Month: December 2021

An article A multifunctional triazine-based nanoporous polymer as a versatile organocatalyst for CO2 utilization and C-C bond formation WOS:000487669300023 published article about CATALYTIC CONVERSION; CYCLIC CARBONATES; REDUCTION; NITROGEN; CYCLOADDITION; IMIDAZOLIUM; FRAMEWORK; EPOXIDES; CAPTURE in [Sharma, Ruchi; Bansal, Ankushi; Mohanty, Paritosh] IIT Roorkee, Dept Chem, Funct Mat Lab, Roorkee 247667, Uttarakhand, India; [Ramachandran, C. N.] IIT Roorkee, Dept Chem, Theoret & Computat Chem Lab, Roorkee 247667, Uttarakhand, India in 2019.0, Cited 40.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Formula: C7H6O2

A triazine-based nanoporous multifunctional polymer with a SA(BET) of 304 m(2) g(-1) has shown versatile catalytic activity in the conversion of CO2 to cyclic carbonates at 4 bar with almost 100% yield and selectivity, and in the conversion of CO2 to methanol and methane electrochemically. Additionally, it also catalyzes C-C bond formation via the Knoevenagel reaction.

Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Sharma, R; Bansal, A; Ramachandran, CN; Mohanty, P or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H8O. Authors Yasukata, T; Masui, M; Ikarashi, F; Okamoto, K; Kurita, T; Nagai, M; Sugata, Y; Miyake, N; Hara, S; Adachi, Y; Sumino, Y in AMER CHEMICAL SOC published article about in [Yasukata, Tatsuro; Ikarashi, Fumiya; Okamoto, Kazuya; Sumino, Yukihito] Shionogi & Co Ltd, CMC R&D Div, API R&D Lab, 1-3,Kuise Terajima 2 Chome, Amagasaki, Hyogo 6600813, Japan; [Kurita, Takanori; Miyake, Naoki] Shionogi & Co Ltd, Mfg Div, Prod Technol Dept, 1-3,Kuise Terajima 2 Chome, Amagasaki, Hyogo 6600813, Japan; [Masui, Moriyasu; Nagai, Masahiko; Sugata, Yoshihide; Hara, Shinichiro; Adachi, You] Shionogi & Co Ltd, Shionogi Pharmaceut Res Ctr, 1-1,Futaba Cho 3 Chome, Toyonaka, Osaka 5610825, Japan in 2019.0, Cited 19.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

A highly efficient and practical synthetic method for the preparation of pyrone diesters was established. The pyrone diester 3c can be prepared from readily available starting materials on a multihundred gram scale. The pyrone diester 3c can easily be converted to dolutegravir sodium (1). The synthetic route demonstrated herein provides an efficient and atom-economical synthetic method for preparing this potent anti-HIV agent.

COA of Formula: C7H8O. Welcome to talk about 100-51-6, If you have any questions, you can contact Yasukata, T; Masui, M; Ikarashi, F; Okamoto, K; Kurita, T; Nagai, M; Sugata, Y; Miyake, N; Hara, S; Adachi, Y; Sumino, Y or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about MOLECULAR CHAPERONE; ANTICANCER AGENTS; FORCE-FIELD; CANCER; DYNAMICS; DOCKING; DESIGN; OPTIMIZATION; PERFORMANCE; GENERATION, Saw an article supported by the Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt; Natural Sciences and Engineering Research Council (NSERC) of CanadaNatural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN-2017-04233]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Mohamady, S; Ismail, MI; Mogheith, SM; Attia, YM; Taylor, SD. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone. HPLC of Formula: C8H8O2

Although hepatocellular carcinoma (HCC)-related mortality has increased over the past decades, treatment options are still very limited, underlining the need for developing new therapeutic strategies. The molecular chaperone heat shock protein 90 (Hsp90) plays a key role in post-translational maturation of many oncogenic client proteins that are important for survival and proliferation of cancer cells. Thus, inhibitors of Hsp90 are promising targets for many cancer types. In this study, 15 diarylpyrazole compounds were screened against MCF7 and HepG2 cell lines. Compound 8, which contained a thiophene group, demonstrated the highest antiproliferative activity against HepG2 cells having an IC50, of 0.083 mu M. Four additional diarylpyrazoles, each containing a thiophene group, were prepared and screened for antiproliferative activity. None of these four compounds exhibited superior activity to compound 8 on HepG2 cells. Therefore, compound 8 was selected for further in vitro assays. Cell cycle arrest was observed at the G2 phase in compound 8-treated cells. Compound 8 also caused a 7.7-fold increase in caspase-3. These results confirm the apoptotic effect of compound 8 on HepG2 cells. Moreover, compound 8 inhibited Hsp90 (IC50, = 2.67 +/- 0.18 mu M) in an in vitro assay and caused a 70.8% reduction in Hsp90 levels in a HepG2 cell-based assay. Additionally, compound 8 caused significant reduction in the levels of Hsp90 client proteins (Akt, c-Met, c-Raf, and EGFR) and a 1.57-fold increase in Hsp70. Molecular docking studies were also performed to predict the binding mode of compound 8 and followed by molecular dynamics simulations to give further insights into the binding mode of 8.

HPLC of Formula: C8H8O2. Welcome to talk about 99-93-4, If you have any questions, you can contact Mohamady, S; Ismail, MI; Mogheith, SM; Attia, YM; Taylor, SD or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Sun, MM; Chen, WD; Xia, XY; Shen, GD; Ma, YM; Yang, JG; Ding, HF; Wang, ZM in AMER CHEMICAL SOC published article about ALLYLIC ALKYLATIONS; BOND ACTIVATION; FUNCTIONALIZATION; ALLYLATION; ALKENES; ARYLATION; ACETATES; SP(3) in [Sun, Manman; Chen, Weida; Xia, Xiangyu; Ma, Yongmin; Yang, Jianguo; Wang, Zhiming] Taizhou Univ, Adv Res Inst, Taizhou 318000, Peoples R China; [Sun, Manman; Chen, Weida; Xia, Xiangyu; Ma, Yongmin; Yang, Jianguo; Wang, Zhiming] Taizhou Univ, Dept Chem, Taizhou 318000, Peoples R China; [Shen, Guodong] Liaocheng Univ, Sch Chem & Chem Engn, Sch Pharm, Liaocheng 252000, Shandong, Peoples R China; [Ding, Hanfeng] Zhejiang Univ, Dept Chem, Hangzhou 310058, Peoples R China in 2020, Cited 82. Recommanded Product: (E)-2-Methylbut-2-enoic acid. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1

A palladium-catalyzed tandem dehydrogenative [4 + 2] annulation of terminal olefins with N-sulfonyl amides via C(sp(2))-H activation, allylic C(sp(3))-H activation, and homoallylic C(sp(3))-H elimination processes has been developed. Promoted by the DMSO ligand, various benzamides, heterocyclic arylamides, alkenyl carboxamides, and commercial olefins are found to be efficient substrates to construct important heterocyclic compounds bearing a vinyl substituent with high E stereoselectivity. Using air as the terminal oxidant also provides a great advantage regarding environmental friendliness.

Welcome to talk about 80-59-1, If you have any questions, you can contact Sun, MM; Chen, WD; Xia, XY; Shen, GD; Ma, YM; Yang, JG; Ding, HF; Wang, ZM or send Email.. Recommanded Product: (E)-2-Methylbut-2-enoic acid

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 150-76-5. Authors Jia, RF; Zhang, J; Bertagnin, C; Cherukupalli, S; Ai, W; Ding, X; Li, Z; Zhang, JW; Ju, H; Ma, XL; Loregian, A; Huang, B; Zhan, P; Liu, XY in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about in [Jia, Ruifang; Cherukupalli, Srinivasulu; Ai, Wei; Ding, Xiao; Li, Zhuo; Zhang, Jiwei; Ju, Han; Zhan, Peng; Liu, Xinyong] Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Dept Med Chem,Key Lab Chem Biol,Minist Educ, 44 West Culture Rd, Jinan 250012, Shandong, Peoples R China; [Zhang, Jian] Shandong Univ, Hosp 2, Cheeloo Coll Med, Inst Med Sci, Jinan 250033, Shandong, Peoples R China; [Bertagnin, Chiara; Loregian, Arianna] Univ Padua, Dept Mol Med, Via Gabelli 63, I-35121 Padua, Italy; [Ma, Xiuli; Huang, Bing] Shandong Acad Agr Sci, Inst Poultry Sci, 1 Jiaoxiao Rd, Jinan 250023, Shandong, Peoples R China; [Zhan, Peng; Liu, Xinyong] China Belgium Collaborat Res Ctr Innovat Antivira, 44 West Culture Rd, Jinan 250012, Shandong, Peoples R China in 2021, Cited 41. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

Encouraged by our earlier discovery of N1-selective inhibitors, the 150-cavity of influenza virus neuraminidases (NAs) could be further exploited to yield more potent oseltamivir derivatives. Herein, we report the design, synthesis and biological evaluation of a series of novel oseltamivir derivatives via the structural modifications at C-5-NH2 of oseltamivir targeting 150-cavity. Among them, compound 5c bearing 4-(3-methoxybenzyloxy)benzyl group exhibited the most potent activity, which was lower or modestly improved activities than oseltamivir carboxylate (OSC) against N1 (H1N1), N1 (H5N1) and N1 (H5N1-H274Y). Specifically, there was 30-fold loss of activity against the wild-type strain H1N1. However, 5c displayed 4.85-fold more potent activity than OSC against H5N1-H274Y NA. Also, 5c demonstrated low cytotoxicity in vitro and no acute toxicity in mice. Molecular docking studies provided insights into the high potency of 5c against N1 and N1-H274Y mutant NAs. Besides, the in silico prediction of physicochemical properties and CYP enzymatic inhibitory ability of representative compounds were conducted to evaluate their drug-like properties. (C) 2020 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 150-76-5, If you have any questions, you can contact Jia, RF; Zhang, J; Bertagnin, C; Cherukupalli, S; Ai, W; Ding, X; Li, Z; Zhang, JW; Ju, H; Ma, XL; Loregian, A; Huang, B; Zhan, P; Liu, XY or send Email.. SDS of cas: 150-76-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about TETRAPROPYLAMMONIUM BROMIDE; BIOLOGICAL EVALUATION; DERIVATIVES; CATALYST; WATER, Saw an article supported by the Urmia University. Category: indole-building-block. Published in WILEY in HOBOKEN ,Authors: Marjani, AP; Khalafy, J; Farajollahi, A. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, H-1-NMR, and C-13-NMR spectral data and elemental analysis.

Welcome to talk about 86-95-3, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or send Email.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article 4,6-Diphenylpyrimidine Derivatives as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease WOS:000456351300032 published article about BIOLOGICAL EVALUATION; FUTURE TREATMENTS; DIRECTED LIGANDS; CELL MODEL; DONEPEZIL; MAO; CHOLINESTERASE; SYMPTOMS; HYBRIDS; DESIGN in [Kumar, Bhupinder; Dwivedi, Ashish Ranjan; Kumar, Vinod] Cent Univ Punjab, Dept Pharmaceut Sci & Nat Prod, Lab Organ & Med Chem, Bathinda 151001, Punjab, India; [Sarkar, Bibekananda; Mantha, Anil K.; Parkash, Jyoti] Cent Univ Punjab, Sch Basic & Appl Sci, Dept Anim Sci, Bathinda 151001, Punjab, India; [Gupta, Sukesh Kumar; Krishnamurthy, Sairam] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut Engn & Technol, Varanasi 221005, Uttar Pradesh, India in 2019.0, Cited 46.0. Quality Control of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Alzheimer’s disease (AD) is a neurodegenerative disorder with multifactorial pathogenesis. Monoamine oxidase (MAO) and acetylcholinesterase enzymes (AChE) are potential targets for the treatment of AD. A total of 15 new propargyl containing 4,6-diphenylpyrimidine derivatives were synthesized and screened for the MAO and AChE inhibition activities along with ROS production inhibition and metal-chelation potential. All the synthesized compounds were found to be selective and potent inhibitors of MAO-A and AChE enzymes at nanomolar concentrations. VB1 was found to be the most potent MAO-A and BuChE inhibitor with IC50 values of 18.34 +/- 0.38 nM and 0.666 +/- 0.03 mu M, respectively. It also showed potent AChE inhibition with an IC50 value of 30.46 +/- 0.23 nM. Compound VB8 was found to be the most potent AChE inhibitor with an IC50 value of 9.54 +/- 0.07 nM and displayed an IC50 value of 1010 +/- 70.42 nM against the MAO-A isoform. In the cytotoxic studies, these compounds were found to be nontoxic to the human neuroblastoma SH-SYSY cells even at 25 mu M concentration. All the compounds were found to be reversible inhibitors of MAO-A and AChE enzymes. In addition, these compounds also showed good neuroprotective properties against 6-OHDA- and H2O2-induced neurotoxicity in SH-SYSY cells. All the compounds accommodate nicely to the hydrophobic cavity of MAO-A and AChE enzymes. In the molecular dynamics simulation studies, both VB1 and VB8 were found to be stable in the respective cavities for 30 ns. Thus, 4,6-diphenylpyrimidine derivatives can act as promising leads in the development of dual-acting inhibitors targeting MAO-A and AChE enzymes for the treatment of Alzheimer’s disease.

Welcome to talk about 99-93-4, If you have any questions, you can contact Kumar, B; Dwivedi, AR; Sarkar, B; Gupta, SK; Krishnamurthy, S; Mantha, AK; Parkash, J; Kumar, V or send Email.. Quality Control of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 4-Methoxybenzaldehyde. In 2021 J MOL STRUCT published article about DISCOVERY; BINDING in [Nath, Rajarshi; Pathania, Shelly; Grover, Gourav; Akhtar, Md Jawaid] ISF Coll Pharm, Dept Pharmaceut Chem, Ferozpur GT Rd, Moga 142001, Punjab, India; [Yar, M. Shahar] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut Chem, New Delhi 110062, India; [Debnath, Biplab] Bharat Technol, Dept Pharm, Howrah 711316, W Bengal, India in 2021, Cited 33. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

A series of N-(substituted benzothiazole-2-yl)-2-(2,3 dioxoindolin-1-yl)acetamide (4a-i) and substituted-[3-((5-phenyl-1,3,4-oxadiazole-2-yl)imino)indolene-2-one] (5a-f) were designed, synthesized fulfilling the structural requirement of pharmacophore and evaluated for anticonvulsant activities using maximal electroshock test (MES), subcutaneous pentylenetetrazole (scPTZ) seizures and neurotoxicity by motor impairment model in mice. The most active compound N-(5-chlorobenzo[d]thiazol-2-yl)-2-(2,3-dioxoindolin-1-yl)acetamide (4a) has shown significant anticonvulsant activity against both MES and scPTZ screens and emerged as most effective anticonvulsant compound with median dose of 35.7 mg/kg (MES ED50), 88.15 mg/kg (scPTZ ED50) and toxic dose (TD50) was found to be > 500mg/kg. In silico studies including molecular docking study was carried to establish the molecular interaction of potent compound (4a) in both Na+ channel and GABA(A) receptors. The prediction of pharmacokinetic parameters and distance mapping of compounds were also performed to establish the drug likeness property. (C) 2020 Elsevier B.V. All rights reserved.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Nath, R; Yar, MS; Pathania, S; Grover, G; Debnath, B; Akhtar, MJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Silva, P; Freitas, J; Nunes, FM; Camara, JS in AMER CHEMICAL SOC published article about in [Silva, Pedro; Freitas, Jorge; Camara, Jose S.] Univ Madeira, Ctr Quim Madeira, P-9020105 Funchal, Portugal; [Nunes, Fernando M.] Univ Tras Os Montes & Alto Douro, Ctr Quim Vila Real, Dept Quim, CQ VR, P-5001801 Vila Real, Portugal; [Camara, Jose S.] Univ Madeira, Fac Ciencias Exactas & Engn, Dept Quim, Campus Penteada, P-9020105 Funchal, Portugal in 2021.0, Cited 28.0. COA of Formula: C7H8O2. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

Sugarcane (SC) is a perennial grass widely cultivated in tropical and subtropical regions. However, its cultivation in Europe is residual, where Madeira Island, Portugal, is the only region where SC continues to be extensively cultivated. For the first time, the volatile profiles of regional cultivars were established by solid-phase microextraction combined with gas chromatography-mass spectrometry. Different volatile profiles for each cultivar were recognized, identifying 260 volatile organic compounds belonging to 15 chemical classes, such as aldehydes, alcohols, ketones, hydrocarbons, esters, and terpenes. Chemometric analysis procedure, namely, one-way ANOVA with Tukey’s test, principal component analysis, partial least-square analysis, linear discriminant analysis, and hierarchical clustering analysis, allowed the differentiation between all regional cultivars. This study represents an important contribution for the maintenance of biodiversity and subsistence of the SC industry in Europe. Furthermore, it is also a valuable contribution to establish the typicality of traditional SC-based products, such as SC honey.

Welcome to talk about 150-76-5, If you have any questions, you can contact Silva, P; Freitas, J; Nunes, FM; Camara, JS or send Email.. COA of Formula: C7H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 150-19-6. Cai, MK; Lv, HF; Cao, C; Zhang, LP; Cao, R; Xu, B in [Cai, Mengke; Lv, Huangfei; Cao, Cong; Zhang, Liping; Cao, Rui; Xu, Bin] Anhui Agr Univ, Sch Forestry & Landscape Architecture, Hefei 230036, Anhui, Peoples R China published Evaluation of antimicrobial activity of Pterocarpus extracts in 2019, Cited 32. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

Pterocarpus is one of the most widely used timber resources on the market. But the utilization rate has been low. In order to improve the utilization of Pterocarpus processing residue, as well as explore the reason of its good decay-resistance. In this study, the antifungal mechanism of Peterocarpes spp., aqueous extracts and ethanol extracts of three Pterocarpus species were studied. The antimicrobial active factors were analyzed by gas chromatography-mass spectrometry. Italian poplar (Populus euramevicana cv. ‘I-214’) wood was immersed in the extracts and then inoculated with both Coriolus versicolor and Glaeophyllum trabeum. The antimicrobial properties of the extracts were studied, and the mechanism underlying these properties were analyzed using gas chromatography-mass spectrometry. The results showed that the yield of ethanol extracts from the three Pterocarpus species was significantly higher than that of aqueous extracts. Pterocarpus soyauxii and Pterocarpus macarocarpus produced the highest yield of ethanol extracts (28.59%) and aqueous extracts (14.31%), respectively. With increasing concentrations, the antimicrobial activities of aqueous extracts of Pterocarpus angolensis and Pterocarpus macarocarpus gradually increased, while the antimicrobial activity of other extracts remained constant. Gas chromatography-mass spectrometry analysis identified a considerable number of phenols, ketones, amines, and aromatic compounds in all extracts, which is consistent with their antimicrobial activity and suggests synergism among the chemicals.

Product Details of 150-19-6. Welcome to talk about 150-19-6, If you have any questions, you can contact Cai, MK; Lv, HF; Cao, C; Zhang, LP; Cao, R; Xu, B or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles