Month: November 2022

Lakhdar, Sami; Appel, Roland; Mayr, Herbert published an article in 2009, the title of the article was How Does Electrostatic Activation Control Iminium-Catalyzed Cyclopropanations?.Related Products of 79815-20-6 And the article contains the following content:

Prediction of lg k=s(N+E) verified: In contrast to previous statements, ordinary α,β-unsaturated iminium ions do react with sulfur ylides. Electrostatic interactions accelerate the reactions by a factor of more than 105 and are responsible for the high stereoselectivity. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Related Products of 79815-20-6

The Article related to electrostatic activation iminium catalyzed cyclopropanation stereoselectivity, Physical Organic Chemistry: Ring Formation, Cleavage, Enlargement, and Contraction and other aspects.Related Products of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 16, 2005, Kunz, Roxanne K.; MacMillan, David W. C. published an article.Application In Synthesis of H-Idc-OH The title of the article was Enantioselective organocatalytic cyclopropanations. The identification of a new class of iminium catalyst based upon directed electrostatic activation. And the article contained the following:

A new method for enantioselective organocatalytic cyclopropanation is described. This study outlines the identification of a new class of iminium catalyst based on the concept of directed electrostatic activation (DEA). This novel organocatalytic mechanism exploits dual activation of ylide and enal substrates through a proposed electrostatic activation and stereodirected protocol. Formation of trisubstituted cyclopropanes with high levels of enantio- and diastereo-induction is accomplished for a variety of α,β-unsaturated aldehydes and sulfonium ylides. In addition, mechanistic studies have found that this cyclopropanation reaction exhibits enantioselectivity and reactivity profiles that are in accord with the proposed DEA step. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Application In Synthesis of H-Idc-OH

The Article related to enantioselective iminium organocatalyst cyclopropanation electrostatic activation, Physical Organic Chemistry: Ring Formation, Cleavage, Enlargement, and Contraction and other aspects.Application In Synthesis of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On September 30, 2014, Vakarov, S. A.; Gruzdev, D. A.; Chulakov, E. N.; Sadretdinova, L. Sh.; Ezhikova, M. A.; Kodess, M. I.; Levit, G. L.; Krasnov, V. P. published an article.Category: indole-building-block The title of the article was Diastereoselective Acylation of Racemic Heterocyclic Amines with N-Tosyl-(S)-Prolyl Chloride and its Structural Analogs. And the article contained the following:

A comparative study on the kinetic resolution of racemic amines (2,3-dihydro-4H-1,4-benzoxazine and 1,2,3,4-tetrahydroquinoline derivatives) by a diastereoselective acylation with N-tosyl-(S)-prolyl chloride and its structural analogs was performed. The effect of resolving agent structure on the stereoselectivity of heterocyclic amine acylation was examined The highest stereoselectivity was achieved in the case of acylation with acyl chlorides bearing a conformationally restricted pyrrolidine ring and an aromatic substituent in the protecting group at the nitrogen atom. The synthesis of the target compounds was achieved by a reaction of (2S)-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinecarbonyl chloride (proline chloride), (2S)-1-[(2-naphthalenyl)sulfonyl]-2-pyrrolidinecarbonyl chloride, (2S)-1-[(1-naphthalenyl)sulfonyl]-2-pyrrolidinecarbonyl chloride, (αS)-α-[methyl[(4-methylphenyl)sulfonyl]amino]benzenepropanoyl chloride, (2S)-tetrahydro-2-furancarbonyl chloride.(2S)-2,3-dihydro-1H-indole-2-carbonyl chloride with 7,8-difluoro-3,4-dihydro-3-methyl-2H-1,4-benzoxazine, 3,4-dihydro-3-methyl-2H-1,4-benzoxazine, 1,2,3,4-tetrahydro-2-methylquinoline. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Category: indole-building-block

The Article related to acyl chloride proline racemic amine acylation kinetic resolution, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Irvine, Robert W.; Summers, John C.; Taylor, Walter C. published an article in 1983, the title of the article was Photochemistry of dimethyl quinoline-3,4-dicarboxylate N-oxides.Safety of Methyl 2-methyl-1H-indole-3-carboxylate And the article contains the following content:

The photochem. rearrangement of di-Me 2-methyl- and 2-aryl-substituted quinoline-3,4-dicarboxylate N-oxides are examined In MeOH or MeOH-CHCl3 the major product was the 1-methyl- or 1-arylquinolin-2(1H)-one in which the substituent at C-2 has migrated to the N atom. The yield of these products was increased in a dark reaction subsequent to the irradiation In MeCN the inital major product was the corresponding 3,1-benzoxazepine; subsequent reactions yielded inter alia indole derivatives The intermediacy of fused oxaziridines or their ring opened isomeric zwittterions is discussed. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Safety of Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to photochem rearrangement mechanism quinolinedicarboxylate oxide, Physical Organic Chemistry: Rearrangements, Including Isomerization and Tautomerization and other aspects.Safety of Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On September 12, 2013, Liu, Jin-Qiang; Cao, Xin-Xiang; Ji, Baoming; Zhao, Bangtun published an article.Name: H-Idc-OH The title of the article was Determination and Correlation of Solubilities of (S)-Indoline-2-carboxylic Acid in Six Different Solvents from (283.15 to 358.15) K. And the article contained the following:

The solubilities of (S)-indoline-2-carboxylilc acid (SIn2CA) in six pure solvents including water, methanol, ethanol, 1-propanol, 2-propanol, and 1-butanol were determined from (283.15 to 358.15) K at atm. pressure using the synthetic method. The solubility was determined by a laser monitoring observation technique and found to increase with the rise of temperature The exptl. solubilities were correlated by the modified Apelblat and λh (Buchowski) equations with the relative deviation less than 3.65% with the modified Apelblat equation and less than 0.023% with the λh equation. Thermodn. functions of the solution of SIn2CA in different solvents including apparent dissolution enthalpy and entropy were obtained by van’t Hoff equation, and the apparent dissolution Gibbs free energy change was also calculated The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Name: H-Idc-OH

The Article related to correlation solubility indolinecarboxylate water methanol ethanol propanol butanol, Phase Equilibriums, Chemical Equilibriums, and Solutions: Phase Equilibriums, Solubility and other aspects.Name: H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Shi, Yao; Ke, Zhihai; Yeung, Ying-Yeung published an article in 2018, the title of the article was Environmentally benign indole-catalyzed position-selective halogenation of thioarenes and other aromatics.Category: indole-building-block And the article contains the following content:

An environmentally benign protocol for the synthesis of aryl bromides RBr [R = 3,4-di-MeOC6H3, 4-MeSC6H4, 2-Me-thienyl, etc.] was developed via regioselective electrophilic bromination of aromatic compounds Indole-catalyst was suitable for a wide range of substrates including thioarenes. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Category: indole-building-block

The Article related to bromoarene green preparation regioselective, thioether bromination indole organocatalyst, arene bromination indole organocatalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On May 27, 2021, Jing, Peng; Guo, Qiang; Dou, Fei; Wan, Zehong; Hu, Zhijing published a patent.Name: 6-Chloro-2,3-dihydro-1H-indole The title of the patent was Fused heterocyclic derivative and application. And the patent contained the following:

The invention disclosed a kind of fused heterocyclic derivative, its preparation method and application for treating neuropsychiatric diseases. The claimed compound is shown in structure I (Z = O or S C2-8 chain or halo substituted C2-8 chain; A = II; R = heteroaryl; Q = N or CH; Y = O or S; R1,R2,R3 = H, halo, C1-6 alkyl, etc.; n1 = 1-3 integers). The claimed compound is prepared via multiple steps (procedure given). The prepared compound can be used for treating neuropsychiatric diseases such as schizophrenia, depression, anxiety, sleep disorders, neurodegenerative diseases, bipolar disorder, post-traumatic stress syndrome, addiction disorders, abstinence syndrome, or attention deficit. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Name: 6-Chloro-2,3-dihydro-1H-indole

The Article related to fused heterocyclic derivative preparation neuropsychiatric disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Name: 6-Chloro-2,3-dihydro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chen, Xiaohong; Zheng, Guangfan; Song, Guoyong; Li, Xingwei published an article in 2018, the title of the article was Rhodium(III)-Catalyzed Synthesis of Cinnolinium Salts from Azobenzenes and Diazo Compounds.Recommanded Product: 65417-22-3 And the article contains the following content:

A Rh(III)-catalyzed C-H activation of azobenzenes in the coupling with diazo compounds has been realized, providing a straightforward strategy to access functionalized cinnolinium triflates, e.g., I in high yields. This protocol features silver free mild reaction conditions and compatibility with diverse functional groups. The coupling proceeds via initial Rh(III)-catalyzed C-H alkylation, followed by zinc triflate-mediated cyclization, where zinc triflate acts as a Lewis acid as well as a triflate source. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Recommanded Product: 65417-22-3

The Article related to cinnolinium salt preparation, azobenzene diazo compound carbon hydrogen activation coupling rhodium catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Recommanded Product: 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On September 30, 1993, Guven, Alaattin; Jones, R. Alan published an article.Recommanded Product: Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Potentially tautomeric 1,2-dihydro-1-oxo-5H-pyridazino[4,5-b]indole and 3,4-dihydro-4-oxo-5H-pyridazino[4,5-b]indole. And the article contained the following:

The potentially tautomeric title compounds I and II were synthesized from Et 2-formylindole-3-carboxylate and hydrazine and from Et 3-formylindole-2-carboxylate and hydrazine, resp., and their tautomeric equilibrium confirmed by their electronic spectra and their acidity functions. Many related compounds were examined for their tautomeric equilibrium between hydroxyl and oxo groups. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Recommanded Product: Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to tautomerism dihydrooxopyridazinoindole, pyridazinoidole dihydrooxo tautomerism, electronic spectra dihydrooxopyridazinoindole, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Recommanded Product: Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On August 11, 2015, Yang, Shyh-Ming; Kuo, Gee-Hong; Gaul, Micheal D.; Rano, Thomas A. published a patent.COA of Formula: C8H8ClN The title of the patent was Substituted piperidinyl-pyridazinyl derivatives useful as scd 1 inhibitors. And the patent contained the following:

The present invention is directed to novel piperidinyl-pyridazinyl derivatives, pharmaceutical compositions containing them and their use as inhibitors of SCD1, useful in the treatment of obesity, type-II diabetes and other related metabolic disorders. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).COA of Formula: C8H8ClN

The Article related to piperidinyl pyridazinyl derivative preparation scd1 inhibitor, obesity type 2 diabetes treatment piperidinyl pyridazinyl derivative preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.COA of Formula: C8H8ClN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles