Month: April 2022

HPLC of Formula: 1008-89-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Aliphatic Group-Tethered Iridium Complex as a Theranostic Agent against Malignant Melanoma Metastasis. Author is Wu, Ke-Jia; Ho, Shih-Hsin; Dong, Jia-Yi; Fu, Ling; Wang, Shuang-Peng; Liu, Hao; Wu, Chun; Leung, Chung-Hang; Wang, Hui-Min David; Ma, Dik-Lung.

Malignant melanoma is a very aggressive form of skin cancer, with a low long-term survival rate. Developing multifunctional theranostic agents to simultaneously track and inhibit the activity of tumor targets is a potential strategy for combating melanoma metastasis. S100B expression is directly correlated with the degree of malignant metastatic melanoma and is overexpressed in the majority of malignant melanoma patients. Herein, the Ir(III) complex 7 was identified as a potent theranostic agent with nanomolar potency against S100B and selectivity over related substrates. Complex 7 exhibited desirable photophys. properties including a large Stokes shift and high photostability, while its long emission lifetime enabled its luminescence signal to be discriminated from a highly autofluorescent background by use of time-resolved emission spectroscopy. Importantly, complex 7 showed strong colocalization with S100B protein in melanoma cells with a stable signal up to at least 12 h, revealing its potential as a cellular probe for S100B. Moreover, complex 7 impeded the interaction between S100B and the C-terminus of p53 in the cytoplasm, thereby restoring the binding of p53 to its target promoters. Finally, complex 7 suppressed tumor growth and restrained lung metastases in vivo in two sep. melanoma mouse models. To our knowledge, complex 7 is the first reported theranostic agent for simultaneously monitoring S100B and suppressing malignant melanoma metastasis in vivo via targeting S100B protein.

The article 《Aliphatic Group-Tethered Iridium Complex as a Theranostic Agent against Malignant Melanoma Metastasis》 also mentions many details about this compound(1008-89-5)HPLC of Formula: 1008-89-5, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Abbasi Boji, Massomeh; Ghorbanloo, Massomeh published the article 《Synthesis, characterization, and fabrication of silver nanoparticles in 1-vinyl imidazole-based hydrogels and their use in olefin oxidation, hydrogen generation, and oxo-anion adsorption》. Keywords: olefin vinyl imidazole silver nanoparticle hydrogel oxidation adsorption.They researched the compound: 1,4-Dibromobutane( cas:110-52-1 ).HPLC of Formula: 110-52-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:110-52-1) here.

Poly(1-vinylimidazole), (p(1-VIm)), hydrogels were synthesized via free radical polymerization reaction and modified with different alkyl dihalides of variable chain lengths such as 1,2-dibromoethane (1,2-BE) and 1,4-dibromobutane (1,4-BB) to obtain polymeric ionic liquid The chem. structure of synthesized p(1-VIm) macroporous hydrogel was confirmed by Fourier transform IR spectroscopy (FT-IR) and SEM. P(1-VIm)-Ag, 1,2-BE-p(1-VIm)-Ag, and 1,4-BB-p(1-VIm)-Ag were prepared by reducing Ag(CH3COO) metal salts loaded into p(1-VIm) hydrogels and then reducing with NaBH4. Metal nanoparticles embedded p(1-VIm)-Ag were visualized by transmission electron microscopy. The metal content of all composites was estimated via at. absorption spectroscopy, and its amount was 4.44 mmol/g hydrogel, 5.44 mmol/g hydrogel, and 8.39 mmol/g hydrogel, for p(1-VIm), 1,2-BE-p(1-VIm), and 1,4-BB-p(1-VIm), resp. According to the results, metal content of quaternized hydrogels is higher than nonquaternized. P(1-VIm)-Ag, 1,2-BE-p(1-VIm)-Ag, and 1,4-BB-p(1-VIm)-Ag composites were used as catalyst in the aerobic oxidation of olefins by emphasizing the effects of different parameters such as temperature, substituent effect, etc. Olefin oxidation reaction was carried out in higher oxidation conversion by 1,2-BE-p(1-VIm)-Ag and 1,4-BB-p(1-VIm)-Ag than p(VIm)-Ag, due to high hydrophobicity of quaternized composites. The prepared porous hydrogel composites were also used as catalyst in H2 generation from hydrolysis of sodium borohydride (NaBH4). The activation energies, enthalpy, and entropy for NaBH4 hydrolysis catalyzed by composites were determined According to the results, p(VIm)-Ag showed higher catalytic activity. Low performance of 1,4-BB-p(1-VIm)-Ag than 1,2-BE-p(1-VIm)-Ag and p(1-VIm)-Ag is due to high hydrophobicity of this hydrogel than the other catalytic systems whiles reaction medium is water. Furthermore, the p(1-VIm), 1,2-BE-p(1-VIm), and 1,4-BB-p(1-VIm) were utilized in the adsorption of oxo-anions such as Cr2O7-2, CrO4-2 and MnO4-. Between hydrogels, 1,4-BB-p(1-VIm) has better performance than 1,2-BE-p(1-VIm) and p(1-VIm). Because of that, ion absorption capacity is increased with an increase in the number of carbon atoms in the chain of the alkylation agents. In addition, pH dependency of adsorbents was investigated and p(VIm) showed high pH dependency. Indeed, hydrophilic/hydrophobic character and permanent pos. charges of Q-p(VIm) hydrogels made them independent of the solution pH. Finally, the catalyst was easily recovered from the reaction medium, and it could be reused for other four runs without significant loss of activity. Durability of catalyst structure without leaching confirmed by FT-IR spectra and at. absorption spectroscopy, resp.

The article 《Synthesis, characterization, and fabrication of silver nanoparticles in 1-vinyl imidazole-based hydrogels and their use in olefin oxidation, hydrogen generation, and oxo-anion adsorption》 also mentions many details about this compound(110-52-1)HPLC of Formula: 110-52-1, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《An N-Heterocyclic-Carbene-Derived Distonic Radical Cation》. Authors are Gallagher, Nolan M.; Ye, Hong-Zhou; Feng, Shuting; Lopez, Jeffrey; Zhu, Yun Guang; Van Voorhis, Troy; Shao-Horn, Yang; Johnson, Jeremiah A..The article about the compound:1,3-Bis(2,4,6-trimethylphenyl)-1,3-dihydro-2H-imidazol-2-ylidenecas:141556-42-5,SMILESS:CC1=CC(C)=CC(C)=C1[N+]2=[C-]N(C3=C(C)C=C(C)C=C3C)C=C2).Application of 141556-42-5. Through the article, more information about this compound (cas:141556-42-5) is conveyed.

We present the discovery of a novel radical cation formed through one-electron oxidation of an N-heterocyclic carbene-carbodiimide (NHC-CDI) zwitterionic adduct. This compound possesses a distonic electronic structure (spatially sep. spin and charge regions) and displays persistence under ambient conditions. We demonstrate its application in a redox-flow battery exhibiting minimal voltage hysteresis, a flat voltage plateau, high Coulombic efficiency, and no performance decay for at least 100 cycles. The chem. tunability of NHCs and CDIs suggests that this approach could provide a general entry to redox-active NHC-CDI adducts and their persistent radical ions for various applications.

The article 《An N-Heterocyclic-Carbene-Derived Distonic Radical Cation》 also mentions many details about this compound(141556-42-5)Application of 141556-42-5, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Molecular Structure called Pure rotational spectrum and structural determination of 1,1-difluoro-1-silacyclopentane, Author is Moon, Nicole T.; Marshall, Frank E.; McFadden, Thomas M. C.; Ocola, Esther J.; Laane, Jaan; Guirgis, Gamil A.; Grubbs, Garry S. II, which mentions a compound: 110-52-1, SMILESS is BrCCCCBr, Molecular C4H8Br2, Formula: C4H8Br2.

The ground state, pure rotational spectrum of 1,1-difluoro-1-silacyclopentane has been studied using chirped-pulse, Fourier transform microwave (CP-FTMW) spectroscopy and observed in the 6-20.3 GHz region of the electromagnetic spectrum. This spectrum was acquired leveraging the deep averaging capability of the technique. The parent species, 13C, 29Si, and 30Si singly substituted isotopologues were observed in natural abundance and are reported. Only one conformer, the C2 conformer (half-chair), was observed This is confirmed with a determined CCCC dihedral angle of -48.1(11)°. The spectrum is comprised of entirely a-type transitions in accordance with quantum chem. calculations Multiple split transitions are present in the spectrum which have been attributed to a ring-twisting of the carbon atoms attached to the silicon atom in the ring. This motion has the carbons crossing the a-axis in the bc-plane leading to an inversion potential. Potential energy surfaces for the ring-twisting motion were undertaken and the exptl. determined energy level difference observed in comparison to these surfaces is reasonable. A Kraitchman anal. of the exptl. determined, singly substituted isotopologues is in agreement with the optimized, twisted (nonplanar) equilibrium structure. This structure has been compared to other similar silicon-containing ring mols. using second moment arguments and these comparisons are discussed.

The article 《Pure rotational spectrum and structural determination of 1,1-difluoro-1-silacyclopentane》 also mentions many details about this compound(110-52-1)Formula: C4H8Br2, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zarate, Cayetana; Yang, Haifeng; Bezdek, Mate J.; Hesk, David; Chirik, Paul J. published an article about the compound: Nickel(II) chloride ethylene glycol dimethyl ether complex( cas:29046-78-4,SMILESS:COCCOC.Cl[Ni]Cl ).HPLC of Formula: 29046-78-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:29046-78-4) through the article.

The synthesis and spectroscopic characterization of a family of Ni-X (X = Cl, Br, I, H) complexes supported by the bulky α-diimine chelate N,N’-bis(1R,2R,3R,5S)-(-)-isopinocampheyl-2,3-butanediimine (ipcADI) are described. Diimine-supported, three-coordinate Ni(I)-X complexes are proposed as key intermediates in a host of catalytic transformations such as C-C and C-heteroatom cross-coupling and C-H functionalization but have until now remained synthetically elusive. A combination of structural, spectroscopic, electrochem., and computational studies were used to establish the electronic structure of each monomeric [(ipcADI)NiX] (X = Cl, Br, I) complex as a Ni(I) derivative supported by a redox-neutral α-diimine chelate. The dimeric Ni hydride, [(ipcADI)Ni(μ2-H)]2, was prepared and characterized by x-ray diffraction; however, magnetic measurements and 1H NMR spectroscopy support monomer formation at ambient temperature in THF solution This Ni hydride was used as a precatalyst for the H isotope exchange (HIE) of C-H bonds in arenes and pharmaceuticals. By virtue of the multisite reactivity and high efficiency, the new Ni precatalyst provided unprecedented high specific activities (50-99 Ci/mmol) in radiolabeling, meeting the threshold required for radioligand binding assays. Use of air-stable and readily synthesized Ni precursor, [(ipcADI)NiBr2], broad functional group tolerance, and compatibility with polar protic solvents are addnl. assets of the Ni-catalyzed HIE method.

The article 《Ni(I)-X Complexes Bearing a Bulky α-Diimine Ligand: Synthesis, Structure, and Superior Catalytic Performance in the Hydrogen Isotope Exchange in Pharmaceuticals》 also mentions many details about this compound(29046-78-4)HPLC of Formula: 29046-78-4, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Annunziata, Rita; Benaglia, Maurizio; Cinquini, Mauro; Cozzi, Franco published the article 《Synthesis of a bifunctional ligand for the sequential enantioselective catalysis of various reactions》. Keywords: asym cyclopropanation dihydroxylation styrene bisoxazoline dihydroquinidine ligand.They researched the compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane( cas:132098-59-0 ).Reference of Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:132098-59-0) here.

A new bifunctional ligand (I) capable of promoting various enantioselective catalytic transformations has been prepared by connecting a bis(oxazoline) to dihydroquinidine via a spacer. This ligand has been employed in a one-pot procedure in which the asym. cyclopropanation and dihydroxylation of styrene were accomplished in a sequential fashion with good enantioselectivity.

The article 《Synthesis of a bifunctional ligand for the sequential enantioselective catalysis of various reactions》 also mentions many details about this compound(132098-59-0)Reference of Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wang, Wanhe; Wu, Ke-Jia; Vellaisamy, Kasipandi; Leung, Chung-Hang; Ma, Dik-Lung published the article 《Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells》. Keywords: peptide conjugate theranostic imaging GRPr cancer immune cell; gastrin-releasing peptide receptor (GRPr); peptide-conjugated transition-metal complexes; theranostic agents; time-resolved emission spectroscopy.They researched the compound: 2-Phenylpyridine( cas:1008-89-5 ).Name: 2-Phenylpyridine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1008-89-5) here.

Gastrin-releasing peptide receptor (GRPr) plays proliferative and inflammatory roles in living systems. Here, the authors report a highly selective GRPr antagonist (JMV594)-tethered iridium(III) complex for probing GRPr in living cancer cells and immune cells. This probe exhibited desirable photophys. properties and also displayed negligible cytotoxicity, overcoming the inherent toxicity of the iridium(III) complex. Its long emission lifetime enabled its luminescence signal to be readily distinguished from the interfering fluorescence of organic dyes by using a time-resolved technique. This probe selectively visualized living cancer cells via specific binding to GRPr, while it also modulated the function of GRPr on TNF-α secretion in immune cells. To the authors′ knowledge, this is the first peptide-conjugated iridium(III) complex developed as a GRPr bioimaging probe and modulator of GRPr activity. This theranostic agent shows great potential at unmasking the diverse roles of GRPr in living systems.

The article 《Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells》 also mentions many details about this compound(1008-89-5)Name: 2-Phenylpyridine, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: 2208-59-5. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Prototropic equilibria of 2-pyridylbenzimidazoles in aqueous solution. Author is Novo, Mercedes; Mosquera, Manuel; Rodriguez Prieto, Flor.

The acid-base behavior of 2-(n’-pyridyl)benzimidazoles (n’ = 2,3,4) and some Me derivatives was studied in aqueous solution over a wide range of acidity; interesting features with respect to competition in protonation between the benzimidazole N3 and the pyridyl N were observed along with the existence of the corresponding 2 monocations in equilibrium in the case of n’ = 4. The influence of pH on the electronic absorption spectra of all these compounds was studied to identify the ground-state species present as a function of acidity and to obtain the acidity constants of the various prototropic equilibrium occurring in the wide range of acidity studied.

The article 《Prototropic equilibria of 2-pyridylbenzimidazoles in aqueous solution》 also mentions many details about this compound(2208-59-5)HPLC of Formula: 2208-59-5, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Cobalt-catalyzed intramolecular decarbonylative coupling of acylindoles and diarylketones through the cleavage of C-C bonds, published in 2020, which mentions a compound: 1008-89-5, mainly applied to indole preparation; acyl indole intramol decarbonylative coupling cobalt catalyzed; aryl pyridine preparation; diaryl ketone intramol decarbonylative coupling cobalt catalyzed, Synthetic Route of C11H9N.

A cobalt-N-heterocyclic carbene catalytic systems for the intramol. decarbonylative coupling through the chelation-assisted C-C bond cleavage of acylindoles and diarylketones was reported. The reaction tolerated a wide range of functional groups such as alkyl, aryl and heteroaryl groups, giving the decarbonylative products in moderate to excellent yields. This transformation involved the cleavage of two C-C bonds and formation of a new C-C bond without the use of noble metals, thus reinforcing the potential application of decarbonylation as an effective tool for C-C bond formation.

The article 《Cobalt-catalyzed intramolecular decarbonylative coupling of acylindoles and diarylketones through the cleavage of C-C bonds》 also mentions many details about this compound(1008-89-5)Synthetic Route of C11H9N, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]) to get more information.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Crystal Growth & Design called Anion-Controlled Assembly of Silver(I) Complexes of Multiring Heterocyclic Ligands: A Structural and Photophysical Study, Author is Kundu, Nabanita; Audhya, Anandalok; Abtab, Sk Towsif Md; Ghosh, Sanjib; Tiekink, Edward R. T.; Chaudhury, Muktimoy, which mentions a compound: 2208-59-5, SMILESS is C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1, Molecular C12H9N3, Safety of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole.

Four multiring heterocyclic ligands with benzimidazole (L1 and L3) and benzothiazole nuclei (L2 and L4) are reported. Their silver(I) complexes involving a variety of anions (both organic and inorganic) have been prepared by the process of self-assembly and structurally characterized by single-crystal x-ray diffraction analyses. Discrete metallocyclic complexes [Ag(L3)(X)]2 (X = NO3-, 3a; cis-HOOCCH:CHCOO-, 3b; 0.5SiF62-, 3c) and [Ag(L4)(Y)]2 (Y = NO3-, 4a; CF3SO3-, 4b) have been formed with the ligands L3 and L4, resp., where the pyridine nitrogen atom N1 is in the 3-position as against the coordination polymers [Ag(L1)(H2O)(NO3)]n, 1a, [Ag(L1)(CF3COO)]n, 1b and {2[Ag(L2)2(ClO4)].0.5.C2H5OH}n 2a, and [Ag(L2)2(cis-HOOCCH:CHCOO)]n, 2b, with the ligands L1 and L2, resp., in which the N1 atom occupies the 4-position in the pyridine ring. In addition to the primary ligands (L1-L4), the counteranions also have a dominant influence on the overall structures of these compounds Secondary bonding interactions, namely, hydrogen bonding, π···π-stacking, and C-H···π interactions, are also proven effective in shaping the dimensionalities of the solid state structures. Thus, a zigzag chain structure of 1a mediated by a nitrate anion generates a more complicated double layer structure in 1b where trifluoroacetate has replaced nitrate as the counterion. Discrete 12-membered metallocycles in 3a-3c generate 2-D arrays of flat (3a) and undulating topologies (3b and 3c), depending upon the type of their associated anions. Metallocycles 4a and 4b have less complicated structures compared to those of 3a-3c because of the replacement of NH by S in the heterocyclic ring, thereby reducing the hydrogen-bonding potential in the primary ligand in going from L3 to L4. In the solid state, the complexes show enhanced phosphorescence at 77 K with triplet lifetime in the range of 0.5-0.8 s, much shorter than those for the free ligands (2.3 – 3.3 s) because of increased spin-orbit coupling introduced by the coordinated Ag+ ion. This heavy-atom effect also has a causative influence in shortening the fluorescence lifetimes of these compounds

The article 《Anion-Controlled Assembly of Silver(I) Complexes of Multiring Heterocyclic Ligands: A Structural and Photophysical Study》 also mentions many details about this compound(2208-59-5)Safety of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles