Month: November 2021

Formula: C9H10O3. Authors Kumar, M; Joshi, G; Arora, S; Singh, T; Biswas, S; Sharma, N; Bhat, ZR; Tikoo, K; Singh, S; Kumar, R in MDPI published article about in [Kumar, Manvendra; Joshi, Gaurav; Arora, Sahil; Biswas, Sajal; Kumar, Raj] Cent Univ Punjab, Sch Hlth Sci, Dept Pharmaceut Sci & Nat Prod, Lab Drug Design & Synth, Bathinda 151401, Punjab, India; [Joshi, Gaurav] Graph Era Hill Univ, Sch Pharm, Dehra Dun 248171, Uttarakhand, India; [Singh, Tashvinder; Singh, Sandeep] Cent Univ Punjab, Dept Human Genet & Mol Med, Bathinda 151401, Punjab, India; [Sharma, Nisha; Bhat, Zahid Rafiq; Tikoo, Kulbhushan] Natl Inst Pharmaceut Educ & Res, Dept Pharmacol & Toxicol, Sas Nagar 160062, Punjab, India in 2021.0, Cited 33.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

A series of 30 non-covalent imidazo[1,2-a]quinoxaline-based inhibitors of epidermal growth factor receptor (EGFR) were designed and synthesized. EGFR inhibitory assessment (against wild type) data of compounds revealed 6b, 7h, 7j, 9a and 9c as potent EGFR(WT) inhibitors with IC50 values of 211.22, 222.21, 193.18, 223.32 and 221.53 nM, respectively, which were comparable to erlotinib (221.03 nM), a positive control. Furthermore, compounds exhibited excellent antiproliferative activity when tested against cancer cell lines harboring EGFR(WT); A549, a non-small cell lung cancer (NSCLC), HCT-116 (colon), MDA-MB-231 (breast) and gefitinib-resistant NSCLC cell line H1975 harboring EGFR(L858R/T790M). In particular, compound 6b demonstrated significant inhibitory potential against gefitinib-resistant H1975 cells (IC50 = 3.65 mu M) as compared to gefitinib (IC50 > 20 mu M). Moreover, molecular docking disclosed the binding mode of the 6b to the domain of EGFR (wild type and mutant type), indicating the basis of inhibition. Furthermore, its effects on redox modulation, mitochondrial membrane potential, cell cycle analysis and cell death mode in A549 lung cancer cells were also reported.

Formula: C9H10O3. Welcome to talk about 120-14-9, If you have any questions, you can contact Kumar, M; Joshi, G; Arora, S; Singh, T; Biswas, S; Sharma, N; Bhat, ZR; Tikoo, K; Singh, S; Kumar, R or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C9H10O3. Authors Holota, S; Komykhov, S; Sysak, S; Gzella, A; Cherkas, A; Lesyk, R in MDPI published article about in [Holota, Serhii; Sysak, Stepan; Lesyk, Roman] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmaceut Organ & Bioorgan Chem, Pekarska 69, UA-79010 Lvov, Ukraine; [Holota, Serhii] Lesya Ukrainka Volyn Natl Univ, Dept Organ Chem & Pharm, Volya Ave 13, UA-43025 Lutsk, Ukraine; [Komykhov, Sergiy] Natl Acad Sci Ukraine, Inst Single Crystals, State Sci Inst, Nauky Ave 60, UA-61072 Kharkiv, Ukraine; [Komykhov, Sergiy] Kharkov Natl Univ, Appl Chem Dept, Svobody Sq 4, UA-61022 Kharkiv, Ukraine; [Gzella, Andrzej] Poznan Univ Med Sci, Dept Organ Chem, Grunwaldzka 6, PL-60780 Poznan, Poland; [Cherkas, Andriy] Danylo Halytsky Lviv Natl Med Univ, Dept Internal Med 1, Pekarska 69, UA-79010 Lvov, Ukraine; [Lesyk, Roman] Univ Informat Technol & Management Rzeszow, Fac Med, Dept Publ Hlth Dietet & Lifestyle Disorders, Sucharskiego 2, PL-35225 Rzeszow, Poland; [Cherkas, Andriy] Sanofi Aventis Deutschland GmbH, Team Early Projects Type Diabet 1, Therapeut Area Diabet & Cardiovasc Med, Res & Dev, Ind Pk Hochst H831, D-65926 Frankfurt, Germany in 2021.0, Cited 55.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

The present paper is devoted to the search for drug-like molecules with anticancer properties using the thiazolo[3,2-b][1,2,4]triazole-6-one scaffold. A series of 24 novel thiazolo-[3,2-b][1,2,4]triazole-6-ones with 5-aryl(heteryl)idene- and 5-aminomethylidene-moieties has been synthesized employing three-component and three-stage synthetic protocols. A mixture of Z/E-isomers was obtained in solution for the synthesized 5-aminomethylidene-thiazolo[3,2-b]-[1,2,4]triazole-6-ones. The compounds have been studied for their antitumor activity in the NCI 60 lines screen. Some compounds present excellent anticancer properties at 10 mu M. Derivatives 2h and 2i were the most active against cancer cell lines without causing toxicity to normal somatic (HEK293) cells. A preliminary SAR study had been performed for the synthesized compounds.

COA of Formula: C9H10O3. Welcome to talk about 120-14-9, If you have any questions, you can contact Holota, S; Komykhov, S; Sysak, S; Gzella, A; Cherkas, A; Lesyk, R or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Chheda, PR; Kummer, DA; Nishimura, RT; McClure, KJ; Venkatesan, H in AMER CHEMICAL SOC published article about in [Kummer, David A.] Lundbeck La Jolla Res Ctr Inc, San Diego, CA 92121 USA; [Chheda, Pratik R.; Nishimura, Rachel T.; McClure, Kelly J.; Venkatesan, Hariharan] Janssen Res & Dev, Discovery Chem, San Diego, CA 92121 USA in 2021, Cited 63. SDS of cas: 86-95-3. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

A one-pot, Hantzsch ester-mediated Knoevenagel condensation-reduction reaction has been developed for alkylation of a wide range of substituted 2,4-quinoline diols and 2,4-pyridine diols with aldehydes. The process is operationally simple to perform, scalable, and provides highly useful C-3 alkylated quinoline and pyridine diols in yields of 58-92%. The alkylation products can be converted to 2,4-dihaloquinoline and pyridine substrates for further functionalization.

SDS of cas: 86-95-3. Welcome to talk about 86-95-3, If you have any questions, you can contact Chheda, PR; Kummer, DA; Nishimura, RT; McClure, KJ; Venkatesan, H or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 J IRAN CHEM SOC published article about PI-PI INTERACTIONS; CRYSTAL-STRUCTURES; MODEL ENERGIES; CYCLOOXYGENASE-2; INHIBITORS; ESTER in [Singh, Ved Prakash; Dowarah, Jayanta] Mizoram Univ, Sch Phys Sci, Dept Chem, Aizawl 796004, India; [Tewari, Ashish Kumar] Banaras Hindu Univ, Inst Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India; [Geiger, David K.] CUNY, Coll Genesco, Dept Chem, Geneseo, NY USA in 2020.0, Cited 27.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. SDS of cas: 99-93-4

Three phenyl dimer compounds, namely 3,3 ‘-Diformyldiphenoxyethane (C16H14O4) (1), 1-(4-[2-(4-Acetyl-phenoxy)-ethoxy]-phenyl)-ethanone (C17H16N2O3) (2), 1-{4-[2-(4-Acetyl-phenoxymethyl)-benzyloxy]-phenyl}-ethanone (C24H22O4) (3), were obtained and fully characterized, including their crystal structure determinations. The structural properties of two compounds 4, 4(‘)-(ethylenedioxy)dibenzaldehyde) (C16H14O4) (Tewari et al. Acta Cryst. E63:o1930, 2007) [1] (4) and 4-(2-Phenoxy-ethoxy)-benzaldehyde (C15H14O3) (Valgera et al. CCDC 710835, 2016) [2] (5) are discussed with the role of the substituent in crystal packing. In vivo, anti-inflammatory activities of all compounds were studied on Wistar strain albino rats. All the compounds exhibited anti-inflammatory activity except 5. Compounds 1, 2, 4 have shown moderate-to-intermediate effects on inhibitory properties. Compound (3) with restricted rotation in the compound-like SC-558 drug was shown to possess good inhibitory properties at 180 min. In silico analysis was performed and compared with experimental in vivo results.

SDS of cas: 99-93-4. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of Benzyl Alcohol. Agafonova, AV; Smetanin, IA; Rostovskii, NV; Khlebnikov, AF; Novikov, MS in [Agafonova, Anastasiya, V; Smetanin, Ilia A.; Rostovskii, Nikolai, V; Khlebnikov, Alexander F.; Novikov, Mikhail S.] St Petersburg State Univ, Inst Chem, 7-9 Univ Skaya Nab, St Petersburg 199034, Russia published Easy Access to 2-Fluoro- and 2-Iodo-2H-azirines via the Halex Reaction in 2019.0, Cited 33.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

A simple gram-scale method for the preparation of esters and dialkylamides of 2-(fluoro/iodo)-2H -azirine-2-carboxylic acids via the halogen exchange (Halex) reaction of 2-bromo-substituted analogues is reported. The method operates with inexpensive and safe reagents-, Bu4NF and potassium iodide, providing high product yields. Alternatively, 2-fluoro-2H-azirine-2-carboxylates can be prepared from 2-iodo- and 2-chloro-analogues. The latter compounds can be obtained in practically quantitative yield by treating the 2-iodo- and 2-bromo-2H-azirine-2-carboxylic esters with Bu4NCl.

Quality Control of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Agafonova, AV; Smetanin, IA; Rostovskii, NV; Khlebnikov, AF; Novikov, MS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of m-Methoxyphenol. Recently I am researching about AROMATIC-COMPOUNDS; GREEN SYNTHESIS; PYRROLOMYCIN-C; BISMUTH(III); REAGENT; ARENES; MILD, Saw an article supported by the CONACyTConsejo Nacional de Ciencia y Tecnologia (CONACyT) [CB-2013/220836]; JSPS KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [JP26220803, JP17H06450]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Juarez-Ornelas, KA; Jimenez-Halla, JOC; Kato, T; Solorio-Alvarado, CR; Maruoka, K. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

The first catalytic procedure for the electrophilic nitration of phenols was developed using iodosylbenzene as an organocatalyst based on iodine(III) and aluminum nitrate as a nitro group source. This atom-economic protocol occurs under mild, non-Bronsted acidic and open-flask reaction conditions with a broad functional-group tolerance including several heterocycles. Density functional theory (DFT) calculations at the (SMD:MeCN)Mo8-HX/(LANLo8+f,6-311+G*) level indicated that the reaction proceeds through a cationic pathway that efficiently generates the NO2+ ion, which is the nitrating species under neutral conditions.

Quality Control of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Juarez-Ornelas, KA; Jimenez-Halla, JOC; Kato, T; Solorio-Alvarado, CR; Maruoka, K or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 4-Methoxybenzaldehyde. In 2021.0 FLAVOUR FRAG J published article about ESSENTIAL OIL; CHEMICAL-COMPOSITION; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT; FRUITS; CO2 in [Maitusong, Jumai; Aimila, Aoken; Zhang, Junping; Mahinur, Bakri; Maiwulanjiang, Maitinuer; Aisa, Haji Akber] Chinese Acad Sci, State Key Lab Basis Xinjiang Indigenous Med Plant, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China; [Maitusong, Jumai; Aimila, Aoken; Zhang, Junping; Mahinur, Bakri; Maiwulanjiang, Maitinuer; Aisa, Haji Akber] Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China; [Maitusong, Jumai; Aimila, Aoken] Univ Chinese Acad Sci, Beijing, Peoples R China; [Maitusong, Jumai] Coll Xinjiang Uyghur Med, Hotan, Peoples R China in 2021.0, Cited 30.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Fennel (seeds of Foeniculum vulgare Mill.) is the widely used aromatic and medicinal plant throughout the world. In this research, supercritical carbon dioxide (SC-CO2) extraction was carried out to extract the aromatic extract from F vulgare seeds under various operating conditions, and aromatic extract samples were characterized for properties such as yield and trans-anethole content. A three-level Box-Behnken design from response surface method was applied to optimize the extraction parameters such as pressure, temperature, and extraction time with an aim to obtain high yield and rich trans-anethole content. The optimum extraction conditions were found to be 177 bar, 40 degrees C and 68 min where the predicted oil yield and trans-anethole contents were found to be 3.798% and 95 mg/g, respectively. Under the optimum conditions, the experimental oil yield was 3.85%, and the content of trans-anethole was 94 mg/g. The results were very close to the values predicted by the model. At the same time, the chemical compositions of the oils from two different extraction methods, hydrodistillation and SC-CO2, were compared. The chemical constituents of oils from two different extraction methods found to be the same, and they showed slight difference in terms of the quantity of the main chemicals. Antibacterial and antioxidant effects of the oils obtained by the two extraction methods were compared, and they showed similar effects.

Welcome to talk about 123-11-5, If you have any questions, you can contact Maitusong, J; Aimila, A; Zhang, JP; Mahinur, B; Maiwulanjiang, M; Aisa, HA or send Email.. Safety of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article An orally antitumor chalcone hybrid inhibited HepG2 cells growth and migration as the tubulin binding agent WOS:000475627500022 published article about CANCER; DERIVATIVES in [Wang Yan; Chen Xiangyu; Li Ya; Wang Yu; Xu Feng] Zhengzhou Univ, Affiliated Hosp 1, Dept Gastroenterol, Zhengzhou 450052, Henan, Peoples R China in 2019.0, Cited 34.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

Liver cancer is a kind of high mortality cancer due to the difficulty of early diagnosis. It is necessary to develop the anticancer agents to treat liver cancer. Here, a novel chalcone derivative was synthesized and evaluated for anticancer activity in vitro against liver cancer cell lines (HepG2, SNU-423, SMMC7221, and SNU-398). The chalcone hybrid 9 displayed the antiproliferative effect against HepG2, SNU-423, SMMC7221 and SNU-398 cells with IC50 values of 0.9 mu M, 2.7 mu M, 6.2 mu M and 4.6 mu M, respectively. Cellular mechanisms showed that derivative 9 could obviously inhibit HepG2 cells growth and colony formation in a concentration-dependent manner. Analogue 9 inhibited the migration by regulating the expression levels of migration-releated markers and transcription factors (Snail and Slug). Tubulin polymerization inhibition assay illustrated that chalcone hybrid 9 might be a potent tubulin polymerization inhibitor. Importantly, compound 9 displayed the antitumor activity against liver cancer HepG2 cells in vivo with the low toxicity toward mice. Therefore, compound 9 as a novel tubulin polymerization inhibitor deserves further investigation to treat liver cancer.

Welcome to talk about 99-93-4, If you have any questions, you can contact Wang, Y; Chen, XY; Li, Y; Wang, Y; Xu, F or send Email.. Safety of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 4′-Hydroxyacetophenone. In 2019 CHEMPLUSCHEM published article about SOLID-STATE NMR; CHARGED DENDRONIZED POLYMERS; GUEST MOLECULES; IONIC CLUSTERS; SPIN-TRAP; ELUCIDATION; DENDRIMERS; DYNAMICS; SHELL; DEER in [Hauenschild, Till; Hinderberger, Dariush] Martin Luther Univ Halle Wittenberg, Inst Chem, Phys Chem Complex Self Organizing Syst, Von Danckelmann Pl 4, D-06120 Halle, Saale, Germany in 2019, Cited 45. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

A large number (63) of well-defined nitroxide radicals, all phenol-based TEMPO and PROXYL esters, were synthesized using different strategies based on well-established Steglich esterifications. All of these radicals can be used as spin probes (SPs) and spin labels (SLs) for electron paramagnetic resonance (EPR) spectroscopy of supramolecular systems. Depending on the nature of the functional group(s) on each SP/SL, the synthesized nitroxide radicals serve as polyphilic molecular toolbox for the EPR-spectroscopic detection and characterization of specific types of interactions, e. g. pi-pi interactions, sulfur-sulfur interactions, hydrogen bonding, electrostatic and dipole-dipole interactions, and van der Waals and hydrophobic interactions, in the presence of the selected supramolecular systems of interest (e. g. proteins, peptides). For each synthesized SP/SL the water solubility was gravimetrically determined for use in aqueous solution at pH 7.

Welcome to talk about 99-93-4, If you have any questions, you can contact Hauenschild, T; Hinderberger, D or send Email.. Quality Control of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ansari, MY; Kumar, N; Kumar, A in [Ansari, Mohd Yeshab; Kumar, Navaneet; Kumar, Atul] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Sect 10,Sitapur Rd,POB 173, Lucknow 226031, Uttar Pradesh, India; [Kumar, Atul] Acad Sci & Innovat Res, New Delhi 110001, India published Regioselective Intermolecular Sulfur-Oxygen Difunctionalization (Phenoxysulfonylation) of Alkynes: One-Pot Construction of (Z)-beta-Phenoxy Vinylsulfones in 2019, Cited 54. Category: indole-building-block. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

The first regioselective phenoxysulfonylation of alkynes with sodium sulfinate and phenol catalyzed by I-2/base has been uncovered. This metal-free, one-pot alkyne difunctionalization process provides various (Z)-beta-phenoxy vinylsulfones under mild reaction conditions. A variety of terminal as well as internal alkynes and sodium sulfinates and a wide range of phenols/thiophenols and naphthols are viable in this transformation. Green protocol and wide substrate scope are the remarkable characteristics of this multicomponent procedure.

Bye, fridends, I hope you can learn more about C7H5F3O, If you have any questions, you can browse other blog as well. See you lster.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles