Month: January 2022

SDS of cas: 86-95-3. Authors Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S in SAGE PUBLICATIONS LTD published article about in [Aly, Ashraf A.; Hassan, Alaa A.; Mohamed, Nasr K.; Abd El-Haleem, Lamiaa E.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Brase, Stefan] Karlsruhe Inst Technol, Inst Biol & Chem Syst Funct Mol Syst IBCS FMS, Eggenstein Leopoldshafen, Germany in 2020, Cited 13. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

A novel series of 7,8-dichlorobenzofuro[3,2-c]quinoline-6,9,10(5H)-triones was obtained regioselectively in good yields. The products were formed by the reactions of the 4-hydroxy-2(1H)-quinolinones with 3,4,5,6-tetrachloro-1,2-benzoquinone in tetrahydrofuran as the solvent. Infrared, nuclear magnetic resonance (two-dimensional nuclear magnetic resonance), mass spectra and elemental analysis were used to elucidate the structures of new compounds.

SDS of cas: 86-95-3. Welcome to talk about 86-95-3, If you have any questions, you can contact Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 86-95-3. Aly, AA; El-Sheref, EM; Bakheet, MEM; Mourad, MAE; Brase, S; Ibrahim, MAA; Nieger, M; Garvalov, BK; Dalby, KN; Kaoud, TS in [Aly, Ashraf A.; El-Sheref, Essmat M.; Bakheet, Momtaz E. M.; Ibrahim, Mahmoud A. A.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Mourad, Mai A. E.] Port Said Univ, Med Chem Dept, Fac Pharm, Port Said 42526, Egypt; [Kaoud, Tamer S.] Menia Univ, Fac Pharm, Dept Med Chem, El Minia 61519, Egypt; [Brase, Stefan] Karlsruhe Inst Technol, Inst Toxikol & Genet, Hermann von Helmholts Pl 1,Campus Nord, D-76344 Eggenstein Leopoldsha, Germany; [Brase, Stefan] Inst Toxikol & Genet, Hermann von Helmholts Pl 1,Campus Nord, D-76344 Eggenstein Leopoldsha, Germany; [Nieger, Martin] Univ Helsinki, Dept Chem, POB 55, Helsinki 00014, Finland; [Garvalov, Boyan K.] Mannhe Univ Heidelberg, Ctr Biomed & Med Technol Mannheim, Med Fac, D-68167 Mannheim, Germany; [Dalby, Kevin N.; Kaoud, Tamer S.] Univ Texas Austin, Div Chem Biol & Med Chem, Austin, TX 78712 USA published Design, synthesis and biological evaluation of fused naphthofuro[3,2-c]quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma in 2019, Cited 57. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

Approximately 60% of human cancers exhibit enhanced activity of ERK1 and ERK2, reflecting their multiple roles in tumor initiation and progression. Acquired drug resistance, especially mechanisms associated with the reactivation of the MAPK (RAF/MEK/ERK) pathway represent a major challenge to current treatments of melanoma and several other cancers. Recently, targeting ERK has evolved as a potentially attractive strategy to overcome this resistance. Herein, we report the design and synthesis of novel series of fused naphthofuro[3,2-c] quinoline-6,7,12-triones 3a-f and pyrano[3,2-c]quinoline-6,7,8,13-tetraones 5a,b and 6, as potential ERK inhibitors. New inhibitors were synthesized and identified by different spectroscopic techniques and X-ray crystallography. They were evaluated for their ability to inhibit ERK1/2 in an in vitro radioactive kinase assay. 3b and 6 inhibited ERK1 with IC50s of 0.5 and 0.19 mu M, and inhibited ERK2 with IC50s of 0.6 and 0.16 mu M respectively. Kinetic mechanism studies revealed that the inhibitors are ATP-competitive inhibitors where 6 inhibited ERK2 with a K-i of 0.09 mu M. Six of the new inhibitors were tested for their in vitro anticancer activity against the NCI-60 panel of tumor cell lines. Compound 3b and 6 were the most potent against most of the human tumor cell lines tested. Moreover, 3b and 6 inhibited the proliferation of the BRAF mutant A375 melanoma cells with IC50s of 3.7 and 0.13 mu M, respectively. In addition, they suppressed anchorage-dependent colony formation. Treatment of the A375 cell line with 3b and 6 inhibited the phosphorylation of ERK substrates p-90RSK and ELK-1 and induced apoptosis in a dose dependent manner. Finally, a molecular docking study showed the potential binding mode of 3b and 6 within the ATP catalytic binding site of ERK2.

Product Details of 86-95-3. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; El-Sheref, EM; Bakheet, MEM; Mourad, MAE; Brase, S; Ibrahim, MAA; Nieger, M; Garvalov, BK; Dalby, KN; Kaoud, TS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 86-95-3. In 2020 MONATSH CHEM published article about DERIVATIVES; INHIBITORS; FUROQUINOLINE; ALKALOIDS; MODEL in [Aly, Ashraf A.; Mohamed, Asmaa H.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Ishak, Esam] Al Azhar Univ, Fac Sci, Dept Chem, Assiut, Egypt; [Ishak, Esam] Jouf Univ, Coll Sci & Arts, Dept Chem, Alquurrayate, Saudi Arabia; [Shwaky, Ahmed M.] Umm Al Qura Univ, STU, Mecca, Saudi Arabia in 2020, Cited 31. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

Quinoline-2,4-diones reacted with 2-[bis(methylthio)methylene]malononitrile in DMF/Et3N to produce 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carbonitriles and 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carboxamides in state of 2-imino-substituted 4-(methylthio)-5,6-dihydro-2H-pyrano[3,2-c]quinolone-3-carbonitriles. The structures of all new products were proved using NMR, IR, and mass spectral data. The possible mechanism for the reaction is also discussed. Graphic abstract

SDS of cas: 86-95-3. Welcome to talk about 86-95-3, If you have any questions, you can contact Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Li, YX; Li, XQ; Li, XW; Shi, DY in ROYAL SOC CHEMISTRY published article about in [Li, Yuxiu; Li, Xiangqian; Li, Xiaowei; Shi, Dayong] Shandong Univ, State Key Lab Microbial Technol, 72 Binhai Rd, Qingdao 266237, Shandong, Peoples R China; [Li, Yuxiu; Li, Xiangqian; Li, Xiaowei; Shi, Dayong] Shandong Univ, Marine Biotechnol Res Ctr, 72 Binhai Rd, Qingdao 266237, Shandong, Peoples R China; [Shi, Dayong] Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, 168 Wenhai Rd, Qingdao 266237, Shandong, Peoples R China in 2021.0, Cited 60.0. Application In Synthesis of 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Regioselective synthesis of alpha-fluoro-beta-arylalkenyl sulfides has been established with gem-difluoroalkenes and sodium sulfinates in a transition-metal-free manner. A series of control experiments were executed to demonstrate thiol radicals and anions as the proposed intermediates. Notably, regioselective Z -> E isomerization was achieved under green light irradiation in the absence of a photoinitiator.

Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 4′-Hydroxyacetophenone. Recently I am researching about DERIVATIVES; CHALCONE; DESIGN; AMONAFIDE; DOCKING; INHIBITORS; APOPTOSIS; BINDING; BCL-2, Saw an article supported by the Department of Science and Technology (DST), New Delhi, India, under INSPIRE programmeDepartment of Science & Technology (India)Department of Science & Technology (DOST), Philippines [Shalini IF160180]; National Research Foundation South AfricaNational Research Foundation – South Africa [121276]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Shalini; Pankaj; Saha, ST; Kaur, M; Oluwakemi, E; Awolade, P; Singh, P; Kumar, V. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

A series of naphthalimide-chalcone/pyrazoline conjugates was prepared and evaluated for their anti-breast cancer potential against estrogen responsive, i.e. MCF-7 (ER+), and triple-negative, i.e. MDA-MB-231 (ER-), cell lines. The structure-activity-relationship (SAR) was deduced based on the influence of linker length, substituents on the phenyl ring and the generated functionalities, on anti-proliferative activities. Docking simulations further delineate the type of interactions of the designed molecules with the selected targets. This report discloses the scope of triazole tethered naphthalimide-chalcone/pyrazoline conjugates as anti breast cancer agents.

Welcome to talk about 99-93-4, If you have any questions, you can contact Shalini; Pankaj; Saha, ST; Kaur, M; Oluwakemi, E; Awolade, P; Singh, P; Kumar, V or send Email.. Application In Synthesis of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C8H8O2. In 2019.0 TETRAHEDRON LETT published article about ELECTRON-SPIN-RESONANCE; C-H FUNCTIONALIZATION; DERIVATIVES; BIOACTIVITY; OXIDATION; KETOXIMES; ANALOGS; DESIGN; AGENTS in [Han, Ziwei; Shen, Subo; Hu, Han; Zhang, Jianmin] Shanghai Univ, Coll Sci, Dept Chem, Shanghai 200444, Peoples R China; [Zheng, Feng] Shanghai Aerosp Chem Applicat Res Inst, Shanghai 201109, Peoples R China; [Zhang, Jianmin; Zhu, Shizheng] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China in 2019.0, Cited 40.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

An efficient Cu(II)-catalyzed radical addition of maleimides has been achieved. The identified copper catalyst enables the formation of oxime radicals (N-O-center dot) by cleaving the O-H bond in ketoximes, followed by the radical addition to N-substituted maleimides. The oxime radicals (N-O-center dot) were detected and confirmed by EPR spectroscopy and variable-temperature H-1 NMR. The simple one-pot reaction realizes the facile preparation of a variety of oxime ether adduct products in moderate to good yields. (C) 2019 Elsevier Ltd. All rights reserved.

COA of Formula: C8H8O2. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of m-Methoxyphenol. Authors Fereidoonnezhad, M; Tabaei, SMH; Sakhteman, A; Seradj, H; Faghih, Z; Faghih, Z; Mojaddami, A; Sadeghian, B; Rezaei, Z in ELSEVIER published article about in [Fereidoonnezhad, Masood; Mojaddami, Ayyub] Ahvaz Jundishapur Univ Med Sci, Sch Pharm, Dept Med Chem, Ahvaz, Iran; [Fereidoonnezhad, Masood; Tabaei, S. Mohammad Hossein; Sakhteman, Amirhossein; Seradj, Hassan; Faghih, Zeinab; Mojaddami, Ayyub; Sadeghian, Batool; Rezaei, Zahra] Shiraz Univ Med Sci, Dept Med Chem, Sch Pharm, Shiraz, Iran; [Fereidoonnezhad, Masood; Tabaei, S. Mohammad Hossein; Sakhteman, Amirhossein; Seradj, Hassan; Faghih, Zeinab; Mojaddami, Ayyub; Sadeghian, Batool; Rezaei, Zahra] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Sch Pharm, Shiraz, Iran; [Faghih, Zahra] Shiraz Univ Med Sci, Sch Med, Shiraz Inst Canc Res, Shiraz, Iran in 2020, Cited 38. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

Dichloroacetate (DCA) as a mitochondria-targeting small molecule, through inhibition of pyruvate dehydrogenase kinases (PDK1-4), promotes mitochondria-regulated apoptosis and hence, inhibits tumour growth and reduces its proliferation. In this study, a series of novel N-aryl-2,2-dichloroacetamide and aryl-2,2-dichloroacetate derivatives were designed and synthesized. Their cytotoxic activities against various human cancer cell lines including A549, HCA-7, MCF-7, MDA-MB-231, KB and SKOV3 were evaluated. These compounds showed satisfactory potencies with much higher anticancer activity than the parent compound DCA, against the studied cancer cell lines. Molecular docking studies were also done to find their binding site and types of their interactions with PDKs isoenzymes. Among the synthesized compounds, 2,2-dichloro-N-(9,10-dioxo-9,10-dihydroanthracen-1-yl)acetamide (f1) can also induce A549 cells apoptosis. Therefore, compound f1 might have a potential value for further study in drug development. QSAR studies of this class of compounds were also explored using a collection of chemometrics methods. (C) 2020 Published by Elsevier B.V.

Quality Control of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Fereidoonnezhad, M; Tabaei, SMH; Sakhteman, A; Seradj, H; Faghih, Z; Faghih, Z; Mojaddami, A; Sadeghian, B; Rezaei, Z or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Nandi, J; Hutcheson, EL; Leadbeater, NE in PERGAMON-ELSEVIER SCIENCE LTD published article about VISIBLE-LIGHT IRRADIATION; AEROBIC OXIDATION; SALT OXIDATIONS; ALDEHYDES; AMINES; TEMPO in [Nandi, Jyoti; Hutcheson, Ellen L.; Leadbeater, Nicholas E.] Univ Connecticut, Dept Chem, 55 North Eagleville Rd, Storrs, CT 06269 USA in 2021, Cited 32. Recommanded Product: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A methodology is reported for converting alcohols to the corresponding carboxylic acids. A dual catalytic system involving a merger of photoredox catalysis and 4-acetamido-TEMPO is employed to carry out this oxidation process. (C) 2020 Elsevier Ltd. All rights reserved.

Welcome to talk about 123-11-5, If you have any questions, you can contact Nandi, J; Hutcheson, EL; Leadbeater, NE or send Email.. Recommanded Product: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Rh-Catalyzed C-H Amination/Annulation of Acrylic Acids and Anthranils by Using -COOH as a Deciduous Directing Group: An Access to Diverse Quinolines published in 2020. Name: (E)-2-Methylbut-2-enoic acid, Reprint Addresses Gao, Y (corresponding author), Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China.; Hu, XQ (corresponding author), South Cent Univ Nationalities, Sch Chem & Mat Sci, Key Lab Catalysis & Energy Mat Chem, Minist Educ, Wuhan 430074, Hubei, Peoples R China.; Hu, XQ (corresponding author), South Cent Univ Nationalities, Sch Chem & Mat Sci, Hubei Key Lab Catalysis & Mat Sci, Wuhan 430074, Hubei, Peoples R China.. The CAS is 80-59-1. Through research, I have a further understanding and discovery of (E)-2-Methylbut-2-enoic acid

A method for the synthesis of diverse polysubstituted quinolines from readily available acrylic acids and anthranils has been developed. The weakly coordinating -COOH directing group, which can be tracelessly removed in the cascade cyclization, is essential for this reaction. Diverse polysubstituted quinolines were obtained under mild reaction conditions with simple H2O and CO2 as byproducts. More importantly, 1,2,3,4-tetrahydroacridine, which is the core skeleton of tacrine (an Alzheimer’s disease drug), was conveniently synthesized.

Welcome to talk about 80-59-1, If you have any questions, you can contact Gao, Y; Nie, JH; Li, YB; Li, XW; Chen, Q; Huo, YP; Hu, XQ or send Email.. Name: (E)-2-Methylbut-2-enoic acid

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about RING-OPENING POLYMERIZATION; METAL-FREE; MULTIBLOCK COPOLYMERS; MICROPHASE SEPARATION; CYCLIC ANHYDRIDES; CARBON-DIOXIDE; LEWIS PAIRS; EPOXIDES; MIXTURES; TERPOLYMERIZATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21734004, 21674038]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Li, H; He, GC; Chen, Y; Zhao, JP; Zhang, GZ. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol. Formula: C7H8O

Phthalic anhydride and propylene/ethylene oxide are copolymerized at room temperature by a bicomponent metal-free catalyst comprising a mild phosphazene base and triethylborane. Provided with proper loadings of the two catalytic components, block copolymers with strict (AB)(n)B-m type sequence structures and controlled molar mass (up to 60 kg mol(-1)) can be generated in one synthetic step, and the block architecture can be enriched by the use of mono-, di-, or tetrahydroxy initiators. The obtained polyester-polyether block copolymers readily undergo microphase-separation in bulk and nanoaggregation in selective (aqueous and alcoholic) solvents.

Formula: C7H8O. Bye, fridends, I hope you can learn more about C7H8O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles