Day: December 9, 2021

I found the field of Chemistry; Science & Technology – Other Topics; Materials Science; Physics very interesting. Saw the article Synthesis of Poly(Malic Acid) Derivatives End-Functionalized with Peptides and Preparation of Biocompatible Nanoparticles to Target Hepatoma Cells published in 2021.0. Application In Synthesis of Benzyl Alcohol, Reprint Addresses Cammas-Marion, S (corresponding author), Univ Rennes, Ecole Natl Super Chim Rennes, CNRS, ISCR,UMR 6226,ScanMAT,UMS2001, F-35000 Rennes, France.; Loyer, P; Lepareur, N; Cammas-Marion, S (corresponding author), Univ Rennes, INSERM, INRAE,UMR S 1241, Inst NUMECAN Nutr Metabol & Canc UMR 1341 A 1341, F-35000 Rennes, France.; Lepareur, N (corresponding author), Comprehens Canc Ctr Eugene Marquis, F-35000 Rennes, France.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

Recently, short synthetic peptides have gained interest as targeting agents in the design of site-specific nanomedicines. In this context, our work aimed at developing new tools for the diagnosis and/or therapy of hepatocellular carcinoma (HCC) by grafting the hepatotropic George Baker (GB) virus A (GBVA10-9) and Plasmodium circumsporozoite protein (CPB)-derived peptides to the biocompatible poly(benzyl malate), PMLABe. We successfully synthesized PMLABe derivatives end-functionalized with peptides GBVA10-9, CPB, and their corresponding scrambled peptides through a thiol/maleimide reaction. The corresponding nanoparticles (NPs), varying by the nature of the peptide (GBVA10-9, CPB, and their scrambled peptides) and the absence or presence of poly(ethylene glycol) were also successfully formulated using nanoprecipitation technique. NPs were further characterized by dynamic light scattering (DLS), electrophoretic light scattering (ELS) and transmission electron microscopy (TEM), highlighting a diameter lower than 150 nm, a negative surface charge, and a more or less spherical shape. Moreover, a fluorescent probe (DiD Oil) has been encapsulated during the nanoprecipitation process. Finally, preliminary in vitro internalisation assays using HepaRG hepatoma cells demonstrated that CPB peptide-functionalized PMLABe NPs were efficiently internalized by endocytosis, and that such nanoobjects may be promising drug delivery systems for the theranostics of HCC.

Application In Synthesis of Benzyl Alcohol. Bye, fridends, I hope you can learn more about C7H8O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 4′-Hydroxyacetophenone. Authors Abdel-Rahman, IM; Mustafa, M; Mohamed, SA; Yahia, R; Abdel-Aziz, M; Abuo-Rahma, GEA; Hayallah, AM in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Abdel-Rahman, Islam M.; Mustafa, Muhamad; Abuo-Rahma, Gamal El-Din A.; Hayallah, Alaa M.] Deraya Univ, Fac Pharm, Dept Pharmaceut Chem, New Minia 61519, Minia, Egypt; [Mohamed, Soad A.] Deraya Univ, Fac Pharm, Dept Pharmaceut, New Minia 61519, Minia, Egypt; [Yahia, Ramadan] Deraya Univ, Fac Pharm, Dept Microbiol, New Minia 61519, Minia, Egypt; [Abdel-Aziz, Mohamed; Abuo-Rahma, Gamal El-Din A.] Menia Univ, Fac Pharm, Dept Med Chem, Al Minya 61519, Egypt; [Hayallah, Alaa M.] Assiut Univ, Fac Pharm, Pharmaceut Organ Chem, Assiut, Egypt; [Hayallah, Alaa M.] Sphinx Univ, Fac Pharm, Dept Pharmaceut Chem, New Assiut, Egypt in 2021, Cited 45. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

The design, synthesis and identification of a novel series of Mannich bases of ciprofloxacin was reported. Naphthol derivatives 2a and 2b showed highly potent cytotoxic activity among the tested compounds. Compound 2a showed broad spectrum antiproliferative activity with GI(50) of 2.5-6.79 mu M with remarkable selectivity towards renal and prostate cancers with selectivity ratios ranging from 0.17 to 6.79. Independently, 2a showed outstanding activity against colon cancer HOP-92 cell lines with IC50 of 6.66 mu M while 2b showed highly potent activity against ovarian cancer cell lines with IC50 of 0.97 mu M. Results showed that 2b induced cell cycle arrest at G2/M phase and apoptosis; compound 2b showed over-expression of caspase-3 protein level (449.2 +/- 7.95) compared to doxorubicin (578.7 +/- 14.4 pg/mL). Meanwhile, compounds 2a and 2b experienced outstanding activity against both Gram-positive and Gram-negative microorganisms. Interestingly, compound 2j experienced high activity against Escherichia coli and Pseudomonas aeruginosa with MIC of 0.036 and 0.043, respectively. Compound 2d revealed 27 folds and 22 folds, respectively increasing of activity over ciprofloxacin against Staphylococcus aureus and MRSA(reference strain). Compound 2d showed high activity against Staphylococcus aureus, MRSA (reference strain) and MRSA (clinical strain) with MIC of 0.57, 0.52, 0.082 mu g/mL, respectively. Interestingly, the most active tested compounds were found to have promising physicochemical and drug likeness properties. The Mannich bases 2j, 2d and 2g showed promising antibacterial activities, while naphthols 2a and 2b showed promising antiproliferative and antibacterial activities that require further optimization.

Safety of 4′-Hydroxyacetophenone. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Shahari, MSB; Junaid, A; Tiekink, ERT; Dolzhenko, AV in GEORG THIEME VERLAG KG published article about in [Shahari, Muhammad Syafiq Bin; Dolzhenko, Anton, V] Monash Univ Malaysia, Sch Pharm, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor Darul, Malaysia; [Junaid, Ahmad] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA; [Tiekink, Edward R. T.] Sunway Univ, Res Ctr Crystalline Mat, Sch Med & Life Sci, 5 Jalan Univ, Bandar Sunway 47500, Selangor Darul, Malaysia; [Dolzhenko, Anton, V] Curtin Univ, Fac Hlth Sci, Sch Pharm & Biomed Sci, Curtin Hlth Innovat Res Inst, GPO Box U1987, Perth, WA 6845, Australia in 2021.0, Cited 47.0. Safety of 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

A new method for the fast synthesis of diverse 4-aryl-6-cycloamino-1,3,5-triazin-2-amines was developed. The synthesis is performed under microwave irradiation in a one-pot manner from cyanoguanidine, aromatic aldehydes, and cyclic amines. Their three-component reaction in the presence of hydrochloric acid produced dihydrotriazines, which were then converted (without isolation) into the targeted compounds via aromatic dehydrogenation in the presence of alkali. The reaction tolerated various aromatic aldehydes (including heterocyclic) and cyclic amities. Crystal structures of two representative 4-aryl-6-morpholino-1,3,5-triazin-2-amines were established by X-ray crystallography. The results of preliminary biological screening identified potent antileukemic activity for 6-[3,4-dihydroisoquinolin-2(1H)-yl]-4- phenyl-1,3,5-triazin-2-amine.

Safety of 3,4-Dimethoxybenzaldehyde. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Handore, KN; Chabukswar, VV; Pawar, D; Dallavalle, S in TAYLOR & FRANCIS INC published article about ONE-POT SYNTHESIS; IMPROVED PROTOCOL CONDITIONS; CALCIUM-CHANNEL BLOCKERS; BIGINELLI REACTION; EFFICIENT CATALYST; REUSABLE CATALYST; HETEROPOLY ACID; BROMIDE; DIHYDROPYRIMIDINONES; ESTERS in [Handore, Kalpana N.; Chabukswar, Vasant V.; Pawar, Digamber] Savitribai Phule Pune Univ, Dept Chem, Nowrosjee Wadia Coll, Pune 411001, Maharashtra, India; [Dallavalle, Sabrina] Univ Milan, Dept Food Environm & Nutr Sci, Milan, Italy in 2021, Cited 33. HPLC of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

This paper describes the synthesis of polyindole by chemical oxidative polymerization using copper chloride as oxidant. Polyindole was characterized by various spectroscopic techniques like FT-IR, XRD, FESEM, and TGA. The XRD pattern confirms the semi-crystalline nature of polyindole. An efficient, solvent-free, ultrasound-assisted synthesis of biologically active 3,4-dihydropyrimidin-2(1 H)-one/thiones (DHPM) derivatives is reported by using polyindole as a recyclable catalyst. The advantages of this method are mild reaction conditions, short reaction time, excellent yields with high purity and low loading of catalyst. Polyindole can be used several times without loss of significant catalytic activity as compared to the other reported catalysts. Factors affecting on the rate of reaction, like use of ultrasonication, temperature, solvent, amount, and recyclability of catalyst have also been studied.

HPLC of Formula: C8H8O2. Welcome to talk about 123-11-5, If you have any questions, you can contact Handore, KN; Chabukswar, VV; Pawar, D; Dallavalle, S or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article A multifunctional triazine-based nanoporous polymer as a versatile organocatalyst for CO2 utilization and C-C bond formation WOS:000487669300023 published article about CATALYTIC CONVERSION; CYCLIC CARBONATES; REDUCTION; NITROGEN; CYCLOADDITION; IMIDAZOLIUM; FRAMEWORK; EPOXIDES; CAPTURE in [Sharma, Ruchi; Bansal, Ankushi; Mohanty, Paritosh] IIT Roorkee, Dept Chem, Funct Mat Lab, Roorkee 247667, Uttarakhand, India; [Ramachandran, C. N.] IIT Roorkee, Dept Chem, Theoret & Computat Chem Lab, Roorkee 247667, Uttarakhand, India in 2019.0, Cited 40.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Formula: C7H6O2

A triazine-based nanoporous multifunctional polymer with a SA(BET) of 304 m(2) g(-1) has shown versatile catalytic activity in the conversion of CO2 to cyclic carbonates at 4 bar with almost 100% yield and selectivity, and in the conversion of CO2 to methanol and methane electrochemically. Additionally, it also catalyzes C-C bond formation via the Knoevenagel reaction.

Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Sharma, R; Bansal, A; Ramachandran, CN; Mohanty, P or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H8O. Authors Yasukata, T; Masui, M; Ikarashi, F; Okamoto, K; Kurita, T; Nagai, M; Sugata, Y; Miyake, N; Hara, S; Adachi, Y; Sumino, Y in AMER CHEMICAL SOC published article about in [Yasukata, Tatsuro; Ikarashi, Fumiya; Okamoto, Kazuya; Sumino, Yukihito] Shionogi & Co Ltd, CMC R&D Div, API R&D Lab, 1-3,Kuise Terajima 2 Chome, Amagasaki, Hyogo 6600813, Japan; [Kurita, Takanori; Miyake, Naoki] Shionogi & Co Ltd, Mfg Div, Prod Technol Dept, 1-3,Kuise Terajima 2 Chome, Amagasaki, Hyogo 6600813, Japan; [Masui, Moriyasu; Nagai, Masahiko; Sugata, Yoshihide; Hara, Shinichiro; Adachi, You] Shionogi & Co Ltd, Shionogi Pharmaceut Res Ctr, 1-1,Futaba Cho 3 Chome, Toyonaka, Osaka 5610825, Japan in 2019.0, Cited 19.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

A highly efficient and practical synthetic method for the preparation of pyrone diesters was established. The pyrone diester 3c can be prepared from readily available starting materials on a multihundred gram scale. The pyrone diester 3c can easily be converted to dolutegravir sodium (1). The synthetic route demonstrated herein provides an efficient and atom-economical synthetic method for preparing this potent anti-HIV agent.

COA of Formula: C7H8O. Welcome to talk about 100-51-6, If you have any questions, you can contact Yasukata, T; Masui, M; Ikarashi, F; Okamoto, K; Kurita, T; Nagai, M; Sugata, Y; Miyake, N; Hara, S; Adachi, Y; Sumino, Y or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about MOLECULAR CHAPERONE; ANTICANCER AGENTS; FORCE-FIELD; CANCER; DYNAMICS; DOCKING; DESIGN; OPTIMIZATION; PERFORMANCE; GENERATION, Saw an article supported by the Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt; Natural Sciences and Engineering Research Council (NSERC) of CanadaNatural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN-2017-04233]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Mohamady, S; Ismail, MI; Mogheith, SM; Attia, YM; Taylor, SD. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone. HPLC of Formula: C8H8O2

Although hepatocellular carcinoma (HCC)-related mortality has increased over the past decades, treatment options are still very limited, underlining the need for developing new therapeutic strategies. The molecular chaperone heat shock protein 90 (Hsp90) plays a key role in post-translational maturation of many oncogenic client proteins that are important for survival and proliferation of cancer cells. Thus, inhibitors of Hsp90 are promising targets for many cancer types. In this study, 15 diarylpyrazole compounds were screened against MCF7 and HepG2 cell lines. Compound 8, which contained a thiophene group, demonstrated the highest antiproliferative activity against HepG2 cells having an IC50, of 0.083 mu M. Four additional diarylpyrazoles, each containing a thiophene group, were prepared and screened for antiproliferative activity. None of these four compounds exhibited superior activity to compound 8 on HepG2 cells. Therefore, compound 8 was selected for further in vitro assays. Cell cycle arrest was observed at the G2 phase in compound 8-treated cells. Compound 8 also caused a 7.7-fold increase in caspase-3. These results confirm the apoptotic effect of compound 8 on HepG2 cells. Moreover, compound 8 inhibited Hsp90 (IC50, = 2.67 +/- 0.18 mu M) in an in vitro assay and caused a 70.8% reduction in Hsp90 levels in a HepG2 cell-based assay. Additionally, compound 8 caused significant reduction in the levels of Hsp90 client proteins (Akt, c-Met, c-Raf, and EGFR) and a 1.57-fold increase in Hsp70. Molecular docking studies were also performed to predict the binding mode of compound 8 and followed by molecular dynamics simulations to give further insights into the binding mode of 8.

HPLC of Formula: C8H8O2. Welcome to talk about 99-93-4, If you have any questions, you can contact Mohamady, S; Ismail, MI; Mogheith, SM; Attia, YM; Taylor, SD or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Sun, MM; Chen, WD; Xia, XY; Shen, GD; Ma, YM; Yang, JG; Ding, HF; Wang, ZM in AMER CHEMICAL SOC published article about ALLYLIC ALKYLATIONS; BOND ACTIVATION; FUNCTIONALIZATION; ALLYLATION; ALKENES; ARYLATION; ACETATES; SP(3) in [Sun, Manman; Chen, Weida; Xia, Xiangyu; Ma, Yongmin; Yang, Jianguo; Wang, Zhiming] Taizhou Univ, Adv Res Inst, Taizhou 318000, Peoples R China; [Sun, Manman; Chen, Weida; Xia, Xiangyu; Ma, Yongmin; Yang, Jianguo; Wang, Zhiming] Taizhou Univ, Dept Chem, Taizhou 318000, Peoples R China; [Shen, Guodong] Liaocheng Univ, Sch Chem & Chem Engn, Sch Pharm, Liaocheng 252000, Shandong, Peoples R China; [Ding, Hanfeng] Zhejiang Univ, Dept Chem, Hangzhou 310058, Peoples R China in 2020, Cited 82. Recommanded Product: (E)-2-Methylbut-2-enoic acid. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1

A palladium-catalyzed tandem dehydrogenative [4 + 2] annulation of terminal olefins with N-sulfonyl amides via C(sp(2))-H activation, allylic C(sp(3))-H activation, and homoallylic C(sp(3))-H elimination processes has been developed. Promoted by the DMSO ligand, various benzamides, heterocyclic arylamides, alkenyl carboxamides, and commercial olefins are found to be efficient substrates to construct important heterocyclic compounds bearing a vinyl substituent with high E stereoselectivity. Using air as the terminal oxidant also provides a great advantage regarding environmental friendliness.

Welcome to talk about 80-59-1, If you have any questions, you can contact Sun, MM; Chen, WD; Xia, XY; Shen, GD; Ma, YM; Yang, JG; Ding, HF; Wang, ZM or send Email.. Recommanded Product: (E)-2-Methylbut-2-enoic acid

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 150-76-5. Authors Jia, RF; Zhang, J; Bertagnin, C; Cherukupalli, S; Ai, W; Ding, X; Li, Z; Zhang, JW; Ju, H; Ma, XL; Loregian, A; Huang, B; Zhan, P; Liu, XY in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about in [Jia, Ruifang; Cherukupalli, Srinivasulu; Ai, Wei; Ding, Xiao; Li, Zhuo; Zhang, Jiwei; Ju, Han; Zhan, Peng; Liu, Xinyong] Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Dept Med Chem,Key Lab Chem Biol,Minist Educ, 44 West Culture Rd, Jinan 250012, Shandong, Peoples R China; [Zhang, Jian] Shandong Univ, Hosp 2, Cheeloo Coll Med, Inst Med Sci, Jinan 250033, Shandong, Peoples R China; [Bertagnin, Chiara; Loregian, Arianna] Univ Padua, Dept Mol Med, Via Gabelli 63, I-35121 Padua, Italy; [Ma, Xiuli; Huang, Bing] Shandong Acad Agr Sci, Inst Poultry Sci, 1 Jiaoxiao Rd, Jinan 250023, Shandong, Peoples R China; [Zhan, Peng; Liu, Xinyong] China Belgium Collaborat Res Ctr Innovat Antivira, 44 West Culture Rd, Jinan 250012, Shandong, Peoples R China in 2021, Cited 41. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

Encouraged by our earlier discovery of N1-selective inhibitors, the 150-cavity of influenza virus neuraminidases (NAs) could be further exploited to yield more potent oseltamivir derivatives. Herein, we report the design, synthesis and biological evaluation of a series of novel oseltamivir derivatives via the structural modifications at C-5-NH2 of oseltamivir targeting 150-cavity. Among them, compound 5c bearing 4-(3-methoxybenzyloxy)benzyl group exhibited the most potent activity, which was lower or modestly improved activities than oseltamivir carboxylate (OSC) against N1 (H1N1), N1 (H5N1) and N1 (H5N1-H274Y). Specifically, there was 30-fold loss of activity against the wild-type strain H1N1. However, 5c displayed 4.85-fold more potent activity than OSC against H5N1-H274Y NA. Also, 5c demonstrated low cytotoxicity in vitro and no acute toxicity in mice. Molecular docking studies provided insights into the high potency of 5c against N1 and N1-H274Y mutant NAs. Besides, the in silico prediction of physicochemical properties and CYP enzymatic inhibitory ability of representative compounds were conducted to evaluate their drug-like properties. (C) 2020 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 150-76-5, If you have any questions, you can contact Jia, RF; Zhang, J; Bertagnin, C; Cherukupalli, S; Ai, W; Ding, X; Li, Z; Zhang, JW; Ju, H; Ma, XL; Loregian, A; Huang, B; Zhan, P; Liu, XY or send Email.. SDS of cas: 150-76-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about TETRAPROPYLAMMONIUM BROMIDE; BIOLOGICAL EVALUATION; DERIVATIVES; CATALYST; WATER, Saw an article supported by the Urmia University. Category: indole-building-block. Published in WILEY in HOBOKEN ,Authors: Marjani, AP; Khalafy, J; Farajollahi, A. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, H-1-NMR, and C-13-NMR spectral data and elemental analysis.

Welcome to talk about 86-95-3, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or send Email.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles