Barnes, Keith D.;Chen, Ping;Chang, Yingyan;Lewis, Robert M.;Manley, Christopher M.;Mayhew, Nicholas J.;Steffke, Stephen H.;Wang, Guixing;Wang, Yi;Yang, Yuh-Lin A.;Lippert, John W. III published 《Lactam coupling as a versatile route to indoprofen analogs》 in 2011. The article was appeared in 《Synthetic Communications》. They have made some progress in their research.Reference of 6-Methoxyisoindolin-1-one The article mentions the following:
A convergent synthesis of indoprofen via a palladium-catalyzed Buchwald-Hartwig cross-coupling approach was reported. Using this methodol., indoprofen and a set of analogs of indoprofen were readily prepared6-Methoxyisoindolin-1-one (cas: 132680-54-7) were involved in the experimental procedure.
The crystal structure of 6-Methoxyisoindolin-1-one(cas:132680-54-7 Reference of 6-Methoxyisoindolin-1-one) has been determined using x-ray crystallography and cell studies. It was found that 6-Methoxyisoindolin-1-one inhibits the interactions of chk1 with substructures of DNA, such as the major groove and minor groove.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles