Month: October 2022

Quality Control of 1H-IndoleIn 2019 ,《An insight into the medicinal perspective of synthetic analogs of indole: A review》 appeared in European Journal of Medicinal Chemistry. The author of the article were Thanikachalam, Punniyakoti Veeraveedu; Maurya, Rahul Kumar; Garg, Vishali; Monga, Vikramdeep. The article conveys some information:

A review. Heterocycles occupy a salient place in chem. due to their wide range of activity in the fields of drug design, photochem., agrochems., dyes, and so on. Amongst all, indole scaffold is considered as one of the most promising heterocycles found in natural and synthetic sources and has been shown to possess various biol. activity, including anti-inflammatory, anti-HIV, antitubercular, antimalarial, anticonvulsant, antidiabetic, antihypertensive, analgesics, antidepressant, anticancer, antioxidant, antifungal, and antimicrobial, etc. All the reported indole mols. bind to multiple receptors with high affinity, thus expedite the research on the development of novel biol. active compounds through the various approach. In this review, we aimed to highlight synthetic and medicinal perspective on the development of indole-based analogs. In addition, structural activity relationship (SAR) study to correlate for their biol. activity also discussed. In the experiment, the researchers used many compounds, for example, 1H-Indole(cas: 120-72-9Quality Control of 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Quality Control of 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Struve, Daniel K.; Moser, Bruno C. published an article on January 31 ,1984. The article was titled 《Auxin effects on root regeneration of scarlet oak seedlings》, and you may find the article in Journal of the American Society for Horticultural Science.Quality Control of Potassium 4-(1H-indol-3-yl)butanoate The information in the text is summarized as follows:

Dipping root systems of scarlet oak seedlings (Quercus coccinea) in indol-3-butyric acid K salt (K-IBA) [60096-23-3], 2,4-D  [94-75-7], 2,4,5-T  [93-76-5], 2,4,5-trichloropropanoic acid  [93-72-1], β-naphthoxyacetic acid  [120-23-0], and NAA  [86-87-3], induced a 6-fold increase in adventitious root regeneration, as compared to control seedlings. Time to first root initiation was increased and root elongation rate was decreased for auxin-treated seedlings relative to untreated controls. Under field conditions, 1-yr-old seedlings treated with NAA, at 3000 mg/L, or K-IBA, at 1000 or 3000 mg/L, regenerated more roots and developed greater root length than did control plants. Toothpicks impregnated with a 1000 mg/L K-IBA solution and inserted into tap roots stimulated an 18-fold increase in root length, as compared to control seedlings. In the part of experimental materials, we found many familiar compounds, such as Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3Quality Control of Potassium 4-(1H-indol-3-yl)butanoate)

Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3) is auxin-family plant hormone, and is thought to be a precursor of indole-3-acetic acid (IAA) the most abundant and the basic auxin natively occurring and functioning in plants. IAA generates the majority of auxin effects in intact plants, and is the most potent native auxin.Quality Control of Potassium 4-(1H-indol-3-yl)butanoate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Yildiz, Halit; Tokalioglu, Serife; Soykan, Cengiz published an article in 2021. The article was titled 《Preparation of polyacrylonitrile/polyindole conducting polymer composite and its use for solid phase extraction of copper in a certified reference material》, and you may find the article in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy.Application In Synthesis of 1H-Indole The information in the text is summarized as follows:

A polyacrylonitrile/polyindole (PAN/PIN) [50, 50] conducting polymer composite was chem. synthesized using FeCl3 as an oxidizing agent in chloroform solution and nitrogen atm. at 10°C. The formation of the composite was supported by Fourier transform IR spectroscopy. The morphol. properties of the composite were investigated by at. force microscopy and SEM. The thermal properties of the composite were examined by using thermogravimetric analyses. It was found that the composite had good thermal stability. The conducting polymer composite was used for the first time as an adsorbent for solid phase extraction of Cu (II). The optimum pH was found to be 7. The adsorption and elution shaking times were 5 and 15 min, resp. The elution was done with 5 mL of 2 mol L-1 HNO3. The accuracy of the developed method was confirmed by analyzing certified reference material (TMDA-70.2 Lake Water). In the experiment, the researchers used 1H-Indole(cas: 120-72-9Application In Synthesis of 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application In Synthesis of 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2016,International Journal of Pharmaceutical Sciences Review and Research included an article by Sekhar, Abinitha S.; Saranya, T. S.; Baskar, Vaishnav; Manakadan, Asha Ashokan. Application of 162100-42-7. The article was titled 《In silico approach of apoptosis induing ability of different indole derivatives by interaction with caspase9》. The information in the text is summarized as follows:

Indole compounds are well known for their wide variety of pharmacol. activities. It is the combination of benzene with pyrrole ring. Compounds having indole group are biol. important. They are used as antimicrobial, antiviral, antitubercular, antiinflammatory, anticancer, ant-diabetic and anticonvulsant agents. Because of the wide variety of biol. application, several substituted indole derivatives are studied for their mol. structure, mol. docking and bioavailability. The purpose of the study is to carry out the docking studies of indole derivatives containing electrophilic substitution and nucleophilic substitution with the anticancer target casp9. Fifty compounds were designed and by using Argus lab version 4.0.1. Their docking score was calculated and compared with the standard drug casodex. The drug likeness of compounds was performed using Lipinski rule of five. Result showed that 1,1′-(1H-indole-5,6-diyl)diethanone and 5-(trichloromethyl)-1H-indole and the phytoconstituent curcumin showed better docking score than that of the standard drug casodex. It is concluded that certain indole derivatives show greater affinity with casp9 protein. These compounds may be helpful in studying anticancer targets for casp9 protein. In the part of experimental materials, we found many familiar compounds, such as 6-Chloro-5-methyl-1H-indole(cas: 162100-42-7Application of 162100-42-7)

6-Chloro-5-methyl-1H-indole(cas: 162100-42-7) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application of 162100-42-7

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Biphasic chemotaxis of Escherichia coli to the microbiota metabolite indole》 was written by Yang, Jingyun; Chawla, Ravi; Rhee, Kathy Y.; Gupta, Rachit; Manson, Michael D.; Jayaraman, Arul; Lele, Pushkar P.. Application of 120-72-9 And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2020. The article conveys some information:

Bacterial chemotaxis to prominent microbiota metabolites such as indole is important in the formation of microbial communities in the gastrointestinal (GI) tract. However, the basis of chemotaxis to indole is poorly understood. Here, we exposed Escherichia coli to a range of indole concentrations and measured the dynamic responses of individual flagellar motors to determine the chemotaxis response. Below 1 mM indole, a repellent-only response was observed At 1 mM indole and higher, a time-dependent inversion from a repellent to an attractant response was observed The repellent and attractant responses were mediated by the Tsr and Tar chemoreceptors, resp. Also, the flagellar motor itself mediated a repellent response independent of the receptors. Chemotaxis assays revealed that receptor-mediated adaptation to indole caused a bipartite response-wild-type cells were attracted to regions of high indole concentration if they had previously adapted to indole but were otherwise repelled. We propose that indole spatially segregates cells based on their state of adaptation to repel invaders while recruiting beneficial resident bacteria to growing microbial communities within the GI tract. The results came from multiple reactions, including the reaction of 1H-Indole(cas: 120-72-9Application of 120-72-9)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application of 120-72-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor》 was written by Scott, Samantha A.; Fu, Jingjing; Chang, Pamela V.. Formula: C8H7NThis research focused ontryptophan metabolite gut barrier aryl hydrocarbon receptor disease human; Crohn disease ulcerative colitis inflammatory bowel disease cytokine; colitis; gut microbiome; inflammatory bowel disease; intestinal epithelium. The article conveys some information:

Inflammatory bowel diseases (IBDs), including Crohn’s disease and ulcerative colitis, are associated with dysbiosis of the gut microbiome. Emerging evidence suggests that small-mol. metabolites derived from bacterial breakdown of a variety of dietary nutrients confer a wide array of host benefits, including amelioration of inflammation in IBDs. Yet, in many cases, the mol. pathways targeted by these mols. remain unknown. Here, we describe roles for three metabolites-indole-3-ethanol, indole-3-pyruvate, and indole-3-aldehyde-which are derived from gut bacterial metabolism of the essential amino acid tryptophan, in regulating intestinal barrier function. We determined that these metabolites protect against increased gut permeability associated with a mouse model of colitis by maintaining the integrity of the apical junctional complex and its associated actin regulatory proteins, including myosin IIA and ezrin, and that these effects are dependent on the aryl hydrocarbon receptor. Our studies provide a deeper understanding of how gut microbial metabolites affect host defense mechanisms and identify candidate pathways for prophylactic and therapeutic treatments for IBDs. In the experiment, the researchers used many compounds, for example, 1H-Indole(cas: 120-72-9Formula: C8H7N)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Formula: C8H7N

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles