Day: December 1, 2021

In 2019 J AGR FOOD CHEM published article about MICROBIAL-PRODUCTION; SALICYLATE BIOSYNTHESIS; PURIFICATION; ENZYME in [Choo, Hye Jeong; Ahn, Joong-Hoon] Konkuk Univ, Bio Mol Informat Ctr, Dept Biosci & Biotechnol, Seoul 05029, South Korea in 2019, Cited 31. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3. Category: indole-building-block

Intermediates in aromatic amino acid biosynthesis can serve as substrates for the synthesis of bioactive compounds. In this study we used two intermediates in the shikimate pathway of Escherichia coli, chorismate and anthranilate, to synthesize three bioactive compounds: 4-hydroxycoumarin (4-HC), 2,4-dihydroxyquinoline (DHQ), and 4-hydroxy-1-methyl-2(1H)-quinolone (NMQ). We introduced genes for the synthesis of salicylic acid from chorismate to supply the substrate for 4-HC and the gene encoding N-methyltransferase for the synthesis of N-methylanthranilate from anthranilate. Polyketide synthases and coenzyme (Co)A ligases were tested to determine the optimal combination of genes for the synthesis of each compound. We also tested several constructs and identified the best one for increasing levels of endogenous substrates for chorismate, anthranilate, and malonyl-CoA. With the use of these strategies, 255.4 mg/L 4-HC, 753.7 mg/L DHQ, and 17.5 mg/L NMQwere synthesized. This work provides a basis for the synthesis of diverse coumarin and quinoline derivatives with potential medical applications.

Bye, fridends, I hope you can learn more about C9H7NO2, If you have any questions, you can browse other blog as well. See you lster.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C7H8O2. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Design, synthesis and biological evaluation of imidazole and triazole-based carbamates as novel aromatase inhibitors published in 2021.0, Reprint Addresses Ammazzalorso, A (corresponding author), Univ G dAnnunzio, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy.. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol.

In the search for novel aromatase inhibitors, a series of triazole and imidazole-based carbamate derivatives were designed and synthesized. Final compounds were thus evaluated against human aromatase by in vitro kinetic experiments in a fluorimetric assay in comparison with letrozole. The effect of most active derivatives 13a and 15c was then evaluated in vitro on the human breast cancer cell line MCF7 by MTT assay, cytotoxicity assay (LDH release) and cell cycle analysis, revealing a dose-dependent inhibition profile of cell viability and low micromolar IC50 values. In addition, docking simulations were also carried out to elucidate at a molecular level of detail the binding modes adopted to target human aromatase. (C) 2020 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 150-76-5, If you have any questions, you can contact Ammazzalorso, A; Gallorini, M; Fantacuzzi, M; Gambacorta, N; De Filippis, B; Giampietro, L; Maccallini, C; Nicolotti, O; Cataldi, A; Amoroso, R or send Email.. Computed Properties of C7H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Exploring the ability of dihydropyrimidine-5-carboxamide and 5-benzyl-2,4-diaminopyrimidine-based analogues for the selective inhibition of L. major dihydrofolate reductase WOS:000604903800032 published article about DRUG DISCOVERY; LEISHMANIA; DESIGN; DOCKING; ANTIBACTERIAL; METHOTREXATE; SYSTEM; TARGET in [Bibi, Maria; Farooq, Umar; Ullah, Azmat; Khan, Farhan A.; Rashid, Umer] COMSATS Univ Islamabad, Dept Chem, Abbottabad Campus, Abbottabad 22060, Khyber Pakhtunk, Pakistan; [Qureshi, Naveeda Akhter; Shaheen, Nargis] Quaid I Azam Univ, Dept Anim Sci, Islamabad 45320, Pakistan; [Sadiq, Abdul] Univ Malakand, Fac Biol Sci, Dept Pharm, Dir L 18000, KP, Pakistan; [Hassan, Abbas] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan; [Asghar, Irfa; Umer, Duaa] COMSATS Univ Islamabad, Dept Biotechnol, Abbottabad Campus, Abbottabad 22060, Khyber Pakhtunk, Pakistan; [Salman, Muhammad] Natl Inst Hlth NIH, Dept Microbiol, Islamabad 45320, Pakistan; [Bibi, Ahtaram] Kohat Univ Sci & Technol, Fac Phys Sci, Dept Chem, Kohat 26000, Kp, Pakistan in 2021, Cited 42. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Recommanded Product: 4-Methoxybenzaldehyde

To tackle leishmaniasis, search for efficient therapeutic drug targets should be pursued. Dihydrofolate reductase (DHFR) is considered as a key target for the treatment of leishmaniasis. In current study, we are interested in the design and synthesis of selective antifolates targeting DHFR from L. major. We focused on the development of new antifolates based on 3,4-dihydropyrimidine-2-one and 5-(3,5-dimethoxybenzyl)pyrimidine-2,4-diamine motif. Structure activity relationship (SAR) studies were performed on 4-phenyl ring of dihydropyrimidine (26-30) template. While for 5-(3,5-dimethoxybenzyl) pyrimidine-2,4-diamine, the impact of different amino acids (valine, tryptophan, phenylalanine, and glutamic acid) and two carbon linkers were explored (52-59). The synthesized compounds were assayed against LmDHFR. Compound 59 with the IC50 value of 0.10 mu M appeared as potent inhibitors of L. major. Selectivity for parasite DHFR over human DHFR was also determined. Derivatives 55-59 demonstrated excellent selectivity for LmDHFR. Highest selectivity for LmDHFR was shown by compounds 56 (SI = 84.5) and 58 (SI = 87.5). Compounds Antileishmanial activity against L. major and L. donovani promastigotes was also performed. To explore the interaction pattern of the synthesized compounds with biological macromolecules, the docking studies were carried out against homology modelled LmDHFR and hDHFR targets. (C) 2020 Elsevier Masson SAS. All rights reserved.

Recommanded Product: 4-Methoxybenzaldehyde. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article A lysosome specific theranostic NO donor inhibits cancer cells by stimuli responsive molecular self-decomposition with an on-demand fluorescence pattern published in 2019.0. Name: Benzyl Alcohol, Reprint Addresses Gou, SH (corresponding author), Southeast Univ, Pharmaceut Res Ctr, Nanjing 211189, Jiangsu, Peoples R China.; Gou, SH (corresponding author), Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China.; Gou, SH (corresponding author), Southeast Univ, Jiangsu Prov Hitech Key Lab Biomed Res, Nanjing 211189, Jiangsu, Peoples R China.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

The anticancer mechanism of NO is difficult to study owing to its short lifetime and high reactivity. Thus, a theranostic anticancer NO donor assembled with NO on-demand release abilities, accurate lysosome location capabilities and signal feedback behavior was developed. Profiting from the theranostic properties, the specific mechanism was comprehensively studied. Spectral and cell imaging studies revealed that the as prepared NO donors could release NO in solution or within cancer cells. Fluorescence co-dyeing experiments demonstrated that Mo-Nap-NO entered lysosomes specifically and disrupted them after being triggered by light. Upon irradiation with 460 nm visible light, both the donors demonstrated considerable in vitro anticancer effects. A further mechanistic study showed that after entering the lysosome and being triggered by 460 nm irradiation, NO ruptured the lysosome, resulting in the release of cathepsin D into the cytosol, which activated the caspase3 mediated apoptosis pathway.

Welcome to talk about 100-51-6, If you have any questions, you can contact Hua, WY; Zhao, J; Wang, XY; Pei, SN; Gou, SH or send Email.. Name: Benzyl Alcohol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 J MOL STRUCT published article about DENSITY-FUNCTIONAL THERMOCHEMISTRY; INTERMOLECULAR INTERACTIONS; PROMOTED SYNTHESIS; SULFURIC-ACID; EFFICIENT; DERIVATIVES; 1,8-DIOXO-OCTAHYDROXANTHENES; ALDEHYDES in [Shashi, R.; Begum, Noor Shahina] Bangalore Univ, Dept Studies Chem, Bangalore 560056, Karnataka, India; [Panday, Anoop Kumar] Indian Inst Technol, Dept Chem, Bihta 801103, Bihar, India in 2021, Cited 45. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Category: indole-building-block

A highly versatile and efficient ultrasound promoted synthesis of xanthenedione derivatives is achieved through condensation of dimedone with various aromatic aldehydes using boric acid as catalyst in ethanol-water medium. The advantages of this method being, mild reaction conditions, short reaction time, easy work-up, purification of products by non-chromatographic methods and additionally this method provides excellent yields. Two of the Xanthendiones derivatives 3a and 3b gave good crystals on recrystallization and their molecular structures were confirmed by crystallographic studies. The molecules in the crystal lattice are held together by weak intermolecular C-H center dot center dot center dot O and C-H center dot center dot center dot N interactions. Further insights into these interactions using Hirshfeld surface analysis and DFT/B3LYP studies show that in compound 3a H center dot center dot center dot H (54.7%), O center dot center dot center dot H (18.3%) and in 3b H center dot center dot center dot H (53.7%), O center dot center dot center dot H (17.6%) are the major contributors to the intermolecular interactions which stabilize the crystal structures. In order to determine molecular electrical transport properties, we studied the energy difference between Highest Occupied, HOMO, and Lowest Unoccupied, LUMO orbitals and the HOMO and LUMO energy gap for compounds 3a and 3b was found to be 3.9261 eV and 4.6436 eV respectively. The 2D fingerprint plot provided percentage contribution of each individual atom-to-atom interactions. The Mulliken atomic charges and molecular electrostatic potential on molecular van der Waals surface were calculated to know the electrophilic and nucleophilic regions of the molecular surface. (C) 2020 Elsevier B.V. All rights reserved.

Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Nakkeeran, S; Surya, T; Vinodkumar, S in [Nakkeeran, Sevugapperumal; Surya, Thangavel; Vinodkumar, Selvaraj] Tamil Nadu Agr Univ, Ctr Plant Protect Studies, Dept Plant Pathol, Coimbatore 641003, Tamil Nadu, India published Antifungal Potential of Plant Growth Promoting Bacillus Species Against Blossom Blight of Rose in 2020.0, Cited 64.0. Product Details of 100-51-6. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Blossom blight caused by Botrytis cinerea is one among the most devastating diseases that cause complete post-harvest loss in flower crops. The present study focuses on the development of effective bioformulation towards suppression of blossom blight and plant growth promotion in rose. Bacillus amyloliquefaciens (VB2) and Bacillus subtilis (AP) effectively inhibited mycelial growth of B. cinerea in vitro. Genome screening of VB2 and AP revealed the presence of antimicrobial peptide genes including, ituD, ipa14, bacA, bacD, srfA, sfP, spaC, spaS responsible for the biosynthesis of antibiotics such as iturin, bacilysin, bacillomycin, surfactin and subtilin. Further, the presence of volatile antifungal compounds in the bacterial secretome was identified through gas chromatography-mass spectrometry (GC/MS) analysis. Upon treatment, AP accelerated the metabolite profile of the plants and a rise in peak area of antifungal compounds such as, pentadecanoic acid, n-hexadecanoic acid, octadecanoic acid (stearic acid) and tetradecanoic acid was observed. In vitro, VB2 produced maximum indole acetic acid (9.17 mu g/ml) and gibberellic acid (8.20 mu g/ml) in nutrient broth. Under field conditions, foliar spray of VB2 at 0.5% (5 ml/l), four times at weekly interval suppressed blossom blight incidence (64% reduction over control) and also promoted yield. Future research towards development of an effective bioformulation with extended shelf life will aid in the management of various fungal, bacterial and viral diseases in different crop plants.

Welcome to talk about 100-51-6, If you have any questions, you can contact Nakkeeran, S; Surya, T; Vinodkumar, S or send Email.. Product Details of 100-51-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor WOS:000464108100012 published article about GROWTH-FACTOR RECEPTOR; NF-KAPPA-B; NITRIC-OXIDE; ACTIVATION; PATHWAY; MACROPHAGES in [Elkamhawy, Ahmed; Roh, Eun Joo] KIST, Chem Kin Res Ctr, Seoul 02792, South Korea; [Elkamhawy, Ahmed] Mansoura Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Mansoura 35516, Egypt; [Hassan, Ahmed H. E.] Mansoura Univ, Fac Pharm, Dept Med Chem, Mansoura 35516, Egypt; [Hassan, Ahmed H. E.; Lee, Yong Sup] Kyung Hee Univ, Coll Pharm, Dept Pharm, Med Chem Lab, Seoul 02447, South Korea; [Paik, Sora; Lee, Yong Sup] Kyung Hee Univ, Coll Pharm, Dept Fundamental Pharmaceut Sci, Seoul 02447, South Korea; [Lee, Hwi-Ho; Shin, Ji-Sun; Lee, Kyung-Tae] Kyung Hee Univ, Coll Pharm, Dept Life & Nanopharmaceut Sci, Seoul 02447, South Korea; [Lee, Hwi-Ho; Shin, Ji-Sun; Lee, Kyung-Tae] Kyung Hee Univ, Coll Pharm, Dept Pharmaceut Biochem, Seoul 02447, South Korea; [Roh, Eun Joo] Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South Korea in 2019, Cited 44. Quality Control of 3-(Trifluoromethyl)phenol. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

EGFR inhibitors are well-known as anticancer agents. Quite differently, we report our effort to develop EGFR inhibitors as anti-inflammatory agents. Pyrimidinamide EGFR inhibitors eliciting low micromolar IC50 and the structurally close non-EGFR inhibitor urea analog were synthesized. Comparing their nitric oxide (NO) production inhibitory activity in peritoneal macrophages and RAW 246.7 macrophages indicated that their anti-inflammatory activity in peritoneal macrophages might be a sequence of EGFR inhibition. Further evaluations proved that compound 4d significantly and dose-dependently inhibits LPS-induced iNOS expression and IL-1 beta, IL-6, and TNF-alpha production via NF-kappa B inactivation in peritoneal macrophages. Compound 4d might serve as a lead compound for development of a novel class of anti-inflammatory EGFR inhibitors.

Welcome to talk about 98-17-9, If you have any questions, you can contact Elkamhawy, A; Hassan, AHE; Paik, S; Lee, YS; Lee, HH; Shin, JS; Lee, KT; Roh, EJ or send Email.. Quality Control of 3-(Trifluoromethyl)phenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 4-Methoxybenzaldehyde. Authors Ali, S; Khan, A in ROYAL SOC CHEMISTRY published article about in [Ali, Saghir; Khan, Abu T.] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, Assam, India in 2021, Cited 17. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

An efficient and expedient synthetic protocol is reported for the synthesis of 2,3-diarylquinoline derivatives from readily available aryl amines, aryl aldehydes and styrene oxides using 10 mol% copper(ii) triflate by employing three-component reaction. This approach involves the reaction between the in situ generated imine (derived from the aryl amine and aryl aldehyde) and styrene oxide, which enables the formation of the desired products. The present method has several advantages such as high atom-economy, high regioselectivity, easy handling, consecutive one C-N and two C-C bond formation, shorter reaction time and broader substrate scope with good yields.

Safety of 4-Methoxybenzaldehyde. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 EUR J MED CHEM published article about NATURAL-PRODUCTS; ANTIPROLIFERATIVE ACTIVITY; TRYPANOSOMA-CRUZI; IN-VITRO; 1,2,3-TRIAZOLE; PHTHALIDE; APOPTOSIS; TOXICITY; EXTRACTS; DRUGS in [Rodrigues, Michelle Peixoto; Tomaz, Deborah Campos; Teixeira, Robson Ricardo] Univ Fed Vicosa, Dept Quim, Vicosa, MG, Brazil; [de Souza, Luciana Angelo; Onofre, Thiago Souza; de Menezes, Wemerson Aquiles; de Almeida, Marcia Rogeria; Bressan, Gustavo Costa; Rangel Fietto, Juliana Lopes] Univ Fed Vicosa, Dept Bioquim & Biol Mol, Vicosa, MG, Brazil; [Onofre, Thiago Souza] Univ Fed Sao Paulo, Escola Paulista Med, Campus Sao Paulo, Sao Paulo, SP, Brazil; [Almeida-Silva, Juliana; Suarez-Fontes, Ana Marcia; Vannier-Santos, Marcos Andre] Fiocruz MS, Inst Oswaldo Cruz, Rio De Janeiro, RJ, Brazil; [Silva, Adalberto Manoel] Inst Fed Educ Ciencia & Tecnol Catarinense, Araquari, SC, Brazil in 2019.0, Cited 63.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Recommanded Product: 100-51-6

Leishmania braziliensis is one of the pathogenic agents of cutaneous and mucocutanoeous leishmaniasis. There are no validated vaccines to prevent the infection and the treatment relies on drugs that often present severe side effects, which justify the efforts to find new potential antileishmanial drugs. An alternative to promote the discovery of new drugs would be the association of different chemical groups of bioactive compounds. Here we describe the synthesis and bioactivity evaluation against L. braziliensis of cinnamic acid derivatives possessing isobenzofuranone and 1,2,3-triazole functionalities. We tested 25 compounds at 10 mu M concentration against extracellular promastigotes and intracellular amastigotes during macrophage infection. Most compounds were more active against amastigotes than to promastigotes. The derivatives (E)-3-oxo-1,3-dihydroisobenzofuran-5-yl-(3,4,5-trimethoxy) cinnamate (5c), (1-(3,4-difluorobenzyl)-1H-1,2,3-triazol-4-yl)methyl cinnamate (9g), and (1-(2-bromobenzyl)-1H-1,2,3triazol-4-yl)methyl cinnamate (91) were the most effective presenting over 80% toxicity on L braziliensis amastigotes. While compound 5c is a cinnamate with an isobenzofuranone portion, 9g and 9l are triazolic cinnamic acid derivatives. The action of these compounds was comparable to amphotericin B used as positive control. Ultrastructural analysis revealed that 5c-treated parasites showed impaired cytokinesis and apoptosis triggering. Taken together, these results highlight the potential of cinnamic acid derivatives in development of novel anti-leishmanial drugs. (C) 2019 Elsevier Masson SAS. All rights reserved.

Recommanded Product: 100-51-6. Welcome to talk about 100-51-6, If you have any questions, you can contact Rodrigues, MP; Tomaz, DC; de Souza, LA; Onofre, TS; de Menezes, WA; Almeida-Silva, J; Suarez-Fontes, AM; de Almeida, MR; Silva, AM; Bressan, GC; Vannier-Santos, MA; Fietto, JLR; Teixeira, RR or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. Authors Chu, PC; Wu, YC; Chen, CY; Hung, YS; Chang, CS in FUTURE SCI LTD published article about in [Chu, Po-Chen] China Med Univ, Dept Cosmeceut, Taichung 40402, Taiwan; [Chu, Po-Chen] China Med Univ, Grad Inst Cosmeceut, Taichung 40402, Taiwan; [Chu, Po-Chen; Chang, Chih-Shiang] China Med Univ, Drug Dev Ctr, Taichung 40402, Taiwan; [Wu, Yu-Chieh; Chen, Chien-Yu; Hung, Yu-Syuan; Chang, Chih-Shiang] China Med Univ, Sch Pharm, Coll Pharm, Taichung 40402, Taiwan in 2021, Cited 35. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Aim: Tumor cells adapt to hypoxic microenvironments by releasing the key transcription factor HIF-1 alpha, which promotes angiogenesis, glycolytic phenotype, metastasis and erythropoiesis, allowing proliferation amid low oxygen levels. Therefore, therapeutic targeting of HIF-1 alpha represents a viable strategy for cancer therapy. Methods & Results: The authors synthesized a series of novel tetrahydroquinazoline derivatives in six steps and demonstrated that their development had a unique ability to suppress HIF-1 alpha expression through proteasomal degradation. Conclusion: Among these compounds, CDMP-TQZ (8bf) exhibited the highest antiproliferative potency in human cancer cells, in part through downregulation of HIF-1 alpha.

Computed Properties of C8H8O2. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles