Day: October 18, 2022

Liu, Xiao Gao; Jain, Rakesh K.; Saha, Raj; Matta, Khushi L. published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Synthesis of Gal-β-(1→4)-6-O-SO3Na-GlcNAc-β-(1→6)-Man-α-OR as a part of glycoprotein (gp) 120》.Safety of Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside The author mentioned the following in the article:

The synthesis of Gal-β-(1→4)-6-O-SO2Na-GlcNAc-β-(1→6)-Man-α-OR (as a part of gp 120) containing an anomeric p-nitrophenyl group was accomplished via stereoselective glycosidation of Et 3,4,6-tri-O-chloroacetyl-2-deoxy-2-phthalimido-1-thio-β-D-glucopyranoside. Title oligosaccharide can act as acceptor of α-2,3-sialyltransferase to give NeuAcα-(2→3)-Gal-β-(1→4)-6-O-SO2Na-GlcNAc-β-(1→6)-Man-α-OR which occurs as a part of gp 120. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2Safety of Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside)

Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Safety of Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranosideThey are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Silwanis, Basim Azmy; El-Sokkary, Ramadan I.; Nashed, Mina A.; Paulsen, Hans published their research in Journal of Carbohydrate Chemistry on December 31 ,1991. The article was titled 《A comparison in the efficiency of six standard 2-amino-2-deoxyglucosyl donors for the synthesis of (2-deoxy-2-phthalimido-β-D-glucopyranosyl) (1→4)-β-D-glucopyranosides》.Recommanded Product: Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside The article contains the following contents:

A systematic study is presented for the most common methods used for the preparation of the disaccharide benzyl O-(3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)-(1→4)-3,6-di-O-benzoyl-2-deoxy-2-phthalimido-β-D-glucopyranoside from standard 2-amino-2-deoxyglucopyranosyl donors, e.g. I (R = Br, Cl, F, OAc, OC(NH)CCl3, SEt, R1 = phthalimido), and benzyl 3,6-di-O-benzoyl-2-deoxy-2-phthalimido-β-D-glucopyranoside as an acceptor. It was found that the highest yield was obtained when the trichloroacetimidate derivative I was coupled to the 4 position of acceptor 7. After reading the article, we found that the author used Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2Recommanded Product: Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside)

Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Recommanded Product: Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranosideThey are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Toward Fully Synthetic Homogeneous β-Human Follicle-Stimulating Hormone (β-hFSH) with a Biantennary N-Linked Dodecasaccharide. Synthesis of β-hFSH with Chitobiose Units at the Natural Linkage Sites》 was written by Nagorny, Pavel; Fasching, Bernhard; Li, Xuechen; Chen, Gong; Aussedat, Baptiste; Danishefsky, Samuel J.. Recommanded Product: Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside And the article was included in Journal of the American Chemical Society on April 29 ,2009. The article conveys some information:

A highly convergent synthesis of the sialic acid-rich biantennary N-linked glycan found in human glycoprotein hormones and its use in the synthesis of a fragment derived from the β-domain of human FSH (hFSH) are described. The synthesis highlights the use of the Sinay radical glycosidation protocol for the simultaneous installation of both biantennary side-chains of the dodecasaccharide as well as the use of glycal chem. to construct the tetrasaccharide core in an efficient manner. The synthetic glycan was used to prepare the glycosylated 20-27aa domain of the β-subunit of hFSH under a Lansbury aspartylation protocol. The proposed strategy for incorporating the prepared N-linked dodecasaccharide-containing 20-27aa domain into β-hFSH subunit was validated in the context of a model system, providing protected β-hFSH subunit functionalized with chitobiose at positions 7 and 24. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2Recommanded Product: Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside)

Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Recommanded Product: Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranosideThey are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Reference of Potassium 4-(1H-indol-3-yl)butanoateOn March 31, 2008, Griffin, Jason J. published an article in Journal of Environmental Horticulture. The article was 《IBA formulation, concentration, and stock plant growth stage affect rooting of stem cuttings of Viburnum rufidulum》. The article mentions the following:

Viburnum rufidulum Raf. (southern or rusty blackhaw) has potential to be a popular landscape plant as it is an attractive large shrub tolerant of many common landscape stresses. However, propagation difficulties have thus far limited wide scale use. Therefore, the influence of IBA formulation and concentration on adventitious rooting of stem cuttings of southern blackhaw taken at different stock plant growth stages throughout the year were investigated. Liquid formulations of the potassium salt (K-salt) of indolebutyric acid (K-IBA) at 0, 3000, 6000, or 9000 ppm (0, 0.3, 0.6, or 0.9%) as well as talc formulations of IBA at 1000, 3000, or 8000 ppm (0.1, 0.3 or 0.8%) were utilized. Talc formulations failed to stimulate rooting regardless of concentration or growth stage. A quick-dip of K-IBA increased rooting percentage at all growth stages. Softwood and hardwood cuttings had the highest rooting percentages. Hardwood cuttings treated with 6000 ppm (0.6%) or 9000 ppm (0.9%) rooted 90 and 100%, resp. Softwood cuttings treated with 6000 ppm (0.6%) rooted 87%. K-IBA improved root number per rooted cutting for softwood cuttings, whereas root length was unaffected by K-IBA at any growth stage. In the experiment, the researchers used Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3Reference of Potassium 4-(1H-indol-3-yl)butanoate)

Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3) is auxin-family plant hormone, and is thought to be a precursor of indole-3-acetic acid (IAA) the most abundant and the basic auxin natively occurring and functioning in plants. IAA generates the majority of auxin effects in intact plants, and is the most potent native auxin.Reference of Potassium 4-(1H-indol-3-yl)butanoate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Related Products of 99409-32-2On March 31, 2009, Minuth, Tobias; Irmak, Mustafa; Groschner, Annika; Lehnert, Tobias; Boysen, Mike M. K. published an article in European Journal of Organic Chemistry. The article was 《Sweets for catalysis – facile optimization of carbohydrate-based bis(oxazoline) ligands》. The article mentions the following:

A new type of carbohydrate-based bis(oxazoline) ligands was prepared from inexpensive D-glucosamine and tested in asym. cyclopropanation reactions. For optimization, modified ligands with 3-O substituents of varying size and electronic properties were prepared as well as a 3-OH unprotected and a perpivaloylated derivative All new ligands were tested in asym. cyclopropanation, revealing a strong dependence of enantioselectivity on steric demand and electronic properties of the 3-O residue. Also, a significant influence of the pyranose conformation, which is determined by the presence or absence of the cyclic acetal group, was observed Thus, it was easily possible to tune the new carbohydrate bis(oxazoline) ligands to a given reaction. The results came from multiple reactions, including the reaction of Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2Related Products of 99409-32-2)

Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Related Products of 99409-32-2They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Jana, Manas; Ghosh, Anirban; Santra, Abhishek; Kar, Rajiv Kumar; Misra, Anup Kumar; Bhunia, Anirban published an article in Journal of Colloid and Interface Science. The title of the article was 《Synthesis of novel muramic acid derivatives and their interaction with lysozyme: Action of lysozyme revisited》.Name: Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside The author mentioned the following in the article:

The interaction of lysozyme with the N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) unit of peptidoglycan (PGN) polymer of the bacterial cell wall is of immense importance to understand the mechanism of lysozyme on PGN. The synthesis of three novel NAM derivatives containing fused oxazinone ring to the NAM moiety has been achieved. The synthesized compounds were evaluated for their potential as a glycomimetic acceptor of lysozyme using different biophys. and computational methods such as 1H NMR, STD NMR, DOSY and Mol. docking. Novel modified muramic acid derivatives have been synthesized in excellent yield containing fused cyclooxazine ring embedded on the muramic acid moiety using a newly developed hydrazinolysis reaction condition. From various biophys. studies, it has been established that the compound containing endo modified muramic acid moiety (compound 1) shows significant binding property for the lysozyme while the other isomer (compound 2) did not bind to the lysozyme. The catalytic residues Glu35 and Asp52 were found to be in the close proximity for the active mol. which justifies the selectivity of this mol. in conjunction to lysozyme enzymic activity. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2Name: Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside)

Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranoside(cas: 99409-32-2) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Name: Ethyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-thioglucopyranosideThey are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019,Advanced Synthesis & Catalysis included an article by Pillaiyar, Thanigaimalai; Uzair, Muhammad; Ullah, Saif; Schnakenburg, Gregor; Mueller, Christa E.. Application In Synthesis of 5-Fluoro-1H-indole. The article was titled 《Decarboxylative Coupling Reaction of 2-(1H-indol-3-yl)acetic Acids with Indole, Azaindole, Benzimidazole and Indazole Derivatives》. The information in the text is summarized as follows:

A new, mild and efficient copper(II)-promoted decarboxylative coupling reaction of 2-(1H-indol-3-yl)acetic acid derivatives I (R = H, 4-Cl, 5-OCH3, 6-F, 5-Cl, 6-Cl; R1 = H, CH3) with a variety of (substituted) indoles II (R2 = H, Ph, CO2Et; R3 = H, CH3; R4 = H, Me, F, Br, MeO, CHO; R5 = H, MeO, CHO, F; R6 = H, Cl, Br, MeO, Et, CN; R7 = H, Br; R6R7 = CH=CH-CH=CH) yielding (un)sym. substituted 3,3′-diindolylmethanes (DIMs) III have been reported. Reaction of 2-(1H-indol-3-yl)acetic acid I (R = R1 = H) with 7-azaindole led to 3-((1H-indol-3-yl)methyl)-1H-pyrrolo[2,3-b]pyridine, while 4-, 5-, and 6-azaindoles and benzimidazole reacted at the N1-nitrogen atom. Reaction of I (R = R1 = H) with 1H-indazole led to a mixture of 1-((1H-indol-3-yl)methyl)-1H-indazole and 2-((1H-indol-3-yl)methyl)-2H-indazole. The new method allows large-scale synthesis of biol. active DIMs. After reading the article, we found that the author used 5-Fluoro-1H-indole(cas: 399-52-0Application In Synthesis of 5-Fluoro-1H-indole)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Application In Synthesis of 5-Fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 1H-IndoleIn 2021 ,《Recent advances in indole dimers and hybrids with antibacterial activity against methicillin-resistant Staphylococcus aureus》 appeared in Archiv der Pharmazie (Weinheim, Germany). The author of the article were Meng, Tingting; Hou, Yani; Shang, Congshan; Zhang, Jing; Zhang, Bo. The article conveys some information:

A review. Methicillin-resistant Staphylococcus aureus (MRSA), one of the major and most dangerous pathogens in humans, is a causative agent of severe pandemic of mainly skin and soft tissue and occasionally fatal infections. Therefore, it is imperative to develop potent and novel anti-MRSA agents. Indole derivatives could act against diverse enzymes and receptors in bacteria, occupying a salient place in the development of novel antibacterial agents. Dimerization and hybridization are common strategies to discover new drugs, and a number of indole dimers and hybrids possess potential antibacterial activity against a panel of clin. important pathogens including MRSA. Accordingly, indole dimers and hybrids are privileged scaffolds for the discovery of novel anti-MRSA agents. This outlines the recent development of indole dimers and hybrids with a potential activity against MRSA, covering articles published between 2010 and 2020. The structure-activity relationship and the mechanism of action are also discussed to facilitate further rational design of more effective candidates. In the experiment, the researchers used 1H-Indole(cas: 120-72-9Safety of 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Safety of 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of Potassium 4-(1H-indol-3-yl)butanoateOn September 30, 1987 ,《Increasing production of new roots by potted roses with root applied IBA》 was published in Journal of Environmental Horticulture. The article was written by Starbuck, C. J.. The article contains the following contents:

Dormant bare root rose (Rosa × hybrida ‘Las Vegas’) plants with roots dipped in a 500 ppm solution of indole-3-butyric acid (IBA) produced 50% more new roots than untreated plants. However, plants treated with 100 and 500 ppm IBA had fewer open flower buds 8 wks after potting and shorter average shoot length after 18 wks than did controls. Treatment with the potassium salt of IBA (KIBA) at 100 and 500 ppm also stimulated new root production and retarded flower bud development but did not reduce shoot length. Addition of starch-polyacrylate gel to treatment solutions counteracted the root promoting effect of IBA but not of KIBA. Gel itself also caused a reduction in average shoot length. In the experimental materials used by the author, we found Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3Application In Synthesis of Potassium 4-(1H-indol-3-yl)butanoate)

Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3) is auxin-family plant hormone, and is thought to be a precursor of indole-3-acetic acid (IAA) the most abundant and the basic auxin natively occurring and functioning in plants. IAA generates the majority of auxin effects in intact plants, and is the most potent native auxin.Application In Synthesis of Potassium 4-(1H-indol-3-yl)butanoate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles