Month: January 2023

Generation of aminyl radicals using sulfenamides as synthetic precursors was written by Bowman, W. Russell;Clark, David N.;Marmon, Robert J.. And the article was included in Tetrahedron in 1994.Recommanded Product: 14204-27-4 This article mentions the following:

Sulfenamides R¹R²NSPh (R¹, R² = alkyl, cycloalkyl, bicycloalkyl, aryl et al.)are synthesized from reactions of R¹R²NH and N-(benzenesulfenyl)phthalimide or PhSCl. The sulfenamides undergo reaction with Bu₃SnH to yield aminyl radicals which can be cyclized onto suitable alkenes. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Recommanded Product: 14204-27-4).

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Recommanded Product: 14204-27-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Gold- and Silver-Catalyzed Intramolecular Cyclizations of Indolylcyclopropenes for the Divergent Synthesis of Azepinoindoles and Spiroindoline Piperidines was written by Zhu, Peng-Long;Zhang, Zhen;Tang, Xiang-Ying;Marek, Ilan;Shi, Min. And the article was included in ChemCatChem in 2015.Safety of 5-Chloroindole-3-carboxaldehyde This article mentions the following:

Gold- and silver-catalyzed intramol. cycloisomerizations of nitrogen or carbon-tethered indolylcyclopropenes I [X = 4-BrC₆H₄SO₂N, 4-O₂NC₆H₄SO₂, 4-H₃CC₆H₄SO₂, C(CO₂CH₃)₂; Y = CH₂, CH₂CH₂; R¹ = H, 5-Me, 7-Me, etc.; R² = Et, Me, Bn] to furnish biol. and pharmaceutically valuable azepino[4,5-b]indoles II and spiro[indoline-3,4′-piperidine] derivatives III have been developed. Both reactions exhibit high chemoselectivity and stereospecificity through completely different reaction pathways. Based on mechanistic studies, it is well demonstrated that gold and silver catalysts act differently to promote the anti- and syn-addition and the steric effect of the catalysts play an important role to switch the addition mode, affording the catalyst-controlled-divergent synthesis. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Safety of 5-Chloroindole-3-carboxaldehyde).

5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Safety of 5-Chloroindole-3-carboxaldehyde

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Auxins. Part 3. Structure-activity differences between indoleacetic acid auxins on pea and wheat was written by Katekar, GerardF.;Geissler, Art E.. And the article was included in Phytochemistry (Elsevier) in 1983.Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid This article mentions the following:

A series of halogenated indoleacetic acids were assessed for auxin activity on pea stem and wheat coleoptile sections. Activity differences between the 2 species were found. These are discussed in terms of differences in receptor models for pea and wheat, with the models differing in the areas covered by the 6- and 7-substituted compounds In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid).

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Copper(I)-catalyzed synthesis of natural alkaloid tryptanthrin and its derivatives was written by Hong, Jiankai;Zhang, Min;Shi, Liang;Liu, Peng;Guo, Yuchao;Zhao, Ting;Li, Qing X.;Yang, Liuqing. And the article was included in New Journal of Chemistry in 2022.Safety of 5,6-Difluoroindoline-2,3-dione This article mentions the following:

A mild method for the preparation of tryptanthrin and its derivatives by copper(I) catalysis with two identical isatins in the presence of KHCO₃ as a base was described. Furthermore, more complicated tryptanthrin derivatives were obtained in two steps with two different isatins in one pot. This work featured readily available starting materials, mild reaction conditions, simple operation, good functional group tolerance, high yields and selectivity. This transformation not only provided a new method to access tryptanthrin and its derivatives, but also enriched the chem. of isatins and copper catalysis. In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindoline-2,3-dione (cas: 774-47-0Safety of 5,6-Difluoroindoline-2,3-dione).

5,6-Difluoroindoline-2,3-dione (cas: 774-47-0) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Safety of 5,6-Difluoroindoline-2,3-dione

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Au(I)/Au(III) Catalytic Allylation Involving π-Allyl Au(III) Complexes was written by Rodriguez, Jessica;Vesseur, David;Tabey, Alexis;Mallet-Ladeira, Sonia;Miqueu, Karinne;Bourissou, Didier. And the article was included in ACS Catalysis in 2022.Recommanded Product: 6-Nitro-1H-indole This article mentions the following:

A (MeDalphos)AuCl complex was found to efficiently catalyze the cross-coupling of indoles and allyl acetates/alcs. The reaction tolerated many functional groups and selectively affords the branched C3-allylated products from both α- and γ-substituted allyl substrates. It took the advantage of the hemilabile character of the PN ligand. The C(sp²)-C(sp³) coupling operated via a Au(I)/Au(III) redox cycle and involves a dicationic π-allyl Au(III) complex as a key intermediate. In this case, the allyl moiety adopted an asym. σ + π-coordination mode, as substantiated by NMR spectroscopy and d. functional theory (DFT) calculations In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Recommanded Product: 6-Nitro-1H-indole).

6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Recommanded Product: 6-Nitro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Antioxidant activity profile of some new benzimidazole carbamates was written by Rani, B. Shoba;Priyanka, K. Blessi;Harikiran, L.;Sammaiah, G.. And the article was included in International Journal of Pharmacy and Biological Sciences in 2016.Category: indole-building-block This article mentions the following:

The present study involves the antioxidant study of 3-((5-((6-benzoyl)-1H-benzo[d]imidazol -2-yl) amino)-1, 3, 4-oxadiazol-2-yl imino) substituted indolin-2-ones by DPPH assay method. Among the compounds, compound without any substitution possessed good activity when compared with Ascorbic acid. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Category: indole-building-block).

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Cobalt(II) Phthalocyanine-Catalyzed Highly Chemoselective Reductive Amination of Carbonyl Compounds in a Green Solvent was written by Kumar, Vishal;Sharma, Upendra;Verma, Praveen K.;Kumar, Neeraj;Singh, Bikram. And the article was included in Advanced Synthesis & Catalysis in 2012.Reference of 5388-42-1 This article mentions the following:

Cobalt phthalocyanine has been employed for the highly chemoselective reductive amination of aldehydes and ketones in ethanol as a green solvent. A large range of functional groups such as nitro, acid, amide, ester, nitrile, halogen, lactone, methoxy, hydroxy, alkene, N-benzyl, O-benzyl and heterocyclic rings were well tolerated under the present reaction conditions. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Reference of 5388-42-1).

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Reference of 5388-42-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold: A Study Combining Structure-Activity Relationship and X-ray Crystallography was written by Nazare, Marc;Will, David W.;Matter, Hans;Schreuder, Herman;Ritter, Kurt;Urmann, Matthias;Essrich, Melanie;Bauer, Armin;Wagner, Michael;Czech, Joerg;Lorenz, Martin;Laux, Volker;Wehner, Volkmar. And the article was included in Journal of Medicinal Chemistry in 2005.Quality Control of Methyl 5-fluoro-1H-indole-2-carboxylate This article mentions the following:

Structure-activity relationships within a series of highly potent 2-carboxyindole-based factor Xa inhibitors incorporating a neutral P1 ligand are described with particular emphasis on the structural requirements for addressing subpockets of the factor Xa enzyme. Interactions with the subpockets were probed by systematic substitution of the 2-carboxyindole scaffold, in combination with privileged P1 and P4 substituents. Combining the most favorable substituents at the indole nucleus led to the discovery of a remarkably potent factor Xa inhibitor displaying a K_i value of 0.07 nM. X-ray crystallog. of inhibitors bound to factor Xa revealed substituent-dependent switching of the inhibitor binding mode and provided a rationale for the SAR obtained. These results underscore the key role played by the P1 ligand not only in determining the binding affinity of the inhibitor by direct interaction but also in modifying the binding mode of the whole scaffold, resulting in a nonlinear SAR. In the experiment, the researchers used many compounds, for example, Methyl 5-fluoro-1H-indole-2-carboxylate (cas: 167631-84-7Quality Control of Methyl 5-fluoro-1H-indole-2-carboxylate).

Methyl 5-fluoro-1H-indole-2-carboxylate (cas: 167631-84-7) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Quality Control of Methyl 5-fluoro-1H-indole-2-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ultraviolet spectra of indoles in strong sulfuric acid was written by Mollan, R. C.;Harmey, M. A.;Donnelly, D. M. X.. And the article was included in Phytochemistry (Elsevier) in 1973.SDS of cas: 6639-06-1 This article mentions the following:

Measurement of the uv spectra in 12.7M H2SO4 at 30 and 70° provides a simple, quant. and specific method for the identification of variously substituted, naturally occurring plant indoles in μg quantities. In the experiment, the researchers used many compounds, for example, 3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1SDS of cas: 6639-06-1).

3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.SDS of cas: 6639-06-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Asymmetric organocatalytic sulfenylation for the construction of a diheteroatom-bearing tetrasubstituted carbon centre was written by Tan, Qingfa;Chen, Qianping;Zhu, Zitong;Liu, Xiaohua. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Synthetic Route of C14H9NO2S This article mentions the following:

Catalytic enantioselective sulfenylation to construct diheteroatom-bearing carbon centers was achieved by employing chiral guanidine organocatalysts. This protocol provided a facile route toward the synthesis of α-fluoro-α-sulfenyl-β-ketoamides, azlactone adducts and α-sulfur-substituted amino acid derivatives in high yields with good to excellent enantioselectivities. A possible working mode was proposed to elucidate the chiral control of the process. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Synthetic Route of C14H9NO2S).

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Synthetic Route of C14H9NO2S

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles