Month: October 2022

Hrizi, Asma; Cailler, Manon; Romdhani-Younes, Moufida; Carcenac, Yvan; Thibonnet, Jerome published the artcile< Synthesis of New Highly Functionalized 1H-Indole-2-carbonitriles via Cross-Coupling Reactions>, Reference of 399-76-8, the main research area is alkenyl indole carbonitrile preparation; aryl indole carbonirile preparation; 1H-indole-2-carbonitriles; Heck; Sonogashira; Stille; Suzuki–Miyaura.

An approach for the preparation of polysubstituted indole-2-carbonitriles through a cross-coupling reaction of compounds 1-(but-2-ynyl)-1H-indole-2-carbonitriles and 1-benzyl-3-iodo-1H-indole-2-carbonitriles was described. The reactivity of indole derivatives with iodine at position 3 was studied using cross-coupling reactions. The Sonogashira, Suzuki-Miyaura, Stille and Heck cross-couplings afforded a variety of di-, tri- and tetra-substituted indole-2-carbonitriles.

Molecules published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 399-76-8 belongs to class indole-building-block, and the molecular formula is C9H6FNO2, Reference of 399-76-8.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wu, Ke-Xin; Xu, Yi-Ze; Cheng, Liang; Wu, Run-Shi; Liu, Peng-Ze; Xu, Da-Zhen published the artcile< Iron-catalyzed oxidative bis-arylation of indolin-2-ones for direct construction of quaternary carbons>, Computed Properties of 20870-77-3, the main research area is oxindole bis indolyl preparation chemoselective green chem; indolinone indole oxidative bis arylation iron catalyst.

A direct construction of all-carbon quaternary centers from secondary C(sp3)-H substrates through a dehydrogenative cross-coupling reaction was described. Using FeCl2·4H2O as the catalyst and employing air (mol. oxygen) as the terminal oxidant, the cross-coupling of indolin-2-ones I (R1 = H, Me, Ph, Bn; R2 = H, 6-Cl, 5-F, etc.) with indoles such as 5-fluoroindole, N-methylindole, 3-methylindole, etc. proceeded smoothly under mild, ligand-free and base-free conditions, providing 3,3-disubstituted oxindoles bearing all-carbon quaternary centers II (R3 = 5-fluoroindol-3-yl, N-methylindol-3-yl, 3-methylindol-2-yl, etc.) with excellent chemoselectivities.

Green Chemistry published new progress about Arylation (chemoselective). 20870-77-3 belongs to class indole-building-block, and the molecular formula is C8H6ClNO, Computed Properties of 20870-77-3.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ghosh, Ayndrila; Mandal, Saurodeep; Das, Sujoy; Shaw, Pallab; Chattopadhyay, Ansuman; Sahoo, Prithidipa published the artcile< Insights into the phenomenon of acquisition and accumulation of Fe3+ in Hygrophila spinosa through fluorimetry and fluorescence images>, Product Details of C30H36N4O2, the main research area is Hygrophila ferric uptake fluorescent probe imaging.

Rhodamine functionalized fluorescent probe IP has been synthesized to investigate the phenomenon of Fe3+ acquisition and accumulation in Hygrophila spinosa. H. spinosa is a tropical medicinal plant which is iron rich and consumed for the treatment of the patients suffering from anemia. IP is capable of selectively binding Fe3+ by enhancing fluorescent intensity via “”turn on”” mechanism due to complex formation. Spectroscopic studies and microscopic tools helped in better understanding about the acquisition as well as the quant. accumulation of Fe3+ in different parts of the plant.

Tetrahedron Letters published new progress about Fluorescence imaging. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Product Details of C30H36N4O2.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Li, Ruo-Pu; Wang, Zheng-Lin; Zhang, Yun-Hao; Tan, Zhi-Yu; Xu, Da-Zhen published the artcile< Iodine-Catalyzed Oxidative Coupling of Indolin-2-ones with Indoles: Synthesis of 3,3-Disubstituted Oxindole Compounds>, Application of C8H6ClNO, the main research area is disubstituted oxindole preparation; indolinone indole oxidative coupling iodine catalyst.

Here, an iodine-catalyzed oxidative coupling of indolinones with indoles for the construction of compounds with all-carbon quaternary centers such as 1H,1”H-[3,3′:3′,3”-terindol]-2′(1’H)-ones I [R1 = H, Me, Bn, etc.; R2 = H, 5-Br, 5-F, etc.; R3 = H, Me, R4 = H, 2-Me, 5-OMe, etc.] was described. The method performed under metal-free and peroxide-free conditions, providing 3,3-disubstituted oxindoles via two C-C bond formations from secondary C(sp3)-Hs in a straightforward manner.

ChemistrySelect published new progress about C-C bond formation. 20870-77-3 belongs to class indole-building-block, and the molecular formula is C8H6ClNO, Application of C8H6ClNO.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Tang, Tengxuan; Wang, Jing; Xu, Dongmei published the artcile< Synthesis of a novel hyperbranched polymer and its application in multi-channel sensing Fe3+>, COA of Formula: C30H36N4O2, the main research area is hyperbranched polymer fluorescent sensor iron.

A novel hyperbranched polymer was designed and synthesized as a spectral probe for Fe3+. The polymer showed high selectivity and sensitivity to Fe3+ in CH3CN/H2O (75/25, volume/volume). Fe3+ caused a new peak at 560 nm in UV-Vis absorption, a 31 nm fluorescence red shift, a 35-fold enhancement in fluorescence intensity at 575 nm and an 8.3-fold enhancement in fluorescence quantum yield, accompanied by a visual color change from colorless to pink and a fluorescence from dark to bright orange. The colorimetric and fluorescent detection limits were 1.29 and 1.88 μM, resp. The detection was almost not interfered by other common metal cations. The polymer could be applied in assaying Fe3+ in real sample with similar precision to that of at. absorption spectroscopy.

Research on Chemical Intermediates published new progress about Colorimetric sensors. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, COA of Formula: C30H36N4O2.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Hajiali, Mahtab; Keyvan Rad, Jaber; Ghezelsefloo, Sara; Mahdavian, Ali Reza published the artcile< Solvent-free and anticounterfeiting fluorescent inks based on epoxy-functionalized polyacrylic nanoparticles modified with Rhodamine B for cellulosic substrates>, Application In Synthesis of 950846-89-6, the main research area is epoxy functionalized polyacrylic nanoparticle anticounterfeiting fluorescent ink cellulosic substrate; rheol photophys property.

Nowadays, anticounterfeiting technol. and information security by solvent-free photoluminescent polymeric latex nanoparticles are of considerable interest in variety of hi-tech systems. Herein and for the first time, Rhodamine B ethylenediamine acrylate (N-RhBAc) was synthesized and copolymerized with Me methacrylate and glycidyl methacrylate to obtain epoxy-functionalized fluorescent latex nanoparticles (RhAcL-series) through emulsion polymerization Inclusion of N-RhBAc into the spherical polyacrylic nanoparticles with average particle size of 40-70 nm enhanced its absorption intensity (λmax of 571 nm) and emission intensity (λem of 588 nm) up to 8 and 3.5-fold with respect to N-RhBAc in the solution state (λmax of 524 nm and λem of 582 nm), resp. The nanometric size of particles and decorated epoxy functional groups on their outer layer provided well-wetting and fine-diffusion into the cellulosic nanofiber. To obtain anticounterfeiting inks with high-resolution marking on cellulosic paper without spreading and tracing, fluorescent RhAcL-1 was formulated with required thickening agent and defoamer. The painted pattern by the above ink could immediately be developed and illuminated with brilliant red-pink fluorescence emission upon UV irradiation

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about Emulsion polymerization. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Application In Synthesis of 950846-89-6.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Li, Honghe; Yan, Xiaoqiang; Zhang, Jitan; Guo, Weicong; Jiang, Jijun; Wang, Jun published the artcile< Enantioselective Synthesis of C-N Axially Chiral N-Aryloxindoles by Asymmetric Rhodium-Catalyzed Dual C-H Activation>, Product Details of C8H6ClNO, the main research area is arylnaphthyl oxindole atropisomer enantioselective preparation; rhodium catalyst enantioselective activation cycloaddition aryl alkyne aryloxindole; C−H activation; alkynes; axial chirality; heterocycles; rhodium.

In the presence of a diindolocyclononane-fused cyclopentadiene rhodium complex and AgNTf2, N-aryloxindoles such as I underwent enantioselective Satoh-Miura-type cycloaddition reactions with diaryl alkynes such as diphenylacetylene to yield atropisomeric tetraarylnaphthyl oxindoles such as II in up to 99% yield and in 8-99% ee (all but one product in >60% ee).

Angewandte Chemie, International Edition published new progress about Atropisomers. 20870-77-3 belongs to class indole-building-block, and the molecular formula is C8H6ClNO, Product Details of C8H6ClNO.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Yoo, Woo-Jin; Nguyen, Thanh V. Q.; Capdevila, Montse Guiteras; Kobayashi, Shu published the artcile< Lithium tert-butoxide-mediated carboxylation reactions of unprotected indoles and pyrroles with carbon dioxide>, SDS of cas: 23077-43-2, the main research area is indole carbon dioxide lithium butoxide Friedel Crafts type carboxylation; indolecarboxylic acid preparation; pyrrole carbon dioxide lithium butoxide Friedel Crafts type carboxylation; pyrrolecarboxylic acid preparation.

Unprotected indoles and pyrroles were found to underwent base-mediated carboxylation reactions under ambient pressure of carbon dioxide. It was found that this transition metal-free carboxylation reaction proceeded smoothly with the use of a large excess of LiOtBu.

Heterocycles published new progress about Aromatic carboxylic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 23077-43-2 belongs to class indole-building-block, and the molecular formula is C9H6FNO2, SDS of cas: 23077-43-2.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Kan, Chun; Shao, Xiaotao; Song, Fan; Xu, Jinbao; Zhu, Jing; Du, Lei published the artcile< Bioimaging of fluorescence rhodamine-based probe for reversible detection of Hg(II) and its application in real water environment>, COA of Formula: C30H36N4O2, the main research area is rhodamine mercury lake water fluorescence quenching biol imaging.

Mercury is a typical serious pollutant certified by relevant authorities, it is harmful not only to biol. health but also to the ecol. environment and its superior detection approach remains challenging. About this research, a novel reversible fluorescent probe (RBST) based on 2-thiopheneacetyl chloride and Rhodamine B was designed, synthesized and established to develop as a chemosensor. Its sensing behavior, especially for various common metal ions, was detected by UV-visible spectrum and fluorescence spectrum. RBST displayed a satisfactory sensitivity and selectivity fluorescent response towards Hg2+ in a solution of EtOH/H2O (2,1, volume/volume), giving a higher combining constant of 3.03 × 104 M-1 and a lower detection limit of 0.11μM resp. Fluorescence quenched presented a reversible behavior with a certain amount of S2- was added under the condition of containing Hg2+. Besides, the practicality of the probe in sensing Hg2+ in real water samples was further proved. Results of this study suggested that the fluorescent reversible probe excels in biol. applications and can be applied in MCF-7 cells, zebrafish and soybean rhizome tissues to detect Hg2+.

Microchemical Journal published new progress about Biological imaging. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, COA of Formula: C30H36N4O2.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Sako, Kumiko; Aoyama, Hiroshi; Sato, Shinichi; Hashimoto, Yuichi; Baba, Masanori published the artcile< γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity>, COA of Formula: C10H9NO, the main research area is bovine viral diarrhea virus carboline derivative preparation SAR.

Based on anti-viral screening of our heteroaromatics derived from thalidomide, the γ-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. BVDV is thought to be a good model for human hepatitis C virus. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-γ-carboline), with the EC50 of 0.26 μM.

Bioorganic & Medicinal Chemistry published new progress about Antiviral agents. 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, COA of Formula: C10H9NO.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles