Day: February 10, 2022

Authors El-Malah, A; Mahmoud, Z; Salem, HH; Abdou, AM; Soliman, MMH; Hassan, RA in TAYLOR & FRANCIS LTD published article about ONE-POT SYNTHESIS; ANTIFUNGAL ACTIVITY; CATALYST; GREEN; DERIVATIVES; ACID; RESISTANCE; INHIBITORS; BLOCKERS; PROTOCOL in [El-Malah, Afaf; Mahmoud, Zeinab; Hassan, Rasha A.] Cairo Univ, Fac Pharm, Pharmaceut Organ Chem Dept, 33 Kasr El Aini St, Cairo 11562, Egypt; [El-Malah, Afaf] King Abdulaziz Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Jeddah, Saudi Arabia; [Hamed Salem, Heba] King Khalid Univ, Fac Pharm, Abha, Saudi Arabia; [Hamed Salem, Heba] Cairo Univ, Biochem Dept, Fac Pharm, Cairo, Egypt; [Abdou, Amr M.; Soliman, Mona M. H.] Natl Res Ctr, Microbiol & Immunol Dept, Giza, Dokki, Egypt in 2021, Cited 50. Application In Synthesis of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

New ecofriendly Biginelli reaction procedures have been adapted to prepare new dihydropyrimidines (DHPMs) using a multicomponent one-pot reaction. All the synthesized compounds were evaluated for their anticancer activity against 59 human cancer cell lines and evaluated for their antimicrobial activities against representatives of both Gram-positive and Gram-negative bacteria. Compound 4 showed marked wide spectrum anticancer activity towards most of the tested cancer cell lines with a percentage of growth inhibition of 29.04-71.68% against leukemia cell line (K-562 and SR), lung cancer cell line (NCI-H522), five colon cancer cell lines (HCT-116, HCT-15, HT29, KM12 and SW-620), CNS cancer cell line (SF-295 and SNB-75), melanoma cell lines (MALME-3M and M14), renal cancer cell line (CAKI-1) and breast cancer cell lines (MCF7 and MDA-MB-468). The highest observed anticancer activity was against leukemia cell lines K-562 and SR with inhibition percentages of 64.97 and 71.68%, respectively. The renal cancer cell line (UO-31) was particularly sensitive towards all the evaluated compounds. Compounds including 2b and 5c exhibited antibacterial activity against S. aureus while 2a and 5b exhibited antifungal activity against C. albicans. The results also showed that compounds 2c and 5e exhibited both antibacterial and antifungal activity against S. aureus and C. albicans respectively.

Application In Synthesis of 4-Methoxybenzaldehyde. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Enantioselective [3+2] annulation of 4-isothiocyanato pyrazolones and alkynyl ketones under organocatalysis WOS:000617008600021 published article about ASYMMETRIC-SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; AZOMETHINE YLIDES; DIASTEREOSELECTIVE SYNTHESIS; STEREOGENIC CENTERS; SPIROPYRAZOLONES; OXINDOLES; CONSTRUCTION; CASCADE; SPIROOXINDOLES in [Wang, Wenyao; Wei, Shiqiang; Bao, Xiaoze; Nawaz, Shah; Qu, Jingping; Wang, Baomin] Dalian Univ Technol, Sch Chem Engn, Dept Pharmaceut Sci, State Key Lab Fine Chem, Dalian 116024, Peoples R China in 2021.0, Cited 52.0. Name: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

An asymmetric [3 + 2] annulation reaction of 4-isothiocyanato pyrazolones with alkynyl ketones in the presence of an organic catalyst derived from a cinchona alkaloid under mild conditions is realized. This protocol provides unprecedented expeditious access to a wide range of optically active spiro[pyrroline-pyrazolones] with various electronic properties in high yields with good to excellent enantioselectivities.

Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.. Name: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Wang, D; Cao, FR; Lu, GY; Ren, JM; Zeng, BB in PERGAMON-ELSEVIER SCIENCE LTD published article about SOLVENT-FREE; CHEMOSELECTIVE ACETALIZATION; EFFICIENT CATALYST; HIGHLY EFFICIENT; ACID CATALYSTS; ALDEHYDES; ACETALS; MILD; KETALIZATION in [Wang, Di; Cao, Fu-Rong; Lu, Guangying; Ren, Jiangmeng; Zeng, Bu-Bing] East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China in 2021.0, Cited 72.0. Quality Control of 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

A novel PVP-I catalyzed acetalizations/transacetalizations of carbonyl compounds has been developed processing with a mild and easy handling fashion. Different types of Acyclic and cyclic acetals were prepared from carbonyl compounds or their acetals successfully. Further applications of newly developed catalytic combination were testified. This protocol featured with simplicity of operation, mild reaction condition, short reaction time, recyclable of catalyst and broad substrates scope with excellent yields. (c) 2021 Elsevier Ltd. All rights reserved.

Quality Control of 3,4-Dimethoxybenzaldehyde. Welcome to talk about 120-14-9, If you have any questions, you can contact Wang, D; Cao, FR; Lu, GY; Ren, JM; Zeng, BB or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Visible Light-Emitting Diode Light-Driven Cu0.9Fe0.1@RCAC-Catalyzed Highly Selective Aerobic Oxidation of Alcohols and Oxidative Azo-Coupling of Anilines: Tandem One Pot Oxidation-Condensation to Imidazoles and Imines WOS:000505078800020 published article about ACTIVE PLASMONIC PHOTOCATALYSTS; BENZYL ALCOHOL; PHOTOREDOX CATALYSIS; MULTICOMPONENT SYNTHESIS; BIMETALLIC CATALYSTS; FE3O4 NANOPARTICLES; HYDROGEN-PEROXIDE; CARBON; GOLD; EFFICIENT in [Patel, Ashok Raj; Patel, Geetika; Banerjee, Subhash] Guru Ghasidas Vishwavidyalaya, Dept Chem, Bilaspur 495009, Chhattisgarh, India in 2019.0, Cited 80.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Application In Synthesis of 4′-Hydroxyacetophenone

Here, we have demonstrated visible light-emitting diode light-driven selective and efficient aerobic oxidation of primary/secondary alcohols to aldehydes/ketones and oxidative azo-coupling of anilines using biomass rice husk-derived chemically activated carbon sheet-supported copper-iron bimetallic hybrid nanomaterials (CuxFe1-x@ RCAC) under oxidant and additive-free conditions. The catalytic activity of the CuxFe1-x@RCAC materials has been investigated for the oxidation of alcohols and anilines, and Cu0.9Fe0.1@RCAC was established as the best catalyst. Moreover, a tandem one-pot protocol has been developed for the sequential oxidation of alcohols followed by condensation to functionalized imidazole and imine derivatives in high isolated yields. The hybrid materials were highly robust and stable under the reaction conditions and were recovered simply by filtration and recycled up to 12th run without considerable loss in catalytic activity.

Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about PHOTODYNAMIC ANTIMICROBIAL CHEMOTHERAPY; GRAPHENE QUANTUM DOTS; CANDIDA-ALBICANS; THERAPY; INACTIVATION; SUBSTITUENTS; CULTURES; BINDING; DESIGN; HYBRID, Saw an article supported by the Department of Science and Innovation (DSTI), South Africa through DSI/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology [UID 62620]; National Research Foundation (NRF) , South Africa through DSI/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology [UID 62620]; Rhodes University; Organization for Women in Science for the Developing World (OWSD); Swedish International Development Cooperation Agency (Sida). SDS of cas: 99-93-4. Published in ELSEVIER SCIENCE SA in LAUSANNE ,Authors: Openda, YI; Nyokong, T. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Photodynamic antimicrobial therapy (PACT) is a powerful technic recommended to eliminate life-threatening pathogens that cause localized and superficial infections as pathogens cannot develop resistance to it. For this reason, new positively charged chalcone substituted zinc (3a) and indium (4a) metalated phthalocyanines (Pcs) were synthesized and were pi-pi interacted with detonation nanodiamonds (DNDs) nanoparticles to form new water soluble nanoplatfoms 3a@DNDs and 4a@DNDs. The conjugates generated high singlet oxygen quantum yields (Phi(Delta)) in water (1% DMSO, used for PACT studies) with values of 0.46 and 0.47 for 3a@DNDs and 4a@DNDs, respectively. Hence, they were tested for PACT against biofilms of S. aureus and E. coli, as well as their planktonic cells. The quaternized Pcs alone 3a and 4a as well as their nanoconjugates 3a@DNDs and 4a@DNDs were effective PACT agents with log(10) CFU > 9 for E. coli and S. aureus. The quaternized derivatives were found to have higher ability to completely suppress both planktonic and biofilms of S. aureus and E. coli in vitro. Therefore, they could be used as appropriate photosensitive agents.

SDS of cas: 99-93-4. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-beta-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates published in 2021.0. Recommanded Product: 99-93-4, Reprint Addresses Ma, LY; Qin, SS (corresponding author), Zhengzhou Univ, State Key Lab Esophageal Canc Prevent & Treament, Key Lab Technol Drug Preparat,Inst Pharmaceut Res, Minist Educ China,Key Lab Henan Prov Drug Qual &, Zhengzhou 450001, Henan, Peoples R China.; Ma, LY; Qin, SS (corresponding author), Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China.; Yu, DQ (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

New Delhi metallo-beta-lactamase-1 (NDM-1) is capable of hydrolyzing nearly all beta-lactam antibiotics, posing an emerging threat to public health. There are currently less effective treatment options for treating NDM-1 positive superbug, and no promising NDM-1 inhibitors were used in clinical practice. In this study, structure-activity relationship based on thiosemicarbazone derivatives was systematically characterized and their potential activities combined with meropenem (MEM) were evaluated. Compounds 19bg and 19bh exhibited excellent activity against 10 NDM-positive isolate clinical isolates in reversing MEM resistance. Further studies demonstrated compounds 19bg and 19bh were uncompetitive NDM-1 inhibitors with Ki = 0.63 and 0.44 mu mol/L, respectively. Molecular docking speculated that compounds 19bg and 19bh were most likely to bind in the allosteric pocket which would affect the catalytic effect of NDM-1 on the substrate meropenem. Toxicity evaluation experiment showed that no hemolysis activities even at concentrations of 1000 mg/mL against red blood cells. In vivo experimental results showed combination of MEM and compound 19bh was markedly effective in treating infections caused by NDM-1 positive strain and prolonging the survival time of sepsis mice. Our finding showed that compound 19bh might be a promising lead in developing new inhibitor to treat NDM-1 producing superbug. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

Recommanded Product: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Zhao, B; Zhang, XH; Yu, TT; Liu, Y; Zhang, XL; Yao, YF; Feng, XJ; Liu, HM; Yu, DQ; Ma, LY; Qin, SS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Burmaoglu, S; Yilmaz, AO; Polat, MF; Kaya, R; Gulcin, I; Algul, O in TAYLOR & FRANCIS LTD published article about CARBONIC-ANHYDRASE INHIBITORS; TROUT ONCORHYNCHUS-MYKISS; ERYTHROCYTE ISOZYMES I; CRYSTAL-STRUCTURE; ANTICHOLINERGIC ACTIVITIES; BIOLOGICAL EVALUATION; MEDICINAL CHEMISTRY; 1ST SYNTHESIS; HALOGEN BOND; ACETYLCHOLINESTERASE in [Burmaoglu, Serdar] Erzincan Binali Yildirim Univ, Tercan Vocat High Sch, TR-24800 Erzincan, Turkey; [Burmaoglu, Serdar; Yilmaz, Ali Osman; Gulcin, Ilhami] Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey; [Polat, M. Fatih] Erzincan Binali Yildirim Univ, Fac Pharm, Dept Pharmaceut Basic Sci, Erzincan, Turkey; [Kaya, Ruya] Ibrahim Cecen Univ Agri, Cent Res & Applicat Lab, Agri, Turkey; [Algul, Oztekin] Mersin Univ, Fac Pharm, Dept Pharmaceut Chem, Mersin, Turkey in 2021, Cited 86. Formula: C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

In this study, we report the synthesis of novel tris-chalcones and testing of human carbonic anhydrase I, and II isoenzymes (hCA I, and hCA II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glycosidase (alpha-Gly) inhibitors for the development of novel chalcone structures towards for treatment of some diseases. The compounds demonstrated K-i values between 13.6 +/- 1.1 and 50.0 +/- 17.1 nM on hCA I, 9.9 +/- 0.8 and 39.5 +/- 15.1 nM on hCA II, 3.1 +/- 0.2 and 20.1 +/- 1.9 nM on AChE, 4.9 +/- 0.4 and 14.7 +/- 5.2 nM on BChE and 3.9 +/- 0.2 and 22.4 +/- 10.7 nM on alpha-Gly enzymes. The results revealed that novel tris-chalcones can have promising drug potential for glaucoma, leukaemia, epilepsy; Alzheimer’s disease that was associated with the high enzymatic activity of hCA I, hCA II, AChE, and BChE enzymes.

Welcome to talk about 120-14-9, If you have any questions, you can contact Burmaoglu, S; Yilmaz, AO; Polat, MF; Kaya, R; Gulcin, I; Algul, O or send Email.. Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Aly, AA; Hassan, AA; Mohamed, NK; Abd El-Haleem, LE; Brase, S in SAGE PUBLICATIONS LTD published article about in [Aly, Ashraf A.; Hassan, Alaa A.; Mohamed, Nasr K.; Abd El-Haleem, Lamiaa E.] Menia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt; [Brase, Stefan] Karlsruhe Inst Technol, Inst Biol & Chem Syst Funct Mol Syst IBCS FMS, Eggenstein Leopoldshafen, Germany in 2020, Cited 13. Recommanded Product: 86-95-3. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3

A novel series of 7,8-dichlorobenzofuro[3,2-c]quinoline-6,9,10(5H)-triones was obtained regioselectively in good yields. The products were formed by the reactions of the 4-hydroxy-2(1H)-quinolinones with 3,4,5,6-tetrachloro-1,2-benzoquinone in tetrahydrofuran as the solvent. Infrared, nuclear magnetic resonance (two-dimensional nuclear magnetic resonance), mass spectra and elemental analysis were used to elucidate the structures of new compounds.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 123-11-5. Authors Xie, YW; Zhao, ZN; Lin, ZW; Wang, YH; Liu, YQ; Huang, YY in ROYAL SOC CHEMISTRY published article about in [Xie, Yi-Wen; Zhao, Zhen-Ni; Lin, Zi-Wei; Wang, Yu-Hao; Liu, Ya-Qun; Huang, Yi-Yong] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Dept Chem, Wuhan 430070, Peoples R China in 2021, Cited 47. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The Petasis reaction using (1S,2R)-1-amino-2-indanol as the substrate and an activator to construct alpha- and beta-butadienyl amines in optically pure forms was realized, which are otherwise difficult to prepare. The reactions feature a metal-free nature, broad substrate scope, complete regioselectivities (gamma-selectivity of pinacol homoallenyl- and isoprenylboronates), and high to excellent chirality induction (up to >20 : 1 dr). The favored nucleophilic addition across the Si-face of the imine intermediate was explained using DFT calculations of the six-membered chair-like transition state.

Welcome to talk about 123-11-5, If you have any questions, you can contact Xie, YW; Zhao, ZN; Lin, ZW; Wang, YH; Liu, YQ; Huang, YY or send Email.. Product Details of 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Ionic liquid-assisted synthesis of dihydropyrimidin(thi)one Biginelli adducts and investigation of their mechanism of urease inhibition WOS:000488843000015 published article about BOVINE SERUM-ALBUMIN; ONE-POT SYNTHESIS; MOLECULAR DOCKING; HELICOBACTER-PYLORI; NATURAL-PRODUCTS; ACID; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; EFFICIENT; CYCLOADDITION; DERIVATIVES in [Braga, Aniris Cafiero; de Fatima, Angelo] Univ Fed Minas Gerais, Dept Quim, GEQOB, Belo Horizonte, MG, Brazil; [Silva, Thamara Ferreira; Modolo, Luzia Valentina] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bot, Grp Estudos Bioquim Plantas GEBioPlan, Belo Horizonte, MG, Brazil; [Silva Maciel, Thamilla Maria; Figueiredo, Isis Martins; Caldas Santos, Josue Carinhanha] Univ Fed Alagoas, Inst Quim & Biotecnol, Lab Instrumentacao & Desenvolvimento Quim Analit, Maceio, AL, Brazil; [Dantas da Silva, Edjan Carlos; Da Silva-Junior, Edeildo Ferreira; de Aquino, Thiago Mendonca] Univ Fed Alagoas, Inst Quim & Biotecnol, NAPRMN, Maceio, AL, Brazil in 2019.0, Cited 80.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 3-Hydroxybenzaldehyde

Twenty-six Biginelli adducts were synthesized through an ionic liquid-assisted synthesis with up to 92% yield. Sixteen of these Biginelli adducts were then assayed to determine their antiureolytic activity against purified urease from jack beans. The substances BA7-S, BA9-S and BA11-S were shown to be as efficient inhibitors as hydroxyurea, a positive control used in in vitro screening assay against urease. Fluorescence studies revealed that BA7-S, BA9-S, BA11-S and BA5-S possessed high binding constant values of 5.95, 6.72, 4.55, and 4.28 M-1, respectively, while BAS12-S, without substituents, showed a low value of log K-b = 2.16 M-1. In addition, in the most thermodynamically favorable BA5-S and BA7-S urease complexes, the corresponding Biginelli adducts were capable of interacting with the active site of urease through non-ionic interactions, such as hydrophobic interactions, or hydrogen and van der Waals interactions, respectively. In silico studies also supported that the BAs interact with the active site, confirming the fluorescence and kinetic assay studies, which clearly indicate that BA5-S and BA7-S are competitive inhibitors (K-i = 0.96 and 0.57 mM, respectively). In silico studies also showed that the substituents in the aromatic ring interact with Ni atoms to form a stable complex.

Recommanded Product: 3-Hydroxybenzaldehyde. Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles