Recently I am researching about FATTY-ACID SYNTHASE; EPIGALLOCATECHIN GALLATE; NATURAL INHIBITOR; OVEREXPRESSION; POLYPHENOLS; ACTIVATION; APOPTOSIS; PATHWAY; KINASE; GROWTH, Saw an article supported by the Ministry of Education, Republic of SingaporeMinistry of Education, Singapore [R148000234 114, 8143000681112, R713000216720]; National University of SingaporeNational University of Singapore [R148000234 114, 8143000681112, R713000216720]; Ministry of Education; NUS Drug Development Unit. HPLC of Formula: C7H6O2. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Tan, YJ; Ali, A; Tee, SY; Teo, JT; Xi, Y; Go, ML; Lam, YL. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde
Fatty acid synthase (FASN) is a lipogenic enzyme that is selectively upregulated in malignant cells. There is growing consensus on the oncogenicity of FASN-driven lipogenesis and the potential of FASN as a druggable target in cancer. Here, we report the synthesis and FASN inhibitory activities of two novel galloyl esters of trans-stilbene EC1 and EC5. Inhibition of FASN was accompanied by a loss in AKT activation and profound apoptosis in several non-small cell lung cancer (NSCLC) cells at the growth inhibitory concentrations of EC1 and EC5. Both FASN and phospho-AKT levels were concurrently downregulated. However, addition of a lipid concentrate to the treated cells reinstated cell viability and reversed the loss of FASN and AKT protein levels, thus recapitulating the causal relationship between FASN inhibition and the loss in cell viability. (C) 2019 Elsevier Masson SAS. All rights reserved.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles