Month: December 2021

Authors Chao, CL; Huang, HC; Ding, HY; Lai, JH; Lin, HC; Chang, WL in TAYLOR & FRANCIS LTD published article about FANG-FENG-CAO; ANISOMELES-INDICA; AERIAL PARTS; GLYCOSIDES; OVATODIOLIDE; CONSTITUENTS; GLUCOSIDES; PHENOLS; CELLS in [Chao, Chen-Liang; Lin, Hang-Ching] Sinphar Pharm Co Ltd, Res & Dev Ctr, Ilan, Taiwan; [Huang, Hui-Chi] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, Taichung, Taiwan; [Ding, Hsiou-Yu] Chia Nan Univ Pharm & Sci, Dept Cosmet Sci, Tainan, Taiwan; [Lai, Jenn-Haung] Triserv Gen Hosp, Dept Med, Rheumatol Immunol & Allergy, Taipei, Taiwan; [Lin, Hang-Ching; Chang, Wen-Liang] Natl Def Med Ctr, Sch Pharm, Taipei, Taiwan in 2020.0, Cited 43.0. COA of Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

A new macrocyclic diterpenoid, 4 beta,5 beta-dihydroxyovatodiolide (1), together with twenty-two known compounds (2-23) were isolated from the MeOH extract of the dried aerial parts ofAnisomeles indica(L.) O. Kuntze (Labiatae). The structure of1was established on the basis of spectral evidence. Phenylethanoids, acteoside (5) and isoacteoside (6) showed significant inhibitory to IL-2 secretion of with respect to phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood T cells.

Welcome to talk about 99-93-4, If you have any questions, you can contact Chao, CL; Huang, HC; Ding, HY; Lai, JH; Lin, HC; Chang, WL or send Email.. COA of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Noha, RM; Abdelhameid, MK; Ismail, MM; Mohammed, MR; Salwa, E in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about BIOLOGICAL EVALUATION; CHROMOSOME INSTABILITY; TOPOISOMERASE-I; DERIVATIVES; TUBULIN; APOPTOSIS; DEFECTS; CRYSTAL; ANALOGS; VITRO in [Noha, Ryad M.; Ismail, M. Mohsen] Misr Univ Sci & Technol, Coll Pharmaceut Sci & Drug Mfg, Pharmaceut Organ Chem Dept, POB 77, Giza, Egypt; [Abdelhameid, Mohammed K.; Ismail, M. Mohsen; Salwa, Elmeligie] Cairo Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Cairo 11561, Egypt; [Mohammed, Manal R.] Natl Ctr Radiat Res & Technol, Dept Radiat Biol, Cairo 11787, Egypt; [Abdelhameid, Mohammed K.] 33 Kasr El Aini St, Cairo, Egypt in 2021, Cited 39. Recommanded Product: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A novel series of benzimidazole derivatives with methoxylated aryl groups was designed and synthesized as molecules with potential cytotoxic activity. In vitro cytotoxic activity over HCT-116 cells showed that N-(benzimidazothiazolone)acetamides 11a, 11b and 11c were found to be the most cytotoxic compounds compared camptothecin (CPT). The tested compounds had a dual topoisomerase I-beta (Topo I-beta) and tubulin inhibiting activities when compared to CPT and Podophyllotoxin (Podo) where, compounds l0a, l0b, 11a and 11b exhibited a potent inhibitory activity on Topo I-b enzyme in nano-molar concentration, on the other hand, compounds 12b and 13b exhibited the best inhibitory activity beta-tubulin polymerization. Results of the cell cycle analysis as well as the results of annexin-V on HCT-116 cells showed that benzimidazothiazoles 12b and 13b had a pro-apoptotic activity higher than CPT by 1.33- and 1.30-folds, respectively. Moreover, the concentration of p53, Bax/Bcl-2 ratio and caspase 3/7 increased in compounds l0b, 11b, l2b, 13b, especially, compounds 11b and 13b exhibited an increased level of these mediators than CPT. Finally, compound 11b regulated the radiosensitizing activity of the HCT-116 cells by modulating the chromosomal instability. (c) 2020 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 123-11-5, If you have any questions, you can contact Noha, RM; Abdelhameid, MK; Ismail, MM; Mohammed, MR; Salwa, E or send Email.. Recommanded Product: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 BIOORG CHEM published article about COLCHICINE BINDING-SITE; BIOLOGICAL EVALUATION; COMBRETASTATIN A-4; TUBULIN; INHIBITORS; CHEMOTHERAPY; DERIVATIVES; DESIGN; SERIES in [Zhang, Ya-Liang; Yang, Rong; Xia, Lin-Ying; Man, Ruo-Jun; Chu, Yi-Chun; Wang, Zhong-Chang; Zhu, Hai-Liang] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China; [Man, Ruo-Jun] Guangxi Univ Nationalities, Guangxi Biol Polysaccharide Separat Purificat & M, Nanning 530006, Peoples R China; [Jiang, Ai-Qin] Nanjing Univ, Med Sch, Nanjing 210093, Jiangsu, Peoples R China in 2019.0, Cited 29.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 3-Hydroxybenzaldehyde

Twenty-four 1,2-diarylbenzimidazole derivatives were designed, synthesized and biologically evaluated. It turned out that most of them were potential anticancer drugs. Among them, compound c24 showed the highest anti-tumor activity (GI(50) = 0.71-2.41 mu M against HeLa, HepG2, A549 and MCF-7 cells), and low toxicity to normal cells (CC50 > 100 mu M against L02 cells). In the microtubule binding assay, c24 showed the most potent inhibition of microtubule polymerization (IC50 = 8.47 mu M). The binding ability of compound c24 to tubulin crystal was verified by molecular docking simulation experiment. Further studies on HepG2 and HeLa cells showed that compound c24 could cause mitotic arrest of tumor cells to G2/M phase then inducing apoptosis. To sum up, compound c24 is a promising microtubule assembly inhibitor.

Recommanded Product: 3-Hydroxybenzaldehyde. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Camarena-Pozos, DA; Flores-Nunez, VM; Lopez, MG; Partida-Martinez, LP in WILEY published article about in [Camarena-Pozos, D. A.; Flores-Nunez, V. M.; Partida-Martinez, L. P.] Ctr Invest & Estudios Avanzados, Dept Ingn Genet, Irapuato 36824, Mexico; [Lopez, M. G.] Ctr Invest & Estudios Avanzados, Dept Biotecnol & Bioquim, Irapuato 36824, Mexico in 2021.0, Cited 76.0. HPLC of Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

Fungi represent a group of eukaryotic microorganisms that are an important part of the plant microbiome. They produce a vast array of metabolites, including fungal volatile organic compounds (fVOCs). However, the diversity and biological activities of fVOCs emitted by the mycobiota of plants native to arid and semi-arid environments remain under-explored. We characterized the chemical diversity of fVOCs produced by 22 representative members of the microbiome of agaves and cacti using SPME-GC-MS. We further tested the effects of pure compounds on the growth and development of Arabidopsis thaliana and host plants. Members of the Sordariomycetes (nine strains), Eurotiomycetes (three), Dothideomycetes (eight), Saccharomycetes (one) and Mucoromycetes (one) were included in our study. We identified 94 fungal organic volatiles classified into nine chemical classes. Terpenes showed the greatest chemical diversity, followed by alcohols and aliphatic compounds. We discovered that camphene and benzyl benzoate, together with the widely distributed and already tested benzyl alcohol, 2-phenylethyl alcohol and 3-methyl-1-butanol, improved plant growth and development of A. thaliana, Agave tequilana and Agave salmiana. Our studies on the fungal VOCs from desert plants underscore an untapped chemical diversity with promising biotechnological applications.

HPLC of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Camarena-Pozos, DA; Flores-Nunez, VM; Lopez, MG; Partida-Martinez, LP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 FLAVOUR FRAG J published article about ARABICA COFFEE; VOLATILE COMPOUNDS; AROMA; IMPACT; COMPONENTS; PROFILE; COCOA in [Kim, Su-Jin; Lee, Sul; Bang, Eunjung; Lee, Sunho; Na, Yun-Cheol] Korea Basic Sci Inst, Western Seoul Ctr, 150 Bugahyeon Ro, Seoul 03759, South Korea; [Kim, Su-Jin; Lee, Sunho; Rhee, Jin-Kyu] Ewha Womans Univ, Dept Food Sci & Engn, 52 Ewhayeodae Gil, Seoul 03760, South Korea; [Lee, Sul; Na, Yun-Cheol] Ewha Womans Univ, Dept Chem & Nano Sci, 52 Ewhayeodae Gil, Seoul 03760, South Korea in 2019.0, Cited 36.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Recommanded Product: Benzyl Alcohol

Specific fermentation processes such as digestive bioprocessing and monsooning have been of interest to coffee consumers. Volatile compounds of beans during the different fermentation processes vary considerably and exhibit different profiles. The representative flavor compounds for the luwak green bean were found to be pentamethyl heptane and 3-methyl-1-butanol, while more diverse and distinct compounds were observed from the monsooned green bean, namely alkyl butanals, pinenes, benzaldehyde and butanediols. However, after roasting, the fermented form of both beans contained similar types of volatiles and their relative contents compared to those of non-fermented roasted beans, except for alpha-pinene in luwak and 2-methyl furan in monsooned beans. In principal components analysis and partial least squares-discriminant analysis (PLS-DA), the different fermented beans were clearly distinguished by the extracted peak entities from their total ion chromatograms. The s-plot and variable importance on projection (VIP) values related to PLS-DA showed the significant compounds contributing to the identification of the groups. 3-Methyl-1-butanol was the most distinctive compound for the luwak green bean, and beta-pinene, ethylbenzene and benzaldehyde were found to be the significant compounds in the monsooned green bean. In roasted beans, the most significant compounds to distinguish luwak were furfural, alpha-pinene and 3-carene with high variable in the projection (VIP) values. A significant presence of pyrazine, alkyl pyrazines, pyridine and alkyl pyridines contributed to differentiating both fermented roasted coffee beans from the unfermented roasted beans.

Recommanded Product: Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Kim, SJ; Lee, S; Bang, E; Lee, S; Rhee, JK; Na, YC or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Choo, HJ; Ahn, JH in [Choo, Hye Jeong; Ahn, Joong-Hoon] Konkuk Univ, Bio Mol Informat Ctr, Dept Biosci & Biotechnol, Seoul 05029, South Korea published Synthesis of Three Bioactive Aromatic Compounds by Introducing Polyketide Synthase Genes into Engineered Escherichia coli in 2019, Cited 31. Recommanded Product: 86-95-3. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

Intermediates in aromatic amino acid biosynthesis can serve as substrates for the synthesis of bioactive compounds. In this study we used two intermediates in the shikimate pathway of Escherichia coli, chorismate and anthranilate, to synthesize three bioactive compounds: 4-hydroxycoumarin (4-HC), 2,4-dihydroxyquinoline (DHQ), and 4-hydroxy-1-methyl-2(1H)-quinolone (NMQ). We introduced genes for the synthesis of salicylic acid from chorismate to supply the substrate for 4-HC and the gene encoding N-methyltransferase for the synthesis of N-methylanthranilate from anthranilate. Polyketide synthases and coenzyme (Co)A ligases were tested to determine the optimal combination of genes for the synthesis of each compound. We also tested several constructs and identified the best one for increasing levels of endogenous substrates for chorismate, anthranilate, and malonyl-CoA. With the use of these strategies, 255.4 mg/L 4-HC, 753.7 mg/L DHQ, and 17.5 mg/L NMQwere synthesized. This work provides a basis for the synthesis of diverse coumarin and quinoline derivatives with potential medical applications.

About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Choo, HJ; Ahn, JH or concate me.. Recommanded Product: 86-95-3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Total synthesis and stereochemical revision of relgro and 10 ‘-oxorelgro WOS:000482917600021 published article about HYDROLYTIC KINETIC RESOLUTION; BETA-RESORCYLIC MACROLIDE; BIOLOGICAL EVALUATION; ACID LACTONES; HSP90; TRANSFORMATION; RADICICOL; KINASE in [Gaddam, Janardhan; Reddy, G. Sudhakar; Mohapatra, Debendra K.] Indian Inst Chem Technol, CSIR, Dept Organ Synth & Proc Chem, Hyderabad 500007, Andhra Pradesh, India; [Gaddam, Janardhan; Reddy, G. Sudhakar; Mohapatra, Debendra K.] Acad Sci & Innovat Res AcSIR, New Delhi 110025, India; [Marumudi, Kanakaraju; Kunwar, Ajit C.] Indian Inst Chem Technol, CSIR, Ctr NMR & Struct Chem, Hyderabad 500007, Andhra Pradesh, India; [Yadav, Jhillu S.] Indrashil Univ, Sch Sci, Kadi 382740, Gujarat, India in 2019.0, Cited 57.0. Category: indole-building-block. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

The first asymmetric total synthesis and stereochemical assignments of 10-membered macrolactones relgro and 10 ‘-oxorelgro are disclosed. To this end, palladium-catalyzed Stille coupling, the Mitsunobu reaction, ring-closing metathesis, EDCI promoted coupling and the Jacobsen hydrolytic kinetic resolution are used as key steps. The total synthesis followed by thorough evaluation of the optical rotation and CD spectral data led to the revision of the absolute configuration at C-6 ‘ for both relgro and 10 ‘-oxorelgro. Moreover, the H-1 as well as C-13 NMR data are reported for the first time for relgro.

Category: indole-building-block. Welcome to talk about 100-51-6, If you have any questions, you can contact Gaddam, J; Reddy, GS; Marumudi, K; Kunwar, AC; Yadav, JS; Mohapatra, DK or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 FITOTERAPIA published article about ROOTS in [Kutluay, Vahap Murat; Saracoglu, Iclal] Hacettepe Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey; [Ishiuchi, Kan’ichiro; Makino, Toshiaki] Nagoya City Univ, Grad Sch Pharmaceut Sci, Dept Pharmacognosy, Nagoya, Aichi 4678603, Japan in 2019.0, Cited 25.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. COA of Formula: C8H8O2

The phytochemical studies on the aerial parts of Digitalis davisiana Heywood led to the isolation of three undescribed phenylethanoid glycosides named as digidavisoside A (5), digidavisoside B (7), and davisoside (8), along with 9 known compounds, ferruginoside B (1), isolugrandoside (2), lugrandoside (3), maxoside (4), 3 ””-O-methylmaxoside (6), trans-lamiuside E (9), digiciliside B (10), p-hydroxyacetophenone (11), and chrysoeriol (12). For the first time compound 11 was reported for Digitalis genus. The chemotaxonomical significance of these compounds in Plantaginaceae family was evaluated and 3′-O-glucosyl substituted phenylethanoid glycosides 4-8 and 10 were found to be chemotaxonomically important for the family. Cytotoxic activity of the aqueous fraction of the methanolic extract was also tested against HEp-2 (human larynx epidermoid carcinoma) and HepG2 (human hepatocellular carcinoma) cancer cell lines. The aqueous fraction showed stronger cytotoxicity on HEp-2 cells than on HepG2. Therefore, the cytotoxic activity of 1-4, 6, 7 and 9 were tested against HEp-2 and L929 (mouse fibroblast cell) cell lines. Other isolated compounds could not be tested due to their insufficient amount. The results were evaluated in the point of structure-activity relationships. IC50 values against HEp-2 cells were established in a range of 71.9-220 mu M. Maxoside (4), isolugrandoside (2) and lugrandoside (3) showed higher cytotoxicity against HEp.2 cell line than other isolated compounds.

Welcome to talk about 99-93-4, If you have any questions, you can contact Kutluay, VM; Ishiuchi, K; Makino, T; Saracoglu, I or send Email.. COA of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. Authors Mansour, HS; Abd El-wahab, HAA; Ali, AM; Aboul-Fadl, T in ROYAL SOC CHEMISTRY published article about in [Mansour, Hany S.; Abd El-wahab, Hend A. A.; Ali, Ahmed M.; Aboul-Fadl, Tarek] Assiut Univ, Dept Med Chem, Fac Pharm, Assiut, Egypt in 2021.0, Cited 39.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The structure-based design of some CDK2 inhibitors with a 3-(benzylidene)indolin-2-one scaffold as potential anticancer agents was realized. Target compounds were obtained as E/Z mixtures and were resolved to corresponding E- and Z-diastereomers. In silico studies using MOE 2019.01 software revealed better docking on the targeted enzyme for the Z-diastereomer compared to the E-one. A time-dependent kinetic isomerization study was carried out for the inversion of E/Z diastereomers in DMSO-d(6) at room temperature, and were found to obey the first order kinetic reactions. Furthermore, a determination of the kinetic inter-conversion rate order by graphical analysis method and calculation of the rate constant and half-life of this kinetic process were carried out. For the prediction of the stability of the diastereomer(s), a good multiple regression equation was generated between the reaction rates of isomerization and some QM parameters with significant p value.

Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Discrimination of Platycodon grandiflorum and Codonopsis lanceolata using gas chromatography-mass spectrometry-based metabolomics approach WOS:000449443900067 published article about BETA-ELEMENE; IDENTIFICATION; CELLS; PENICILLAMINE; APOPTOSIS; LEUKEMIA; ARREST; ROOTS; AROMA; RICE in [Park, Hyeon-Yong; Boo, Hee-Ock] Chosun Univ, Dept Life Sci, Gwangju 61452, South Korea; [Shin, Jeoung-Hwa] Korea Basic Sci Inst, Seoul Ctr, Seoul 02855, South Korea; [Gorinstein, Shela] Hebrew Univ Jerusalem, Hadassah Med Sch, Sch Pharm, Inst Drug Res, IL-91120 Jerusalem, Israel; [Ahn, Yun Gyong] Korea Basic Sci Inst, Western Seoul Ctr, Seoul 03760, South Korea in 2019, Cited 27. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. COA of Formula: C7H8O

Species of herbaceous flowering perennial plant of the family Campanulaceae such as Platycodon grandiflorum (P. grandiflorum) and Codonopsis lanceolata (C. lanceolata) widely used in traditional medicine to treat different diseases. In spite of different medicinal results after consumption of the plants, it is hard to distinguish between two of them, because of their similar morphological characteristics. In this study, a gas chromatography-mass spectrometry (GC-MS) – based metabolite profiling approach was performed and examined to discriminate tuberous roots of P. grandiflorum and C. lanceolate for medicinal purposes. Two basic approaches for sample preparation, headspace solid-phase microextraction (HS-SPME) and solvent extraction were adopted. Multivariate statistical techniques, such as orthogonal partial least-squares discriminant analysis (OPLS-DA) plots showed significant differences between P. grandiflorum and C. lanceolata for polar primary and volatile organic metabolites. A number of potential candidates were suggested as the chemomarkers for discrimination of two plants.

COA of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Park, HY; Shin, JH; Boo, HO; Gorinstein, S; Ahn, YG or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles