With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.900514-08-1,5-Chloro-3-iodo-7-azaindole,as a common compound, the synthetic route is as follows.
900514-08-1, To a stirred solution of 5-chloro-3-iodo-IH-pyrrolo[2,3-b]pyridlne (16 g, 57.5 mmd) and NaH(4.2 g, 172.4 mol) in DMF (100 mL) was added (2-(chloromethoxy)ethyl)t,imethylsilane(9.57 g, 1724 mmol) drop wise at 0C and stirred for 0:5 h. Afterwards, the reaction mixture was diluted with water (30 mL) and extracted with EtOAc (30 mL twice). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give a crude product, which was purified by silica gel flash chromatography (petroleumether EtOAc = 10:1) to afford the title compound (10 g, 43% yIeld) as a solid. MS: 409.0 [M+H].
As the paragraph descriping shows that 900514-08-1 is playing an increasingly important role.
Reference：
Patent; SAVIRA PHARMACEUTICALS GMBH; EUROPEAN MOLECULAR BIOLOGY LABORATORY; TAN, Xuefei; ZBINDEN, Katrin Groebke; KUHN, Bernd; WANG, Lisha; LIU, Yongfu; WU, Jun; SHEN, Hong; SHI, Tianlai; (174 pag.)WO2017/133664; (2017); A1;,
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