Quality Control of 3,4-Dimethoxybenzaldehyde. Authors Ha, H; Choi, HJ; Park, H; Gwon, Y; Lee, J; Kwak, J; Kim, M; Jung, B in WILEY-V C H VERLAG GMBH published article about in [Ha, Hyeonbin; Choi, Ho Jeong; Kim, Min] Chungbuk Natl Univ, Dept Chem, Cheongju 28644, South Korea; [Park, Hahyoun; Gwon, Yunyeong; Lee, Jiin; Jung, Byunghyuck] Daegu Gyeongbuk Inst Sci & Technol DGIST, Dept Emerging Mat Sci, Daegu 42988, South Korea; [Kwak, Jaesung] Korea Res Inst Chem Technol KRICT, Infect Dis Therapeut Res Ctr, Daejeon 34114, South Korea in 2021.0, Cited 66.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9
The Pd-catalyzed gamma-position sp(3)-C-H arylation of primary amines bearing an aliphatic chain or cycloalkyl substituent and related mechanistic studies are disclosed. 3-Bromo-2-hydroxybenzaldehyde plays a key role in gamma-position sp(3)-C-H arylation as a transient directing group (TDG) to assist the regio- and stereoselective C-H activation of a Pd catalyst, and the development of a tandem reaction to transform 1 degrees-amines into gamma-aryl-substituted ketones demonstrates synthetic utility. Density functional theory (DFT)-based calculations revealed the detailed reaction mechanism and the origins of the high selectivity (gamma-position and cis-only). The X-ray crystal structure of the isolated endo-palladacycle intermediate supported the DFT results, and a kinetic isotope experiment confirmed the results of DFT calculations indicating that the C-H activation step via simultaneous palladation and deprotonation is rate-determining.
Quality Control of 3,4-Dimethoxybenzaldehyde. Welcome to talk about 120-14-9, If you have any questions, you can contact Ha, H; Choi, HJ; Park, H; Gwon, Y; Lee, J; Kwak, J; Kim, M; Jung, B or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles