Day: February 20, 2023

Synthesis of a near-IR cyanine and its application in determination of biomolecules was written by Zheng, Hong;Li, Donghui;Chen, Qiuying;Xy, Jingou. And the article was included in Yingyong Huaxue in 1999.Product Details of 146368-07-2 This article mentions the following:

A novel water soluble near-IR cyanine dye (HMC) was synthesized and its structure was characterized by NMR and MS. The absorption and fluorescence spectral characteristics of HMC in aqueous solutions were also studied. It was found that in acidic solution of HMC the presence of protein could cause a hypochromic effect at 776 nm, that was used as a probe for the determination of total protein in human serum. The low fluorescence of in situ HMC dimer caused by cationic surfactant CTAB has been tested as a probe for nucleic acid determination In the experiment, the researchers used many compounds, for example, 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2Product Details of 146368-07-2).

1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Product Details of 146368-07-2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis, cytotoxic, antioxidant and anti-inflammatory activity of 3-((3-((6-benzoyl-1H-benz [D]imidazol-2-YL) amino)-5-mercapto- 4H-1,2, 4-triazol-4-YL) imino)substituted indol-2-ones was written by Rani, B. Shoba;Blessi, Priyanka K.;Sammaiah, G.. And the article was included in American Journal of PharmTech Research in 2016.HPLC of Formula: 112656-95-8 This article mentions the following:

In the present study novel series of 3-((3-((6-benzoyl-1H-benz[d]imidazol-2-yl) amino)-5- mercapto-4H-1, 2, 4-triazol-4-yl)imino)substituted indolin-2-ones have been synthesized in good yields and characterized by IR, NMR and Mass spectral analyses. Compounds were evaluated for their preliminary in vitro cytotoxic activity against HCT-116 (colon), MCF-7 (breast), HeLa (cervical) and HepG2 (hepatocellular) cancer cell lines by standard MTT assay method, antioxidant activity by standard DPPH assay method and also were screened for in vitro antiinflammatory activity. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8HPLC of Formula: 112656-95-8).

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.HPLC of Formula: 112656-95-8

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Identification of Novel d-Amino Acid Oxidase Inhibitors by in Silico Screening and Their Functional Characterization in Vitro was written by Katane, Masumi;Osaka, Naoko;Matsuda, Satsuki;Maeda, Kazuhiro;Kawata, Tomonori;Saitoh, Yasuaki;Sekine, Masae;Furuchi, Takemitsu;Doi, Issei;Hirono, Shuichi;Homma, Hiroshi. And the article was included in Journal of Medicinal Chemistry in 2013.Application In Synthesis of 4-Bromo-1H-indole-2-carboxylic acid This article mentions the following:

D-Amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for d-amino acids, including d-serine and d-alanine, which are potential coagonists of the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders such as schizophrenia. Hence, a DAO inhibitor that augments the brain levels of d-serine and/or d-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia. In the search for potent DAO inhibitor(s), a large number of compounds were screened in silico, and several compounds were estimated as candidates. These compounds were then characterized and evaluated as novel DAO inhibitors in vitro. The results reported in this study indicate that some of these compounds are possible lead compounds for the development of a clin. useful DAO inhibitor and have the potential to serve as active site probes to elucidate the structure-function relationships of DAO. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2Application In Synthesis of 4-Bromo-1H-indole-2-carboxylic acid).

4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application In Synthesis of 4-Bromo-1H-indole-2-carboxylic acid

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Isoindoles from phthalimidines. N-Arylisoindoles was written by Kovtunenko, V. A.;Kucherenko, T. T.;Kornilov, M. Yu.;Tyltin, A. K.;Turov, A. V.;Babichev, F. S.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1987.Electric Literature of C14H11NO This article mentions the following:

N-Arylisoindoles I (R = Ph, 4-MeC₆H₄, 4-BrC₆H₄) were prepared by reduction of the resp. phthalimidines II (same R) with Li[(MeOCH₂CH₂O)₂AlH₂]. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Electric Literature of C14H11NO).

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Electric Literature of C14H11NO

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Organocatalytic Friedel-Crafts Alkylation/Lactonization Reaction of Naphthols with 3-Trifluoroethylidene Oxindoles: The Asymmetric Synthesis of Dihydrocoumarins was written by Zhao, Yun-Long;Lou, Qin-Xin;Wang, Long-Sheng;Hu, Wen-Hui;Zhao, Jun-Ling. And the article was included in Angewandte Chemie, International Edition in 2017.Computed Properties of C8H6BrNO This article mentions the following:

Naphthols and 3-trifluoroethylidene oxindoles were found to undergo an asym. Friedel-Crafts alkylation/lactonization reaction, catalyzed by only 2.5 mol % of a quinine-derived squaramide catalyst, to afford the corresponding 婵?aryl-闁?trifluoromethyl dihydrocoumarin derivatives I (R¹ = H, 5-Me, 5-Cl, 5-Br, 7-F, 7-Br; R² = H, 6-MeO, 6-OBn, 6-Ph, etc.) in high yields (up to 99 %) with excellent enantio- and diastereoselectivities (up to 98 % ee, >20:1 d.r.). Importantly, the lactonization proceeded by nucleophilic attack of the naphthol hydroxy group at the amide motif of the oxindoles under mild reaction conditions. This protocol represents a new strategy for the formation of dihydrocoumarins by an efficient intramol. amide C-N bond-cleavage and esterification process. In the experiment, the researchers used many compounds, for example, 7-Bromooxindole (cas: 320734-35-8Computed Properties of C8H6BrNO).

7-Bromooxindole (cas: 320734-35-8) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Computed Properties of C8H6BrNO

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Green Oxidation of Indoles Using Molecular Oxygen over a Copper Nitride Nanocube Catalyst was written by Xu, Hang;Yamaguchi, Sho;Mitsudome, Takato;Mizugaki, Tomoo. And the article was included in European Journal of Organic Chemistry in 2022.Application of 4583-55-5 This article mentions the following:

Oxidative transformation of indoles is a promising approach for synthesizing valuable nitrogen-containing compounds; however, conventional methods use toxic oxidants and additives. Herein, authors report for the first time the catalytic oxidative trimerization and the oxygenative cleavage (Witkop oxidation) of indoles using mol. oxygen under additive-free conditions accomplished by a copper nitride nanocube (Cu₃N NC) catalyst. The Cu₃N NC catalyst exhibits excellent activity to produce various indolin-3-ones and 2-ketoanilides with high functional group tolerance. Owing to this excellent catalytic performance, the Cu₃N NC catalyst is distinguished from the conventional copper catalysts, demonstrating the high catalytic potential of metal nitride in organic synthesis. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Application of 4583-55-5).

5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application of 4583-55-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na_V1.7 Inhibitors for the Treatment of Pain was written by Luo, Guanglin;Chen, Ling;Easton, Amy;Newton, Amy;Bourin, Clotilde;Shields, Eric;Mosure, Kathy;Soars, Matthew G.;Knox, Ronald J.;Matchett, Michele;Pieschl, Rick L.;Post-Munson, Debra J.;Wang, Shuya;Herrington, James;Graef, John;Newberry, Kimberly;Sivarao, Digavalli V.;Senapati, Arun;Bristow, Linda J.;Meanwell, Nicholas A.;Thompson, Lorin A.;Dzierba, Carolyn. And the article was included in Journal of Medicinal Chemistry in 2019.Category: indole-building-block This article mentions the following:

3-Aryl-indole and 3-aryl-indazole derivatives were identified as potent and selective Na_v1.7 inhibitors. Compound I was shown to be efficacious in the mouse formalin assay and also reduced complete Freund’s adjuvant (CFA)-induced thermal hyperalgesia and chronic constriction injury (CCI) induced cold allodynia and models of inflammatory and neuropathic pain, resp., following i.p. (IP) doses of 30 mg/kg. The observed efficacy could be correlated with the mouse dorsal root ganglion exposure and Na_V1.7 potency associated with I. In the experiment, the researchers used many compounds, for example, 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid (cas: 898746-35-5Category: indole-building-block).

1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid (cas: 898746-35-5) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An expedient and convenient approach for one-pot synthesis of 1H-isoindole-1,3(2H)-diones was written by Ekhtiari, Zeinab;Havasi, Forugh;Nikpour, Farzad. And the article was included in Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences in 2016.SDS of cas: 24407-32-7 This article mentions the following:

An easy and expedient method for the one-pot synthesis of 1H-isoindole-1,3(2H)-diones, e.g., 3-hydroxy-2,3-dihydro-1H-isoindol-1-one has been developed by the reaction of corresponding cyclic anhydrides, e.g., 3-hydroxy-1,3-dihydro-2-benzofuran-1-one with guanidinium chloride as a nitrogen source in the presence of FeCl₃ as a catalyst under mild reaction conditions. In the experiment, the researchers used many compounds, for example, 4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7SDS of cas: 24407-32-7).

4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.SDS of cas: 24407-32-7

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Manufacture of foods. I. Influence of growth regulators on germination of barley and rye. 1. Amylase activity was written by Obara, Tetsujiro;Ogasawara, Yasokichi;Kimura, Tsugie. And the article was included in Nippon Shokuhin Kogyo Gakkaishi in 1963.Recommanded Product: 1912-45-4 This article mentions the following:

Influences of 婵?naphthaleneacetic acid and gibberellin were tested on amylase activities and growth of germinating barley and rye. Both barley and rye germinated best on a medium containing 0.1-1.0 ppm. gibberellin. Gibberellin increased the formation of amylase 60-100% at 1 ppm., while 婵?naphthaleneacetic acid had no effect. The highest amylase activity was produced after 80 hrs. of incubation in the presence of 1 ppm. gibberellin. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Recommanded Product: 1912-45-4).

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Recommanded Product: 1912-45-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Preparation of methylamine was written by Jones, Hilton Ira;Wheatley, Roth. And the article was included in Journal of the American Chemical Society in 1918.Name: 4,5,6,7-Tetrabromoisoindoline-1,3-dione This article mentions the following:

A study of the equations given by Werner to explain the mechanism of the reaction between HCHO and NH₄Cl shows that if the temperature should be kept down and the decomposition of the HCO₂H as It formed should be hastened MeNH₂ should be almost the sole product, a deduction which has been verified by experiment Of 4 experiments, one was a duplication of W.’s, the 2nd was a slow distillation like the first but under 20 mm., in the 3rd the material was refluxed 8 hrs. under atm. pressure before the distillation (also under atm. pressure). while in the 4th the refluxing (4.5 hrs.) and distillation were carried out under 20 mm. Working with 150 g. NH₄Cl and 300 g. of 40% HCHO, the following results were obtained in the 4 experiments, resp.: unchanged NH₄Cl, 46.47, 79.9, 33.5, 27.18; MeNH₂Cl, 70.67, 44.83, 67.60, 82.50; Me₂NH₂Cl, 12.40, 9.66, 17.35, 7.90; non-crystallizing residue, 45.53, 23.53, 64-73, 54.43 g. The sp. gr. and rotations of the distillates and the approx. amounts of HCO₂Me and HCO₂H present were also determined The results all accord with W.’s theory. In the experiment, the researchers used many compounds, for example, 4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7Name: 4,5,6,7-Tetrabromoisoindoline-1,3-dione).

4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Name: 4,5,6,7-Tetrabromoisoindoline-1,3-dione

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles