With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20289-27-4,7-(Benzyloxy)-1H-indole,as a common compound, the synthetic route is as follows.
EXAMPLE 5 Preparation of 3(Pyridin-3-yl)-7-(7-phenylmethoxyindol-3-yl)carbonyl-1H,3H-pyrrolo[1,2-c]thiazole The title compound was prepared by the procedure described in Example 1 using 7-phenylmethoxyindole instead of indole. The crude product was purified by flash chromatography (15 p.s.i.) on 250 g silica gel eluding with 1:1 THF/hexane and then recrystallized from ethyl acetate/ether to afford the title compound. m.p. 184-188 C. 1 H NMR (DMSO-d6, 300 MHz) delta4.45 (d, J=15 Hz, 1H), 4.62 (dd, J=15, 2 Hz, 1H), 6.68 (d, J=3 Hz, 1H), 6.76 (d, J=1 Hz, 1H), 6.85 (d, J=3 Hz, 1H), 6.89 (d, J=8 Hz, 1H), 7.08 (t, J=8 Hz, 1H), 7.31-7.46 (m, 4H), 7.56-7.67 (m, 3H), 7.83 (d, J=8 Hz, 1H), 8.03 (d, J=3 Hz, 1H), 8.53-8.58 (m, 2H), 12.06 (d, J=3 Hz). Anal calcd for C27 H21 N3 O2 S: C, 71.82; H, 4.69; N, 9.31. Found: C, 71.33; H, 4.70; N, 9.16. MS (DCI/NH3) m/e 452 (M+H)+.
20289-27-4, The synthetic route of 20289-27-4 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Abbott Laboratories; US5459152; (1995); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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