Day: October 14, 2022

《The copper(II)-catalyzed and oxidant-promoted regioselective C-2 difluoromethylation of indoles and pyrroles》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Zhang, Dong; Fang, Zheng; Cai, Jinlin; Liu, Chengkou; He, Wei; Duan, Jindian; Qin, Ning; Yang, Zhao; Guo, Kai. Reference of 5-Fluoro-1H-indole The article mentions the following:

A novel and efficient approach for the highly selective C-2 difluoromethylation of indole derivatives was developed by using sodium difluoromethylsulfinate (HCF2SO2Na) as the source of difluoromethyl groups and a Cu(II) complex as the catalyst. Various substrates were well tolerated in this transformation and the desired products, such as I [R = H, 3-Me, 4-Me, etc.] were obtained in moderate to good yields. Moreover, the late-stage C-2 difluoromethylation of bioactive mols. containing an indole ring was achieved in good yields. Generally, this reaction features excellent functional group compatibility, broad substrate scope and excellent C-2 selectivity. In the experiment, the researchers used 5-Fluoro-1H-indole(cas: 399-52-0Reference of 5-Fluoro-1H-indole)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Reference of 5-Fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Liu, Xiaoyu; He, Kun; Gao, Na; Jiang, Peiyun; Lin, Jun; Jin, Yi published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《A radical-mediated multicomponent cascade reaction for the synthesis of azide-biindole derivatives》.Formula: C8H6FN The article contains the following contents:

A radical-mediated, one-pot, multicomponent cascade reaction was developed for the synthesis of azide-biindole derivatives Mechanistic studies demonstrated that the nitrogen-centered free radical were formed by the reaction of heterocyclic N-H with CuII and PIFA and initiated the cascade reaction with indole to obtain the biindole intermediate. The obtained biindole intermediate then reacted with sodium azide in the presence of CuII catalyst and PIFA which then resulted in final products. This methodol. was useful for constructing other azido heterocycles. In the part of experimental materials, we found many familiar compounds, such as 5-Fluoro-1H-indole(cas: 399-52-0Formula: C8H6FN)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Formula: C8H6FN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Pillaiyar, Thanigaimalai; Sedaghati, Masoud; Mahardhika, Andhika B.; Wendt, Lukas L.; Mueller, Christa E. published their research in Beilstein Journal of Organic Chemistry in 2021. The article was titled 《Iodine-catalyzed electrophilic substitution of indoles: synthesis of (un)symmetrical diindolylmethanes with a quaternary carbon center》.Related Products of 399-52-0 The article contains the following contents:

A novel, versatile approach for the synthesis of unsym. 3,3′-diindolylmethanes (DIMs) with a quaternary carbon center has been developed via iodine-catalyzed coupling of trifluoromethyl(indolyl)phenylmethanols with indoles. In contrast to previously reported methods, the new procedure is characterized by chemoselectivity, mild conditions, high yields, and scalability to obtain gram amounts for biol. studies. Selected compounds were found to display affinity for cannabinoid receptors, which are promising drug targets for the treatment of inflammatory and neurodegenerative diseases. The results came from multiple reactions, including the reaction of 5-Fluoro-1H-indole(cas: 399-52-0Related Products of 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Related Products of 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C12H12KNO2On September 30, 2004 ,《Rooting of Cercis siliquastrum cuttings influenced by cutting position on the branch and indole-butyric acid》 was published in Journal of Horticultural Science & Biotechnology. The article was written by Karam, N. S.; Gebre, G. H.. The article contains the following contents:

The effects of cutting position within the source shoot and concentration of 1H-indole-3-butyric acid (IBA) or its potassium salt (K-IBA) on rooting in Cercis siliquastrum were assessed. Stem cuttings were taken from terminal or basal portions of the shoots in early spring, early summer, or winter and treated with 0, 24, 48, 72 or 96 mM IBA in 50% ethanol or K-IBA in water. Terminal cuttings were also treated with a com. rooting powder containing 0.1, 0.3 or 0.8% IBA. Rooting was unsuccessful except when cuttings were taken in the summer. Percent rooting was not significantly affected by concentration of IBA, but terminal cuttings exhibited higher rooting (43%) than basal ones (13%). Length and dry mass of roots produced per rooted cutting were significantly increased with increasing concentration of IBA. Basal cuttings performed poorly irresp. of K-IBA concentration, whereas terminal cuttings treated with the higher concentrations (72 and 96 mM) exhibited greater rooting than those treated with the lower concentrations (0-48 mM). The highest rooting percentage (80%) was obtained at 72 mM K-IBA, but the shape of the response curve suggests that the optimum concentration is probably slightly above 96 mM, the highest concentration tested. The quantity of roots produced per rooted cutting was not affected by cutting position or K-IBA concentration Treating terminal cuttings with 0.3 or 0.8% IBA powder resulted in 60% or 73% rooting, resp. The slope of the response curve suggests that the optimum might be above 0.8%, the highest concentration tested. The quantity of roots was not affected by IBA powder concentration The results came from multiple reactions, including the reaction of Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3Computed Properties of C12H12KNO2)

Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3) is auxin-family plant hormone, and is thought to be a precursor of indole-3-acetic acid (IAA) the most abundant and the basic auxin natively occurring and functioning in plants. IAA generates the majority of auxin effects in intact plants, and is the most potent native auxin.Computed Properties of C12H12KNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Lambert, Christopher R.; Blazich, Frank A.; LeBude, Anthony V. published an article in Journal of Environmental Horticulture. The title of the article was 《Propagation of Ilex vomitoria ‘Dare County’ by stem cuttings》.HPLC of Formula: 60096-23-3 The author mentioned the following in the article:

Semi-hardwood or hardwood stem cuttings of Ilex vomitoria Soluble ex Ait. ‘Dare County’ [‘Dare County’ yaupon holly (syn. ‘Virginia Dare’ yaupon holly)] were treated with solutions of the potassium (K) salt (K-salt) of indolebutyric acid (K-IBA) at 0 to 8000 mg·liter-1 (ppm). Nontreated semi-hardwood cuttings rooted at 78% whereas, regardless of auxin treatment, hardwood cuttings taken on two dates rooted at ≤ 15%. Treatment of cuttings with K-IBA was generally ineffective and resulted in a linear decrease (P ≤ 0.05) in percent rooting of semi-hardwood cuttings. The results came from multiple reactions, including the reaction of Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3HPLC of Formula: 60096-23-3)

Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3) is auxin-family plant hormone, and is thought to be a precursor of indole-3-acetic acid (IAA) the most abundant and the basic auxin natively occurring and functioning in plants. IAA generates the majority of auxin effects in intact plants, and is the most potent native auxin.HPLC of Formula: 60096-23-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The author of 《Rooting of shoot cuttings of ornamental shrubs after immersion in auxin-containing solutions》 were Van Bragt, J.; Van Gelder, H.; Pierik, R. L. M.. And the article was published in Scientia Horticulturae (Amsterdam, Netherlands) in 1976. Reference of Potassium 4-(1H-indol-3-yl)butanoate The author mentioned the following in the article:

Shoot cuttings of Berberis hybrido-gagne painii, B. ottawensis, Cotoneaster salicifolia, Lavandula angustifolia Prunus laurocerasus, Pyracantha, and Viburnum plicatum were immersed in a solution of the auxins, IAA K salt (I K salt) [2338-19-4] and IBA K salt [60096-23-3], in water. In general, this treatment gave better rooting than the commonly used method of dipping the basal part of the cutting in a powder mixture containing auxin. After reading the article, we found that the author used Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3Reference of Potassium 4-(1H-indol-3-yl)butanoate)

Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3) is auxin-family plant hormone, and is thought to be a precursor of indole-3-acetic acid (IAA) the most abundant and the basic auxin natively occurring and functioning in plants. IAA generates the majority of auxin effects in intact plants, and is the most potent native auxin.Reference of Potassium 4-(1H-indol-3-yl)butanoate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Related Products of 99409-32-2On September 21, 1998 ,《Application of β-1,4-galactosyltransferase in the synthesis of complex branched-chain oligosaccharide mimics of fragments of the capsular polysaccharide of Streptococcus pneumoniae type 14》 was published in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry. The article was written by Niggemann, Jutta; Kamerling, Johannis P.; Vliegenthart, Johannes F. G.. The article contains the following contents:

The chemoenzymic synthesis is described of β-D-Galp-(1→4)-β-D-Glcp-(1→6)-[β-D-Galp-(1→4)]-β-D-GlcpNAc-(1→O[CH2]3O→4)-β-D-Glcp-(1→OCH2CH:CH2) and β-D-Galp-(1→4)-β-D-GlcpNAc-(1→O[CH2]3O→4)-β-D-Glcp-(1→6)-[β-D-Galp-(1→4)]-β-D-GlcpNAc-(1→O[CH2]3O→4)-β-D-Glcp-(1→OCH2-CH:CH2), representing hexa- and octasaccharide mimics of fragments of the Streptococcus pneumoniae type 14 polysaccharide. In a chem. approach the intermediate linear oligosaccharide mimics I (R1 = CH2CH:CH2; R2 = Q; R3 = H) and I (R2 = Q1) were synthesized, wherein both terminal and non-terminal N-acetyl-β-D-glucosamine residues were not yet galactosylated. The alkyl-bridged derivatives were found to be good acceptor substrates for bovine milk β-1,4-galactosyltransferase. Reaction of the anomeric allyl functions with cysteamine under UV-irradiation gave the corresponding 3-(2-aminoethylthio)propyl glycosides I (R1 = (CH2)3S(CH2)2NH2; R3 = Q) (II) and II (R2 = Q1; R3 = Q) suitable for further coupling of the oligosaccharide mimics to protein carriers. After reading the article, we found that the author used Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2Related Products of 99409-32-2)

Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Related Products of 99409-32-2They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles