170147-29-2, tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a 250 mL flask was placed tert-butyl 5-(BENZYLOXY)-1H-INDOLE-1-CARBOXYLATE (3.3 g, 14 MMOL) in 100 mL of acetone. 1,3-Dibromopropane (5.74 mL, 56.6 MMOL) was added, followed by cesium carbonate (5.5 g, 17 MMOL). The reaction was heated to reflux for 5 h. The reaction was cooled to room temperature and diluted with water (200 mL). The mixture was transferred to a separatory funnel and extracted with ethyl acetate (2 x 150 mL). The combined organics were dried (MGS04), filtered, and evaporated. The residue was then purified via flash chromatography to provide 4.7 g of TERT-BUTYL 5- (3- BROMOPROPOXY)-1H-INDOLE-1-CARBOXYLATE (94%). 1H-NMR (DMSO-D6) No. 7.99-7. 89 (d, 1H), 7.61 (s, 1H), 7.17 (s, 1H), 6.98-6. 91 (d, 1H), 6.62 (s, 1H), 4.16-4. 05 (t, 2H), 3.64 (t, 2H), 2.37-2. 20 (m, 2H). LCMS RT= 3.55 min; [M] += 254. 1., 170147-29-2
The synthetic route of 170147-29-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2004/43950; (2004); A1;,
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