Month: January 2022

An article Targeting Mechanoresponsive Proteins in Pancreatic Cancer: 4-Hydroxyacetophenone Blocks Dissemination and Invasion by Activating MYH14 WOS:000487699000013 published article about MYOSIN-II; CELL MECHANICS; EXPRESSION; CYTOKINESIS; METASTASIS; CARCINOMA; FILAMIN; ACTININ-4; STIFFNESS; PATHWAYS in [Surcel, Alexandra; Schiffhauer, Eric S.; Thomas, Dustin G.; DiNapoli, Kathleen T.; West-Foyle, Hoku; Iglesias, Pablo A.; Robinson, Douglas N.] Johns Hopkins Univ, Sch Med, Dept Cell Biol, Baltimore, MD USA; [Zhu, Qingfeng; Anders, Robert A.] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA; [DiNapoli, Kathleen T.; Iglesias, Pablo A.] Johns Hopkins Univ, Dept Elect & Comp Engn, Whiting Sch Engn, Baltimore, MD 21218 USA; [Herbig, Maik; Otto, Oliver; Jacobi, Angela; Kraeter, Martin; Plak, Katarzyna; Guck, Jochen] Tech Univ Dresden, Ctr Mol & Cellular Bioengineering, Biotechnol Ctr, Dresden, Germany; [Jaffee, Elizabeth M.] Johns Hopkins Univ, Sidney Kimmel Canc Ctr Johns Hopkins, Skip Viragh Pancreat Canc Ctr, Dept Oncol, Baltimore, MD USA; [Jaffee, Elizabeth M.] Johns Hopkins Univ, Bloomberg Kimmel Inst, Baltimore, MD USA; [Robinson, Douglas N.] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA; [Robinson, Douglas N.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA; [Otto, Oliver] Ernst Moritz Arndt Univ Greifswald, Ctr Innovat Competence, Humoral Immune React Cardiovasc Dis Biomech, Greifswald, Germany in 2019.0, Cited 65.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Quality Control of 4′-Hydroxyacetophenone

Metastasis is complex, involving multiple genetic, epigenetic, biochemical, and physical changes in the cancer cell and its microenvironment. Cells with metastatic potential are often characterized by altered cellular contractility and deformability, lending them the flexibility to disseminate and navigate through different microenvironments. We demonstrate that mechanoresponsiveness is a hallmark of pancreatic cancer cells. Key mechanoresponsive proteins, those that accumulate in response to mechanical stress, specifically nonmuscle myosin IIA (MYH9) and IIC (MYH14), alpha-actinin 4, and filamin B, were highly expressed in pancreatic cancer as compared with healthy ductal epithelia. Their less responsive sister paralogs-myosin IIB (MYH10), alpha-actinin 1, and filamin A-had lower expression differential or disappeared with cancer progression. We demonstrate that proteins whose cellular contributions are often overlooked because of their low abundance can have profound impact on cell architecture, behavior, and mechanics. Here, the low abundant protein MYH14 promoted metastatic behavior and could be exploited with 4-hydroxyacetophenone (4-HAP), which increased MYH14 assembly, stiffening cells. As a result, 4-HAP decreased dissemination, induced cortical actin belts in spheroids, and slowed retrograde actin flow. 4-HAP also reduced liver metastases in human pancreatic cancer-bearing nude mice. Thus, increasing MYH14 assembly overwhelms the ability of cells to polarize and invade, suggesting targeting the mechanoresponsive proteins of the actin cytoskeleton as a new strategy to improve the survival of patients with pancreatic cancer. Significance: This study demonstrates that mechanoresponsive proteins become upregulated with pancreatic cancer progression and that this system of proteins can be pharmacologically targeted to inhibit the metastatic potential of pancreatic cancer cells.

Quality Control of 4′-Hydroxyacetophenone. Welcome to talk about 99-93-4, If you have any questions, you can contact Surcel, A; Schiffhauer, ES; Thomas, DG; Zhu, QF; DiNapoli, KT; Herbig, M; Otto, O; West-Foyle, H; Jacobi, A; Krater, M; Plak, K; Guck, J; Jaffee, EM; Iglesias, PA; Anders, RA; Robinson, DN or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Backlund, CM; Parhamifar, L; Minter, L; Tew, GN; Andresen, TL in [Backlund, Coralie M.; Tew, Gregory N.] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA; [Minter, Lisa; Tew, Gregory N.] Univ Massachusetts, Dept Mol & Cellular Biol, Amherst, MA 01003 USA; [Minter, Lisa; Tew, Gregory N.] Univ Massachusetts, Dept Vet & Anim Sci, Amherst, MA 01003 USA; [Parhamifar, Ladan; Andresen, Thomas L.] Tech Univ Denmark, Dept Hlth Technol, DK-2800 Lyngby, Denmark published Protein Transduction Domain Mimics Facilitate Rapid Antigen Delivery into Monocytes in 2019.0, Cited 37.0. Product Details of 100-51-6. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Delivering peptides and proteins with intracellular function represents a promising avenue for therapeutics, but remains a challenge due to the selective permeability of the plasma membrane. The successful delivery of cytosolically active proteins would enable many opportunities, including improved vaccine development through major histocompatibility complex (MHC) class I antigen display. Extended research using cell-penetrating peptides (CPPs) has aimed to facilitate intracellular delivery of exogenous proteins with some success. A new class of polymer-based mimics termed protein transduction domain mimics (PTDMs), which maintain the positive charge and amphiphilic nature displayed by many CPPs, was developed using a poly-norbornene-based backbone. Herein, we use a previously characterized PTDM to investigate delivery of the model antigen SIINFEKL into leukocytes. Peptide delivery into over 90% of CD14+ monocytes was detected in less than 15 min with nominal inflammatory cytokine response and high cell viability. The co-delivery of a TLR9 agonist and antigen using the PTDM into antigen presenting cells in vitro showed presentation of SIINFEKL in association with MHC class I molecules, in addition to upregulation of classical differentiation markers revealing the ability of the PTDM to successfully deliver cargo intracellularly and show application in the field of immunotherapy.

Welcome to talk about 100-51-6, If you have any questions, you can contact Backlund, CM; Parhamifar, L; Minter, L; Tew, GN; Andresen, TL or send Email.. Product Details of 100-51-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about DIVALENT LANTHANIDE DERIVATIVES; RADICAL CYCLIZATION CASCADES; ELECTRON-TRANSFER REDUCTION; SAMARIUM DIIODIDE; CARBONYL-COMPOUNDS; ORGANIC-SYNTHESIS; SMI2 REACTIONS; PROTON DONORS; SOLID-STATE; KETONES, Saw an article supported by the National Science FoundationNational Science Foundation (NSF) [CHE 1565741]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Maity, S; Flowers, RA. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol. HPLC of Formula: C7H8O

Samarium diiodide (SmI2) is one of the most widely used single electron reductants available to organic chemists because it is effective in reducing and coupling a wide range of functional groups. Despite the broad utility and application of SmI2 in synthesis, the reagent is used in stoichiometric amounts and has a high molecular weight, resulting in a large amount of material being used for reactions requiring one or more equivalents of electrons. few approaches to develop catalytic reactions have been designed, they are not widely used or require specialized conditions. As a consequence, general solutions to develop catalytic reactions of Sm(II) remain elusive. Herein, we report mechanistic studies on catalytic reactions of Sm(II) employing a terminal magnesium reductant and trimethylsilyl chloride in concert with a non coordinating proton donor source. Reactions using this approach permitted reductions with as little as 1 mol % Sm. Mechanistic studies provide strong evidence that during the reaction, SmI2 transforms into SmCl2, therefore broadening the scope of accessible reactions. Furthermore, this mechanistic approach enabled catalysis employing HMPA as a ligand, facilitating the development of catalytic Sm(II) 5-exo-trig ketyl olefin cyclization reactions. The initial work described herein will enable further development of both useful and user-friendly catalytic reactions, a long-standing, but elusive goal in Sm(II) chemistry.

HPLC of Formula: C7H8O. Bye, fridends, I hope you can learn more about C7H8O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Silica-supported heterogeneous catalysts-mediated synthesis of chalcones as potent urease inhibitors: in vitro and molecular docking studies WOS:000505350200003 published article about ALPHA,BETA-UNSATURATED KETONES; DERIVATIVES; ANALOGS in [Sultan, Aeysha; Mehr-un-Nisa; Rehman, Mian Habib Ur] Univ Educ, Dept Chem, Faisalabad Campus, Faisalabad, Pakistan; [Shajahan, Shanavas] Periyar Univ, Dept Phys, Nano & Hybrid Mat Lab, Salem 636011, India; [Ahamad, Tansir; Alshehri, Saad M.] King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia; [Sajjad, Noreen] Univ Lahore, Dept Chem, Lahore, Pakistan; [Torun, Lokman] Yilditz Univ Engn & Technol, Dept Chem, Istanbul, Turkey; [Khalid, Muhammad] Khawaja Ghulam Fareed Univ Engn & Technol, Dept Chem, Rahim Yar Khan, Pakistan; [Acevedo, Roberto] Univ San Sebastian, Fac Ingn & Tecnol, Bellavista 7, Santiago 420524, Chile in 2020.0, Cited 43.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Recommanded Product: 4′-Hydroxyacetophenone

We herein report a facile and high yielding protocol for silica-supported heterogeneous catalysts-mediated synthesis of chalcones. A comparison of results of our synthesis with conventional synthetic protocols is also being offered to assess the efficiency of the prepared catalysts. Biological evaluation of the newly synthesized compounds as urease inhibitors was performed. Most of the compounds were found to have potent urease inhibition activity. The chalcone 3-(3-hydroxyphenyl)-1-phenylpropenone was found to be the most potent with percentage inhibition 86.17 +/- 0.89 and half maximal inhibitory concentration (IC50) value 11.51 +/- 0.03 mu M. The molecular docking study emphasized that the same congeners 3-(furan-2-yl)-1-(4-hydroxyphenyl)propenone, 3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)propanone, and 3-[4-(dimethylamino)phenyl]-1-(p-tolyl)propenone showed very good inhibitory potential against urease and show a higher docking scores 5718, 5940, 5596 and an ACE of – 246.66, – 244.79, and – 243.06 kJ/mol, respectively than the control ligand.

Welcome to talk about 99-93-4, If you have any questions, you can contact Sultan, A; Shajahan, S; Ahamad, T; Alshehri, SM; Sajjad, N; Mehr-un-Nisa; Rehman, MHU; Torun, L; Khalid, M; Acevedo, R or send Email.. Recommanded Product: 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis, Evaluation of Biological Activity, Docking and Molecular Dynamic Studies of Pyrimidine Derivatives WOS:000631153800007 published article about ANTICANCER AGENTS; INHIBITORS; CELECOXIB; DESIGN in [Boumi, Shahin; Moghimirad, Jafar; Amanlou, Massoud; Amini, Mohsen] Univ Tehran Med Sci, Inst Pharmaceut Sci TIPS, Drug Design & Dev Res Ctr, Dept Med Chem,Fac Pharm, Tehran, Iran; [Ostad, Seyed Nasser; Tavajohi, Shohreh] Univ Tehran Med Sci, Fac Pharm, Dept Toxicol & Pharmacol, Tehran, Iran; [Ostad, Seyed Nasser; Tavajohi, Shohreh] Univ Tehran Med Sci, Poisoning Res Ctr, Tehran, Iran in 2021, Cited 18. Safety of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The microtubule is composed of alpha beta-tubulin heterodimers and is an attractive target for the design of anticancer drugs. Over the years, various compounds have been developed and their effect on tubulin polymerization has been studied. Despite great efforts to make an effective drug, no drug has been introduced which inhibit colchicine binding site. In the current work, a series of pyrimidine derivatives were designed and synthesized. Furthermore, their cytotoxic activities were evaluated and molecular docking studies were performed. Twenty compounds of pyrimidine were synthesized in 2 different groups. In the first group, 4,6-diaryl pyrimidine was connected to the third aryl group via thiomethylene spacer. In the second group, this linker was substituted by S-CH2-triazole moiety. The cytotoxic activity of these compounds was evaluated against 4 different cell lines (HT-29, MCF-7, T47D, NIH3T3). Compounds 6d, 6m, 6p showed potent cytotoxic activity against MCF7 cancerous cell lines. Between these compounds, compound 6p did not show cytotoxic activity against NIH- 3T3 (normal cell) cell line. Docking studies show that these compounds occupy colchicine binding site in tubulin protein and probably their anticancer mechanism is inhibition of tubulin polymerization. Altogether, with respect to obtained results, it is attractive and beneficial to further investigation on pyrimidine scaffold as antimitotic agents. Attention to the selectivity index of 6p on MCF7 cell line could be valuable in design new chemical agents for the treatment of breast cancer.

Welcome to talk about 123-11-5, If you have any questions, you can contact Boumi, S; Moghimirad, J; Amanlou, M; Ostad, SN; Tavajohi, S; Amini, M or send Email.. Safety of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H5F3O. Authors Kutt, A; Tshepelevitsh, S; Saame, J; Lokov, M; Kaljurand, I; Selberg, S; Leito, I in WILEY-V C H VERLAG GMBH published article about in [Kutt, Agnes; Tshepelevitsh, Sofja; Saame, Jaan; Lokov, Mart; Kaljurand, Ivari; Selberg, Sigrid; Leito, Ivo] Univ Tartu, Inst Chem, Ravila 14a, EE-50411 Tartu, Estonia in 2021, Cited 77. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

The equilibrium acidity scale (pK(a) scale) in acetonitrile has been supplemented by numerous new compounds and new Delta pK(a) measurements. It now contains altogether 231 acids – over twice more than published previously – linked by 569 Delta pK(a) measurements and spans between the pK(a) values of hydrogen iodide (2.8) and indole (32.57), covering close to 30 orders of magnitude. Measurement results acquired over the last 15 years were added to the scale and new least-squares treatment was carried out. The treatment yielded revised pK(a) values for the compounds published previously, with the root mean square difference between revised and previous values 0.04, demonstrating very good stability of the scale. Correlation equations were developed for estimating pK(a) values for the studied types of compounds in water, DMSO, DMF, and 1,2-dichloroethane on the basis of pK(a) values in acetonitrile. These equations enable predicting pK(a) values with an average error around or less than 1 pK(a) unit, which is a sufficient accuracy for many applications. The scale is expected to be a useful tool for the widest possible research areas in organic chemistry, electrochemical power sources, catalysis, etc.

Welcome to talk about 98-17-9, If you have any questions, you can contact Kutt, A; Tshepelevitsh, S; Saame, J; Lokov, M; Kaljurand, I; Selberg, S; Leito, I or send Email.. COA of Formula: C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 4-Hydroxyquinolin-2(1H)-one. Authors Chheda, PR; Kummer, DA; Nishimura, RT; McClure, KJ; Venkatesan, H in AMER CHEMICAL SOC published article about in [Kummer, David A.] Lundbeck La Jolla Res Ctr Inc, San Diego, CA 92121 USA; [Chheda, Pratik R.; Nishimura, Rachel T.; McClure, Kelly J.; Venkatesan, Hariharan] Janssen Res & Dev, Discovery Chem, San Diego, CA 92121 USA in 2021, Cited 63. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

A one-pot, Hantzsch ester-mediated Knoevenagel condensation-reduction reaction has been developed for alkylation of a wide range of substituted 2,4-quinoline diols and 2,4-pyridine diols with aldehydes. The process is operationally simple to perform, scalable, and provides highly useful C-3 alkylated quinoline and pyridine diols in yields of 58-92%. The alkylation products can be converted to 2,4-dihaloquinoline and pyridine substrates for further functionalization.

Welcome to talk about 86-95-3, If you have any questions, you can contact Chheda, PR; Kummer, DA; Nishimura, RT; McClure, KJ; Venkatesan, H or send Email.. Quality Control of 4-Hydroxyquinolin-2(1H)-one

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 3-(Trifluoromethyl)phenol. In 2021 ANGEW CHEM INT EDIT published article about ASYMMETRIC CATALYSIS; BINOL; DERIVATIVES; 2-NAPHTHOL; ACTIVATION; LIGANDS; ACID in [Zhao, Xiao-Jing; Li, Zi-Hao; Ding, Tong-Mei; Tian, Jin-Miao; Tu, Yong-Qiang; Wang, Ai-Fang; Xie, Yu-Yang] Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China; [Tu, Yong-Qiang] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Tu, Yong-Qiang] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China in 2021, Cited 70. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

A challenging direct asymmetric catalytic aerobic oxidative cross-coupling of 2-naphthylamine and 2-naphthol, using a novel Cu-I/SPDO system, has been successfully developed for the first time. Enantioenriched 3,3 ‘-disubstituted NOBINs were achieved and could be readily derived to divergent chiral ligands and catalysts. This reaction features high enantioselectivities (up to 96 % ee) and good yields (up to 80 %). The DFT calculations suggest that the F-H interactions between CF3 of L17 and H-1,8 of 2-naphthol, and the pi-pi stacking between the two coupling partners could play vital roles in the enantiocontrol of this cross-coupling reaction.

Safety of 3-(Trifluoromethyl)phenol. Welcome to talk about 98-17-9, If you have any questions, you can contact Zhao, XJ; Li, ZH; Ding, TM; Tian, JM; Tu, YQ; Wang, AF; Xie, YY or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Design synthesis and cytotoxicity studies of some novel indomethacin-based heterocycles as anticancer and apoptosis inducing agents WOS:000609160500010 published article about ANTIINFLAMMATORY DRUG INDOMETHACIN; IN-VITRO; COLON-CANCER; BIOLOGICAL EVALUATION; DIETARY ANTIOXIDANT; CELL-DEATH; INHIBITION; PROLIFERATION; CARCINOMA; DELPHINIDIN in [Harras, Marwa F.; Sabour, Rehab; Farrag, Amel M.; Eissa, Sally I.] Al Azhar Univ, Fac Pharm Girls, Dept Pharmaceut Chem, Cairo, Egypt; [Ammar, Yousry A.] Al Azhar Univ, Fac Sci Boys, Dept Organ Chem, Cairo, Egypt; [Mehany, Ahmed B. M.] Al Azhar Univ, Fac Sci Boys, Dept Zool, Cairo, Egypt; [Eissa, Sally I.] Almaarefa Univ, Coll Pharm, Riyadh, Saudi Arabia in 2021, Cited 48. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Name: 4-Methoxybenzaldehyde

Indomethacin is a well-known nonsteroidal anti-inflammatory drug that has cytotoxic activity. In this study, a new series of structurally related indomethacin analogues was synthesized using simple chemical approaches, and their cytotoxic effects against five different human cancer cell lines (colon cancer cell lines HCT-116, HT-29 and Caco-2, hepatic cell line HepG-2 and breast cell line MCF-7) were evaluated. Most of the tested compounds displayed potent anti-cancer activity, especially against the three colon cancer cell lines. Among all tested derivatives, compound 12 demonstrated the most potent cytotoxic activity compared to the parent drug indomethacin and the reference compound 5-fluorouracil, with IC 50 values ranging 0.83-1.54 mu M. A mechanistic study of the most active compound against the HCT-116, HT-29 and Caco-2 cell lines revealed cell cycle arrest during the G2/M phase. Compound 12 was found to induce apoptosis through the up-regulation of Bax and p53 by 7.4 and 8.5-fold, respectively, and also the downregulation of Bcl-2 by 3.2-fold compared to the control. Western blot assay was performed on HCT-116 cells and demonstrated marked inhibition of CDK1 and Bcl-2 expression together with an increase in the expression of caspase-3, Bax and p53 in a concentration-dependent manner. Finally, a prediction of the chemo-informatic properties of compounds 11 and 12 indicated that they are orally bioavailable with no permeation of the blood-brain barrier. (C) 2020 Elsevier B.V. All rights reserved.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Harras, MF; Sabour, R; Ammar, YA; Mehany, ABM; Farrag, AM; Eissa, SI or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Laskar, K; Paul, S; Bora, U in PERGAMON-ELSEVIER SCIENCE LTD published article about EFFICIENT HETEROGENEOUS CATALYST; OXIDATIVE HYDROXYLATION; ANTIOXIDANT ACTIVITY; PHENOLIC-COMPOUNDS; GREEN; NANOPARTICLES; METAL; MILD; CONVERSION; SOLVENTS in [Laskar, Khairujjaman; Paul, Subham; Bora, Utpal] Tezpur Univ, Dept Chem Sci, Napaam 784028, Assam, India in 2019, Cited 43. Recommanded Product: 98-17-9. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

Cellulose catalyzed oxidative hydroxylation of aryl and hetero-arylboronic acids to the corresponding phenols under metal and base free strategy has been demonstrated. The sustainable ipso-hydroxylation takes place using hydrogen peroxide as an oxidant in water under mild condition in shorter period of time. Interestingly, easy recovery and reusability of heterogeneous catalyst without significant loss in catalytic yield makes the protocol environmentally benign. (C) 2019 Elsevier Ltd. All rights reserved.

Recommanded Product: 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Laskar, K; Paul, S; Bora, U or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles