162100-42-7, 6-Chloro-5-methyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,162100-42-7
To a solution of Compound D (3.5 g, 21 mmol) in AcOH (40 mL) was added sodium cyanoborohydride (2.7 g, 43 mmol) and the mixture was purged with N2 for 1 h at room temperature.The reaction was complete by TLC (PE / EA = 10/1), further ethyl acetate EA (200 ml) was added and the mixture was made basic with a 5N NaOH solution (200 ml) at a pH of about 8. The organic layer was separated, Wash once, fullAnd brine once, dried over anhydrous sodium sulfate, dried to give 3.5g of brown solid Compound E, spare. Yield 98%.
162100-42-7 6-Chloro-5-methyl-1H-indole 10773354, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; Douchuang (Shanghai) Pharmaceutical Technology Co., Ltd.; Wang Lei; Wang Xiaolei; Gao Jixiang; (9 pag.)CN106278987; (2017); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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