An article Reductive Hydroxymethylation of 4-Heteroarylpyridines WOS:000510037900001 published article about TRANSFER HYDROGENATION; NITROGEN-HETEROCYCLES; CONJUGATE ADDITION; ARYLBORONIC ACIDS; ACTIVATING GROUPS; EFFICIENT; (MC)R-2; VINYLAZAARENES; ARYLATION; REAGENTS in [Hepburn, Hamish B.; Donohoe, Timothy J.] Univ Oxford, Dept Chem, Chem Res Lab, Mansfield Rd, Oxford OX1 3TA, England in 2020.0, Cited 45.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Safety of Benzyl Alcohol
The activation of pyridinium salts with electron-withdrawing heterocycles enables an iridium-catalyzed reductive hydroxymethylation reaction to proceed smoothly, facilitating the preparation of useful 3D heteroaryl-substituted functionalized piperidines. The methodology is used to prepare 3-hydroxymethylated analogues of pharmaceutical agents. Mechanistically, formaldehyde acts as both a hydride donor and the electrophile, leading to the formation of two new carbon-hydrogen bonds and one new carbon-carbon bond under relatively mild conditions.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles