The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Benzimidazole derivatives》. Authors are Novelli, Armando.The article about the compound:2-(Pyridin-4-yl)-1H-benzo[d]imidazolecas:2208-59-5,SMILESS:C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1).SDS of cas: 2208-59-5. Through the article, more information about this compound (cas:2208-59-5) is conveyed.
The preparation of benzimidazoles related to pharmacologically active substances is described. The Mannich reaction takes place with 2-substituted benzimidazoles. 2-Benzylbenzimidazole (5.62 g.) in 50 cc. MeOH and 2.4 g. morpholine (I) in 25 cc. MeOH chilled and treated dropwise with 2.4 g. of 38% CH2O (II) yielded on crystallization of the product from C6H6 6 g. 1-morpholinomethyl-2-benzylbenzimidazole, C19H21N3O, m. 118-20°. Similarly, condensation of 6.3 g. (p-nitrobenzyl)benzimidazole in 90 cc. MeOH with 2 g. I in 25 cc. MeOH with dropwise addition of 2.4 g. II in 20 cc. MeOH produced 4 g. (46%) 1-morpho-linomethyl-2-(p-nitrobenzyl)benzimidazole, m. 210°. Refluxing 5 g. o-C6H4(NH2)2 and 10 g. isonicotinic acid (III) with 30 cc./HCl (d. 1.19) and 20 cc. H2O 12 hrs. at 130-50° gave 3-6 g. (40%) 2-(4-pyridyl)benzimidazole, m. 219-20° Similar condensation of 7.5 g. of 4,5,1,2-Me2C6H2(NH2)2 with 12 g. III in HCl 20 hrs. at 150-70° yielded 4 g. (30%) 5,6-dimethyl-2-(4-pyridyl)benzimidazole, m. 239-40°.
There is still a lot of research devoted to this compound(SMILES：C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1)SDS of cas: 2208-59-5, and with the development of science, more effects of this compound(2208-59-5) can be discovered.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles