Day: April 20, 2022

Wang, Wanhe; Wu, Ke-Jia; Vellaisamy, Kasipandi; Leung, Chung-Hang; Ma, Dik-Lung published the article 《Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells》. Keywords: peptide conjugate theranostic imaging GRPr cancer immune cell; gastrin-releasing peptide receptor (GRPr); peptide-conjugated transition-metal complexes; theranostic agents; time-resolved emission spectroscopy.They researched the compound: 2-Phenylpyridine( cas:1008-89-5 ).Name: 2-Phenylpyridine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1008-89-5) here.

Gastrin-releasing peptide receptor (GRPr) plays proliferative and inflammatory roles in living systems. Here, the authors report a highly selective GRPr antagonist (JMV594)-tethered iridium(III) complex for probing GRPr in living cancer cells and immune cells. This probe exhibited desirable photophys. properties and also displayed negligible cytotoxicity, overcoming the inherent toxicity of the iridium(III) complex. Its long emission lifetime enabled its luminescence signal to be readily distinguished from the interfering fluorescence of organic dyes by using a time-resolved technique. This probe selectively visualized living cancer cells via specific binding to GRPr, while it also modulated the function of GRPr on TNF-α secretion in immune cells. To the authors′ knowledge, this is the first peptide-conjugated iridium(III) complex developed as a GRPr bioimaging probe and modulator of GRPr activity. This theranostic agent shows great potential at unmasking the diverse roles of GRPr in living systems.

The article 《Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells》 also mentions many details about this compound(1008-89-5)Name: 2-Phenylpyridine, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: 2208-59-5. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Prototropic equilibria of 2-pyridylbenzimidazoles in aqueous solution. Author is Novo, Mercedes; Mosquera, Manuel; Rodriguez Prieto, Flor.

The acid-base behavior of 2-(n’-pyridyl)benzimidazoles (n’ = 2,3,4) and some Me derivatives was studied in aqueous solution over a wide range of acidity; interesting features with respect to competition in protonation between the benzimidazole N3 and the pyridyl N were observed along with the existence of the corresponding 2 monocations in equilibrium in the case of n’ = 4. The influence of pH on the electronic absorption spectra of all these compounds was studied to identify the ground-state species present as a function of acidity and to obtain the acidity constants of the various prototropic equilibrium occurring in the wide range of acidity studied.

The article 《Prototropic equilibria of 2-pyridylbenzimidazoles in aqueous solution》 also mentions many details about this compound(2208-59-5)HPLC of Formula: 2208-59-5, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Cobalt-catalyzed intramolecular decarbonylative coupling of acylindoles and diarylketones through the cleavage of C-C bonds, published in 2020, which mentions a compound: 1008-89-5, mainly applied to indole preparation; acyl indole intramol decarbonylative coupling cobalt catalyzed; aryl pyridine preparation; diaryl ketone intramol decarbonylative coupling cobalt catalyzed, Synthetic Route of C11H9N.

A cobalt-N-heterocyclic carbene catalytic systems for the intramol. decarbonylative coupling through the chelation-assisted C-C bond cleavage of acylindoles and diarylketones was reported. The reaction tolerated a wide range of functional groups such as alkyl, aryl and heteroaryl groups, giving the decarbonylative products in moderate to excellent yields. This transformation involved the cleavage of two C-C bonds and formation of a new C-C bond without the use of noble metals, thus reinforcing the potential application of decarbonylation as an effective tool for C-C bond formation.

The article 《Cobalt-catalyzed intramolecular decarbonylative coupling of acylindoles and diarylketones through the cleavage of C-C bonds》 also mentions many details about this compound(1008-89-5)Synthetic Route of C11H9N, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]) to get more information.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Crystal Growth & Design called Anion-Controlled Assembly of Silver(I) Complexes of Multiring Heterocyclic Ligands: A Structural and Photophysical Study, Author is Kundu, Nabanita; Audhya, Anandalok; Abtab, Sk Towsif Md; Ghosh, Sanjib; Tiekink, Edward R. T.; Chaudhury, Muktimoy, which mentions a compound: 2208-59-5, SMILESS is C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1, Molecular C12H9N3, Safety of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole.

Four multiring heterocyclic ligands with benzimidazole (L1 and L3) and benzothiazole nuclei (L2 and L4) are reported. Their silver(I) complexes involving a variety of anions (both organic and inorganic) have been prepared by the process of self-assembly and structurally characterized by single-crystal x-ray diffraction analyses. Discrete metallocyclic complexes [Ag(L3)(X)]2 (X = NO3-, 3a; cis-HOOCCH:CHCOO-, 3b; 0.5SiF62-, 3c) and [Ag(L4)(Y)]2 (Y = NO3-, 4a; CF3SO3-, 4b) have been formed with the ligands L3 and L4, resp., where the pyridine nitrogen atom N1 is in the 3-position as against the coordination polymers [Ag(L1)(H2O)(NO3)]n, 1a, [Ag(L1)(CF3COO)]n, 1b and {2[Ag(L2)2(ClO4)].0.5.C2H5OH}n 2a, and [Ag(L2)2(cis-HOOCCH:CHCOO)]n, 2b, with the ligands L1 and L2, resp., in which the N1 atom occupies the 4-position in the pyridine ring. In addition to the primary ligands (L1-L4), the counteranions also have a dominant influence on the overall structures of these compounds Secondary bonding interactions, namely, hydrogen bonding, π···π-stacking, and C-H···π interactions, are also proven effective in shaping the dimensionalities of the solid state structures. Thus, a zigzag chain structure of 1a mediated by a nitrate anion generates a more complicated double layer structure in 1b where trifluoroacetate has replaced nitrate as the counterion. Discrete 12-membered metallocycles in 3a-3c generate 2-D arrays of flat (3a) and undulating topologies (3b and 3c), depending upon the type of their associated anions. Metallocycles 4a and 4b have less complicated structures compared to those of 3a-3c because of the replacement of NH by S in the heterocyclic ring, thereby reducing the hydrogen-bonding potential in the primary ligand in going from L3 to L4. In the solid state, the complexes show enhanced phosphorescence at 77 K with triplet lifetime in the range of 0.5-0.8 s, much shorter than those for the free ligands (2.3 – 3.3 s) because of increased spin-orbit coupling introduced by the coordinated Ag+ ion. This heavy-atom effect also has a causative influence in shortening the fluorescence lifetimes of these compounds

The article 《Anion-Controlled Assembly of Silver(I) Complexes of Multiring Heterocyclic Ligands: A Structural and Photophysical Study》 also mentions many details about this compound(2208-59-5)Safety of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C12H9N3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Synthesis and structure of a binuclear zinc complex [(ZnCl2)(PyBIm)]2. Author is Zhang, Quan-Zheng; Nie, Jiang-Hui; Zhou, Xu; Lu, Hong-Dian; Tian, Chang-An; Zhao, Di-Fang.

A new binuclear zinc complex [(ZnCl2)(PyBIm)]2 (PyBIm = 2-(4-pyridyl)benzimidazole) was synthesized by hydrothermal reaction. The complex crystallizes in triclinic space group P21/n with crystal cell parameters of a 0.77451(4)nm, b = 1.25249( 5) nm, c 1.31596(7) nm, β 100.294(3)° and Z = 2. The crystal x-ray anal. shows that Zn atom is coordinated by two Cl atoms and two N atoms from two PyBIm ligands in a distorted tetrahedral geometry. The Zn···Zn separation is 0.7094(5) nm, and the hydrogen bonding and π···π interactions also exist in the structure.

The article 《Synthesis and structure of a binuclear zinc complex [(ZnCl2)(PyBIm)]2》 also mentions many details about this compound(2208-59-5)Formula: C12H9N3, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called An excursion in the second-order nonlinear optical properties of platinum complexes, published in 2021-11-01, which mentions a compound: 1008-89-5, mainly applied to review platinum complex photochromism hyperpolarizability ddipole moment, COA of Formula: C11H9N.

A review. Electrooptical devices and optical communications need compounds with second-order nonlinear optical (NLO) properties as construction blocks. Typically, to show a large quadratic hyperpolarizability, a compound should be asym., be characterized by a large variation between the dipole moments in the excited and ground states, and have low energy electronic transitions. For example, a large quadratic hyperpolarizability can be reached when an electron-donor moiety is linked by means of a π-conjugated spacer to an acceptor group. In the field of second-order nonlinear optics, particularly attractive are coordination metal complexes because they are often characterized by low-energy and high-intensity intraligand (IL), ligand-to-metal (LM), and metal-to-ligand (ML) charge transfer (CT) electronic transitions, that can be regulated by the choice of the metal and ligands. Among them, platinum(II) complexes are captivating. During this excursion, we will see the quadratic hyperpolarizability of many of them. After some basic NLO notions, the review presents various classes of NLO-active platinum compounds having mono- and bidentate nitrogen ligands (pyridine, bipyridine, phenanthroline), dithiolenes, cyclometalated ligands (imines, phenylpyridine, phenylbipyridine, and dipyridylbenzene), alkynyl ligands. It is shown how to regulate the quadratic hyperpolarizability with suitable ligands and how to photomodulate the NLO properties by means of a dithienylethene (DTE) moiety. Some examples of complexes with redox-switchable NLO properties are also given. Although the accent is on the quadratic hyperpolarizability measured in solution, it is also shown how some NLO-active platinum complexes can be nano-organized to afford thin films with nonlinear optical properties. The report is not comprehensive, but it allows to get into the field of NLO-active platinum compounds and to understand their potential.

After consulting a lot of data, we found that this compound(1008-89-5)COA of Formula: C11H9N can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3,3-Bis(3,5-dibromo-4-hydroxy-2-methylphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxide(SMILESS: CC1=C(Br)C(O)=C(Br)C=C1C2(C3=CC(Br)=C(O)C(Br)=C3C)C4=CC=CC=C4S(O2)(=O)=O,cas:76-60-8) is researched.Computed Properties of C10H14N2. The article 《Uptake of Methylene Blue from Aqueous Solution by Naturally Grown Daedalea africana and Phellinus adamantinus Fungi》 in relation to this compound, is published in ACS Omega. Let’s take a look at the latest research on this compound (cas:76-60-8).

Daedalea africana and Phellinus adamantinus fungi were evaluated for methylene blue (MB) dye uptake. various factors (pH range, exposure time, dye concentration, adsorbed quantity, etc.) were examined for the uptake. adsorption isotherms included Langmuir and Freundlich isotherms. the Langmuir isotherm has been long known to be an adsorption process best fit. the maximum monolayer adsorption capacity for D. africana was 0.5210 mol/kg and 1.8387 mol/kg for P. adamantinus at 298° K. n values (0.8748 and 0.9524) indicated the dye is favorably adsorbed by both adsorbents. a kinetic data anal. showed fungal sorbed MB was pseudo-second-order chemisorption with film and intraparticle diffusion. results showed these fungi are good sorbents for the MB dye uptake.

After consulting a lot of data, we found that this compound(76-60-8)Application of 76-60-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about tert-Butyl N-(diphenylmethylene)glycinate.

Preparation, properties and applications of tert-Bu N-(diphenylmethylene)glycinate as glycine equivalent for the synthesis of various α-amino acids, especially in optically active form have been reviewed.

After consulting a lot of data, we found that this compound(132098-59-0)Category: indole-building-block can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 2208-59-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Visible-light-promoted synthesis of benzimidazoles. Author is Park, Sehyun; Jung, Jaehun; Cho, Eun Jin.

A simple and environmentally friendly synthetic method for benzimidazoles, which are important structural motifs in many applications owing to their various biol. functions, was developed. The reaction of o-phenylenediamine and a variety of aliphatic/aromatic aldehydes in methanol proceeds at room temperature with only natural sources, mol. oxygen and visible light.

After consulting a lot of data, we found that this compound(2208-59-5)SDS of cas: 2208-59-5 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Acidic properties of benzimidazoles and substituent effects. IV. Relationship between the acidities of N’-(substituted phenyl)arylamidines and ring closures to imidazole, the main research direction is benzimidazole substituent effect acidity; amidine aryl cyclization substituent effect; phenylenediamine cyclocondensation pyridinecarboxylic acid; LFER acidity benzimidazole pyridyl.Product Details of 2208-59-5.

Benzimidazoles I (R = H, Me, Cl, MeO, NO2; R1 = Ph, pyridinyl) were prepared by cyclocondensation of 1,2-(H2N)2C6H3R with R1CO2H in polyphosphoric acid at 170-80° or by cyclocondensation of 1,2-(H2N)2C6H3R with R1Me in the presence of S. Alternatively, I were also prepared by cyclization of amidines RC6H4NHC(:NH)R1 (II) by successive treatment with aqueous NaOCl and then with Na2CO3. Cyclization of II (R = C-3 substituted) by the latter method gave mixtures of C-7 and C-5 substituted benzimidazoles which were separated by crystallization Acidities of II increased with increasing electron withdrawing power of R, and, as the acidity of II increased, yields of I from cyclization of II decreased. Acidities of C-7 substituted I were correlated by the Taft equation with ρ = 0.45, whereas acidities of C-5 substituted I (R1 = pyridyl) were correlated by the Hammett equation with ρ = 1.3.

After consulting a lot of data, we found that this compound(2208-59-5)Product Details of 2208-59-5 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles