med Ignacio Garcia Tellez, Unidad Med Alta Especialidad, Unidad Invest Med Yucatan, IMSS, C 41,439, Merida 97150, Yucatan, Mexico in 2020.0, Cited 29.0. Recommanded Product: 99-93-4. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

A series of 15 chalcones-bearing substituents at positions 2, 4, and 5 of rings A and B were synthesized using microwave-assisted Claissen-Smichdt condensation and evaluated for their activity against Giardia lamblia and Green monkey kidney cells. Five compounds exhibited activity against G. lamblia at IC50’s 3m exhibited the highest antigiardial activity (IC50 = 1.03 mu M), even more than the positive control (metronidazole, IC50 = 1.4 mu M), and selectivity (SI = 38.9). A preliminary SAR study suggested that electrophylicity has not relationship with antigiardiasic activity, and the docking study reveals that synthesized chalcones bind at zone 3 of colchicine site, therefore presumably the action mechanism of the synthesized chalcones does not follow the Michael acceptor mechanism.

Recommanded Product: 99-93-4. Welcome to talk about 99-93-4, If you have any questions, you can contact Caceres-Castillo, D; Carballo, RM; Quijano-Quinones, R; Miron-Lopez, G; Graniel-Sabido, M; Moo-Puc, RE; Mena-Rejon, GJ or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Get Up to Speed Quickly on Emerging Topics:100-51-6

Welcome to talk about 100-51-6, If you have any questions, you can contact Zhao, Y; Ke, W; Shao, JJ; Zheng, FJ; Liu, H; Shi, LX or send Email.. Computed Properties of C7H8O

Computed Properties of C7H8O. In 2019.0 ACS APPL MATER INTER published article about AMMONIA BORANE; NANOPARTICLES; GRAPHENE; DEHYDROGENATION; NANOCRYSTALS; REDUCTION; OXIDE; NANOSPHERES; HYDROLYSIS; CARBON in [Zhao, Yuan; Ke, Wei; Zheng, Fangjie; Liu, Han; Shi, Lixia] Jiangnan Univ, Sch Chem & Mat Engn, Key Lab Synthet & Biol Colloids, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China; [Shao, Juanjuan] Hebei Agr Univ, Coll Sci & Technol, Cangzhou 061100, Hebei, Peoples R China in 2019.0, Cited 64.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

The co-decomposition of non-noble metals into Ru nanoparticles (NPs) would provide multiple active centers as well as synergistically alter the reaction pathway, enhancing the catalytic hydrogenation performance. Herein, a facile route for synthesizing trielement Ru-Ni-Fe alloy NPs was proposed. The catalytic hydrogenation performance of NPs was measured using p-nitrophenol as a model. The synergistic effect of these three elements (Ru, Ni, and Fe) and synergistic catalysis of multiple crystal faces greatly improved the catalytic hydrogenation performance of Ru44Ni28Fe28 alloy NPs. Ru with more vacant orbitals showed a strong coordination with BF4- for the generation of active H species. Ni played a major role in transporting electrons and active H species, increasing the accessibility of catalytically active sites. Fe could cooperate with BH4- to produce active H species and promote electrons transfer. Ru44Ni28Fe28 alloy NPs could be reused and applied for the fabrication of films at the oil-water (ethyl acetate-water) interface. The densely packed Ru44Ni28Fe28 NP films were good Raman substrates for monitoring the complete conversion of 4-nitrothiophenol into 4-aminothiophenol. The rational design of Ru44Ni28Fe28 will broaden the application range of Ru-based catalysts and provide new insights into the rational design of other multisite alloy catalysts.

Welcome to talk about 100-51-6, If you have any questions, you can contact Zhao, Y; Ke, W; Shao, JJ; Zheng, FJ; Liu, H; Shi, LX or send Email.. Computed Properties of C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The Best Chemistry compound:86-95-3

Safety of 4-Hydroxyquinolin-2(1H)-one. Welcome to talk about 86-95-3, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or send Email.

In 2019 J HETEROCYCLIC CHEM published article about TETRAPROPYLAMMONIUM BROMIDE; BIOLOGICAL EVALUATION; DERIVATIVES; CATALYST; WATER in [Marjani, Ahmad Poursattar; Khalafy, Jabbar; Farajollahi, Ayda] Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh, Iran in 2019, Cited 41. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3. Safety of 4-Hydroxyquinolin-2(1H)-one

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, H-1-NMR, and C-13-NMR spectral data and elemental analysis.

Safety of 4-Hydroxyquinolin-2(1H)-one. Welcome to talk about 86-95-3, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

How did you first get involved in researching C7H8O

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Wang, W; Song, JR; Li, ZY; Zhong, T; Chi, Q; Ren, H; Pan, WD in [Wang, Wei; Li, Zhi-Yao; Pan, Wei-Dong] Guizhou Univ, Sch Pharmaceut Sci, Huaxi Ave South, Guiyang 550025, Peoples R China; [Song, Jun-Rong; Zhong, Ting; Chi, Qin; Ren, Hai; Pan, Wei-Dong] Guizhou Med Univ, Key Lab Chem Nat Prod Guizhou Prov, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China; [Song, Jun-Rong; Zhong, Ting; Chi, Qin; Ren, Hai; Pan, Wei-Dong] Chinese Acad Sci, Guiyang 550014, Peoples R China published Copper-catalyzed aerobic oxidative radical alkoxycyclization of tryptamines to access 3-alkoxypyrroloindolines in 2021.0, Cited 39.0. Recommanded Product: Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

We report a copper-catalyzed alkoxycyclization of tryptamine derivatives with O-2 as the sole oxidant, leading to a variety of C3a-alkoxypyrroloindolines in good yields with high diastereoselectivities. This reaction involves an interesting double catalytic cycle in which copper-catalyzed carboamination cyclization is favored to form the C-3 radical pyrrolidinoindoline intermediate, then a copper-catalytic radical alkoxylation reaction proceeds smoothly.

Bye, fridends, I hope you can learn more about C7H8O, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: Benzyl Alcohol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Let`s talk about compound :Benzyl Alcohol

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Teixeira, RR; da Silva, AM; Siqueira, RP; Goncalves, VHS; Pereira, HS; Ferreira, RS; Costa, AV; de Melo, EB; Paula, FR; Ferreira, MMC; Bressan, GC in [Teixeira, Robson R.] Univ Fed Vicosa, Dept Quim, Av PH Rolfs S-N, BR-36570900 Vicosa, MG, Brazil; [da Silva, Adalberto M.] Inst Fed Educ Ciencia & Tecnol Catarinense, Campus Araquari,Rodovia BR 280,Km 27,CP 21, BR-89245000 Araquari, SC, Brazil; [Siqueira, Raoni P.; Goncalves, Victor Hugo S.; Pereira, Higor S.; Bressan, Gustavo C.] Univ Fed Vicosa, Dept Bioquim & Biol Mol, Av PH Rolfs S-N, BR-36570900 Vicosa, MG, Brazil; [Ferreira, Rafaela S.] Univ Fed Minas Gerais, Dept Bioquim & Imunol, Av Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil; [Costa, Adilson, V] Univ Fed Espirito Santo, Dept Quim & Fis, Alto Univ S-N, BR-29500000 Alegre, ES, Brazil; [de Melo, Eduardo B.] Univ Estadual Oeste Parana UNIOESTE, Dept Farm, LQMAT, Rua Univ 2069, BR-85819110 Cascavel, PR, Brazil; [Paula, Favero R.] Univ Fed Pampa UNIPAMPA, Dept Farm, BR 472,Km 592,POB 118, BR-97500970 Uruguaiana, RS, Brazil; [Ferreira, Marcia M. C.] Univ Estadual Campinas, Inst Quim, BR-13084971 Campinas, SP, Brazil published Synthesis of Nerol Derivatives Containing a 1,2,3-Triazole Moiety and Evaluation of Their Activities against Cancer Cell Lines in 2019.0, Cited 51.0. Recommanded Product: Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

In the present investigation, a collection of twenty two nerol derivatives, containing 1,2,3-triazolic appendages, was synthesized and screened in vitro for their cytotoxic activity against HL60, Nalm6, and Jurkat human leukemia cells as well as against B16F10 (melanoma cell line). In most cases, derivatives were able to reduce cell viability. The most potent compound (Z)-4-(((3,7-dimethylocta-2,6-dien-1-yl)oxy)methyl)-1-(4-(trifluoromethoxy)benzyl)1H-1,2,3 triazole showed antiproliferative activity against Jurkat cells and reduced B16F10 cell migration. Physicochemical properties of the compounds were calculated in order to evaluate their potential for drug development. Most of the evaluated physicochemical parameters seemed to be favorable for drug development. In addition, for a better understanding of the biological activity results, 3D quantitative structure-activity relationship (QSAR) studies were carried out. 3D-QSAR studies indicate that the anticancer activities observed for the cell lines HL60 and Jurkat may occur by a similar mechanism of action and the same was found for the Nalm6 and B16F10 cell lines.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles