400071-95-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.400071-95-6,5-Bromo-1-methyl-1H-indole-3-carboxylic acid,as a common compound, the synthetic route is as follows.
General procedure: 5-Bromo-1-methyl-indolyl-3-carbohydrazide or 1-methylindolyl-3-carbohydrazide (500 mg, 1.0 eq.) was added to differentindole-3-carboxylic acids (1.87 mmol, 1.0 eq.). To this reactionmixture, 12 vol of polyphosphoric acid was added and heated at90oc over a period of 3.5 he4 h. The reaction mixture was cooled toroom temperature and followed by addition of ice. The PH of theabove reaction mixture was brought to neutral by using sodiumbicarbonate solution. The solid obtained was separated and dried.The crude compoundwas purified by column chromatography withDCM solvent. The solvent was concentrated with rotary undercooling conditions when yellow colored solid was formed. It waswashed with n-hexane and ether solvent to remove non-polar andsemi-polar impurities, which yielded the pure compound in yellowcolor.
400071-95-6 5-Bromo-1-methyl-1H-indole-3-carboxylic acid 11032413, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Article; Sreenivasulu, Reddymasu; Tej, Mandava Bhuvan; Jadav, Surender Singh; Sujitha, Pombala; Kumar, C. Ganesh; Raju, Rudraraju Ramesh; Journal of Molecular Structure; vol. 1208; (2020);,
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