Xie, Jia-Hao; Zheng, Chao; You, Shu-Li published the artcile< Palladium-Catalyzed Dearomative Methoxyallylation of 3-Nitroindoles with Allyl Carbonates>, Formula: C10H9NO2, the main research area is nitroindole allyl carbonate palladium catalyst dearomative methoxyallylation; methoxy nitro propenyl indole carboxylate diastereoselective preparation; 3-nitroindole; allylic substitution; dearomatization; diastereoselectivity; palladium.
A Pd-catalyzed dearomative methoxyallylation of 3-nitroindoles with readily available allyl carbonates was reported. Good yields (up to 86%) and diastereoselectivity (up to >20:1 dr) were obtained for a wide range of substrates. The compatibility of gram-scale synthesis and the relatively low catalyst loading (down to 1 mol % of [Pd]) enhanced the practicality of this method. The kinetic experiments indicated that the rate-determining step of this reaction was the nucleophilic attack of the alkoxide anion.
Angewandte Chemie, International Edition published new progress about Allylation catalysts, stereoselective. 93247-78-0 belongs to class indole-building-block, and the molecular formula is C10H9NO2, Formula: C10H9NO2.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles