Day: December 8, 2021

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis of New Fused Heterocyclic 2-Quinolones and 3-Alkanonyl-4-Hydroxy-2-Quinolones published in 2019. Formula: C9H7NO2, Reprint Addresses Aly, AA (corresponding author), Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt.; Brase, S (corresponding author), Karlsruhe Inst Technol, Inst Organ Chem, D-76131 Karlsruhe, Germany.; Brase, S (corresponding author), Karlsruhe Inst Technol, Inst Toxicol & Genet, D-76344 Eggenstein Leopoldshafen, Germany.. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one

Herein, we report the synthesis of 5,12-dihydropyrazino[2,3-c:5,6-c ‘]difuro[2,3-c:4,5-c ‘]-diquinoline-6,14(5H,12H)diones, 2-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1,4-diphenyl- butane-1,4-diones and 4-(benzo-[d]oxazol-2-yl)-3-hydroxy-1H-[4,5]oxazolo[3,2-a]pyridine-1-one. The new candidates were synthesized and identified by different spectroscopic techniques, and X-ray crystallography.

Welcome to talk about 86-95-3, If you have any questions, you can contact Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S; Polamo, M; Nieger, M; Brown, AB or send Email.. Formula: C9H7NO2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Wang, B; Wang, LR; Liu, LL; Wang, W; Man, RJ; Zheng, DJ; Deng, YS; Yang, YS; Xu, C; Zhu, HL in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Wang, Bin; Wang, Li-Ren; Liu, Lu-Lu; Wang, Wei; Zheng, Da-Jun; Deng, Yu-Shan; Yang, Yu-Shun; Xu, Chen; Zhu, Hai-Liang] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China; [Man, Ruo-Jun] Guangxi Univ Nationalities, Guangxi Biol Polysaccharide Separat Purificat & M, Nanning 530006, Peoples R China in 2021.0, Cited 44.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

In this work, a series of diaryl benzo[b][1,4]thiazepine derivatives D1-D36 were synthesized and screened as tubulin polymerization inhibitors with anti-tumor potency. They were designed by introducing the seven member ring benzothiazepine as the linker for CA-4 modification for the first time. Among them, the hit compound D8 showed potential on inhibiting the growth of several cancer cell lines (IC50 values: 1.48 mu M for HeLa, 1.47 mu M for MCF-7, 1.52 mu M for HT29 and 1.94 mu M for A549), being comparable with the positive controls Colchicine and CA-4P. The calculated IC50 value of D8 as an tubulin polymerization inhibitor was 1.20 mu M. The results of the flow cytometry assay revealed that D8 could induce the mitotic catastrophe and the death of living cancer cells. D8 also indicated the anti-vascular activity. The possible binding pattern was implied by docking simulation, inferring the possibility of introducing interactions with the nearby tubulin chain. Since the novel structural trial has been conducted with preliminary discussion, this work might stimulate new ideas in further modification of tubulin-related anti-cancer agents and therapeutic approaches.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Wang, B; Wang, LR; Liu, LL; Wang, W; Man, RJ; Zheng, DJ; Deng, YS; Yang, YS; Xu, C; Zhu, HL or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article New vinyl-1,2,4-triazole derivatives as antimicrobial agents: Synthesis, biological evaluation and molecular docking studies published in 2020.0. Quality Control of 3-Hydroxybenzaldehyde, Reprint Addresses Stingaci, E (corresponding author), Inst Chem, Lab Organ Synth & Biopharmaceut, 3 Str Acad, Kishinev, Moldova.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

1,2,4-Triazole is a very important scaffold in medicinal chemistry due to the wide spectrum of biological activities and mainly antifungal activity of 1,2,4-triazole derivatives. The main mechanism of antifungal action of the latter is inhibition of 14-alpha-demethylase enzyme (CYP51). The current study presents synthesis and evaluation of eight triazole derivatives for their antimicrobial activity. Docking studies to elucidate the mechanism of action were also performed. The designed compounds were synthesized using classical methods of organic synthesis. The in vivo evaluation of antimicrobial activity was performed by microdilution method. All tested compounds showed good antibacterial activity with MIC and MBC values ranging from 0.0002 to 0.0069 mM. Compound 2 h appeared to be the most active among all tested with MIC at 0.0002-0.0033 mM and MBC at 0.0004-0.0033 mM followed by compounds 2f and 2g. The most sensitive bacterium appeared to be Xanthomonas campestris while Erwinia amylovora was the most resistant. The evaluation of antifungal activity revealed that all compounds showed good antifungal activity with MIC values ranging from 0.02 mM to 0.52 mM and MFC from 0.03 mM to 0.52 mM better than reference drugs ketoconazole (MIC and MFC values at 0.28-1.88 mM and 0.38 mM to 2.82 mM respectively) and bifonazole (MIC and MFC values at 0.32-0.64 mM and 0.64-0.81 mM). The best antifungal activity is displayed by compound 2 h with MIC at 0.02-0.04 mM and MFC at 0.03-0.06 mM while compound 2a showed the lowest activity. The results showed that these compounds could be lead compounds in search for new potent antimicrobial agents. Docking studies confirmed experimental results.

Quality Control of 3-Hydroxybenzaldehyde. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article High Throughput Screening of 3D Printable Resins: Adjusting the Surface and Catalytic Properties of Multifunctional Architectures WOS:000496040500011 published article about PERIODIC MINIMAL-SURFACES; FREE AEROBIC OXIDATION; ALCOHOL OXIDATION; BENZYL ALCOHOL; HETEROGENEOUS COPPER; SELECTIVE OXIDATION; HYDROGEN-PEROXIDE; STEREOLITHOGRAPHY; POLYMERIZATION; BENZALDEHYDE in [Manzano, J. Sebastian; Wang, Hsin; Slowing, Igor I.] US DOE, Ames Lab, Ames, IA 50011 USA; [Manzano, J. Sebastian; Wang, Hsin; Slowing, Igor I.] Iowa State Univ, Dept Chem, Ames, IA 50011 USA in 2019.0, Cited 70.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Safety of Benzyl Alcohol

Identification of 3D printable materials is crucial to expand the breadth of physical and chemical properties attainable by additive manufacturing. Stereolithography (SLA), a wide-spread 3D printing method based on resin photopolymerization, is ideally suited for exploring a large variety of monomers to produce functional three-dimensional solids of diverse properties. However, for most commercial SLA printers, screening monomers and resin compositions requires large volumes (similar to 150 mL) in each printing cycle, making the process costly and inefficient. Herein, a high throughput block (HTB) adaptor was developed to screen arrays of monomers and resin compositions, consuming lower volumes (<2 mL) and less time per print (<1/16 based on a 4 x 4 matrix) than using the original hardware. By use of this approach, a library of materials with different surface hydrophobicities were 3D printed by including long chain acrylates in the resins. In addition, several metal salts were dissolved in an acrylic acid-based resin, 3D printed, and screened as benzyl alcohol oxidation catalysts. Cu(II)-based resins produced the most active structures. Combinations of Cu(II) and long chain acrylate monomers were then used to 3D print complex catalytic architectures with varying degrees of hydrophobicity. Linear relationships were observed between 3D printed surface area, surface hydrophobicity, and catalyst performance. For a high surface Schwarz P topology ca. 60% enhancement in the catalytic activity of Cu(II) was attained by replacing the parent resin with one containing hydrophobic isodecyl groups, indicating that the immediate environment of the catalytic site affected its performance. The HTB enables fast screening of resins for 3D printing multifunctional architectures with intrinsic catalytic activity, tunable surface properties, and minimal waste. Safety of Benzyl Alcohol. Welcome to talk about 100-51-6, If you have any questions, you can contact Manzano, JS; Wang, H; Slowing, II or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Chao, CL; Huang, HC; Ding, HY; Lai, JH; Lin, HC; Chang, WL in TAYLOR & FRANCIS LTD published article about FANG-FENG-CAO; ANISOMELES-INDICA; AERIAL PARTS; GLYCOSIDES; OVATODIOLIDE; CONSTITUENTS; GLUCOSIDES; PHENOLS; CELLS in [Chao, Chen-Liang; Lin, Hang-Ching] Sinphar Pharm Co Ltd, Res & Dev Ctr, Ilan, Taiwan; [Huang, Hui-Chi] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, Taichung, Taiwan; [Ding, Hsiou-Yu] Chia Nan Univ Pharm & Sci, Dept Cosmet Sci, Tainan, Taiwan; [Lai, Jenn-Haung] Triserv Gen Hosp, Dept Med, Rheumatol Immunol & Allergy, Taipei, Taiwan; [Lin, Hang-Ching; Chang, Wen-Liang] Natl Def Med Ctr, Sch Pharm, Taipei, Taiwan in 2020.0, Cited 43.0. COA of Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

A new macrocyclic diterpenoid, 4 beta,5 beta-dihydroxyovatodiolide (1), together with twenty-two known compounds (2-23) were isolated from the MeOH extract of the dried aerial parts ofAnisomeles indica(L.) O. Kuntze (Labiatae). The structure of1was established on the basis of spectral evidence. Phenylethanoids, acteoside (5) and isoacteoside (6) showed significant inhibitory to IL-2 secretion of with respect to phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood T cells.

Welcome to talk about 99-93-4, If you have any questions, you can contact Chao, CL; Huang, HC; Ding, HY; Lai, JH; Lin, HC; Chang, WL or send Email.. COA of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Noha, RM; Abdelhameid, MK; Ismail, MM; Mohammed, MR; Salwa, E in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about BIOLOGICAL EVALUATION; CHROMOSOME INSTABILITY; TOPOISOMERASE-I; DERIVATIVES; TUBULIN; APOPTOSIS; DEFECTS; CRYSTAL; ANALOGS; VITRO in [Noha, Ryad M.; Ismail, M. Mohsen] Misr Univ Sci & Technol, Coll Pharmaceut Sci & Drug Mfg, Pharmaceut Organ Chem Dept, POB 77, Giza, Egypt; [Abdelhameid, Mohammed K.; Ismail, M. Mohsen; Salwa, Elmeligie] Cairo Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Cairo 11561, Egypt; [Mohammed, Manal R.] Natl Ctr Radiat Res & Technol, Dept Radiat Biol, Cairo 11787, Egypt; [Abdelhameid, Mohammed K.] 33 Kasr El Aini St, Cairo, Egypt in 2021, Cited 39. Recommanded Product: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A novel series of benzimidazole derivatives with methoxylated aryl groups was designed and synthesized as molecules with potential cytotoxic activity. In vitro cytotoxic activity over HCT-116 cells showed that N-(benzimidazothiazolone)acetamides 11a, 11b and 11c were found to be the most cytotoxic compounds compared camptothecin (CPT). The tested compounds had a dual topoisomerase I-beta (Topo I-beta) and tubulin inhibiting activities when compared to CPT and Podophyllotoxin (Podo) where, compounds l0a, l0b, 11a and 11b exhibited a potent inhibitory activity on Topo I-b enzyme in nano-molar concentration, on the other hand, compounds 12b and 13b exhibited the best inhibitory activity beta-tubulin polymerization. Results of the cell cycle analysis as well as the results of annexin-V on HCT-116 cells showed that benzimidazothiazoles 12b and 13b had a pro-apoptotic activity higher than CPT by 1.33- and 1.30-folds, respectively. Moreover, the concentration of p53, Bax/Bcl-2 ratio and caspase 3/7 increased in compounds l0b, 11b, l2b, 13b, especially, compounds 11b and 13b exhibited an increased level of these mediators than CPT. Finally, compound 11b regulated the radiosensitizing activity of the HCT-116 cells by modulating the chromosomal instability. (c) 2020 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 123-11-5, If you have any questions, you can contact Noha, RM; Abdelhameid, MK; Ismail, MM; Mohammed, MR; Salwa, E or send Email.. Recommanded Product: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 BIOORG CHEM published article about COLCHICINE BINDING-SITE; BIOLOGICAL EVALUATION; COMBRETASTATIN A-4; TUBULIN; INHIBITORS; CHEMOTHERAPY; DERIVATIVES; DESIGN; SERIES in [Zhang, Ya-Liang; Yang, Rong; Xia, Lin-Ying; Man, Ruo-Jun; Chu, Yi-Chun; Wang, Zhong-Chang; Zhu, Hai-Liang] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China; [Man, Ruo-Jun] Guangxi Univ Nationalities, Guangxi Biol Polysaccharide Separat Purificat & M, Nanning 530006, Peoples R China; [Jiang, Ai-Qin] Nanjing Univ, Med Sch, Nanjing 210093, Jiangsu, Peoples R China in 2019.0, Cited 29.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 3-Hydroxybenzaldehyde

Twenty-four 1,2-diarylbenzimidazole derivatives were designed, synthesized and biologically evaluated. It turned out that most of them were potential anticancer drugs. Among them, compound c24 showed the highest anti-tumor activity (GI(50) = 0.71-2.41 mu M against HeLa, HepG2, A549 and MCF-7 cells), and low toxicity to normal cells (CC50 > 100 mu M against L02 cells). In the microtubule binding assay, c24 showed the most potent inhibition of microtubule polymerization (IC50 = 8.47 mu M). The binding ability of compound c24 to tubulin crystal was verified by molecular docking simulation experiment. Further studies on HepG2 and HeLa cells showed that compound c24 could cause mitotic arrest of tumor cells to G2/M phase then inducing apoptosis. To sum up, compound c24 is a promising microtubule assembly inhibitor.

Recommanded Product: 3-Hydroxybenzaldehyde. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Camarena-Pozos, DA; Flores-Nunez, VM; Lopez, MG; Partida-Martinez, LP in WILEY published article about in [Camarena-Pozos, D. A.; Flores-Nunez, V. M.; Partida-Martinez, L. P.] Ctr Invest & Estudios Avanzados, Dept Ingn Genet, Irapuato 36824, Mexico; [Lopez, M. G.] Ctr Invest & Estudios Avanzados, Dept Biotecnol & Bioquim, Irapuato 36824, Mexico in 2021.0, Cited 76.0. HPLC of Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

Fungi represent a group of eukaryotic microorganisms that are an important part of the plant microbiome. They produce a vast array of metabolites, including fungal volatile organic compounds (fVOCs). However, the diversity and biological activities of fVOCs emitted by the mycobiota of plants native to arid and semi-arid environments remain under-explored. We characterized the chemical diversity of fVOCs produced by 22 representative members of the microbiome of agaves and cacti using SPME-GC-MS. We further tested the effects of pure compounds on the growth and development of Arabidopsis thaliana and host plants. Members of the Sordariomycetes (nine strains), Eurotiomycetes (three), Dothideomycetes (eight), Saccharomycetes (one) and Mucoromycetes (one) were included in our study. We identified 94 fungal organic volatiles classified into nine chemical classes. Terpenes showed the greatest chemical diversity, followed by alcohols and aliphatic compounds. We discovered that camphene and benzyl benzoate, together with the widely distributed and already tested benzyl alcohol, 2-phenylethyl alcohol and 3-methyl-1-butanol, improved plant growth and development of A. thaliana, Agave tequilana and Agave salmiana. Our studies on the fungal VOCs from desert plants underscore an untapped chemical diversity with promising biotechnological applications.

HPLC of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Camarena-Pozos, DA; Flores-Nunez, VM; Lopez, MG; Partida-Martinez, LP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 FLAVOUR FRAG J published article about ARABICA COFFEE; VOLATILE COMPOUNDS; AROMA; IMPACT; COMPONENTS; PROFILE; COCOA in [Kim, Su-Jin; Lee, Sul; Bang, Eunjung; Lee, Sunho; Na, Yun-Cheol] Korea Basic Sci Inst, Western Seoul Ctr, 150 Bugahyeon Ro, Seoul 03759, South Korea; [Kim, Su-Jin; Lee, Sunho; Rhee, Jin-Kyu] Ewha Womans Univ, Dept Food Sci & Engn, 52 Ewhayeodae Gil, Seoul 03760, South Korea; [Lee, Sul; Na, Yun-Cheol] Ewha Womans Univ, Dept Chem & Nano Sci, 52 Ewhayeodae Gil, Seoul 03760, South Korea in 2019.0, Cited 36.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Recommanded Product: Benzyl Alcohol

Specific fermentation processes such as digestive bioprocessing and monsooning have been of interest to coffee consumers. Volatile compounds of beans during the different fermentation processes vary considerably and exhibit different profiles. The representative flavor compounds for the luwak green bean were found to be pentamethyl heptane and 3-methyl-1-butanol, while more diverse and distinct compounds were observed from the monsooned green bean, namely alkyl butanals, pinenes, benzaldehyde and butanediols. However, after roasting, the fermented form of both beans contained similar types of volatiles and their relative contents compared to those of non-fermented roasted beans, except for alpha-pinene in luwak and 2-methyl furan in monsooned beans. In principal components analysis and partial least squares-discriminant analysis (PLS-DA), the different fermented beans were clearly distinguished by the extracted peak entities from their total ion chromatograms. The s-plot and variable importance on projection (VIP) values related to PLS-DA showed the significant compounds contributing to the identification of the groups. 3-Methyl-1-butanol was the most distinctive compound for the luwak green bean, and beta-pinene, ethylbenzene and benzaldehyde were found to be the significant compounds in the monsooned green bean. In roasted beans, the most significant compounds to distinguish luwak were furfural, alpha-pinene and 3-carene with high variable in the projection (VIP) values. A significant presence of pyrazine, alkyl pyrazines, pyridine and alkyl pyridines contributed to differentiating both fermented roasted coffee beans from the unfermented roasted beans.

Recommanded Product: Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Kim, SJ; Lee, S; Bang, E; Lee, S; Rhee, JK; Na, YC or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Choo, HJ; Ahn, JH in [Choo, Hye Jeong; Ahn, Joong-Hoon] Konkuk Univ, Bio Mol Informat Ctr, Dept Biosci & Biotechnol, Seoul 05029, South Korea published Synthesis of Three Bioactive Aromatic Compounds by Introducing Polyketide Synthase Genes into Engineered Escherichia coli in 2019, Cited 31. Recommanded Product: 86-95-3. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

Intermediates in aromatic amino acid biosynthesis can serve as substrates for the synthesis of bioactive compounds. In this study we used two intermediates in the shikimate pathway of Escherichia coli, chorismate and anthranilate, to synthesize three bioactive compounds: 4-hydroxycoumarin (4-HC), 2,4-dihydroxyquinoline (DHQ), and 4-hydroxy-1-methyl-2(1H)-quinolone (NMQ). We introduced genes for the synthesis of salicylic acid from chorismate to supply the substrate for 4-HC and the gene encoding N-methyltransferase for the synthesis of N-methylanthranilate from anthranilate. Polyketide synthases and coenzyme (Co)A ligases were tested to determine the optimal combination of genes for the synthesis of each compound. We also tested several constructs and identified the best one for increasing levels of endogenous substrates for chorismate, anthranilate, and malonyl-CoA. With the use of these strategies, 255.4 mg/L 4-HC, 753.7 mg/L DHQ, and 17.5 mg/L NMQwere synthesized. This work provides a basis for the synthesis of diverse coumarin and quinoline derivatives with potential medical applications.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Choo, HJ; Ahn, JH or concate me.. Recommanded Product: 86-95-3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles