Day: March 14, 2022

61019-05-4, 5-Methoxy-7-methyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

61019-05-4, To a 250 ml round bottom flask was added 7-methyl-5-methoxy-lH-indole (50 mmol)Add 100 ml of toluene to mix it,Further addition of cinnamoyl chloride (60 mmol)Room temperature reaction for 1 hour,After the compound has been completely precipitated,Phenylhydrazine (60 mmol) was added,Heated to 105 C with a heating jacket,Placed on a magnetic stirrer,The reaction was heated under reflux for 6 hours,Reaction process constantly point observation,After the reaction is complete, the heating is stopped and the condensing unit is removed.The reaction solution was distilled and concentrated, and the product was isolated by column chromatography.The crude product was recrystallized from an ethanol-water solution, dried,The product was obtained (pale pink solid 12.71 g, yield 80.2%).

As the paragraph descriping shows that 61019-05-4 is playing an increasingly important role.

Reference：
Patent; Shaanxi University of Science and Technology; Liang Chengyuan; Song Huihui; Zhang Shiyun; Mao Gennian; (17 pag.)CN104230786; (2017); B;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

6127-17-9, 6-Chloro-2-methyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6127-17-9, To a solution of 0.38 g (2.3 mmol) 6-chloro-2-methyl-1H-indole in 20 ml 1,2-dichloroethane at 0 C. were added 0.35 ml (2.5 mmol) trifluoroacetic anhydride. The reaction mixture was quenched with aqueous 2 M sodium carbonate solution after 30 min and extracted with dichloromethane (3*100 ml). The combined organic layers were dried over sodium sulfate and concentrated in vacuo to give the title compound (0.57 g; 95%) as an off-white solid. MS m/e (%): 260 (M-H+, 100).

The synthetic route of 6127-17-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Bissantz, Caterina; Grundschober, Christophe; Ratni, Hasane; Rogers-Evans, Mark; Schnider, Patrick; US2007/27173; (2007); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7506-66-3,cis-Hexahydro-1H-isoindole-1,3(2H)-dione,as a common compound, the synthetic route is as follows.

7506-66-3, To the crude spiro quaternary ammonium hydroxide mixture (280g) was added Example 1 cis-dimethyl cyclohexane imide (84.8g) in MIBK (1272ml) suspension. Under vigorous stirring refluxing, the reaction system after water net, the reaction system temperature was lowered to 50 C-60 C, weighed DMAC (181 g) into the reaction mixture, continue to heat refluxing 7-10 hour. After completion of the reaction and the DMAC MIBK was distilled off, do not pay attention to the reaction system temperature above 135 C, above 135 C after distillation under reduced pressure to remove the DMAC and MIBK, in addition to the net after, the reaction liquid was boiled in boiling water 5- 10 minutes, filtered and cooled, this operation repeated 2-3 times to remove the reaction product mixture of inorganic salts. When, after the remaining material was added ethanol (400ml), at 20 C_40 C conditions, hydrogen chloride gas for 30 minutes to saturation, then refluxed for 30 minutes, concentrating the reaction solution, a large number of crystallization, cooling is cooled until crystallization , crude 175g. The precipitate was available in 95% ethanol was recrystallized as white needles after recrystallization of perospirone hydrochloride (134g). The total product yield was 69.95%, 99.85% purity liquid.

7506-66-3 cis-Hexahydro-1H-isoindole-1,3(2H)-dione 6992236, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Patent; Yantai Besten Pharmaceutical Co., Ltd.; Bi, Haidong; Zhang, Yifang; (8 pag.)CN105669665; (2016); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

399-67-7, 7-Fluoro-1H-indole-2-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: (5-Chloro-7-fluoro-1H-indole-2-yl)-carboxylic acid (5a) (50 mg, 0.23 mmol), N,N-diisopropylethylamine (82 mul, 0.47 mmol) and 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (89 mg, 0.23 mmol) were dissolved in 550 mul N,N-dimethylformamide. After stirring for 10 min 4-methyl-piperazin 6a (26 mul, 0.23 mmol) was added and the reaction mixture was stirred for 16 h at 20 C. The solvent was evaporated under reduced pressure and the crude product was purified using chromatography method P1, yielding 37 mg (53%) of the title compound., 399-67-7

As the paragraph descriping shows that 399-67-7 is playing an increasingly important role.

Reference：
Article; Engelhardt, Harald; De Esch, Iwan J.P.; Kuhn, Daniel; Smits, Rogier A.; Zuiderveld, Obbe P.; Dobler, Julia; Mayer, Moriz; Lips, Sebastian; Arnhof, Heribert; Scharn, Dirk; Haaksma, Eric E.J.; Leurs, Rob; European Journal of Medicinal Chemistry; vol. 54; (2012); p. 660 – 668;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

935269-27-5, 3-Oxoisoindoline-4-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

935269-27-5, Compound 16f was treated with 4-methoxy-benzene-l,2-diamine in 6N HCl to provide Compound 11. 1H NMR (400 MHz, MeOD) 3.87 (s, 3H), 4.56 (s, 2H), 6.92 (d, J = 8.7 Hz, IH), 7.15 (s, IH), 7.55 (broad s, IH), 7.65 (d, J = 7.6 Hz, IH), 7.75 (t, J = 7.6 Hz, IH), 8.56 (d, J = 7.6 Hz, IH); MS (ESI) m/z: 280 (MH+).

935269-27-5 3-Oxoisoindoline-4-carboxylic acid 44579994, aindole-building-block compound, is more and more widely used in various fields.

Reference：
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2007/47646; (2007); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles