Month: November 2022

Synthesis of Oxindole Derivatives via Intramolecular C-H Insertion of Diazoamides Using Ru(II)-Pheox Catalyst was written by Phan Thi Thanh, Nga;Dang Thi Thu, Huong;Tone, Masaya;Inoue, Hayato;Iwasa, Seiji. And the article was included in Tetrahedron in 2020.Recommanded Product: 100831-25-2 The following contents are mentioned in the article:

This work presented the efficient intramol. aromatic C-H insertion of diazoacetamide. The diazo compounds (except for 1k) were converted into their corresponding oxindoles via an intramol. C-H insertion reaction in the presence of a Ru catalyst. The Ru-Pheox catalyst was shown to be highly efficient in this transformation in terms of the regioselectivity, producing the desired products in excellent yield (99%). The efficiency of the Ru catalyst reached 580 (TON) and 156 min-1 (TOF). This study involved multiple reactions and reactants, such as 7-Bromo-1-methylindolin-2-one (cas: 100831-25-2Recommanded Product: 100831-25-2).

7-Bromo-1-methylindolin-2-one (cas: 100831-25-2) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Recommanded Product: 100831-25-2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Dicyclooctabiphenylene. Synthesis and properties was written by Wilcox, Charles F. Jr.;Farley, Erik N.. And the article was included in Journal of the American Chemical Society in 1984.Recommanded Product: 15540-90-6 The following contents are mentioned in the article:

The preparation and properties of the “antiarom.” hydrocarbon dicycloocta[1,2,3,4-def:1′,2′,3′,4′-jkl]biphenylene (I) are described. The observed electronic and ¹H NMR spectra of I agree well with previous predictions. The series of polycycles comprising I, biphenylene (II), and cycloocta[def]biphenylene (III), is examined in terms of resonance energy and qual. aromaticity models. This study involved multiple reactions and reactants, such as 4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6Recommanded Product: 15540-90-6).

4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Recommanded Product: 15540-90-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Reductive Coupling of Acrylates with Ketones and Ketimines by a Nickel-Catalyzed Transfer-Hydrogenative Strategy was written by Buxton, Craig S.;Blakemore, David C.;Bower, John F.. And the article was included in Angewandte Chemie, International Edition in 2017.Quality Control of 4,7-Dimethylindoline-2,3-dione The following contents are mentioned in the article:

Nickel-catalyzed coupling of benzyl acrylates with activated ketones and imines provides γ-butyrolactones and lactams, resp. The benzyl alc. byproduct released during the lactonization/lactamization event is relayed to the next cycle where it serves as the reductant for C-C bond formation. This strategy represents a conceptually unique approach to transfer-1′- C-C bond formation, thus providing examples of reductive heterocyclizations where hydrogen embedded within an alc. leaving group facilitates turnover. This study involved multiple reactions and reactants, such as 4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6Quality Control of 4,7-Dimethylindoline-2,3-dione).

4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Quality Control of 4,7-Dimethylindoline-2,3-dione

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Catalyst-Free Convergent Approach for the Synthesis of Spiro[imidazo[2,1-b][1,3]oxazine-7,3′-indoline] was written by Siddiqui, I. R.;Srivastava, Anushree;Rai, Pragati;Srivastava, Arjita;Srivastava, Anjali. And the article was included in Journal of Heterocyclic Chemistry in 2015.Recommanded Product: 4,7-Dimethylindoline-2,3-dione The following contents are mentioned in the article:

Strategies to address mounting environmental concerns with current approaches include an operationally simple and highly efficient one-pot three-component approach for the synthesis of spiro[imidazo[2,1-b][1,3]oxazine-7,3′-indoline] derivatives, e. g., I, which has been developed via Huisgen zwitter ion intermediate. The significant advantages of this protocol are short reaction time, excellent yields, and facile formation of three new bonds in one operation from easily available starting materials. This study involved multiple reactions and reactants, such as 4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6Recommanded Product: 4,7-Dimethylindoline-2,3-dione).

4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Recommanded Product: 4,7-Dimethylindoline-2,3-dione

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

(2,3-Dihydro-1H-indol-5-ylmethyl)amine was written by Ogurtsov, Vladimir A.;Rakitin, Oleg A.. And the article was included in Molbank in 2021.Electric Literature of C9H14Cl2N2 The following contents are mentioned in the article:

New (2,3-dihydro-1H-indol-5-ylmethyl)amine was synthesized from 2-((1-acetylindolin-5-yl)methyl)isoindoline-1,3-dione by simultaneous deprotection of phthalimide and acetyl groups. The structure of the newly synthesized compounds was established by elemental anal., high resolution mass-spectrometry, ¹H, ¹³C NMR and IR spectroscopy and mass-spectrometry. The resulting compound is a convenient intermediate for various disubstituted 1-(indolin-5-yl)methanamines, which may be of interest as substances with useful pharmacol. properties. This study involved multiple reactions and reactants, such as Indolin-5-ylmethanamine dihydrochloride (cas: 1242338-94-8Electric Literature of C9H14Cl2N2).

Indolin-5-ylmethanamine dihydrochloride (cas: 1242338-94-8) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Electric Literature of C9H14Cl2N2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ligand-Controlled Palladium-Catalyzed Asymmetric [4+3] and [2+3] Annulation Reactions of Spirovinylcyclopropyl Oxindoles with o-Quinone Methides was written by Zhang, Xiyuan;Zhang, Cong;Jiang, Bo;Gao, Yanfeng;Xu, Xiufang;Miao, Zhiwei. And the article was included in Organic Letters in 2022.HPLC of Formula: 100831-25-2 The following contents are mentioned in the article:

Herein, the regiodivergent ligand-controlled palladium-catalyzed asym. cycloaddition reactions between spirovinylcyclopropyl oxindoles and o-quinone methides was reported. Specifically, by using the chiral P,P-ligand Segphos, various spirooxindole-3,4-benzo[b]oxepanes in moderate to good yields with excellent enantioselectivities via [4+3] cycloaddition reactions was obtained. In contrast, reactions involving Trost’s ligand showed different regio- and stereoselectivities, affording bispirooxindole heterocyclic compounds in good yields via [2+3] cycloaddition reactions. This study involved multiple reactions and reactants, such as 7-Bromo-1-methylindolin-2-one (cas: 100831-25-2HPLC of Formula: 100831-25-2).

7-Bromo-1-methylindolin-2-one (cas: 100831-25-2) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). HPLC of Formula: 100831-25-2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Isatin Derived Spirocyclic Analogues with α-Methylene-γ-butyrolactone as Anticancer Agents: A Structure-Activity Relationship Study was written by Rana, Sandeep;Blowers, Elizabeth C.;Tebbe, Calvin;Contreras, Jacob I.;Radhakrishnan, Prakash;Kizhake, Smitha;Zhou, Tian;Rajule, Rajkumar N.;Arnst, Jamie L.;Munkarah, Adnan R.;Rattan, Ramandeep;Natarajan, Amarnath. And the article was included in Journal of Medicinal Chemistry in 2016.Electric Literature of C10H9NO2 The following contents are mentioned in the article:

Design, synthesis, and evaluation of α-methylene-γ-butyrolactone analogs and their evaluation as anticancer agents is described. SAR identified a spirocyclic analog I that inhibited TNFα-induced NF-κB activity, cancer cell growth and tumor growth in an ovarian cancer model. A second iteration of synthesis and screening identified II which inhibited cancer cell growth with low-μM potency. Our data suggest that an isatin-derived spirocyclic α-methylene-γ-butyrolactone is a suitable core for optimization to identify novel anticancer agents. This study involved multiple reactions and reactants, such as 4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6Electric Literature of C10H9NO2).

4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Electric Literature of C10H9NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis and antitumor activity of 5-(5-halogenated-2-oxo-1H-pyrrolo[2,3-b]pyridin-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamides was written by Wang, Minghua;Ye, Cheng;Liu, Mingliang;Wu, Zhaoyang;Li, Linhu;Wang, Chunlan;Liu, Xiujun;Guo, Huiyuan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Product Details of 1190314-60-3 The following contents are mentioned in the article:

We report herein the design and synthesis of a series of novel 5-halogenated-7-azaindolin-2-one derivatives containing a 2,4-dimethylpyrrole moiety. Nine target compounds with ≥70% inhibition against MCF-7 at 30 μM were further evaluated for their in vitro antitumor activity against seven human cancer cell lines by SRB assay. Results reveal that some compounds have potent antitumor activity, and the most active I (IC₅₀s: 4.49-15.39 μM) was found to be more active than Sunitinib (IC₅₀s: 4.70->30 μM) against all of the tested cancer cell lines. This study involved multiple reactions and reactants, such as 5-Chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (cas: 1190314-60-3Product Details of 1190314-60-3).

5-Chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (cas: 1190314-60-3) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Product Details of 1190314-60-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Monothio- and dithiophthalimides: synthesis of dibromo-β-isoindigo and dibromodithio-β-isoindigo derivatives was written by El-Sharief, A. M. S.;Hammad, N. E.. And the article was included in Indian Journal of Chemistry in 1981.Product Details of 82104-06-1 The following contents are mentioned in the article:

5-Bromo-3-oxo-1-thioxoisoindolines and 5-bromo-1,3-dithioxoisoindolines on reaction with amines either in AcOH or under fusion give 2-aryl-1-arylimino-5-bromo-3-isoindolinones and 1-arylimino-5-bromo-3-thioxoisoindolines, resp. Dithione I on reaction with Ph₂CN₂ gives the spiro[isoindoline-thiirane] II. The 5-bromo-3-oxo-1-thioxoisoindolines and 5-bromo-1,3-dithioxoisoindolines when heated with Cu turnings in decalin give the corresponding dibromo-β-isoindigo derivatives e.g. III and dibromodithio-β-isoindigo derivs, e.g. IV. This study involved multiple reactions and reactants, such as 2-Benzyl-5-bromoisoindoline-1,3-dione (cas: 82104-06-1Product Details of 82104-06-1).

2-Benzyl-5-bromoisoindoline-1,3-dione (cas: 82104-06-1) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Product Details of 82104-06-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computational & experimental evaluation of the structure/activity relationship of β-carbolines as DYRK1A inhibitors was written by Drung, Binia;Scholz, Christoph;Barbosa, Valeria A.;Nazari, Azadeh;Sarragiotto, Maria H.;Schmidt, Boris. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Application of 146436-31-9 The following contents are mentioned in the article:

DYRK1A has been associated with Down’s syndrome and neurodegenerative diseases, therefore it is an important target for novel pharmacol. interventions. We combined a ligand-based pharmacophore design with a structure-based protein/ligand docking using the software MOE in order to evaluate the underlying structure/activity relationship. Based on this knowledge we synthesized several novel β-carboline derivatives to validate the theor. model. Furthermore we identified a modified lead structure as a potent DYRK1A inhibitor (IC₅₀ = 130 nM) with significant selectivity against MAO-A, DYRK2, DYRK3, DYRK4 & CLK2. This study involved multiple reactions and reactants, such as 1-Isobutyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid (cas: 146436-31-9Application of 146436-31-9).

1-Isobutyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid (cas: 146436-31-9) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Application of 146436-31-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles