Day: February 22, 2023

Fate of pharmaceuticals and their transformation products in integrated membrane systems for wastewater reclamation was written by Mamo, J.;Garcia-Galan, M. J.;Stefani, M.;Rodriguez-Mozaz, S.;Barcelo, D.;Monclus, H.;Rodriguez-Roda, I.;Comas, J.. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2018.Reference of 15362-40-0 This article mentions the following:

The removal of pharmaceuticals (PhACs) from urban wastewater by membrane bioreactors (MBRs) followed by reverse osmosis (RO) or nanofiltration (NF) membranes has been frequently addressed in the literature. However, data regarding the removal of their main human metabolites and transformation products (TPs) is still scarce. Here, the presence of 13 PhACs and 20 of their metabolites and TPs was monitored during 2 consecutive years in the different treatment steps of urban raw wastewater (sewer, primary treatment, MBR and RO/NF). Rejection of the selected contaminants when using low pressure NF membranes (NF-90) or RO membranes (ESPA 2) after the MBR step was also studied. The analgesic acetaminophen, which was found at the highest concentrations in the sewer and influent samples (18-74 μg/L) over the 2 exptl. periods, was fully eliminated during MBR treatment. Those PhACs that were only partially removed after the MBR, were almost completely removed (>99%) by the RO membrane working under different process conditions. At a similar average permeate fluxes (18 L/m²-h), the NF membrane showed high removal efficiencies (>90%) for all of the PhACs and their metabolites, though lower than those achieved by the RO membrane. When the flux of the NF90 membrane was increased to 30 L/m²-h (while still operating at a feed pressure lower than the RO membrane at 18 L/m²-h) the performance of the membrane increased, achieving 98% rejection of PhACs. In the experiment, the researchers used many compounds, for example, 1-(2,6-Dichlorophenyl)-2-indolinone (cas: 15362-40-0Reference of 15362-40-0).

1-(2,6-Dichlorophenyl)-2-indolinone (cas: 15362-40-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Reference of 15362-40-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis and characterization of cytotoxic activity of certain n-(6-benzoyl-1H-benzo [d] imidazol-2-yl)-2-(2-oxoindolin-3-ylidene) hydrazine carboxamides was written by Rani, B. Shoba;Priyanka, K. Blessi;Sammaiah, G.. And the article was included in International Journal of Pharmacy and Biological Sciences in 2014.SDS of cas: 103030-10-0 This article mentions the following:

A series of N-(6-benzoyl-1H-benzo[d]imidazol-2-yl)-2-(2-oxoindolin-3-ylidene) hydrazine carboxamides I [R = H, 5-CH₃, 5-Cl, 5-Br, 5-NO₂, 7-NO₂, 7-CH₃] were synthesized by treating (5-benzoyl-1H-benzo[d]imidazol-2-yl) carbamates II with different substituted isatins. All the synthesized derivatives I were screened for anticancer activity against Hela using MTT assay and produced a dose dependent inhibition of growth of the cells. The IC₅₀ values of all the synthetic test compounds were found between 16.03 to 41.75. The potency of (IC₅₀ values) of cytotoxicity of compounds was compared with that of known cytotoxic agent, Cisplatin. Among all the synthesized novel compound I (R = 5-Cl) showed the most potent activity against MCF-7 cell lines. In the experiment, the researchers used many compounds, for example, Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0SDS of cas: 103030-10-0).

Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.SDS of cas: 103030-10-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Isatincarboxylic acid was written by Waldmann, Hans. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1937.HPLC of Formula: 103030-10-0 This article mentions the following:

o-H₂NC₆H₄CO₂Me (31.5 g.), 35 g. Cl₃CCHO.H₂O, 54 g. NH₂OH.H₂SO₄ and 25 g. H₂SO₄ in 1400 g. H₂O, heated 8 min., give Me isonitrosoacetoanthranilate (I), m. 180°. Isonitrosoaceto-p-aminobenzoic acid does not m. 310° (Me ester (II), m. 231°); m-isomer (III), m. 228°. Addition of I in small portions to concentrated H₂SO₄ at 70° and then warming for 10 min. at 80° gives the Me ester, yellow, m. 192°, of isatin-7- carboxylic acid, orange, m. 276-7° (Sandmeyer, C. A. 13, 1840, gives 235°); cold alkali gives a blood-red color, disappearing in a short time; with PhAc in EtOH-33% KOH (heating 6 hrs. at 100°) there results 2-phenylquinoline-4,8-dicarboxylic acid, pale yellow, does not melt 310°. Isatin-5-carboxylic acid, orange-yellow, m. 292-3° (decomposition), results from II and concentrated H₂SO₄, purification of which is complicated by the presence of the oxime, yellow, decomposes 282° (Me ester, yellow, m. 264°; oxime, decomposes 280°); 2-phenylquinoline-4,6- dicarboxylic acid does not m. at 310°. III gives isatin-6- carboxylic acid, orange, m. 292° (decomposition)(Me ester, orange-yellow, m. 209°). In the experiment, the researchers used many compounds, for example, Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0HPLC of Formula: 103030-10-0).

Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). HPLC of Formula: 103030-10-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Gas and other chromatographic separations of indolic methyl esters was written by Grunwald, Claus;Vendrell, Miguel;Stowe, Bruce B.. And the article was included in Analytical Biochemistry in 1967.Recommanded Product: Methyl 2-(1H-indol-3-yl)-2-oxoacetate This article mentions the following:

All tested acidic indoles were esterified by diazomethylation without appreciable loss. A group of 10 Me ester derivatives were obtained in crystalline form. These were used to test the relative values of 4 gas chromatographic substrates. Quant. comparisons led to the selection of Versamid 900, HI-EFF 8 BP, and SE-30 as permitting complete separation of all indole esters, while SE-52 was unsatisfactory. Gradient elution column and thin-layer chromatog. as pre- and post-purification techniques for these indole esters were also compared, as was the usefulness of uv spectroscopy and spectrophotofluorometry in acidic indole anal. 20 references. In the experiment, the researchers used many compounds, for example, Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0Recommanded Product: Methyl 2-(1H-indol-3-yl)-2-oxoacetate).

Methyl 2-(1H-indol-3-yl)-2-oxoacetate (cas: 18372-22-0) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Recommanded Product: Methyl 2-(1H-indol-3-yl)-2-oxoacetate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Direct Difluoromethylenation of Carbonyl Compounds Using TMSCF₃: The Right Conditions was written by Prakash, Surya G.;Krishnamoorthy, Sankarganesh;Kothandaraman, Jotheeswari;Saldana, Jacqueline. And the article was included in European Journal of Organic Chemistry in 2016.Recommanded Product: 27421-51-8 This article mentions the following:

Using readily available, inexpensive trifluoromethyltrimethylsilane (TMSCF₃), LiI and PPh₃, deoxygenative difluoromethylenation of carbonyl compounds is reported. The Li+ is proposed to prevent the unproductive exhaustion of TMSCF₃ by keeping the soluble free fluoride concentration in the reaction medium under control. Also, solvent combination strategy to increase the reactivity and thereby reducing the reaction temperature and time is disclosed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-indole-2-carbaldehyde (cas: 27421-51-8Recommanded Product: 27421-51-8).

1-Methyl-1H-indole-2-carbaldehyde (cas: 27421-51-8) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Recommanded Product: 27421-51-8

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In vitro cytotoxicity evaluation of diversely substituted N-aryl-2-oxindoles was written by Manvar, Atul;Bavishi, Abhay;Loriya, Rajesh;Jaggi, Manu;Shah, Anamik. And the article was included in Medicinal Chemistry Research in 2013.Reference of 15362-40-0 This article mentions the following:

In continuation with our previous work, structurally diverse 2-indolinones bearing 2,6-dichloroaryl fragment at N¹ and (hetero)aryl benzylidene at C³ were evaluated for their antitumor activity on a panel of cancer cell lines such as MCF-7 (breast), MiapaCa2 (pancreas), KB (oral), HuTu80 (stomach), L132 (lung), B16F10 (melanoma), and Molt4 (leukemia) from various human organs. Among the screened compound library, mols. 4e,4k, and 4r have shown excellent cytotoxicity on a stomach cancer cell line. Moreover, a significant number of compounds have also shown promising cytotoxicity on pancreas and oral cancer cell lines. In the experiment, the researchers used many compounds, for example, 1-(2,6-Dichlorophenyl)-2-indolinone (cas: 15362-40-0Reference of 15362-40-0).

1-(2,6-Dichlorophenyl)-2-indolinone (cas: 15362-40-0) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Reference of 15362-40-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Thermodynamic properties of alkyl 1H-indole carboxylate derivatives: A combined experimental and computational study was written by Carvalho, Tania M. T.;Amaral, Luisa M. P. F.;Morais, Victor M. F.;Ribeiro da Silva, Maria D. M. C.. And the article was included in Journal of Chemical Thermodynamics in 2016.Recommanded Product: Ethyl 1H-indole-3-carboxylate This article mentions the following:

The standard (p^o = 0.1 MPa) molar enthalpies of formation, in the crystalline phase, of Me 1H-indole-3-carboxylate and Et 1H-indole-2-carboxylate, at T = 298.15 K, were derived from measurements of the standard massic energies of combustion using a static bomb combustion calorimeter. The Knudsen effusion technique was used to measure the vapor pressures as a function of the temperature, which allowed determining the standard molar enthalpies of sublimation of these compounds The standard (p^o = 0.1 MPa) molar enthalpies of formation, in the gaseous phase, at T = 298.15 K, were calculated by combining, for each compound, the standard molar enthalpy of formation, in the crystalline phase, and the standard molar enthalpy of sublimation, yielding -(207.6 ± 3.6) kJ·mol^-1 and -(234.4 ± 2.4) kJ·mol^-1, for Me 1H-indole-3-carboxylate and Et 1H-indole-2-carboxylate, resp.Quantum chem. studies were also conducted, in order to complement the exptl. study. The gas-phase enthalpies of formation were estimated from high level ab initio MO calculations, at the G3(MP2) level, for the compounds studied exptl., extending the study to the Me 1H-indole-2-carboxylate and Et 1H-indole-3-carboxylate. The results obtained were compared with the exptl. data and were also analyzed in terms of structural enthalpic group contributions. In the experiment, the researchers used many compounds, for example, Ethyl 1H-indole-3-carboxylate (cas: 776-41-0Recommanded Product: Ethyl 1H-indole-3-carboxylate).

Ethyl 1H-indole-3-carboxylate (cas: 776-41-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Recommanded Product: Ethyl 1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Polydopamine Films with 2D-like Layered Structure and High Mechanical Resilience was written by Coy, Emerson;Iatsunskyi, Igor;Colmenares, Juan Carlos;Kim, Yeonho;Mrowczynski, Radoslaw. And the article was included in ACS Applied Materials & Interfaces in 2021.Recommanded Product: 3131-52-0 This article mentions the following:

Highly oriented, layered, and mech. resilient films of polydopamine (PDA) have been synthesized from the air/water interface. The films show a unique layered structure, as shown by scanning and transmission electron studies (SEM/TEM) and X-ray diffraction anal. (XRD), which resemble that of 2D layered materials. The films exhibit a composition typical of PDA-based materials, as evidenced by XPS; moreover, the samples present the distinctive resonance modes of PDA-based nanomaterials in Raman and IR spectroscopy (FTIR) experiments The presence of highly ordinated 3-4 protomol. stacking, taking place at the air/water interface, with a unique eumelanin-like supramol. arrangement is presented. Moreover, the films show superior mech. resilience with E = 13 ± 4 GPa and H = 0.21 ± 0.03 GPa, as revealed by nanoindentation experiments, making them highly resilient and easily transferable. Finally, the ordering induced by the interface opens many possibilities for further studies, including those regarding the supramol. structure on PDA due to their similarity to 2D layered materials. In the experiment, the researchers used many compounds, for example, 5,6-Dihydroxyindole (cas: 3131-52-0Recommanded Product: 3131-52-0).

5,6-Dihydroxyindole (cas: 3131-52-0) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Recommanded Product: 3131-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Sequentially Catalyzed Three-Component Masuda-Suzuki-Sonogashira Synthesis of Fluorescent 2-Alkynyl-4-(7-azaindol-3-yl)pyrimidines: Three Palladium-Catalyzed Processes in a One-Pot Fashion was written by Driessen, Daniel;Biesen, Lukas;Mueller, Thomas J. J.. And the article was included in Synlett in 2021.Name: 1H-Pyrrolo[2,3-b]pyridine This article mentions the following:

The Masuda-Suzuki-Sonogashira sequence efficiently united in a one-pot fashion, a borylation, an arylation and an alkynylation in the sense of a sequentially Pd-catalyzed three-component reaction to give fluorescent 2-alkynyl-4-(7-azaindol-3-yl)pyrimidines in yields of 24-83%. Time-dependent d.-functional theory calculations supported the electronic structure of the longest wavelength absorption bands, and revealed that this novel consecutive three-component synthesis opened an efficient access to alkynyl meriolins, a novel class of potential inducers of apoptosis. In the experiment, the researchers used many compounds, for example, 1H-Pyrrolo[2,3-b]pyridine (cas: 271-63-6Name: 1H-Pyrrolo[2,3-b]pyridine).

1H-Pyrrolo[2,3-b]pyridine (cas: 271-63-6) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Name: 1H-Pyrrolo[2,3-b]pyridine

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Decarboxylative Coupling Reaction of 2-(1H-indol-3-yl)acetic Acids with Indole, Azaindole, Benzimidazole and Indazole Derivatives was written by Pillaiyar, Thanigaimalai;Uzair, Muhammad;Ullah, Saif;Schnakenburg, Gregor;Mueller, Christa E.. And the article was included in Advanced Synthesis & Catalysis in 2019.Recommanded Product: 1912-48-7 This article mentions the following:

A new, mild and efficient copper(II)-promoted decarboxylative coupling reaction of 2-(1H-indol-3-yl)acetic acid derivatives I (R = H, 4-Cl, 5-OCH₃, 6-F, 5-Cl, 6-Cl; R¹ = H, CH₃) with a variety of (substituted) indoles II (R² = H, Ph, CO₂Et; R³ = H, CH₃; R⁴ = H, Me, F, Br, MeO, CHO; R⁵ = H, MeO, CHO, F; R⁶ = H, Cl, Br, MeO, Et, CN; R⁷ = H, Br; R⁶R⁷ = CH=CH-CH=CH) yielding (un)sym. substituted 3,3′-diindolylmethanes (DIMs) III have been reported. Reaction of 2-(1H-indol-3-yl)acetic acid I (R = R¹ = H) with 7-azaindole led to 3-((1H-indol-3-yl)methyl)-1H-pyrrolo[2,3-b]pyridine, while 4-, 5-, and 6-azaindoles and benzimidazole reacted at the N1-nitrogen atom. Reaction of I (R = R¹ = H) with 1H-indazole led to a mixture of 1-((1H-indol-3-yl)methyl)-1H-indazole and 2-((1H-indol-3-yl)methyl)-2H-indazole. The new method allows large-scale synthesis of biol. active DIMs. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-indoleacetic acid (cas: 1912-48-7Recommanded Product: 1912-48-7).

1-Methyl-3-indoleacetic acid (cas: 1912-48-7) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Recommanded Product: 1912-48-7

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles