Month: November 2022

Kim, S. H.’s team published research in Hormone and Metabolic Research in 45 | CAS: 330161-87-0

Hormone and Metabolic Research published new progress about 330161-87-0. 330161-87-0 belongs to indole-building-block, auxiliary class Protein Tyrosine Kinase/RTK,Src, name is SU6656, and the molecular formula is C19H21N3O3S, Related Products of indole-building-block.

Kim, S. H. published the artcileInhibition of p21 and Akt potentiates SU6656-induced caspase-independent cell death in FRO anaplastic thyroid carcinoma cells, Related Products of indole-building-block, the publication is Hormone and Metabolic Research (2013), 45(6), 408-414, database is CAplus and MEDLINE.

SU6656 is a small-mol. indolinone that selectively inhibits Src family kinase and induces death of cancer cells. The aim of the present study was to investigate the influence of SU6656 on cell survival and to assess the role of p21 and PI3K/Akt signaling in cell survival resulting from SU6656 treatment in anaplastic thyroid carcinoma (ATC) cells. When 8505C, CAL62, and FRO ATC cells were treated with SU6656, the viability of 8505C and CAL62 ATC cells decreased only after treatment with SU6656 at a dosage of 100 μM for 72 h, while the viability of FRO ATC cells decreased after treatment with SU6656 in a concentration- and time-dependent manner. Cell viability was not changed by pretreatment with the broad-spectrum caspase inhibitor z-VAD-fmk. Phospho-Src protein levels were reduced, and p21 protein levels were elevated. Phospho-ERK1/2 protein levels were multiplied without alteration of total ERK1/2, total Akt, and phospho-Akt protein levels. Regarding FRO ATC cells, the decrement of cell viability, the increment of cleaved PARP-1 protein levels, and the decrement of phospho-Src protein levels were shown in p21 siRNA- or LY294002-pretreated cells compared to SU6656-treated control cells. ERK1/2 siRNA transfection did not affect cell viability and protein levels of cleaved PARP-1, p21, and Akt. In conclusion, these results suggest that SU6656 induces caspase-independent death of FRO ATC cells by overcoming the resistance mechanism involving p21 and Akt. Suppression of p21 and Akt enhances the cytotoxic effect of SU6656 in FRO ATC cells.

Hormone and Metabolic Research published new progress about 330161-87-0. 330161-87-0 belongs to indole-building-block, auxiliary class Protein Tyrosine Kinase/RTK,Src, name is SU6656, and the molecular formula is C19H21N3O3S, Related Products of indole-building-block.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Jiang, Fanwei’s team published research in Huaxue Tongbao in 78 | CAS: 10242-03-2

Huaxue Tongbao published new progress about 10242-03-2. 10242-03-2 belongs to indole-building-block, auxiliary class Indole,Nitro Compound,Carboxylic acid,Indole, name is 6-Nitro-1H-indole-3-carboxylic acid, and the molecular formula is C9H6N2O4, Category: indole-building-block.

Jiang, Fanwei published the artcileSynthesis of substituted indole-3-carboxylic acid derivatives, Category: indole-building-block, the publication is Huaxue Tongbao (2015), 78(4), 378-380, database is CAplus.

Indole-3-carboxylic acid was a kind of important organic intermediate, which could be widely used in the synthesis of medicine and pesticide. Substituted 2-nitro-β-dimethylamino styrene was obtained from the reaction of substituted 2-nitrotoluene and N,N-dimethylformamide di-Me acetal in N,N-dimethylformamide, which was further reacted with iron and acetic acid to give substituted indoles. Five substituted indole-3-carboxylic acids were synthesized from substituted indoles and trifluoroacetic anhydride. The reported synthesis had the advantages of simple post treatment, mild conditions and higher yields.

Huaxue Tongbao published new progress about 10242-03-2. 10242-03-2 belongs to indole-building-block, auxiliary class Indole,Nitro Compound,Carboxylic acid,Indole, name is 6-Nitro-1H-indole-3-carboxylic acid, and the molecular formula is C9H6N2O4, Category: indole-building-block.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Hayato, Yukitaka’s team published research in Kagaku to Kyoiku in 70 | CAS: 2642-37-7

Kagaku to Kyoiku published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Application of Potassium 1H-indol-3-yl sulfate.

Hayato, Yukitaka published the artcileIntroduction and recent achievements of the International Science and Engineering Fair (ISEF), Application of Potassium 1H-indol-3-yl sulfate, the publication is Kagaku to Kyoiku (2022), 70(1), 54-56, database is CAplus.

A review. In this paper, authors would like to introduce one of results of our activities, which was highly evaluated at ISEF2021, by Dr. Sotaka Hayato, Dr. Masafumi Kaneko, and Dr. Hitoshi Yoneaki of Naruto University of Education. The paper outlines award-winning research in ISEF2021 chem. division, its research and about announcement of ISEF2021. The final result was summarized as a research project “selective synthesis of indirubin and photocatalytic activity”, and received the Tokushima Prefectural Examination of Japan Student Science Award 2020.

Kagaku to Kyoiku published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Application of Potassium 1H-indol-3-yl sulfate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Bergmann, Felix’s team published research in Analytical Biochemistry in 10 | CAS: 2642-37-7

Analytical Biochemistry published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Computed Properties of 2642-37-7.

Bergmann, Felix published the artcileDetermination of uric acid and its thio analogs in biological fluids, Computed Properties of 2642-37-7, the publication is Analytical Biochemistry (1965), 10(1), 73-85, database is CAplus and MEDLINE.

Uric acid and its thio derivatives were separated from plasma proteins by the use of Sephadex. Thiouric acids in plasma were determined spectrophotometrically. Uric acid analysis by enzymic oxidation was not disturbed by the presence of the 2- or 8-thio analog. On the other hand, separation of uric acid and its 6-thio derivative on an anion exchanger must precede determination of the former. The absorption spectra of the mercuric complexes of thiouric acids differed characteristically from the spectra of the free thio derivatives Analysis of thiouric acids in urine was based on the difference in absorbance between Hg(II)-free solutions and those containing the metal ion.

Analytical Biochemistry published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C8H6KNO4S, Computed Properties of 2642-37-7.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Krow, Grant R. et al. published their research in Organic Reactions (Hoboken, NJ, United States) in 1993 | CAS: 15540-90-6

4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Safety of 4,7-Dimethylindoline-2,3-dione

The Baeyer-Villiger oxidation of ketones and aldehydes was written by Krow, Grant R.. And the article was included in Organic Reactions (Hoboken, NJ, United States) in 1993.Safety of 4,7-Dimethylindoline-2,3-dione The following contents are mentioned in the article:

A review of the article The Baeyer-Villiger oxidation of ketones and aldehydes. This study involved multiple reactions and reactants, such as 4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6Safety of 4,7-Dimethylindoline-2,3-dione).

4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Safety of 4,7-Dimethylindoline-2,3-dione

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Gareau, Yves et al. published their research in Tetrahedron Letters in 2003 | CAS: 82104-06-1

2-Benzyl-5-bromoisoindoline-1,3-dione (cas: 82104-06-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application of 82104-06-1

Oxidation of aromatic and aliphatic triisopropylsilanylsulfanyls to sulfonyl chlorides: preparation of sulfonamides was written by Gareau, Yves;Pellicelli, Jonathan;Laliberte, Sebastien;Gauvreau, Danny. And the article was included in Tetrahedron Letters in 2003.Application of 82104-06-1 The following contents are mentioned in the article:

Aromatic and aliphatic triisopropylsilanylsulfanyls were prepared and oxidized to the sulfonyl chlorides with KNO3/SO2Cl2. The sulfonyl chlorides were characterized via their conversion to sulfonamides. This study involved multiple reactions and reactants, such as 2-Benzyl-5-bromoisoindoline-1,3-dione (cas: 82104-06-1Application of 82104-06-1).

2-Benzyl-5-bromoisoindoline-1,3-dione (cas: 82104-06-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application of 82104-06-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Worlikar, Shilpa A. et al. published their research in Journal of Organic Chemistry in 2008 | CAS: 82104-06-1

2-Benzyl-5-bromoisoindoline-1,3-dione (cas: 82104-06-1) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Electric Literature of C15H10BrNO2

Palladium-catalyzed one-step synthesis of isoindole-1,3-diones by carbonylative cyclization of o-halobenzoates and primary amines was written by Worlikar, Shilpa A.;Larock, Richard C.. And the article was included in Journal of Organic Chemistry in 2008.Electric Literature of C15H10BrNO2 The following contents are mentioned in the article:

The palladium-catalyzed aminocarbonylation of o-halobenzoates produces 2-substituted isoindole-1,3-diones in good yields. This methodol. provides a good one-step approach to this important class of heterocycles and tolerates a variety of functional groups, including methoxy, alc., ketone, and nitro groups. This study involved multiple reactions and reactants, such as 2-Benzyl-5-bromoisoindoline-1,3-dione (cas: 82104-06-1Electric Literature of C15H10BrNO2).

2-Benzyl-5-bromoisoindoline-1,3-dione (cas: 82104-06-1) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Electric Literature of C15H10BrNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

El-Sharief, A. M. S. et al. published their research in Egyptian Journal of Chemistry in 1982 | CAS: 82104-06-1

2-Benzyl-5-bromoisoindoline-1,3-dione (cas: 82104-06-1) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Computed Properties of C15H10BrNO2

Action of Grignard reagents on halogenated phthalimides was written by El-Sharief, A. M. S.;Eid, F. A.. And the article was included in Egyptian Journal of Chemistry in 1982.Computed Properties of C15H10BrNO2 The following contents are mentioned in the article:

3-Benzalphthalimidines I (R = H, 4-Me, R1 = 6-Br, 7-Cl; R = 2-Me, 2-OMe, 4-Cl, R1 6-Br) were obtained by interaction of PhCH2MgCl with phthalimides, then dehydration of the resulting 3-benzyl-3-hydroxyphthalimidines. Interaction of PhMgBr and EtMgI with bromophthalimides is also discussed. This study involved multiple reactions and reactants, such as 2-Benzyl-5-bromoisoindoline-1,3-dione (cas: 82104-06-1Computed Properties of C15H10BrNO2).

2-Benzyl-5-bromoisoindoline-1,3-dione (cas: 82104-06-1) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Computed Properties of C15H10BrNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Rana, Sandeep et al. published their research in Organic & Biomolecular Chemistry in 2013 | CAS: 15540-90-6

4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Application of 15540-90-6

Face selective reduction of the exocyclic double bond in isatin derived spirocyclic lactones was written by Rana, Sandeep;Natarajan, Amarnath. And the article was included in Organic & Biomolecular Chemistry in 2013.Application of 15540-90-6 The following contents are mentioned in the article:

We report an unusual face selective reduction of the exocyclic double bond in the α-methylene-γ-butyrolactone motif of spiro-oxindole systems I and II [R1 = H, Me, R2 = H; R1 =H, R2 = Me]. The spiro-oxindoles were assembled by an indium metal mediated Barbier-type reaction followed by an acid catalyzed lactonization. This study involved multiple reactions and reactants, such as 4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6Application of 15540-90-6).

4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Application of 15540-90-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Klasek, Antonin et al. published their research in Tetrahedron in 2000 | CAS: 15540-90-6

4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Recommanded Product: 15540-90-6

Synthesis of novel 3-acyloxy-1,3-dihydro-2H-indol-2-ones and isomeric 4-acyl-1,4-dihydro-3,1-benzoxazin-2-ones: double rearrangement of 3-hydroxyquinoline-2,4(1H,3H)-diones was written by Klasek, Antonin;Koristek, Kamil;Polis, Jiri;Kosmrlj, Janez. And the article was included in Tetrahedron in 2000.Recommanded Product: 15540-90-6 The following contents are mentioned in the article:

Substituted 3-hydroxyquinoline-2,4(1H,3H)-diones were transformed into 3-acyloxy-1,3-dihydro-2H-indol-2-ones and isomeric 4-acyl-1,4-dihydro-3,1-benzoxazin-2-ones. The influence of the substituents and the reaction conditions on the course of the reaction was studied. In the proposed mechanism, a double rearrangement takes place; α-ketol rearrangement, leading to a α-hydroxy β-diketone intermediate, is followed by a rearrangement to the isomeric α-ketol esters. This study involved multiple reactions and reactants, such as 4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6Recommanded Product: 15540-90-6).

4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Recommanded Product: 15540-90-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles